The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
ASPP Proteins Specifically Stimulate the Apoptotic Function of p53
Open accessAbstract
We identified a family of proteins termed ASPP. ASPP1 is a protein homologous to 53BP2, the C-terminal half of ASPP2. ASPP proteins interact with p53 and specifically enhance p53-induced apoptosis but not cell cycle arrest. Inhibition of endogenous ASPP function suppresses the apoptotic function of endogenous p53 in response to apoptotic stimuli. ASPP enhance the DNA binding and transactivation function of p53 on the promoters of proapoptotic genes in vivo. Two tumor-derived p53 mutants with reduced apoptotic function were defective in cooperating with ASPP in apoptosis induction. The expression of ASPP is frequently downregulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP regulate the tumor suppression function of p53 in vivo.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The miR-21 targets we identified included p53 homologue, p63, p53 activators JMY, TOPORS, TP53BP2, DAXX, and HNRPK, which can stabilize p53 protein levels by interfering with MDM2 and/or act as p53 transcriptional cofactors, assisting p53 in transactivating genes that can induce apoptosis and growth arrest (21)(22)(23)(24)(25)(26).”
From MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells (2008) · cites this paper as [23]
Citations
Cites
Antibodies, a laboratory manual
(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318
p53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346
Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2
Gorina, S. S., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.1001 · Cited by 575
Two cellular proteins that bind to wild-type but not mutant p53.
Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R. L., & Fields, S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6098 · Cited by 432
In vivo gene expression profile analysis of human breast cancer progression.
Sgroi, D. C., Teng, S., ROBINSON, G. C., LeVangie, R., Hudson, J. R., & Elkahloun, A. G. (1999) · PubMed · Cited by 390
Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function
Ludwig, R. L., Bates, S., & Vousden, K. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4952 · Cited by 278
Hsieh, J.-K., Fredersdorf, S., Kouzarides, T., Martin, K., & Lü, X. (1997) · Genes & Development · doi:10.1101/gad.11.14.1840 · Cited by 278
Self-citationA Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis
Friedlander, P. A., Haupt, Y., Prives, C. L., & Oren, M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4961 · Cited by 277
Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2
Iwabuchi, K., Li, B., Massa, H. F., Trask, B. J., Date, T., & Fields, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.26061 · Cited by 206
Crook, T., Brooks, L. A., Crossland, S., Osin, P., Barker, K. T., Waller, J., Philp, E., Smith, P. D., Yuluğ, I. G., Peto, J., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1202106 · Cited by 179
Self-citation
Cited by
Sorted by citations
Items 101–200 of 663
Sottocornola, R., Royer, C., Vives, V., Tordella, L., Zhong, S., Wang, Y., Ratnayaka, I., Shipman, M., Cheung, A. F. P., Gaston‐Massuet, C., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.003 · Cited by 121
Self-citationMechanisms of regulatory diversity within the p53 transcriptional network
Espinosa, J. M. (2008) · Oncogene · doi:10.1038/onc.2008.37 · Cited by 115
Autophagic activity dictates the cellular response to oncogenic RAS
Wang, Y., Wang, X. D., Lapi, E., Sullivan, A., Jia, W., He, Y.-W., Ratnayaka, I., Zhong, S., Goldin, R. D., Goemans, C. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120193109 · Cited by 117
Self-citationp53: Twenty five years understanding the mechanism of genome protection
Gómez-Lázaro, M., Fernández-Gómez, F.-J., & Jordán, J. (2004) · Journal of Physiology and Biochemistry · doi:10.1007/bf03167075 · Cited by 119
Mutant p53 targeting by the low molecular weight compound STIMA‐1
Zache, N., Lambert, J. M. R., Rökaeus, N., Shen, J., Hainaut, P. L., Bergman, J., Wiman, K. G., & Bykov, V. J. N. (2008) · Molecular Oncology · doi:10.1016/j.molonc.2008.02.004 · Cited by 120
p53 downstream target genes and tumor suppression: a classical view in evolution
Rozan, L. M., & El‐Deiry, W. S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402058 · Cited by 118
DNA Binding Cooperativity of p53 Modulates the Decision between Cell-Cycle Arrest and Apoptosis
Schlereth, K., Beinoraviciute-Kellner, R., Zeitlinger, M. K., Bretz, A. C., Sauer, M., Charles, J. P., Vogiatzi, F., Leich, E., Samans, B., Eilers, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.037 · Cited by 113
Cytoplasmic ASPP1 inhibits apoptosis through the control of YAPPreprint
Vigneron, A. M., Ludwig, R. L., & Vousden, K. H. (2010) · Genes & Development · doi:10.1101/gad.1954310 · Cited by 115
Pharmacogenomic Discovery Using Cell-Based Models
Welsh, M. M., Mangravite, L. M., Medina, M. W., Tantisira, K. G., Zhang, W., Huang, R. S., McLeod, H. L., & Dolan, M. E. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001461 · Cited by 113
E2F1-induced apoptosis: turning killers into therapeutics
Stanelle, J., & Pützer, B. M. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.02.002 · Cited by 112
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
Koldobskiy, M. A., Chakraborty, A., Werner, J. K., Snowman, A. M., Juluri, K. R., Vandiver, M. S., Kim, S., Heletz, S., & Snyder, S. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015671107 · Cited by 112
The C Terminus of p53 Family Proteins Is a Cell Fate Determinant
Harms, K. L., & Chen, X. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.2014-2030.2005 · Cited by 109
Zhao, J., Wu, G., Bu, F., Lü, B., Liang, A., Cao, L., Tong, X., Lü, X., Wu, M., & Guo, Y. (2009) · Hepatology · doi:10.1002/hep.23247 · Cited by 109
Phelps, M., Darley, M., Primrose, J. N., & Blaydes, J. P. (2003) · PubMed · Cited by 109
Hershko, T., Chaussepied, M., Oren, M., & Ginsberg, D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401575 · Cited by 107
Genetic polymorphisms and treatment response in advanced non-small cell lung cancer
Su, D., Ma, S., Liu, P., Jiang, Z., Lv, W., Zhang, Y., Deng, Q., Smith, S., & Yu, H. (2007) · Lung Cancer · doi:10.1016/j.lungcan.2006.12.002 · Cited by 106
Regulation of p53 - insights into a complex process
Boehme, K. A., & Blattner, C. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903401507 · Cited by 107
ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growthPreprint
Vives, V., Su, J., Zhong, S., Ratnayaka, I., Slee, E. A., Goldin, R. D., & Lü, X. (2006) · Genes & Development · doi:10.1101/gad.374006 · Cited by 105
Self-citationZbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation
Weber, A., Marquardt, J., Elzi, D. J., Forster, N., Starke, S., Glaum, A., Yamada, D., Defossez, P., Delrow, J. J., Eisenman, R. N., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.85 · Cited by 104
Structural evolution of C‐terminal domains in the p53 family
Ou, H. D., Löhr, F., Vogel, V., Mäntele, W., & Dötsch, V. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601764 · Cited by 108
Molecular biology of cantharidin in cancer cells
Rauh, R., Kahl, S., Boechzelt, H. G., Bauer, R., Kaina, B., & Efferth, T. (2007) · Chinese Medicine · doi:10.1186/1749-8546-2-8 · Cited by 101
Regulation of the p53 transcriptional activity
Liu, G., & Chen, X. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20700 · Cited by 100
Aylon, Y., Ofir-Rosenfeld, Y., Yabuta, N., Lapi, E., Nojima, H., Lü, X., & Oren, M. (2010) · Genes & Development · doi:10.1101/gad.1954410 · Cited by 100
CagA-mediated pathogenesis of Helicobacter pylori
Tohidpour, A. (2016) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.01.005 · Cited by 100
Kato, I., Maita, H., Takahashi-Niki, K., Saito, Y., Noguchi, N., Iguchi‐Ariga, S. M. M., & Ariga, H. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.01350-12 · Cited by 98
Liu, K., Shi, Y., Guo, X., Wang, S., Ouyang, Y., Hao, M., Liu, D., Qiao, L., Li, N., Zheng, J., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.276 · Cited by 99
A new p38 MAP kinase‐regulated transcriptional coactivator that stimulates p53‐dependent apoptosis
Cuadrado, A., Lafarga, V., Cheung, P., Dolado, I., Llanos, S., Cohen, P., & Nebreda, Á. R. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601657 · Cited by 101
p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics
Hafner, A., Stewart-Ornstein, J., Purvis, J. E., Forrester, W. C., Bulyk, M. L., & Lahav, G. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3452 · Cited by 94
Regulation of the p14ARF-Mdm2-p53 pathway: An overview in breast cancer
Agrawal, A., Yang, J., Murphy, R. F., & Agrawal, D. K. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2006.07.001 · Cited by 95
Some p53-binding proteins that can function as arbiters of life and death
Braithwaite, A. W., Sal, G. D., & Lü, X. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401924 · Cited by 96
Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library
Shiraishi, K., Kato, S., Han, S., Liu, W., Otsuka, K., Sakayori, M., Ishida, T., Takeda, M., Kanamaru, R., Ohuchi, N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310815200 · Cited by 95
Ozaki, T., Wu, D., Sugimoto, H., Nagase, H., & Nakagawara, A. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.127 · Cited by 92
Death-associated Protein 4 Binds MST1 and Augments MST1-induced Apoptosis
Lin, Y., Khokhlatchev, A. V., Figeys, D., & Avruch, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202630200 · Cited by 92
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF–Cohesin bindingPreprint
Gomes, N. P., & Espinosa, J. M. (2010) · Genes & Development · doi:10.1101/gad.1881010 · Cited by 94
Schlereth, K., Heyl, C., Krampitz, A.-M., Mernberger, M., Finkernagel, F., Scharfe, M., Jarek, M., Leich, E., Rosenwald, A., & Stiewe, T. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003726 · Cited by 87
NAD+ Modulates p53 DNA Binding Specificity and Function
McLure, K. G., Takagi, M., & Kastan, M. B. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9958-9967.2004 · Cited by 89
Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation
Mistriotis, P., & Andreadis, S. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.006 · Cited by 89
Restoration of wild‐type p53 function in human cancer: Relevance for tumor therapy
Bossi, G., & Sacchi, A. (2007) · Head & Neck · doi:10.1002/hed.20529 · Cited by 86
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressorPreprint
Stegh, A. H., Brennan, C., Mahoney, J. E., Forloney, K. L., Jenq, H. T., Luciano, J. P., Protopopov, A. I., Chin, L., & DePinho, R. A. (2010) · Genes & Development · doi:10.1101/gad.1924710 · Cited by 88
Versatile functions of p53 protein in multicellular organisms
Chumakov, P. M. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907130019 · Cited by 85
Global dissociation of HuR–mRNA complexes promotes cell survival after ionizing radiation
Masuda, K., Abdelmohsen, K., Kim, M. M., Srikantan, S., Lee, E. K., Tominaga, K., Selimyan, R., Martindale, J. L., Yang, X., Lehrmann, E., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.24 · Cited by 85
Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to p53, p63, and p73
Robinson, R. A., Lü, X., Jones, E. Y., & Siebold, C. (2008) · Structure · doi:10.1016/j.str.2007.11.012 · Cited by 82
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq
Tomalty, K. M. H., Meek, M. H., Stephens, M. R., Rincón, G., Fangue, N. A., May, B. P., & Baerwald, M. R. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.017699 · Cited by 86
Wilson‐Grady, J., Haas, W., & Gygi, S. P. (2013) · Methods · doi:10.1016/j.ymeth.2013.03.031 · Cited by 80
Therapeutic targeting of p53 by small molecules
Selivanova, G. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.02.006 · Cited by 84
p53, apoptosis and axon-guidance molecules
Arakawa, H. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401601 · Cited by 86
Menendez, D., Inga, A., & Resnick, M. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2297-2308.2006 · Cited by 81
A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo
Bell, H. S., Dufès, C., O’Prey, J., Crighton, D., Bergamaschi, D., Lü, X., Schätzlein, A. G., Vousden, K. H., & Ryan, K. M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28920 · Cited by 80
Self-citationRetrograde signaling from autophagy modulates stress responses
Simon, H., Friis, R. R., Tait, S. W. G., & Ryan, K. M. (2017) · Science Signaling · doi:10.1126/scisignal.aag2791 · Cited by 79
The Transcriptional Repressor hDaxx Potentiates p53-dependent Apoptosis
Gostissa, M., Morelli, M., Mantovani, F., Guida, E., Piazza, S., Collavin, L., Brancolini, C., Schneider, C., & Sal, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310801200 · Cited by 79
A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway
Lu, M. M., Žák, J., Chen, S., Sánchez‐Pulido, L., Severson, D. T., Endicott, J., Ponting, C. P., Schofield, C. J., & Lü, X. (2014) · Cell · doi:10.1016/j.cell.2014.05.006 · Cited by 76
The Role of microRNA-21 in the Onset and Progression of Cancer
Singh, A. K., Singh, A. K., Giri, R., Kumar, D., Sharma, R., Vališ, M., Kuča, K., & Garg, N. (2021) · Future Medicinal Chemistry · doi:10.4155/fmc-2021-0096 · Cited by 81
Mori, S., Ito, G., Usami, N., Yoshioka, H., Ueda, Y., Kodama, Y., Takahashi, M., Fong, K. M., Shimokata, K., & Sekido, Y. (2004) · Cancer · doi:10.1002/cncr.20164 · Cited by 76
What have animal models taught us about the p53 pathway?
Lozano, G., & Zambetti, G. P. (2005) · The Journal of Pathology · doi:10.1002/path.1704 · Cited by 78
Bosch, F. X., Ritter, D., Enders, C., Flechtenmacher, C., Abel, U. R., Dietz, A., Hergenhahn, M., & Weidauer, H. (2004) · International Journal of Cancer · doi:10.1002/ijc.11698 · Cited by 75
Cell and tissue responses to genotoxic stress
Coates, P. J., Lorimore, S. A., & Wright, E. G. (2005) · The Journal of Pathology · doi:10.1002/path.1701 · Cited by 77
RNA content in the nucleolus alters p53 acetylation via MYBBP1A
Kuroda, T., Murayama, A., Katagiri, N., Ohta, Y., Fujita, E., Masumoto, H., Ema, M., Takahashi, S., Kimura, K., & Yanagisawa, J. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.23 · Cited by 77
Rozenfeld-Granot, G., Krishnamurthy, J., Kannan, K., Toren, A., Amariglio, N., Givol, D., & Rechavi, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205218 · Cited by 72
Whole-genome cartography of p53 response elements ranked on transactivation potential
Tebaldi, T., Zaccara, S., Alessandrini, F., Bisio, A., Ciribilli, Y., & Inga, A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1643-9 · Cited by 72
TP53 Mutations in Human Cancer: Database Reassessment and Prospects for the Next Decade
Soussi, T. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-386469-7.00005-0 · Cited by 77
iASPP and Chemoresistance in Ovarian Cancers: Effects on Paclitaxel-Mediated Mitotic Catastrophe
Jiang, L., Siu, M. K. Y., Wong, O. G., Tam, K.-F., Lü, X., Lam, E. W. ‐., Ngan, H., Le, X., Wong, E. S. Y., Monteiro, L. J., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0588 · Cited by 75
The p53 response: Emerging levels of co-factor complexity
Coutts, A. S., & La Thangue, N. B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.150 · Cited by 72
Zhang, X. P., Liu, F., & Wang, W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.134650 · Cited by 73
Regulation of p53 by TopBP1: a Potential Mechanism for p53 Inactivation in Cancer
Liu, K., Bellam, N., Lin, H., Wang, B., Stockard, C. R., Grizzle, W. E., & Lin, W.-C. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01140-08 · Cited by 70
TP53 mutations in familial breast cancer: Functional aspects
Gasco, M., Yuluğ, I. G., & Crook, T. (2003) · Human Mutation · doi:10.1002/humu.10173 · Cited by 71
Self-citationHällgren, O., Aits, S., Brest, P., Gustafsson, L., Mossberg, A., Wullt, B., & Svanborg, C. (2007) · Springer eBooks · doi:10.1007/978-0-387-74087-4_8 · Cited by 71
Shen, Y., Takahashi, M., Byun, H., Link, A., Sharma, N., Balaguer, F., Leung, H.-C., Boland, C. R., & Goel, A. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.19604 · Cited by 70
lncRNA MEG3 had anti-cancer effects to suppress pancreatic cancer activity
Gu, L., Zhang, J., Shi, M., Zhan, Q., Shen, B., & Peng, C. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.041 · Cited by 70
p53: a heavily dictated dictator of life and death
Lü, X. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.12.008 · Cited by 69
Requirement of clathrin heavy chain for p53-mediated transcriptionPreprint
Enari, M., Ohmori, K., Kitabayashi, I., & Taya, Y. (2006) · Genes & Development · doi:10.1101/gad.1381906 · Cited by 71
Hudson, C. D., Morris, P. J., Latchman, D. S., & Budhram-Mahadeo, V. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408679200 · Cited by 68
Wu, D., Ozaki, T., Yoshihara, Y., Kubo, N., & Nakagawara, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.402594 · Cited by 69
Sinha, S., Malonia, S. K., Mittal, S. P. K., Singh, K., Sreenath, K., Kamat, R. H., Mukhopadhyaya, R., Pal, J. K., & Chattopadhyay, S. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.395 · Cited by 67
Structure of the Helicobacter pylori CagA oncoprotein bound to the human tumor suppressor ASPP2
Nes̆ić, D., Buti, L., Lü, X., & Stebbins, C. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320631111 · Cited by 67
Agirre, X., Román‐Gómez, J., Jiménez‐Velasco, A., Gárate, L., Montiel‐Duarte, C., Navarro, G., Vázquez, I., Zalacaín, M., Calasanz, M. J., Heiniger, A., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209236 · Cited by 67
Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage
Logan, I. R., McNeill, H. V., Cook, S., Lü, X., Meek, D. W., Fuller-Pace, F. V., Lunec, J., & Robson, C. N. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp180 · Cited by 68
Wild type p53 reactivation: From lab bench to clinic
Selivanova, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.049 · Cited by 68
Chen, J., Xie, F., Zhang, L., & Jiang, W. G. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-694 · Cited by 64
Swan, A., Stekel, D. J., Hodgman, C. T., Allaway, D., Al-Qahtani, M. H., Mobasheri, A., & Bacardit, J. (2015) · BMC Genomics · doi:10.1186/1471-2164-16-s1-s2 · Cited by 61
Implications of apoptosis regulators in tumorigenesis
Malaguarnera, L. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031774.32572.df · Cited by 61
ASPP1 and ASPP2 bind active RAS, potentiate RAS signalling and enhance p53 activity in cancer cells
Wang, Y., Godin-Heymann, N., WANG, X.-D., Bergamaschi, D., Llanos, S., & Lü, X. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.3 · Cited by 60
Self-citationE2F1 death pathways as targets for cancer therapy
Pützer, B. M. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00030.x · Cited by 60
Ohki, R., Kawase, T., Ohta, T., Ichikawa, H., & Taya, Y. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00375.x · Cited by 64
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway
Dhanaraman, T., Singh, S., Killoran, R. C., Singh, A., Xu, X., Shifman, J. M., & Smith, M. J. (2020) · Science Signaling · doi:10.1126/scisignal.abb4778 · Cited by 59
The dual role of p53: DNA protection and antioxidant
Borrás, C., Gómez‐Cabrera, M. C., & Viña, J. (2011) · Free Radical Research · doi:10.3109/10715762.2011.571685 · Cited by 58
Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene
Chen, D., Padiernos, E., Ding, F., Lossos, I. S., & Lopez, C. D. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401536 · Cited by 59
Role for Krüppel-Like Factor 4 in Determining the Outcome of p53 Response to DNA Damage
Zhou, Q., Yuan, H., Zhan, Q., Shen, Y., & Liu, Z. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1345 · Cited by 58
Qian, Y., Jung, Y.-S., & Chen, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203185109 · Cited by 59
P53 transcriptional activities: A general overview and some thoughts
Millau, J., Bastien, N., & Drouin, R. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.002 · Cited by 65
Tied Up in Loops: Positive and Negative Autoregulation of p53Preprint
Lü, X. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000984 · Cited by 58
Wang, Z., Liu, Y., Takahashi, M., Hook, K. V., Kampa-Schittenhelm, K. M., Sheppard, B. C., Sears, R. C., Stork, P. A., & Lopez, C. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201514110 · Cited by 57
Shaked, H., Shiff, I., Kott-Gutkowski, M., Siegfried, Z., Haupt, Y., & Simon, I. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0865 · Cited by 57
Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer
Koster, R., van Vugt, M. A. T. M., Timmer‐Bosscha, H., Gietema, J. A., & de Jong, S. (2013) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2013.13 · Cited by 58
Buti, L., Ruiz‐Puig, C., Sangberg, D., Leissing, T. M., Brewer, R. C., Owen, R. P., Sgromo, B., Royer, C., Ebner, D. V., & Lü, X. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908787117 · Cited by 60
ASPP1 and ASPP2 are new transcriptional targets of E2F
Fogal, V., Kartasheva, N. N., Trigiante, G., Llanos, S., Yap, D., Vousden, K. H., & Lü, X. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401562 · Cited by 57
Self-citationBatta, K., & Kundu, T. K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01064-07 · Cited by 55
Testicular germ cell tumours: The paradigm of chemo-sensitive solid tumours
di Pietro, A., de Vries, E. G. E., Gietema, J. A., Spierings, D. C. J., & de Jong, S. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.06.014 · Cited by 57
The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
Slee, E. A., Gillotin, S., Bergamaschi, D., Royer, C., Llanos, S., Ali, S., Jin, B., Trigiante, G., & Lü, X. (2004) · Oncogene · doi:10.1038/sj.onc.1208088 · Cited by 56
Self-citationSplicing DNA-damage responses to tumour cell death
Crighton, D., & Ryan, K. M. (2004) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2004.09.001 · Cited by 56
Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73
Kawahara, M., Hori, T., Chonabayashi, K., Oka, T., Sudol, M., & Uchiyama, T. (2008) · Blood · doi:10.1182/blood-2007-09-111773 · Cited by 56
Metadata
- Authors
- Samuels-Lev, Y., O'Connor, D. J., Bergamaschi, D., Trigiante, G., Hsieh, J.-K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., & Lu, X.
- Affiliations
- Ludwig Cancer Research (GB)
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 8
- Issue
- 4
- Pages
- 781-794
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2087732778
- Cited by
- 664
- References
- 22
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 15 · 2023: 20 · 2022: 16 · 2021: 26 · 2020: 13 · 2019: 20 · 2018: 8 · 2017: 27 · 2016: 18 · 2015: 23 · 2014: 37 · 2013: 35 · 2012: 31
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- ASPP1, ASPP2, p53, apoptosis, p53 DNA binding, p53 transactivation, tumor suppression, breast cancer, mutant p53, cell cycle arrest
- MeSH terms
- Breast Neoplasms, Carcinoma, Carrier Proteins, Cell Separation, Female, Flow Cytometry, Humans, Microscopy, Fluorescence, Molecular Sequence Data, Peptide Fragments, Promoter Regions, Genetic, Proto-Oncogene Proteins, Tumor Cells, Cultured, Transcriptional Activation, Tumor Suppressor Protein p53, Cyclins, Apoptosis, Protein Structure, Tertiary, Proto-Oncogene Proteins c-bcl-2, Cyclin-Dependent Kinase Inhibitor p21, Apoptosis Regulatory Proteins, bcl-2-Associated X Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review