Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 416

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Proteases Acting on Mutant Huntingtin Generate Cleaved Products that Differentially Build Up Cytoplasmic and Nuclear Inclusions

Open access
Lunkes, Astrid, Lindenberg, Katrin S., Ben-Haı̈em, Léa, Weber, Chantal, Devys, Didier, Landwehrmeyer, G.Bernhard, Mandel, Jean-Louis, Trottier, Yvon·2002·Molecular Cell
DOI 10.1016/s1097-2765(02)00602-0
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s1097-2765(02)00602-0

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 35

  1. Barrett, 2001, The MEROPS database as a protease information system, J. Struct. Biol., 134, 95, 10.1006/jsbi.2000.4332 · DOI
  2. Bence, 2001, Impairment of the ubiquitin-proteasome system by protein aggregation, Science, 292, 1552, 10.1126/science.292.5521.1552 · DOI · Paper page
  3. Craig, 2002, A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export, EMBO J., 21, 31, 10.1093/emboj/21.1.31 · DOI
  4. Davies, 1997, Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation, Cell, 90, 537, 10.1016/S0092-8674(00)80513-9 · DOI · Paper page
  5. Di Figlia, 1997, Aggregation of Huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain, Science, 277, 1990, 10.1126/science.277.5334.1990 · DOI · Paper page
  6. Dorsman, 1999, Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin, Philos. Trans. R. Soc. Lond. B Biol. Sci., 354, 1061, 10.1098/rstb.1999.0459 · DOI
  7. Duncan, 1997, Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2, J. Biol. Chem., 272, 12778, 10.1074/jbc.272.19.12778 · DOI · Paper page
  8. Duncan, 1998, Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning, J. Biol. Chem., 273, 17801, 10.1074/jbc.273.28.17801 · DOI · Paper page
  9. Dyer, 2001, Mutant protein in Huntington disease is resistant to proteolysis in affected brain, Nat. Genet., 29, 270, 10.1038/ng745 · DOI
  10. Gutekunst, 1999, Nuclear and neuropil aggregates in Huntington's disease, J. Neurosci., 19, 2522, 10.1523/JNEUROSCI.19-07-02522.1999 · DOI · Paper page
  11. Hackam, 1998, The influence of huntingtin protein size on nuclear localization and cellular toxicity, J. Cell Biol., 141, 1097, 10.1083/jcb.141.5.1097 · DOI · Paper page
  12. Hackam, 1999, In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease, Hum. Mol. Genet., 8, 25, 10.1093/hmg/8.1.25 · DOI
  13. Hazeki, 2000, Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract, Biochem. Biophys. Res. Commun., 277, 386, 10.1006/bbrc.2000.3682 · DOI
  14. Hodgson, 1999, A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration, Neuron, 23, 181, 10.1016/S0896-6273(00)80764-3 · DOI · Paper page
  15. Jana, 2001, Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release, Hum. Mol. Genet., 10, 1049, 10.1093/hmg/10.10.1049 · DOI · Paper page
  16. Kegel, 2000, Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy, J. Neurosci., 20, 7268, 10.1523/JNEUROSCI.20-19-07268.2000 · DOI · Paper page
  17. Kim, 2001, Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis, Proc. Natl. Acad. Sci. USA, 98, 12784, 10.1073/pnas.221451398 · DOI · Paper page
  18. Klement, 1998, Ataxin-1 nuclear localization and aggregation, Cell, 95, 41, 10.1016/S0092-8674(00)81781-X · DOI · Paper page
  19. Lichtenthaler, 1999, Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein, Proc. Natl. Acad. Sci. USA, 96, 3053, 10.1073/pnas.96.6.3053 · DOI · Paper page
  20. Lunkes, 1998, A cellular model that recapitulates major pathogenic steps of Huntington's disease, Hum. Mol. Genet., 7, 1355, 10.1093/hmg/7.9.1355 · DOI · Paper page
  21. Lunkes, 2000, Cellular models of Huntington's disease, Neuroscience News, 3, 30
  22. Lunkes, 1999, Properties of polyglutamine expansion in vitro and in a cellular model for Huntington's disease, Philos. Trans. R. Soc. Lond. B Biol. Sci., 354, 1013, 10.1098/rstb.1999.0453 · DOI
  23. Nakamura, 2001, SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein, Hum. Mol. Genet., 10, 1441, 10.1093/hmg/10.14.1441 · DOI · Paper page
  24. Perez, 1998, Recruitment and the role of nuclear localisation in polyglutamine-mediated aggregation, J. Cell Biol., 14, 1457, 10.1083/jcb.143.6.1457 · DOI · Paper page
  25. Perutz, 1994, Glutamine repeats as polar zippers, Proc. Natl. Acad. Sci. USA, 91, 5355, 10.1073/pnas.91.12.5355 · DOI · Paper page
  26. Sisodia, 1992, Beta-amyloid precursor protein cleavage by a membrane-bound protease, Proc. Natl. Acad. Sci. USA, 89, 6075, 10.1073/pnas.89.13.6075 · DOI · Paper page
  27. Steffan, 2000, The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription, Proc. Natl. Acad. Sci. USA, 97, 6763, 10.1073/pnas.100110097 · DOI · Paper page
  28. Suhr, 2001, Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression, J. Cell Biol., 153, 283, 10.1083/jcb.153.2.283 · DOI · Paper page
  29. Trottier, 1995, Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form, Nat. Genet., 10, 104, 10.1038/ng0595-104 · DOI · Paper page
  30. Trottier, 1995, Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias, Nature, 378, 403, 10.1038/378403a0 · DOI · Paper page
  31. Vonsattel, 1985, Neuropathological classification of Huntington's disease, J. Neuropathol. Exp. Neurol., 44, 559, 10.1097/00005072-198511000-00003 · DOI · Paper page
  32. Wellington, 2000, Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells, J. Biol. Chem., 275, 19831, 10.1074/jbc.M001475200 · DOI · Paper page
  33. Wheeler, 2000, Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice, Hum. Mol. Genet., 9, 503, 10.1093/hmg/9.4.503 · DOI · Paper page
  34. Yamamoto, 2000, Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease, Cell, 101, 57, 10.1016/S0092-8674(00)80623-6 · DOI · Paper page
  35. Zoghbi, 2000, Glutamine repeats and neurodegeneration, Annu. Rev. Neurosci., 23, 217, 10.1146/annurev.neuro.23.1.217 · DOI · Paper page

Cited by

See all 416

Metadata

Authors
Lunkes, A., Lindenberg, K. S., Ben-Haı̈em, L., Weber, C., Devys, D., Landwehrmeyer, G. B., Mandel, J.-L., & Trottier, Y.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2002-08
Volume
10
Issue
2
Pages
259-269
ISSN
1097-2765 (ISSN-L)
DOI
10.1016/s1097-2765(02)00602-0
OpenAlex
W2134783787
Cited by
416
References
2
FWCI
9.49
Type
journal article
Language
en
Open access
bronze
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Proteases Acting on Mutant Huntingtin Generate Cleaved Products that Differentially Build Up Cytoplasmic and Nuclear Inclusions. https://app.cochat.ai/papers/10.1016/s1097-2765(02)00602-0
The paper
Lunkes, A., Lindenberg, K. S., Ben-Haı̈em, L., Weber, C., Devys, D., Landwehrmeyer, G. B., Mandel, J.-L., & Trottier, Y. (2002). Proteases Acting on Mutant Huntingtin Generate Cleaved Products that Differentially Build Up Cytoplasmic and Nuclear Inclusions. Molecular Cell. https://doi.org/10.1016/s1097-2765(02)00602-0

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.