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Ubiquitin Recognition by the Human TSG101 Protein

Sundquist, Wesley I., Schubert, Heidi L., Kelly, Brian N., Hill, Gina C., Holton, James M., Hill, Christopher P.·2004·Molecular Cell
DOI 10.1016/s1097-2765(04)00129-7
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  • The ESCRT complex interacts with proteins carrying P(S/T)AP and/or PPXY motifs; P(S/T)AP binds TSG101, which binds ALIX, while NEDD4-E3 ligases recruited via PPXY motifs and subsequent ubiquitination facilitate ESCRT recruitment.

    “It is well established that the ESCRT complex interacts with proteins carrying P(S/T)AP and/or PPXY motifs. The P(S/T)AP domain binds to TSG101, which in turn binds ALIX20, while recruitment of NEDD4-E3 ligases via PPXY motifs, and subsequent protein ubiquitination, further facilitates the recruitment of the ESCRT machinery21.”

    From TMEM55B links autophagy flux, lysosomal repair, and TFE3 activation in response to oxidative stress (2024) · cites this paper as [20]

    The Results and Discussion describe TSG101 binding P(T/S)AP motifs and ubiquitin, potentially linking ESCRT-I to ubiquitylated cargo. The copy does not describe PPXY-mediated recruitment of NEDD4-E3 ligases or establish the claimed sequence from their recruitment through ubiquitination to ESCRT recruitment (searched: PPXY, NEDD4). The ALIX statement has a separate citation in the citing sentence. (LLM, conf=0.82)

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Research works printed but not linked: 57

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Metadata

Authors
Sundquist, W. I., Schubert, H. L., Kelly, B. N., Hill, G. C., Holton, J. M., & Hill, C. P.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2004-03
Volume
13
Issue
6
Pages
783-789
ISSN
1097-2765
DOI
10.1016/s1097-2765(04)00129-7
Cited by
223
References
1
Language
en
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