Effects of processing parameters in thermally induced phase separation technique on porous architecture of scaffolds for bone tissue engineering
Abstract
Tissue engineering makes use of 3D scaffolds to sustain three-dimensional growth of cells and guide new tissue formation. To meet the multiple requirements for regeneration of biological tissues and organs, a wide range of scaffold fabrication techniques have been developed, aiming to produce porous constructs with the desired pore size range and pore morphology. Among different scaffold fabrication techniques, thermally induced phase separation (TIPS) method has been widely used in recent years because of its potential to produce highly porous scaffolds with interconnected pore morphology. The scaffold architecture can be closely controlled by adjusting the process parameters, including polymer type and concentration, solvent composition, quenching temperature and time, coarsening process, and incorporation of inorganic particles. The objective of this review is to provide information pertaining to the effect of these parameters on the architecture and properties of the scaffolds fabricated by the TIPS technique.
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Owing to effectual control over morphological features such as average pore size, hierarchical porous architecture, and interconnection of pores, TIPS has drawn great attention in recent years for the preparation of scaffolds.
“Owing to the effectual control over the morphological features like the average size of the pores, hierarchical porous architecture, interconnection of pores, etc of the scaffold, TIPS has drawn great attention in recent years for the preparation of scaffolds [88].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [88]
Cites
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893 · see citing works
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639 · see citing works
Electrospinning: A fascinating fiber fabrication technique
Bhardwaj, N., & Kundu, S. C. (2010) · Biotechnology Advances · doi:10.1016/j.biotechadv.2010.01.004 · Cited by 5,054 · see citing works
Scaffolds in tissue engineering bone and cartilage
Hutmacher, D. W. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00121-6 · Cited by 5,002 · see citing works
Porous scaffold design for tissue engineering
Hollister, S. J. (2005) · Nature Materials · doi:10.1038/nmat1421 · Cited by 3,979 · see citing works
Biological materials: Structure and mechanical properties
Meyers, M. A., Chen, P.-Y., Lin, A. Y.-M., & Seki, Y. (2008) · Progress in Materials Science · doi:10.1016/j.pmatsci.2007.05.002 · Cited by 2,573 · see citing works
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering
Yoshimoto, H., Shin, Y.-S., Terai, H., & Vacanti, J. P. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00635-x · Cited by 1,975 · see citing works
Polymeric Scaffolds in Tissue Engineering Application: A Review
Dhandayuthapani, B., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · International Journal of Polymer Science · doi:10.1155/2011/290602 · Cited by 1,773 · see citing works
Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering
Williams, J. M., Adewunmi, A., Schek, R. M., Flanagan, C. L., Krebsbach, P. H., Feinberg, S. E., Hollister, S. J., & Das, S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.057 · Cited by 1,566 · see citing works
Hutmacher, D. W., Schantz, T., Zein, I., Ng, K. W., Teoh, S. H., & Tan, K. C. (2001) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(200105)55:2 · Cited by 1,438 · see citing works
Polymeric Scaffolds for Bone Tissue Engineering
Liu, X., & Ma, P. X. (2004) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000017544.36001.8e · Cited by 1,346 · see citing works
Sachlos, E., & Czernuszka, J. T. (2003) · European Cells and Materials · doi:10.22203/ecm.v005a03 · Cited by 1,305 · see citing works
Wei, G., & Ma, P. X. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.12.005 · Cited by 1,271 · see citing works
Hutmacher, D. W., Sittinger, M., & Risbud, M. V. (2004) · Trends in biotechnology · doi:10.1016/j.tibtech.2004.05.005 · Cited by 1,124 · see citing works
Polymeric materials for bone and cartilage repair
Puppi, D., Chiellini, E., Piras, A. M., & Chiellini, E. (2010) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.01.006 · Cited by 913 · see citing works
Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering
Kim, S. S., Park, M. S., Jeon, O., Choi, C. Y., & Kim, B. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.08.016 · Cited by 766 · see citing works
Guan, J., Fujimoto, K. L., Sacks, M. S., & Wagner, W. R. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.018 · Cited by 705 · see citing works
Biomimetic nanofibrous scaffolds for bone tissue engineering
Holzwarth, J. M., & Ma, P. X. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.009 · Cited by 648 · see citing works
A review on biodegradable polymeric materials for bone tissue engineering applications
Sabir, M. I., Xu, X., & Li, L. (2009) · Journal of Materials Science · doi:10.1007/s10853-009-3770-7 · Cited by 641 · see citing works
A novel method to fabricate bioabsorbable scaffolds
Whang, K., Thomas, C. H., Healy, K. E., & Nuber, G. (1995) · Polymer · doi:10.1016/0032-3861(95)93115-3 · Cited by 639 · see citing works
Johnson, A. J. W., & Herschler, B. A. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.012 · Cited by 632 · see citing works
Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering
Habraken, W. J. E. M., Wolke, J. G. C., & Jansen, J. A. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.03.011 · Cited by 565 · see citing works
Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering
Liu, X., Callahan, L. A. S., Hu, J., & Ma, P. X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.068 · Cited by 540 · see citing works
Eshraghi, S., & Das, S. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.02.002 · Cited by 525 · see citing works
Preparation of porous scaffolds by using freeze-extraction and freeze-gelation methods
Ho, M.-H., Kuo, P.-Y., Hsieh, H.-J., Hsien, T.-Y., Hou, L.-T., Lai, J.-Y., & Wang, D.-M. (2004) · Biomaterials · doi:10.1016/s0142-9612(03)00483-6 · Cited by 484 · see citing works
Biodegradable polymers applied in tissue engineering research: a review
Martina, M., & Hutmacher, D. W. (2006) · Polymer International · doi:10.1002/pi.2108 · Cited by 449 · see citing works
Phase separation, pore structure, and properties of nanofibrous gelatin scaffolds
Liu, X., & Ma, P. X. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.04.024 · Cited by 446 · see citing works
Biodegradable polymeric microcellular foams by modified thermally induced phase separation method
Nam, Y. S., & Park, T. G. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00073-3 · Cited by 405 · see citing works
Three-dimensional nano-HAp/collagen matrix loading with osteogenic cells in organ culture
Du, C., Cui, F. Z., Zhu, X. D., & de Groot, K. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19990315)44:4 · Cited by 365 · see citing works
Jones, A. C., Arns, C. H., Hutmacher, D. W., et al. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.10.056 · Cited by 348 · see citing works
Microtubular architecture of biodegradable polymer scaffolds
Ma, P. X., & Zhang, R. (2001) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(20010915)56:4 · Cited by 343 · see citing works
Feasibility study of a natural crosslinking reagent for biological tissue fixation
Sung, H., Huang, R., Huang, L. L. H., Tsai, C.-C., & Chiu, C.-T. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19981215)42:4 · Cited by 307 · see citing works
Fundamentals of Biomechanics in Tissue Engineering of Bone
Athanasiou, K. A., Zhu, C. F., Lanctot, D. R., Agrawal, C. M., & Wang, X. (2000) · Tissue Engineering · doi:10.1089/107632700418083 · Cited by 301 · see citing works
Schugens, C., Maquet, V., Grandfils, C., et al. (1996) · Polymer · doi:10.1016/0032-3861(96)87287-9 · Cited by 271 · see citing works
Engineering porous scaffolds using gas-based techniques
Dehghani, F., & Annabi, N. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.04.005 · Cited by 256 · see citing works
Cloud-point curves of polymer solutions from thermooptical measurements
Bae, Y. C., Lambert, S. M., Soane, D. S., & Prausnitz, J. M. (1991) · Macromolecules · doi:10.1021/ma00015a024 · Cited by 249 · see citing works
Engineering thick tissues - the vascularisation problem
Ko, H., MILTHORPE, B. K., & McFarland, C. D. (2007) · European Cells and Materials · doi:10.22203/ecm.v014a01 · Cited by 238 · see citing works
Mondrinos, M. J., Dembzynski, R. S., Lu, L., BYRAPOGU, V., Wootton, D. M., Lelkes, P. I., & Zhou, J. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.049 · Cited by 225 · see citing works
Phase separation induced ordered patterns in thin polymer blend films
Xue, L., Zhang, J., & Han, Y. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.09.001 · Cited by 220 · see citing works
Biphasic Calcium Phosphate Ceramics for Bone Regeneration and Tissue Engineering Applications
Lobo, S. E., & Arinzeh, T. L. (2010) · Materials · doi:10.3390/ma3020815 · Cited by 215 · see citing works
Guilak, F. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03080.x · Cited by 211 · see citing works
Hierarchical starch-based fibrous scaffold for bone tissue engineering applications
Martins, A. M., Chung, S., Pedro, A. J., Sousa, R. A., Marques, A. P., Reis, R. L., & Neves, N. M. (2008) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.132 · Cited by 207 · see citing works
Advances in Polymeric Systems for Tissue Engineering and Biomedical Applications
Ravichandran, R., Sundarrajan, S., Venugopal, J. R., Mukherjee, S., & Ramakrishna, S. (2012) · Macromolecular Bioscience · doi:10.1002/mabi.201100325 · Cited by 202 · see citing works
Jee, S.-S., Thula, T. T., & Gower, L. B. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.03.036 · Cited by 189 · see citing works
Nejati, E., Mirzadeh, H., & Zandi, M. (2008) · Composites Part A Applied Science and Manufacturing · doi:10.1016/j.compositesa.2008.05.018 · Cited by 187 · see citing works
Cui, Y., Liu, Y., Cui, Y., Jing, X., Zhang, P., & Chen, X. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.03.024 · Cited by 186 · see citing works
Bone tissue engineering: from bench to bedside
Woodruff, M. A., Lange, C., Reichert, J., Berner, A., Chen, F., Fratzl, P., Schantz, J.-T., & Hutmacher, D. W. (2012) · Materials Today · doi:10.1016/s1369-7021(12)70194-3 · Cited by 182 · see citing works
Finite Element Method (FEM), Mechanobiology and Biomimetic Scaffolds in Bone Tissue Engineering
Boccaccio, A., Ballini, A., Pappalettere, C., Tullo, D., Cantore, S., & Desiate, A. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.112 · Cited by 178 · see citing works
Sin, D., Miao, X., Liu, G., Wei, F., Chadwick, G., Yan, C., & Friis, T. (2009) · Materials Science and Engineering C · doi:10.1016/j.msec.2009.09.002 · Cited by 177 · see citing works
Hua, F. J., Kim, G. E., Lee, J. D., Son, Y. K., & Lee, D. S. (2002) · Journal of Biomedical Materials Research · doi:10.1002/jbm.10121 · Cited by 163 · see citing works
Thomson, R. C., Shung, A. K., Yaszemski, M. J., et al. (2000) · Elsevier eBooks · doi:10.1016/b978-012436630-5/50025-8 · Cited by 163 · see citing works
Sacks, M. S., & Gloeckner, D. C. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199907)46:1 · Cited by 161 · see citing works
Matsuyama, H., Maki, T., Teramoto, M., et al. (2002) · Journal of Membrane Science · doi:10.1016/s0376-7388(02)00056-x · Cited by 155 · see citing works
Gauthier, O., Bouler, J., Weiss, P., Bosco, J., Daculsi, G., & Aguado, E. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199910)47:1 · Cited by 148 · see citing works
Biomimetic coatings for bone tissue engineering of critical-sized defects
Liu, Y., Wu, G., & de Groot, K. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0115.focus · Cited by 148 · see citing works
Fabrication of a novel porous PGA-chitosan hybrid matrix for tissue engineering
Wang, Y.-C., Lin, M.-C., Wang, D., et al. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00434-9 · Cited by 142 · see citing works
Huang, Y., Ren, J., Chen, C., et al. (2007) · Journal of Biomaterials Applications · doi:10.1177/0885328207077632 · Cited by 138 · see citing works
Blaker, J. J., Knowles, J. C., & Day, R. M. (2007) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.09.011 · Cited by 136 · see citing works
Custom-made composite scaffolds for segmental defect repair in long bones
Reichert, J. C., Wullschleger, M., Cipitria, A., et al. (2010) · International Orthopaedics · doi:10.1007/s00264-010-1146-x · Cited by 133 · see citing works
Wu, Q., Wan, L., & Xu, Z. (2012) · Journal of Membrane Science · doi:10.1016/j.memsci.2012.04.006 · Cited by 127 · see citing works
Chen, Y., Mak, A. F. T., Wang, M., Li, J., & Wong, M. (2006) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2005.12.005 · Cited by 126 · see citing works
Wu, L., Zhang, H., Zhang, J., et al. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1105 · Cited by 122 · see citing works
Hua, F. J., Park, T. G., & Lee, D. S. (2003) · Polymer · doi:10.1016/s0032-3861(03)00025-9 · Cited by 121 · see citing works
He, L., Zhang, Y., Zeng, X., Quan, D., Liao, S., Zeng, Y., Lu, J., & Ramakrishna, S. (2009) · Polymer · doi:10.1016/j.polymer.2009.06.025 · Cited by 121 · see citing works
Roether, J. A., Gough, J. E., Boccaccini, A. R., et al. (2002) · Journal of Materials Science Materials in Medicine · doi:10.1023/a:1021166726914 · Cited by 117 · see citing works
Porous scaffold architecture guides tissue formation
Cipitria, A., Lange, C., Schell, H., et al. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1589 · Cited by 115 · see citing works
Fabrication of poly-DL-lactide/polyethylene glycol scaffolds using the gas foaming technique
Ji, C., Annabi, N., Hosseinkhani, M., Sivaloganathan, S., & Dehghani, F. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.09.028 · Cited by 113 · see citing works
Park, J. K., Shim, J., Kang, K. S., Yeom, J., Jung, H. S., Kim, J. Y., Lee, K. H., Kim, T., Kim, S., Cho, D., et al. (2011) · Advanced Functional Materials · doi:10.1002/adfm.201100612 · Cited by 108 · see citing works
Tu, C., Cai, Q., Yang, J. H., Wan, Y., Bei, J., & Wang, S. (2003) · Polymers for Advanced Technologies · doi:10.1002/pat.370 · Cited by 107 · see citing works
Singh, M. K., Sandhu, B., Scurto, A. M., Berkland, C. J., & Detamore, M. S. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.07.042 · Cited by 92 · see citing works
Manufacture of degradable polymeric scaffolds for bone regeneration
Ge, Z., Jin, Z., & Cao, T. (2008) · Biomedical Materials · doi:10.1088/1748-6041/3/2/022001 · Cited by 88 · see citing works
Long-term in vitro degradation of PDLLA/Bioglass® bone scaffolds in acellular simulated body fluid
Blaker, J. J., Nazhat, S. N., Maquet, V., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.09.013 · Cited by 86 · see citing works
Zhang, H., & Chen, Z. (2010) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911509359486 · Cited by 82 · see citing works
Budyanto, L., Goh, Y. Q., & Ooi, C. P. (2008) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-008-3545-8 · Cited by 81 · see citing works
Scaffold/Extracellular Matrix Hybrid Constructs for Bone‐Tissue Engineering
Thibault, R. A., Mikos, A. G., & Kasper, F. K. (2012) · Advanced Healthcare Materials · doi:10.1002/adhm.201200209 · Cited by 80 · see citing works
A morphological study of porous polylactide scaffolds prepared by thermally induced phase separation
Chen, J.-S., Tu, S.-L., & Tsay, R.-Y. (2010) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2009.08.008 · Cited by 77 · see citing works
Nasr‐Esfahani, M., & Mehrabanian, M. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s21203 · Cited by 76 · see citing works
Liu, L., Xiong, Z., Yan, Y., Zhang, R., Wang, X., & Jin, L. (2008) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31176 · Cited by 74 · see citing works
Labow, R. S., Meek, E., & Santerre, J. P. (2000) · Journal of Biomedical Materials Research · doi:10.1002/1097-4636(200102)54:2 · Cited by 69 · see citing works
Gong, Y., Ma, Z., Gao, C., et al. (2006) · Journal of Applied Polymer Science · doi:10.1002/app.23931 · Cited by 69 · see citing works
Dental materials: 1997 literature review
Whitters, C. J., STRANG, R. H. C., Brown, D. T., et al. (1999) · Journal of Dentistry · doi:10.1016/s0300-5712(99)00007-x · Cited by 64 · see citing works
Design and Dynamic Culture of 3D-Scaffolds for Cartilage Tissue Engineering
El-Ayoubi, R., Degrandpré, C. E., DiRaddo, R. W., et al. (2009) · Journal of Biomaterials Applications · doi:10.1177/0885328209355332 · Cited by 64 · see citing works
Luo, B., Li, Z., Zhang, J., et al. (2008) · Desalination · doi:10.1016/j.desal.2007.09.023 · Cited by 58 · see citing works
Shin, K. C., Kim, B. S., Kim, J., et al. (2005) · Polymer · doi:10.1016/j.polymer.2005.02.114 · Cited by 55 · see citing works
Oh, S. H., Park, S. C., Kim, H. K., Koh, Y. J., Lee, J.-H., Lee, M. C., & Lee, J. H. (2010) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/092050609x12597621891620 · Cited by 54 · see citing works
Effects of designed PLLA and 50:50 PLGA scaffold architectures on bone formation in vivo
Saito, E., Liao, E. E., Hu, W., et al. (2011) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.497 · Cited by 54 · see citing works
Guilak, F., Mooney, D. J., Goldstein, S. A., et al. (2003) · Springer eBooks · doi:10.1007/b97260 · Cited by 54 · see citing works
Martel-Estrada, S.-A., Perez, C. A., Chacón-Nava, J. G., et al. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.03.032 · Cited by 53 · see citing works
Goh, Y. Q., & Ooi, C. P. (2008) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-008-3366-9 · Cited by 52 · see citing works
He, Y., Tang, Y., & Wang, X. (2010) · Journal of Membrane Science · doi:10.1016/j.memsci.2010.11.010 · Cited by 51 · see citing works
Fast Microwave-Mediated Bulk Polycondensation ofd,l-Lactic Acid
Kéki, S., Bodnár, I., Borda, J., Deák, G., & Zsuga, M. (2001) · Macromolecular Rapid Communications · doi:10.1002/1521-3927(20010901)22:13 · Cited by 50 · see citing works
Scaffolds for Tissue Engineering Via Thermally Induced Phase Separation
Carlos, A., Olivas-Armendáriz, I., Javier, S. P., & Perla, E. (2011) · InTech eBooks · doi:10.5772/25476 · Cited by 49 · see citing works
Pisanti, P., Yeatts, A. B., Cardea, S., et al. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34191 · Cited by 49 · see citing works
Microporous collagen spheres produced via thermally induced phase separation for tissue regeneration
Keshaw, H., Thapar, N., Burns, A. J., et al. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.08.044 · Cited by 46 · see citing works
Yen, C., He, H., Lee, L. J., et al. (2009) · Journal of Membrane Science · doi:10.1016/j.memsci.2009.07.024 · Cited by 46 · see citing works
Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition
Barroca, N., Daniel‐da‐Silva, A. L., Vilarinho, P. M., et al. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.03.032 · Cited by 46 · see citing works
Tang, Y., He, Y.-D., & Wang, X. (2012) · Journal of Membrane Science · doi:10.1016/j.memsci.2012.03.052 · Cited by 45 · see citing works
Shao, J., Chen, C., Wang, Y., Chen, X., & Du, C. (2012) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2012.03.014 · Cited by 44 · see citing works
Carrubba, V. L., Pavia, F. C., Brucato, V., et al. (2008) · International Journal of Material Forming · doi:10.1007/s12289-008-0332-5 · Cited by 43 · see citing works
Shao, J., Chen, C., Wang, Y., et al. (2012) · Applied Surface Science · doi:10.1016/j.apsusc.2012.03.110 · Cited by 30 · see citing works
Özdilek, C., Bose, S., Leys, J., et al. (2011) · Polymer · doi:10.1016/j.polymer.2011.07.048 · Cited by 28 · see citing works
Li, X., Liu, H., Xiao, C., et al. (2012) · Journal of Applied Polymer Science · doi:10.1002/app.37919 · Cited by 28 · see citing works
Polyoxymethylene‐homopolymer/hydroxyapatite nanocomposites for biomedical applications
Pielichowska, K. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34752 · Cited by 24 · see citing works
Liu, M., Chen, D., Xu, Z., et al. (2012) · Journal of Applied Polymer Science · doi:10.1002/app.38234 · Cited by 21 · see citing works
Liang, Y., Zheng, X., Zhai, W., et al. (2012) · Journal of Wuhan University of Technology-Mater Sci Ed · doi:10.1007/s11595-012-0450-2 · Cited by 19 · see citing works
Zhang, C., Bai, Y., Gu, J., et al. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34429 · Cited by 16 · see citing works
Composite Scaffolds for Orthopaedic Regenerative Medicine
John, P., & Fergal, J. (2011) · InTech eBooks · doi:10.5772/15033 · Cited by 15 · see citing works
Kitaura, T., Fadzlina, W. N., Ohmukai, Y., et al. (2012) · Journal of Applied Polymer Science · doi:10.1002/app.38001 · Cited by 13 · see citing works
He, L., Zuo, Q.-H., Shi, Y.-F., & Xue, W. (2014) · Journal of Applied Polymer Science · doi:10.1002/app.39436 · Cited by 10 · see citing works
Mehrabanian, M., & Nasr-Esfahani, M. R. (2011) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 10 · see citing works
Li, S., Chen, X., & Li, M. (2010) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2010.534222 · Cited by 9 · see citing works
Development and Characterisation of Completely Degradable Composite Tissue Engineering Scaffolds
Ferrer, M. C.-H. (2007) · doi:10.5821/dissertation-2117-93368 · Cited by 8 · see citing works
Li, S., Wang, K., & Li, M. (2010) · Journal of Macromolecular Science Part B · doi:10.1080/00222341003609138 · Cited by 6 · see citing works
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Kirillova, A., Yeazel, T. R., Asheghali, D., Petersen, S. R., Dort, S., Gall, K., & Becker, M. L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01200 · Cited by 368 · see citing works
Star-shaped and branched polylactides: Synthesis, characterization, and properties
Michalski, A., Brzezinski, M., Lapienis, G., & Biela, T. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2018.10.004 · Cited by 158 · see citing works
Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57 · see citing works
G, R., S, B., Venkatesan, B., & Vellaichamy, E. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.12.133 · Cited by 56 · see citing works
- Authors
- Akbarzadeh, R., & Yousefi, A.
- Affiliations
- Miami University (US)
- Corresponding author
- Yousefi, Azizeh‐Mitra
- Venue
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Publisher
- Wiley
- Published
- 2014-01-15
- Volume
- 102
- Issue
- 6
- Pages
- 1304-1315
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- OpenAlex
- W1915121873
- Cited by
- 208
- References
- 114
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 14 · 2023: 19 · 2022: 18 · 2021: 24 · 2020: 23 · 2019: 23 · 2018: 18 · 2017: 16 · 2016: 14 · 2015: 8 · 2014: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio Third Frontier
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- thermally induced phase separation, bone tissue engineering, porous scaffolds, pore size, pore morphology, interconnected pores, quenching temperature, coarsening, polymer concentration, solvent composition
- MeSH terms
- Animals, Humans, Porosity, Bone Substitutes, Tissue Engineering, Tissue Scaffolds
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