Cited by 208Bone Tissue Engineering MaterialsElectrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative Medicine

Effects of processing parameters in thermally induced phase separation technique on porous architecture of scaffolds for bone tissue engineering

Akbarzadeh, Rosa, Yousefi, Azizeh‐Mitra·2014·Journal of Biomedical Materials Research Part B: Applied Biomaterials

Abstract

Tissue engineering makes use of 3D scaffolds to sustain three-dimensional growth of cells and guide new tissue formation. To meet the multiple requirements for regeneration of biological tissues and organs, a wide range of scaffold fabrication techniques have been developed, aiming to produce porous constructs with the desired pore size range and pore morphology. Among different scaffold fabrication techniques, thermally induced phase separation (TIPS) method has been widely used in recent years because of its potential to produce highly porous scaffolds with interconnected pore morphology. The scaffold architecture can be closely controlled by adjusting the process parameters, including polymer type and concentration, solvent composition, quenching temperature and time, coarsening process, and incorporation of inorganic particles. The objective of this review is to provide information pertaining to the effect of these parameters on the architecture and properties of the scaffolds fabricated by the TIPS technique.

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Crossref · 10.1002/jbm.b.33101

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  • Owing to effectual control over morphological features such as average pore size, hierarchical porous architecture, and interconnection of pores, TIPS has drawn great attention in recent years for the preparation of scaffolds.

    “Owing to the effectual control over the morphological features like the average size of the pores, hierarchical porous architecture, interconnection of pores, etc of the scaffold, TIPS has drawn great attention in recent years for the preparation of scaffolds [88].”

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Authors
Akbarzadeh, R., & Yousefi, A.
Affiliations
Miami University (US)
Corresponding author
Yousefi, Azizeh‐Mitra
Venue
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley
Published
2014-01-15
Volume
102
Issue
6
Pages
1304-1315
ISSN
  • 1552-4973 (ISSN-L)
  • 1552-4981
OpenAlex
W1915121873
Cited by
208
References
114
Citations by year
2026: 10 · 2025: 17 · 2024: 14 · 2023: 19 · 2022: 18 · 2021: 24 · 2020: 23 · 2019: 23 · 2018: 18 · 2017: 16 · 2016: 14 · 2015: 8 · 2014: 4
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ohio Third Frontier
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
thermally induced phase separation, bone tissue engineering, porous scaffolds, pore size, pore morphology, interconnected pores, quenching temperature, coarsening, polymer concentration, solvent composition
MeSH terms
Animals, Humans, Porosity, Bone Substitutes, Tissue Engineering, Tissue Scaffolds

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