The photogenotoxicity of titanium dioxide particles
Abstract
We employed a series of in vitro genotoxicity assays--a single cell gel (SCG) assay with mouse lymphoma L5178Y cells, a microbial mutation assay with Salmonella typhimurium, a mammalian cell mutation assay with L5178Y cells, and a chromosomal aberration assay with Chinese hamster CHL/IU cells--to evaluate the photogenotoxicity of titanium dioxide (TiO2) particles. Without UV/visible light irradiation, TiO2 particles exhibited no or weak genotoxicity. With irradiation, however, TiO2 particles exhibited significant genotoxicity in the SCG and chromosomal aberration assays. Therefore, we concluded that TiO2 particles are photogenotoxic.
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A study showed TiO2 were photogenotoxic in mouse lymphoma and Chinese hamster lung cells.
“The toxicity concern for nanoparticle TiO2 and ZnO arose following a study showing TiO2 were photogenotoxic in mouse lymphoma and Chinese hamster lung cells (67).”
From Photoprotection: a Review of the Current and Future Technologies (2010) · cites this paper as [67]
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- Authors
- Nakagawa, Y., Wakuri, S., Sakamoto, K., & Tanaka, N.
- Affiliations
- Food and Drug Safety Center (JP)
- Corresponding author
- Nakagawa, Yuzuki
- ORCID
- Sakamoto, Kyoko
- Venue
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 394
- Issue
- 1-3
- Pages
- 125-132
- ISSN
- 1383-5718 (ISSN-L)
- OpenAlex
- W1975825403
- Cited by
- 200
- References
- 0
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 17 · 2013: 17 · 2012: 21
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › TiO2 Photocatalysis and Solar Cells
- Keywords
- titanium dioxide, photogenotoxicity, UV irradiation, light-induced DNA damage, chromosomal abnormalities, Salmonella typhimurium mutagenicity
- MeSH terms
- Animals, Cell Line, Chromosome Aberrations, Cricetulus, Cricetinae, Light, Mutagenicity Tests, Salmonella typhimurium, Titanium, Tumor Cells, Cultured, Mice
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