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Cited by 633Phytochemicals and Antioxidant ActivitiesBioactive natural compoundsCurcumin's Biomedical Applications

The DOI matches its Crossref record; 237 of the 237 references it cites were found in a registry or an index.

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

Surh, Young-Joon·1999·Mutation research. Fundamental and molecular mechanisms of mutagenesis
DOI 10.1016/s1383-5742(99)00057-5
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Abstract

Recently, considerable attention has been focused on identifying naturally occurring chemopreventive substances capable of inhibiting, retarding, or reversing the multi-stage carcinogenesis. A wide array of phenolic substances, particularly those present in dietary and medicinal plants, have been reported to possess substantial anticarcinogenic and antimutagenic activities. The majority of these naturally occurring phenolics retain antioxidative and anti-inflammatory properties which appear to contribute to their chemopreventive or chemoprotective activity. Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a pungent ingredient of hot chili pepper, protects against experimentally-induced mutagenesis and tumorigenesis. It also induces apoptosis in various immortalized or malignant cell lines. Plants of ginger family (Zingiberaceae) have been frequently and widely used as spices and also, in traditional oriental medicine. Curcumin, a yellow ingredient from turmeric (Curcuma longa L., Zingiberaceae), has been extensively investigated for its cancer chemopreventive potential. Yakuchinone A [1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone] and yakuchinone B [1-(4'-hydroxy-3'-methoxyphenyl)-7-phenylhept-1-en-3-one] present in Alpinia oxyphylla Miquel (Zingiberaceae) have inhibitory effects on phorbol ester-induced inflammation and skin carcinogenesis in mice, and oxidative stress in vitro. These diarylheptanoids suppress phorbol ester-induced activation of ornithine decarboxylase and production of tumor necrosis factor-alpha or interleukin-1alpha and their mRNA expression. They also nullified the phorbol ester-stimulated induction of activator protein 1 (AP-1) in cultured human promyelocytic leukemia (HL-60) cells. In addition, both yakuchinone A and B induced apoptotic death in HL-60 cells. Ginger (Zingiber officinale Roscoe, Zingiberaceae) contains such pungent ingredients as [6]-gingerol and [6]-paradol, which also have anti-tumor promotional and antiproliferative effects. Resveratrol (3, 5,4'-trihydroxy-trans-stilbene), a phytoalexin found in grapes and other dietary and medicinal plants, and (-)-epigallocatechin gallate, a major antioxidative green tea polyphenol, exert striking inhibitory effects on diverse cellular events associated with multi-stage carcinogenesis. In addition, these compounds have ability to suppress proliferation of human cancer cells via induction of apoptosis.

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Citations

Cites

Research works printed but not linked: 8

  1. Edes, 1993, Beta-carotene and mammary carcinogenesis, J. Am. Coll. Nutr., 8, 426
  2. Hamid, 1995, Interaction of capsaicin with mixed function oxidases: ex vivo and in vivo studies, J. Drug Res. Egypt, 16, 29
  3. Wang, 1984, Antiplatelet effect of capsaicin, Thromb. Res., 36, 497, 10.1016/0049-3848(84)90189-0 · DOI
  4. Chabot-Fletcher, 1997, A role for transcription factor NF-κB in inflammation, Inflammation Res., 46, 1
  5. Mustafa, 1993, Drug development report (9): pharmacology of ginger, Zingiber officinale, J. Drug Dev., 6, 25
  6. Kang, 1998, Induction of apoptosis in HL-60 cells and inhibition of mouse skin tumor promotion by diarylheptanoids from Alpinia oxyphylla Miquel (Zingiberaceae), Proc. Am. Assoc. Cancer Res., 39, 641
  7. Chun, 1999, Inhibition of mouse skin tumor promotion and suppression of phorbol ester-induced NF-κB and AP-1 activation by diarylheptanoids derived from Alpinia oxyphylla Miquel, Proc. Am. Assoc. Cancer Res., 40, 363
  8. Chan, 1995, Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production, Cancer Lett., 96, 23, 10.1016/0304-3835(95)03913-H · DOI

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Metadata

Authors
Surh, Y.-J.
Affiliations
Seoul National University (KR)
Corresponding author
Surh, Young-Joon
ORCID
Surh, Young-Joon
Venue
Mutation research. Fundamental and molecular mechanisms of mutagenesis
Publisher
Elsevier BV
Published
1999-07
Volume
428
Issue
1-2
Pages
305-327
ISSN
  • 0027-5107 (ISSN-L)
  • 1386-1964
DOI
10.1016/s1383-5742(99)00057-5
OpenAlex
W2081093364
Cited by
633
References
237
Citations by year
2025: 5 · 2024: 12 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 20 · 2018: 30 · 2017: 23 · 2016: 23 · 2015: 19 · 2014: 26 · 2013: 23 · 2012: 35
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
  • Ministry of Health and Welfare
  • Korea Science and Engineering Foundation
  • Seoul National University (HMP-96-D-2-1034)
Topics
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Keywords
chemoprevention, phenolic compounds, dietary phytochemicals, medicinal plants, capsaicin, curcumin, diarylheptanoids, ginger, resveratrol, epigallocatechin gallate, apoptosis, oxidative stress, anti-inflammatory activity, anticarcinogenic activity, ornithine decarboxylase
MeSH terms
Resveratrol, Animals, Capsaicin, Catechin, Catechols, Curcumin, Diet, Fatty Alcohols, Humans, Neoplasms, Neoplasms, Experimental, Phenols, Plants, Edible, Plants, Medicinal, Stilbenes, Mice

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