Resveratrol-procyanidin blend: nutraceutical and antiaging efficacy evaluated in a placebo-controlled, double-blind study
Open accessAbstract
BACKGROUND: Skin is constantly exposed to pro-oxidant environmental stress from several sources, including air pollutants, ultraviolet solar light, and chemical oxidants. Reactive oxygen species have been implicated in age-related skin disorders. Dietary bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health. The advantage of a nutritional administration route is that blood delivers nutraceutical bioactive compounds continuously to all skin compartments, ie, the epidermis, dermis, and subcutaneous fat. The purpose of this study was to evaluate the topical and systemic effects of a dietary supplement containing resveratrol and procyanidin on age-related alterations to the skin, the skin antioxidant pool, and systemic oxidative stress levels. METHODS: An instrumental study was performed in 50 subjects (25 treated with supplements and 25 with placebo) to identify clinical features induced by chronoaging or photoaging. Product efficacy was evaluated after 60 days of treatment in terms of in vivo and in situ skin hydration, elasticity, and skin roughness levels, systemic oxidative stress levels by plasmatic derivatives of reactive oxygen metabolites and oxyadsorbent tests, and extent of the skin antioxidant pool. RESULTS: After 60 days of treatment, values for systemic oxidative stress, plasmatic antioxidant capacity, and skin antioxidant power had increased significantly. Additionally, skin moisturization and elasticity had improved, while skin roughness and depth of wrinkles had diminished. Intensity of age spots had significantly decreased, as evidenced by improvement in the individual typological angle. CONCLUSION: Nutraceutical and pharmacological intervention with a supplement characterized by a specific blend of resveratrol and procyanidin may be a promising strategy to support treatments for the reduction of skin wrinkling, as well as reducing systemic and skin oxidative stress.
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In a placebo-controlled double-blind clinical study, facial skin moisturization and elasticity were enhanced, while facial skin roughness and depth of wrinkles were reduced, in subjects orally supplied with a resveratrol-procyanidin blend.
“In a placebo-controlled, double-blind clinical study, facial skin moisturization and elasticity were enhanced, while facial skin roughness and depth of wrinkles were reduced, in subjects who were orally supplied with a resveratrol–procyanidin blend.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [110]
Plasmatic antioxidant capacity and skin antioxidant power increased significantly with a resveratrol-procyanidin blend.
“Additionally, plasmatic antioxidant capacity and skin antioxidant power increased significantly [110].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [110]
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Fariya Ahmed, M., Unnikrishnan, S., & Ramalingam, K. (2023) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-6684-6737-4.ch007
Upadhyay, R., Gadani, M. C., & Badak, S. (2024) · International Journal of Research in Dermatology · doi:10.18203/issn.2455-4529.intjresdermatol20243430
Efficacy of a botanical-based Nutricosmetic ingredient on skin aging-related markers in adult women
Navarro, P., García, A. B., Jones, J., & Caturla, N. (2025) · Journal of Dermatology & Cosmetology · doi:10.15406/jdc.2025.09.00305
Process, Evaluation, and New Trends of Skin Antioxidant Strategies
唐, 榕. (2026) · Hans Journal of Biomedicine · doi:10.12677/hjbm.2026.163045
Uzuner, Y. Y., & Sevinç, H. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18101237
- Authors
- Buonocore, D., Nobile, Cestone, Santin, Bottone, Marzatico, Lazzeretti, & Tocabens
- Affiliations
- University of Pavia (IT)
- Corresponding author
- Buonocore, Daniela
- ORCID
- Buonocore, Daniela
- Venue
- Clinical Cosmetic and Investigational Dermatology
- Publisher
- Informa UK Limited
- Published
- 2012-10
- Volume
- 5
- Pages
- 159
- ISSN
- 1178-7015 (ISSN-L)
- PMC
- PMC3469214
- OpenAlex
- W1989581783
- Cited by
- 57
- References
- 41
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 4
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Cosmetic and Investigational Dermatology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- resveratrol, procyanidins, nutraceuticals, anti-aging, skin aging, photoaging, oxidative stress, skin antioxidants, skin hydration, skin elasticity, skin roughness, wrinkles, liver spots, dietary supplements, polyphenols
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