Cited by 33Skin Protection and AgingSynthesis and biological activitySynthesis of Organic Compounds

Synthesis, antioxidant and photoprotection activities of hybrid derivatives useful to prevent skin cancer

Reis, Juliana Santana, Corrêa, Marcos Antonio, Chung, Man Chin, dos Santos, Jean Leandro·2014·Bioorganic & Medicinal Chemistry

Abstract

Chronic ultraviolet (UV) radiation exposure is a major cause of skin cancer. A novel series of hybrid derivatives (I-VIII) for use in sunscreen formulations were synthesized by molecular hybridization of t-resveratrol, avobenzone, and octyl methoxycinnamate, and were characterized. The antioxidant activity values for VIII were comparable than to those of t-resveratrol. Compounds I-III and VI demonstrated Sun Protector Factor superior to that of t-resveratrol. Compounds I and IV-VIII were identified as new, broad-spectrum UVA filters while II-III were UVB filters. In conclusion, novel hybrid derivatives with antioxidant effects have emerged as novel photoprotective agents for the prevention of skin cancer.

Integrity signals

Registry

Crossref · 10.1016/j.bmc.2014.03.017

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Compounds 128 and 131-135 possess characteristics of broad-spectrum molecules, with 128, 134, and 135 having interesting DPPH radical scavenging activity.

    “Amongst all, compounds 128 and 131–135 possess characteristics of broad-spectrum molecules, having 128, 134, and 135 an interesting DPPH radical scavenging activity.”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [138]

  • Three hybrids among 128-135 (compounds 128, 134, and 135) possess antioxidant potential, with IC50 between 88 μM and 275 μM.

    “Additionally, three hybrids of the total synthetised compounds 128–135 possess antioxidant potential, with an IC50 between 88 µM and 275 µM (compounds 128, 134, and 135) [138].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [138]

  • Molecular hybridisation of avobenzone (11), EHMC (21), and trans-resveratrol (40) resulted in a novel series of hybrids (128-135) with UV filter effect.

    “Molecular hybridisation avobenzone (11), EHMC (21), and trans-resveratrol (40) resulted in the identification of a novel series of hybrids (128–135) with UV filter effect [138].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [138]

  • All hybrids 128-135 revealed photoprotective activity with SPF values between 2 and 5 and ability to absorb UVA region, confirmed by λmax values in the range of 369 nm and 389 nm.

    “All compounds revealed photoprotective activity with SPF values varied between 2 and 5, and an ability to absorb the UVA region of the electromagnetic spectrum, confirmed by their λmax values in the range of 369 nm and 389 nm [138].”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [138]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Reis, J. S., Corrêa, M. A., Chung, M. C., & dos Santos, J. L.
Affiliations
Universidade Estadual Paulista (Unesp) (BR)
Venue
Bioorganic & Medicinal Chemistry
Publisher
Elsevier BV
Published
2014-05
Volume
22
Issue
9
Pages
2733-2738
ISSN
0968-0896 (ISSN-L)
OpenAlex
W2019624009
Cited by
33
References
32
Citations by year
2026: 2 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2014: 2
FWCI
3.30
Type
journal article
Language
en
Open access
closed
Locations
  • Bioorganic & Medicinal Chemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
  • UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo (2012/09237-0)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
  • Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
Keywords
hybrid derivatives, UV filters, photoprotection, skin cancer prevention, antioxidant activity, avobenzone, octyl methoxycinnamate, molecular hybridization, UVA filters, UVB filters, sun protection factor, ultraviolet radiation
MeSH terms
Resveratrol, Antioxidants, Cinnamates, Humans, Propiophenones, Skin Neoplasms, Stilbenes, Sunscreening Agents, Ultraviolet Rays, Sun Protection Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review