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Nomograms in oncology: more than meets the eye

Open access
Balachandran, Vinod P, Gonen, Mithat, Smith, J Joshua, DeMatteo, Ronald P·2015·The Lancet Oncology
DOI 10.1016/s1470-2045(14)71116-7
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Abstract

Summary Nomograms are commonly used tools to estimate prognosis in oncology and medicine. With the ability to generate an individual numerical probability of a clinical event by integrating diverse prognostic and determinant variables, nomograms fulfill our desire for biologically and clinically integrated models and our drive towards personalized medicine. Rapid computation through user friendly digital interfaces, together with increased accuracy, and more easily understood prognoses compared to conventional staging, allow for seamless incorporation of nomogram derived prognosis to aid in clinical decision making. This has lead to the ubiquitous appearance of nomograms on the internet and in medical journals, and increasing nomogram use by patients and physicians alike. However, the statistical foundations of nomogram construction, their precise interpretation, and evidence supporting their use is commonly misunderstood, leading to an under appreciation of the inherent uncertainties regarding nomogram use. We provide a systematic, practical approach to evaluating and comprehending nomogram derived prognoses, with particular emphasis on clarifying common misconceptions and highlighting limitations.

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Metadata

Authors
Balachandran, V. P., Gonen, M., Smith, J. J., & DeMatteo, R. P.
Venue
The Lancet Oncology
Publisher
Elsevier BV
Published
2015-04
Volume
16
Issue
4
Pages
e173-e180
ISSN
1470-2045 (ISSN-L)
DOI
10.1016/s1470-2045(14)71116-7
OpenAlex
W2153505392
Cited by
3,292
References
0
FWCI
40.88
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
National Institutes of Health ((NIH P30 CA008748 and NIH R01 CA102613))

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CoChat. (2026). Citation check: Nomograms in oncology: more than meets the eye. https://app.cochat.ai/papers/10.1016/s1470-2045(14)71116-7
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Balachandran, V. P., Gonen, M., Smith, J. J., & DeMatteo, R. P. (2015). Nomograms in oncology: more than meets the eye. The Lancet Oncology. https://doi.org/10.1016/s1470-2045(14)71116-7

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