Premature ageing of the immune system: the cause of AIDS?

Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men

Gottlieb, M. S., Schroff, R. W., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,723

Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes

Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

Finzi, D., Blankson, J., Siliciano, J. D., Margolick, J. B., Chadwick, K., Pierson, T., Smith, K., Lisziewicz, J., Lori, F., Flexner, C., et al. (1999) · Nature Medicine · doi:10.1038/8394 · Cited by 2,119

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., et al. (1997) · Nature · doi:10.1038/387183a0 · Cited by 2,050

Changes in thymic function with age and during the treatment of HIV infection

Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556

Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques

Jin, X., Bauer, D. E., Tuttleton, S., Lewin, S. R., Gettie, A., Blanchard, J., Irwin, C. E., Safrit, J. T., Mittler, J. E., Weinberger, L. S., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.6.991 · Cited by 1,409

Phenotypic and functional separation of memory and effector human CD8+ T cells

Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366

HIV preferentially infects HIV-specific CD4+ T cells

Douek, D. C., Brenchley, J. M., Betts, M. R., Ambrozak, D. R., Hill, B. J., Okamoto, Y., Casazza, J. P., Kuruppu, J. C., Kunstman, K., Wolinsky, S. M., et al. (2002) · Nature · doi:10.1038/417095a · Cited by 1,261

Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

Borrow, P., Lewicki, H. A., Wei, X., Horwitz, M. S., Peffer, N. J., Meyers, H. L., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A., et al. (1997) · Nature Medicine · doi:10.1038/nm0297-205 · Cited by 1,181

Moringa supplementation improves immunological indices and hematological abnormalities in seropositive patients receiving HAARTs

Aprioku, J. S., Robinson, O., Obianime, A. W., & Tamuno, I. (2022) · African Health Sciences · doi:10.4314/ahs.v22i2.2 · Cited by 15

Premature aging of the immune system affects the response to SARS-CoV-2 mRNA vaccine in β-thalassemia: role of an additional dose

Carsetti, R., Agrati, C., Pinto, V. M., Gianesin, B., Gamberini, R., Fortini, M., Barella, S., Denotti, A. R., Perrotta, S., Casale, M., et al. (2022) · Blood · doi:10.1182/blood.2022017594 · Cited by 14

Sub‐optimal CD4 recovery on long‐term suppressive highly active antiretroviral therapy is associated with favourable outcome

Önen, N., Overton, E. T., Presti, R. M., Blair, C. D., Powderly, W. G., & Mondy, K. E. (2009) · HIV Medicine · doi:10.1111/j.1468-1293.2009.00711.x · Cited by 14

Limited efficiency of endogenous interleukin-7 levels in T cell reconstitution during HIV-1 infection: will exogenous interleukin-7 therapy work?

Réthi, B., Vivar, N., Sammicheli, S., & Chiodi, F. (2009) · AIDS · doi:10.1097/qad.0b013e3283298572 · Cited by 13

Potential role of CD8+CD28− T lymphocytes in immune activation during HIV-1 infection

Vivar, N., Thắng, P. H., Atlas, A., Chiodi, F., & Réthi, B. (2008) · AIDS · doi:10.1097/qad.0b013e3282fce613 · Cited by 13

Impact of Aging, Cytomegalovirus Infection, and Long-Term Treatment for Human Immunodeficiency Virus on CD8+ T-Cell Subsets

Veel, E., Westera, L., van Gent, R., Bont, L., Otto, S. A., Ruijsink, B., Rabouw, H. H., Mudrikova, T., Wensing, A. M. J., Hoepelman, A. I. M., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00572 · Cited by 12

Hepatitis B Vaccine Antibody Response and the Risk of Clinical AIDS or Death

Landrum, M. L., Hullsiek, K. H., O’Connell, R. J., Chun, H., Ganesan, A., Okulicz, J. F., Lalani, T., Weintrob, A., Crum‐Cianflone, N. F., & Agan, B. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033488 · Cited by 12

Growing Old with HIV

Patel, D., & Crane, L. R. (2010) · Current Infectious Disease Reports · doi:10.1007/s11908-010-0146-8 · Cited by 12

Rag2−/− accelerates lipofuscin accumulation in the brain: Implications for human stem cell brain transplantation studies

Jin, M., Alam, M. M., Liu, A. Y. ‐., & Jiang, P. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.09.012 · Cited by 11

Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener’s granulomatosis

Lamprecht, P., Cuero, A. L. V., Müller, A., Csernok, E., Voswinkel, J., Maass, M., Solbach, W., Gross, W. L., & Klenerman, P. (2003) · Cellular Immunology · doi:10.1016/j.cellimm.2003.08.003 · Cited by 12

Increased IL-17 and TGF-β serum levels in peripheral blood of patients with β-thalassemia major: implication for continual transfusions role in T helper17-mediated proinflammatory responses

Baharlou, R., Davami, M. H., Vasmehjani, A. A., & EBRAHIMI, M. (2016) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1409-57 · Cited by 13

Increased Prevalence of Liver Fibrosis in People Living With Human Immunodeficiency Virus Without Viral Hepatitis Compared to Population Controls

Kirkegaard-Klitbo, D. M., Bendtsen, F., Lundgren, J. D., de Knegt, R. J., Kofoed, K. F., Nielsen, S. D., & Benfield, T. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa763 · Cited by 11

Older HIV-infected patients on antiretroviral therapy have B-cell expansion and attenuated CD4 cell increases with immune activation reduction

Kalayjian, R. C., Spritzler, J., Matining, R. M., Fiscus, S. A., Gross, B. H., Francis, I. R., Pollard, R. B., Lederman, M. M., & LANDAY, A. L. (2013) · AIDS · doi:10.1097/qad.0b013e32835fabc2 · Cited by 11

Transcriptional insights into the CD8+ T cell response in mono-HIV and HCV infection

Li, S.-Y., Zhang, Z., Jiang, Y., Fu, Y., & Shang, H. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02252-9 · Cited by 10

Inflammatory Markers and Frailty

Leng, S. X., & Fried, L. P. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_62 · Cited by 11

A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children

Buseyne, F., Catteau, A., Scott‐Algara, D., Corre, B., Porrot, F., Rouzioux, C., Blanche, S., & Rivière, Y. (2005) · Journal of Immunological Methods · doi:10.1016/j.jim.2005.01.003 · Cited by 9

Characterization of HIV-1 Envelope V3 Region Sequences from Virologically Controlled HIV-Infected Older Patients on Long Term Antiretroviral Therapy

Behrens, N. E., Love, M., Bandlamuri, M., Bernhardt, D., Wertheimer, A. M., Klotz, S. A., & Ahmad, N. (2020) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2020.0139 · Cited by 8

Immunology of viral co-infections with HIV.

Northfield, J. W., Harcourt, G., Lucas, M., & Klenerman, P. (2005) · UWA Profiles and Research Repository (University of Western Australia) · Cited by 7

Phenotypic characterization of mononuclear blood cells from pregnant Gabonese and their newborns

Köhler, C., Adégnika, A. A., van der Linden, R., Luty, A. J. F., & Kremsner, P. G. (2011) · Tropical Medicine & International Health · doi:10.1111/j.1365-3156.2011.02812.x · Cited by 6

Higher Activation in CD4 + T Cells But Similar Viral Control Among HIV/Hepatitis C Virus-Coinfected Patients on a Simplification Monotherapy

BenMarzouk‐Hidalgo, O. J., Torres-Cornejo, A., Gutiérrez‐Valencia, A., Ruiz-Valderas, R., Viciana, P., & López-Cortés, L. F. (2015) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0299 · Cited by 6

Culturing of HIV-1-specific cytotoxic T lymphocytes with interleukin-7 and interleukin-15

Lubong, R., Ng, H. L., Uíttenbogaart, C. H., & Yang, O. O. (2004) · Virology · doi:10.1016/j.virol.2004.04.036 · Cited by 6

The Effects of Aging on HIV Disease

Kalayjian, R. C., & Al‐Harthi, L. (2009) · Humana Press eBooks · doi:10.1007/978-1-59745-434-6_16 · Cited by 5

Approaches to studying costimulation of human antiviral T cell responses

Serghides, L., Vidric, M., & Watts, T. H. (2006) · Immunologic Research · doi:10.1385/ir:35:1:137 · Cited by 5

Optimal antiretroviral therapy for aging

Cordery, D. V., & Cooper, D. A. (2011) · Sexual Health · doi:10.1071/sh11026 · Cited by 4

Alteration of T Cell Phenotypes in HIV‐Neurotuberculosis Coinfection

Rao, D., Venkataswamy, M. M., Ravi, V., Satishchandra, P., & Desai, A. S. (2018) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.21746 · Cited by 4

Aging and HIV Disease: Synergistic Immunological Effects?

Effros, R. B. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_47 · Cited by 4

Correction: Shorter Telomere Length - A Potential Susceptibility Factor for HIV-Associated Neurocognitive Impairments in South African Woman

Malan‐Müller, S., Hemmings, S. M. J., Spies, G., Kidd, M., Fennema‐Notestine, C., & Seedat, S. (2013) · PLoS ONE · doi:10.1371/annotation/53ec3c1c-3247-452d-85c7-576fb35bdbe3 · Cited by 5

Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection

Rego, R. T., Albuquerque, A. S., Foxall, R. B., Cavaleiro, R., Soares, R. S., Baptista, A. P., Soares, M. V. D., Gómes, P., & Sousa, A. E. (2012) · AIDS · doi:10.1097/qad.0b013e32835ab234 · Cited by 3

Expression of Werner and Bloom syndrome genes is differentially regulated by in vitro HIV-1 infection of peripheral blood mononuclear cells

Bordi, L., Amendola, A., Ciccosanti, F., Abbate, I., Camilloni, G., & Capobianchi, M. R. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02622.x · Cited by 3

Stress and Immune System Aging

Effros, R. B. (2012) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780195394399.013.0004 · Cited by 3

Differential Expression of Werner and Bloom Syndrome Genes in the Peripheral Blood of HIV-1 Infected Patients

Bordi, L., Gioia, C., Lalle, E., Piselli, P., Poccia, F., Capobianchi, M. R., & Amendola, A. (2006) · Human Immunology · doi:10.1016/j.humimm.2006.11.004 · Cited by 2

HIV-Associated Immune Dysfunction and Hematological Abnormalities: A Detailed Examination of Pathophysiology and Clinical Implications

Kodmiri, Z. E., Ghazi, B., Ouamani, A., & Ahnach, M. (2024) · International Journal of Innovative Science and Research Technology (IJISRT) · doi:10.38124/ijisrt/ijisrt24aug813 · Cited by 2

No difference in Gag and Env immune-response profiles between vaccinated and non-vaccinated rhesus macaques that control immunodeficiency virus replication

Nieuwenhuis, I. G., Beenhakker, N., Bogers, W. M. J. M., Otting, Ń., Bontrop, R. E., Dubois, P. M., Mooij, P., Heeney, J. L., & Koopman, G. (2010) · Journal of General Virology · doi:10.1099/vir.0.022772-0 · Cited by 2

What are the predictors of change in multimorbidity among people with HIV ? A longitudinal observational cohort study

Casten, M., Herbert, S., Smith, D. J., Petoumenos, K., Coorey, C. P., & Edmiston, N. (2023) · HIV Medicine · doi:10.1111/hiv.13483 · Cited by 2

Introduction to the aging of primary lymphoid organs: Cellular or homeostatic failure?

García‐Suárez, O., & Vega, J. A. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10407 · Cited by 2

HIV Infection as a Model of Accelerated Immunosenescence

Appay, V., & Sauce, D. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_50 · Cited by 2

Aging, Immunology and

Appay, V. (2004) · Elsevier eBooks · doi:10.1016/b0-12-475570-4/00052-4 · Cited by 2

New observations on CD8 cell responses

Nixon, D. F., Aandahl, E. M., & Sandberg, J. K. (2003) · AIDS · doi:10.1097/00002030-200317004-00007 · Cited by 2

Predictive value of immune parameters before treatment interruption (TI) for CD4 + T-cell count change during TI in HIV infection

Huang, K. H., Loutfy, M. R., Boulet, S., Toma, E., Tsoukas, C. M., & Bernard, N. F. (2008) · Antiviral Therapy · doi:10.1177/135965350901400304 · Cited by 1

From systemic disease to the eye: Why senescence deserves attention in ocular infections

Maiti, S., & Joseph, J. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111095 · Cited by 1

T Cell Responses During Human Immunodeficiency Virus (HIV)-1 Infection

Chougnet, C. A., & Shacklett, B. L. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0484-2_8 · Cited by 1

Viral, Host and Therapeutic Factors Affecting T-cell Recovery in Virologically Controlled HIV Patients

Pinnetti, C., Bandera, A., Mangioni, D., & Gori, A. (2012) · Future Virology · doi:10.2217/fvl.12.80 · Cited by 1

Update on Pediatric Human Immunodeficiency Virus Infection

Smith, C., & McFarland, E. J. (2016) · Advances in Pediatrics · doi:10.1016/j.yapd.2016.04.007 · Cited by 1

Aging and HIV Disease: Synergistic Immunological Effects?

Effros, R. B. (2019) · Springer eBooks · doi:10.1007/978-3-319-99375-1_47 · Cited by 1

Immune Mechanisms of Viral Control in HIV-2 Infection

Moysi, E., de Silva, T. I., & Rowland-Jones, S. L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-387715-4.00011-3 · Cited by 1

Evaluating the reactivation of herpesviruses and inflammation as cardiovascular and cerebrovascular risk factors in antiretroviral therapy initiators in an African HIV-infected population (RHICCA): a protocol for a longitudinal cohort study

Peterson, I., Ntusi, N., Jambo, K., Kelly, C., Huwa, J. M., Afran, L., Tatuene, J. K., Pett, S. L., Henrion, M., van Oosterhout, J. J., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025576 · Cited by 1

The Immune System

Mitchell, W., & Aspinall, R. (2008) · CRC Press eBooks · doi:10.3109/9781420065985-2 · Cited by 1

The role of parasites in the invasion ecology of Harmonia axyridis

Berry, K. M. (2017) · Stirling Online Research Repository (University of Stirling) · Cited by 1

Characterisation of CD8 T cells in mucosa associated lymphoid tissue : Implications for immune control of HIV-1 infection

Quigley, M. F. (2006) · Figshare

Coreceptor expression and T lymphocyte subset distribution in HIV-infected and TB co-infected South African patients on anti-retroviral therapy

Kabue, J. P. (2009) · SUNScholar (Stellenbosch University)

ALTERED T CELL HOMEOSTASIS DURING HIV-1 INFECTION : CONSEQUENCES OF LYMPHOPENIA AND CHRONIC T CELL ACTIVATION

Vivar, N. (2009) · Figshare

ANÁLISE DE PARÂMETROS IMUNOLÓGICOS EM MULHERES COM TRANSTORNO BIPOLAR TIPO I EUTÍMICAS

do Prado, C. H. (2012) · Americanae (AECID Library)

The role of IL-7 in lymphopenia and bystander apoptosis during HIV-1 infection

Fluur, C. (2007) · Figshare

Investigating markers of cellular aging in Human Immunodeficiency Virus infected and uninfected adults

Zanet, D. L. (2013) · cIRcle (University of British Columbia) · doi:10.14288/1.0165594

Depression

Hammond, E. R., & Treisman, G. J. (2008) · CRC Press eBooks · doi:10.3109/9781420065985-4

Mechanisms Underlying Immunomodulation of HIV-1-Specific T-cell Responses

Herasimtschuk, A. (2012) · Spiral (Imperial College London) · doi:10.25560/10565

Immunosénescence : vieillissement « et » ou « du » système immunitaire

Poli, C., Beauvillain, C., Jeannin, P., Rénier, G., & Chevailler, A. (2016) · Revue Francophone des Laboratoires · doi:10.1016/s1773-035x(16)30281-7

treatment infection: correlation with antigenic load and reversion by antiretroviral Expansion of CD7low and CD7negative CD8 T cell effector subsets in HIV-1

Sandberg, J. K., Lindbäck, S., Hecht, F. M., Rosenberg, M., Quigley, M. F., Moretto, W. J., Moll, M., & Gonzalez, V. D. (2013)

Associação entre senescência celular e comprimento dos telômeros em indivíduos infectados pelo HIV-1 com alterações neurocognitivas

de Araújo, M. L. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2017.tde-06012017-103130

Telomeres, Telomerase and CD28 in Human CD8 T-Cells: Effects on Immunity during Aging and HIV Infection

Fauce, S. R., & Effros, R. B. (2008) · Springer eBooks · doi:10.1007/978-0-387-76842-7_4

References

Christopher Nicholson BA (Hons), M. (. N. (2007) · Heart failure · doi:10.1002/9780470988107.refs

Anti-Aging Medicine LiteratureWatch

(2003) · Rejuvenation Research · doi:10.1089/109454503765361588

Aging and HIV Disease: Synergistic Immunological Effects?

Effros, R. B. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_47-1

Inflamm-Aging

Bucci, L., Ostan, R., Capri, M., Salvioli, S., Cevenini, E., Celani, L., Monti, D., & Franceschi, C. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_45

Faculty Opinions recommendation of CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status.

Rowland‐Jones, S. (2004) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1020455.232596

BIBLIOGRAPHY

(2007) · Elsevier eBooks · doi:10.1016/b978-012373657-4/50008-8

References

MPhil, P. J. G. (2007) · Wiley eBooks · doi:10.1002/9780470988121.refs

A mouse model for the pathogenesis of immunodeficiency virus infection

Marques, R. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)

Hypothèses sur l'implication du biais nucléotidique des lentivirus dans le développement du SIDA et nouvelles stratégies d'atténuation du VIH-1

Vabret, N. (2011) · theses.fr (ABES) · doi:10.70675/644c4553z68c4z4276zab57z19411aaad8bb

Etude des réponses T CD4+ et CD8+ induites chez l’homme par différentes stratégies vaccinales anti-VIH-1 utilisant des lipopeptides

Surénaud, M. (2019) · theses.fr (ABES) · doi:10.70675/614b41efzcc3cz45c3z9c65z9c0c996bef95

Etude de la dynamique des réponses immunitaires et génération d'anticorps monoclonaux à visée thérapeutique dans la pathogenèse du SIV/VIH

Coindre, S. (2020) · theses.fr (ABES) · doi:10.70675/1bae0ea9zc3e2z4cdbz8b4fz06c4e5c8ea0e

Identification of novel factors involved in the exacerbation of HIV-1 infection and spread among macrophages in the tuberculosis context

Dupont, M. (2019) · theses.fr (ABES) · doi:10.70675/a9860843z73b2z4e66zb7d6z858eb79b6cf3

Virus Specific T-Cell Responses

Appay, V. (2005) · Springer eBooks · doi:10.1007/1-4020-3623-x_4

HIV Infection as a Model of Accelerated Immunosenescence

Appay, V., & Sauce, D. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_50 · Cited by 2

Mechanisms of immune aging in HIV

Chauvin, M., & Sauce, D. (2022) · Clinical Science · doi:10.1042/cs20210344 · Cited by 50

Immune activation and immune aging in HIV infection

Appay, V., & Kelleher, A. D. (2016) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000240 · Cited by 91

Accelerated immune senescence and HIV-1 infection

APPAY, V, ALMEIDA, J., SAUCE, D., AUTRAN, B., & PAPAGNO, L. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2006.12.003 · Cited by 236

Immune activation and inflammation in HIV‐1 infection: causes and consequences

Appay, V., & Sauce, D. (2007) · The Journal of Pathology · doi:10.1002/path.2276 · Cited by 780