Cited by 173HIV Research and TreatmentHIV-related health complications and treatmentsT-cell and B-cell Immunology

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Premature ageing of the immune system: the cause of AIDS?

Appay, Victor, Rowland-Jones, Sarah L.·2002·Trends in Immunology

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Abstract

The reasons for the failure of the immune system to control HIV-1 infection, and the resulting immunodeficiency, remain unclear. HIV-1 persists in its host despite vigorous immune responses, including a strong, and probably functional, HIV-specific cytotoxic T-lymphocyte response. Interestingly the immunological features of HIV-1-infected individuals show many similarities to those seen in elderly people without HIV infection. We propose that, through a process of continuous immune activation, HIV-1 infection leads to an acceleration of the adaptive immune system ageing process, resulting in premature exhaustion of immune resources, which participates in the onset of immunodeficiency. This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus.

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Authors: Appay, V., & Rowland-Jones, S. L.
Affiliations: John Radcliffe Hospital (GB)
Corresponding author: Appay, Victor
ORCID: Appay, Victor
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2002-12
Volume: 23
Issue: 12
Pages: 580-585
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/s1471-4906(02)02338-4
OpenAlex: W2157134016
Cited by: 173
References: 75
Citations by year: 2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 12
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: HIV-1 infection, immunodeficiency, immune activation, cytotoxic T lymphocytes, HIV-specific immune response, HIV pathogenesis
MeSH terms: Acquired Immunodeficiency Syndrome, Humans, CD4-Positive T-Lymphocytes, HIV-1, CD8-Positive T-Lymphocytes, Models, Immunological, Aging, Premature

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Premature ageing of the immune system: the cause of AIDS?

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