The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Premature ageing of the immune system: the cause of AIDS?
Abstract
The reasons for the failure of the immune system to control HIV-1 infection, and the resulting immunodeficiency, remain unclear. HIV-1 persists in its host despite vigorous immune responses, including a strong, and probably functional, HIV-specific cytotoxic T-lymphocyte response. Interestingly the immunological features of HIV-1-infected individuals show many similarities to those seen in elderly people without HIV infection. We propose that, through a process of continuous immune activation, HIV-1 infection leads to an acceleration of the adaptive immune system ageing process, resulting in premature exhaustion of immune resources, which participates in the onset of immunodeficiency. This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus.
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“There are numerous aspects of immune and cellular senescence that have been documented in the elderly but only a few of them have been extended to studies in HIV-infected individuals (31,32).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [32]
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Cites
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The aging of the immune system
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Immune activation and inflammation in HIV‐1 infection: causes and consequences
Appay, V., & Sauce, D. (2007) · The Journal of Pathology · doi:10.1002/path.2276 · Cited by 780
Self-citationHIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.
Deeks, S. G., & Phillips, A. N. (2009) · BMJ · doi:10.1136/bmj.a3172 · Cited by 704
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
Brenchley, J. M., Paiardini, M., Knox, K. S., Asher, A. I., Cervasi, B., Asher, T. E., Scheinberg, P., Price, D. A., Hage, C. A., Kholi, L. M., et al. (2008) · Blood · doi:10.1182/blood-2008-05-159301 · Cited by 670
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522
Metadata
- Authors
- Appay, V., & Rowland-Jones, S. L.
- Affiliations
- John Radcliffe Hospital (GB)
- Corresponding author
- Appay, Victor
- ORCID
- Appay, Victor
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 23
- Issue
- 12
- Pages
- 580-585
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2157134016
- Cited by
- 173
- References
- 75
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 12
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- HIV-1 infection, immunodeficiency, immune activation, cytotoxic T lymphocytes, HIV-specific immune response, HIV pathogenesis
- MeSH terms
- Acquired Immunodeficiency Syndrome, Humans, CD4-Positive T-Lymphocytes, HIV-1, CD8-Positive T-Lymphocytes, Models, Immunological, Aging, Premature
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