Cited by 173HIV Research and TreatmentHIV-related health complications and treatmentsT-cell and B-cell Immunology

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Premature ageing of the immune system: the cause of AIDS?

Appay, Victor, Rowland-Jones, Sarah L.·2002·Trends in Immunology

Open this paper in CoChat — free account

Abstract

The reasons for the failure of the immune system to control HIV-1 infection, and the resulting immunodeficiency, remain unclear. HIV-1 persists in its host despite vigorous immune responses, including a strong, and probably functional, HIV-specific cytotoxic T-lymphocyte response. Interestingly the immunological features of HIV-1-infected individuals show many similarities to those seen in elderly people without HIV infection. We propose that, through a process of continuous immune activation, HIV-1 infection leads to an acceleration of the adaptive immune system ageing process, resulting in premature exhaustion of immune resources, which participates in the onset of immunodeficiency. This hypothesis might shed new light on HIV-1 pathogenesis and could suggest the need to reconsider current immunotherapeutic strategies to fight the virus.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s1471-4906(02)02338-4

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men
Gottlieb, M. S., Schroff, R. W., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,723
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8 + Lymphocytes
Schmitz, J. E., Kuroda, M. J., Santra, S., Sasseville, V. G., Simon, M. A., Lifton, M. A., Rácz, P., Tenner‐Racz, K., Dalesandro, M. R., Scallon, B. J., et al. (1999) · Science · doi:10.1126/science.283.5403.857 · Cited by 2,167
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
Finzi, D., Blankson, J., Siliciano, J. D., Margolick, J. B., Chadwick, K., Pierson, T., Smith, K., Lisziewicz, J., Lori, F., Flexner, C., et al. (1999) · Nature Medicine · doi:10.1038/8394 · Cited by 2,119
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., et al. (1997) · Nature · doi:10.1038/387183a0 · Cited by 2,050
Changes in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556
Self-citation
Dramatic Rise in Plasma Viremia after CD8+ T Cell Depletion in Simian Immunodeficiency Virus–infected Macaques
Jin, X., Bauer, D. E., Tuttleton, S., Lewin, S. R., Gettie, A., Blanchard, J., Irwin, C. E., Safrit, J. T., Mittler, J. E., Weinberger, L. S., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.6.991 · Cited by 1,409
Phenotypic and functional separation of memory and effector human CD8+ T cells
Hamann, D., Baars, P. A., Rep, M. H. G., Hooibrink, B., Kerkhof-Garde, S. R., Klein, M. R., & Lier, R. A. W. V. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1407 · Cited by 1,366
HIV preferentially infects HIV-specific CD4+ T cells
Douek, D. C., Brenchley, J. M., Betts, M. R., Ambrozak, D. R., Hill, B. J., Okamoto, Y., Casazza, J. P., Kuruppu, J. C., Kunstman, K., Wolinsky, S. M., et al. (2002) · Nature · doi:10.1038/417095a · Cited by 1,261
Antiviral pressure exerted by HIV-l-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
Borrow, P., Lewicki, H. A., Wei, X., Horwitz, M. S., Peffer, N. J., Meyers, H. L., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A., et al. (1997) · Nature Medicine · doi:10.1038/nm0297-205 · Cited by 1,181
Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein
Schwartz, O., Maréchal, V., Gall, S. L., Lemonnier, F. A., & Heard, J. (1996) · Nature Medicine · doi:10.1038/nm0396-338 · Cited by 1,058
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
Collins, K. L., Chen, B. K., Kalams, S. A., Walker, B. D., & Baltimore, D. (1998) · Nature · doi:10.1038/34929 · Cited by 1,020
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Champagne, P., Ogg, G. S., King, A. S., Knabenhans, C., Ellefsen, K., Nobile, M., Appay, V., Rizzardi, G. P., Fleury, S., Lipp, M., et al. (2001) · Nature · doi:10.1038/35065118 · Cited by 1,002
Self-citation
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors
Migueles, S. A., Sabbaghian, M. S., Shupert, W. L., Bettinotti, M. P., Marincola, F. M., Martino, L., Hallahan, C. W., Selig, S. M., Schwartz, D. H., Sullivan, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050567397 · Cited by 995
HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
Appay, V., Nixon, D. F., Donahoe, S. M., Gillespie, G. M. A., Dong, T., King, A., Ogg, G. S., Spiegel, H. M. L., Conlon, C., Spina, C. A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.1.63 · Cited by 871
Self-citation
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Evidence of HIV-1 Adaptation to HLA-Restricted Immune Responses at a Population Level
Moore, C., John, M., JAMES, I. R., Christiansen, F., Witt, C. S., & Mallal, S. A. (2002) · Science · doi:10.1126/science.1069660 · Cited by 740
Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
Allen, T. M., O’Connor, D. H., Jing, P., Dzuris, J. L., Mothé, B. R., Vogel, T. U., DUNPHY, E. B., Liebl, M. E., Emerson, C. L., Wilson, N. A., et al. (2000) · Nature · doi:10.1038/35030124 · Cited by 679
The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
Kalams, S. A., & Walker, B. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2199 · Cited by 660
Quantifying the uncertainty in forecasts of anthropogenic climate change
Allen, M. R., Stott, P. A., Mitchell, J. F. B., Schnur, R., & Delworth, T. L. (2000) · Nature · doi:10.1038/35036559 · Cited by 657
Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.
Clerici, M., Stocks, N. I., Zajac, R. A., Boswell, R. N., Lucey, D. R., Via, C. S., & Shearer, G. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114376 · Cited by 613
Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
Hellerstein, M. K., Hanley, M. B., Cesar, D., Siler, S., Papageorgopoulos, C., Wieder, E., Schmidt, D. J., Hoh, R., Neese, R. A., Macallan, D. C., et al. (1999) · Nature Medicine · doi:10.1038/4772 · Cited by 592
Characterization of CD4+ CTLs Ex Vivo
Appay, V., Zaunders, J. J., Papagno, L., Sutton, J., Jaramillo, A., Waters, A., Easterbrook, P., Grey, P., Smith, D. E., McMichael, A. J., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5954 · Cited by 545
Self-citation
CD4 T Cell Depletion Is Linked Directly to Immune Activation in the Pathogenesis of HIV-1 and HIV-2 but Only Indirectly to the Viral Load
Sousa, A. E., Carneiro, J., Meier‐Schellersheim, M., Grossman, Z., & Victorino, R. M. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3400 · Cited by 506
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
Franceschi, C., Bonafè, M., & Valensin, S. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00513-7 · Cited by 495
11-color, 13-parameter flow cytometry: Identification of human naive T cells by phenotype, function, and T-cell receptor diversity
Rosa, S. C. D., Herzenberg, L. A., Herzenberg, L. A., & Roederer, M. (2001) · Nature Medicine · doi:10.1038/84701 · Cited by 465
CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?
Grossman, Z., Meier‐Schellersheim, M., Sousa, A. E., Victorino, R. M. M., & Paul, W. E. (2002) · Nature Medicine · doi:10.1038/nm0402-319 · Cited by 450
Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
Wikby, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00212-1 · Cited by 414
Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study
Wikby, A., Maxson, P., Olsson, J., Johansson, B. E. A., & Ferguson, F. G. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00151-6 · Cited by 381
Apoptosis in AIDS
Gougeon, M., & Montagnier, L. (1993) · Science · doi:10.1126/science.8098552 · Cited by 367
Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection
O’Connor, D. H., Allen, T. M., Vogel, T. U., Jing, P., DeSouza, I., Dodds, E. J., Dunphy, E. J., Melsaether, C., Mothé, B. R., Yamamoto, H., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-493 · Cited by 357
Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?
Effros, R. B., & Pawelec, G. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01079-7 · Cited by 337
Telomeres in T and B cells
Hodes, R. J., Hathcock, K. S., & Weng, N. (2002) · Nature reviews. Immunology · doi:10.1038/nri890 · Cited by 317
Ageing of lymphocytes and lymphocytes in the aged
Globerson, A., & Effros, R. B. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01714-x · Cited by 313
T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4 + T Cell Turnover
Wolthers, K. C., Bea, G., Wisman, A., Otto, S. A., de Roda Husman, A.-M., Schaft, N., de Wolf, F., Goudsmit, J., Coutinho, R. A., van der Zee, A. G. J., et al. (1996) · Science · doi:10.1126/science.274.5292.1543 · Cited by 286
Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells
Tarazona, R., DelaRosa, O., Alonso, C., Ostos, B., Espejo, J., Peña, J., & Solana, R. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00199-8 · Cited by 262
Enhanced and coordinated in vivo expression of inflammatory cytokines and nitric oxide synthase by chondrocytes from patients with osteoarthritis
Melchiorri, C., Melicòni, R., Frizziero, L., Silvestri, T., Pulsatelli, L., Mazzetti, I., Borzı̀, R. M., Uguccioni, M., & Facchini, A. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199812)41:12 · Cited by 254
Neutralizing Antibodies Have Limited Effects on the Control of Established HIV-1 Infection In Vivo
Poignard, P., Sabbe, R., Picchio, G., Wang, M., Gulizia, R. J., Katinger, H. W. D., Parren, P. W. H. I., Mosier, D. E., & Burton, D. R. (1999) · Immunity · doi:10.1016/s1074-7613(00)80043-6 · Cited by 243
Regulation of CD27 expression on subsets of mature T-lymphocytes.
Hintzen, R. Q., de Jong, R., Lens, S. M. A., Brouwer, M. C., Baars, P. A., & van Lier, R. A. W. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.5.2426 · Cited by 241
Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection
Lieberman, J., Shankar, P., Manjunath, N., & Andersson, J. (2001) · Blood · doi:10.1182/blood.v98.6.1667 · Cited by 226
Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection.
Fan, J., Bass, H. Z., & Fahey, J. L. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.5031 · Cited by 215
Identification of Naive or Antigen-Experienced Human CD8+ T Cells by Expression of Costimulation and Chemokine Receptors: Analysis of the Human Cytomegalovirus-Specific CD8+ T Cell Response
Wills, M. R., Okecha, G., Weekes, M. P., Gandhi, M. K., Sissons, P., & Carmichael, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.11.5455 · Cited by 208
A Novel Approach to the Analysis of Specificity, Clonality, and Frequency of HIV-Specific T Cell Responses Reveals a Potential Mechanism for Control of Viral Escape
Douek, D. C., Betts, M. R., Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Ngai, K.-L., Karandikar, N. J., Casazza, J. P., & Koup, R. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.6.3099 · Cited by 204
Persistent numbers of tetramer+ CD8+ T cells, but loss of interferon-γ+ HIV-specific T cells during progression to AIDS
Kostense, S., Vandenberghe, K., Joling, J., van Baarle, D., Nanlohy, N. M., Manting, E. H., & Miedema, F. F. (2002) · Blood · doi:10.1182/blood.v99.7.2505 · Cited by 183
Generation of HIV latency during thymopoiesis
Brooks, D. G., Kitchen, S. G., Ramirez, C. M., Scripture-Adams, D. D., & Zack, J. A. (2001) · Nature Medicine · doi:10.1038/86531 · Cited by 180
Faces and phases of human CD8+ T-cell development
Hamann, D., Roos, M. T. L., & van Lier, R. A. W. (1999) · Immunology Today · doi:10.1016/s0167-5699(99)01444-9 · Cited by 179
Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population
Darby, I., Ewart, D. W., Giangrande, I., Spooner, R. J. D., & Rizza, C. R. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91073-9 · Cited by 177
Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D. (2001) · Immunity · doi:10.1016/s1074-7613(01)00246-1 · Cited by 164
Circulating CD8 T Lymphocytes in Human Immunodeficiency Virus-Infected Individuals Have Impaired Function and Downmodulate CD3ζ, the Signaling Chain of the T-Cell Receptor Complex
Trimble, L. A., & Lieberman, J. (1998) · Blood · doi:10.1182/blood.v91.2.585 · Cited by 161
CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus
Wang, E. C. Y., Moss, P. A. H., Frodsham, P., Lehner, P. J., Bell, J. I., & Borysiewicz, L. K. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.10.5046 · Cited by 155
Postthymic Development of CD28−CD8+ T Cell Subset: Age-Associated Expansion and Shift from Memory to Naive Phenotype
Nociari, M., Telford, W. G., & Russo, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3327 · Cited by 154
Dynamics of T Cell Responses in HIV Infection
Appay, V., Papagno, L., Spina, C. A., Hansasuta, P., King, A. S., Jones, L. E., Ogg, G. S., Little, S. J., McMichael, A. J., Richman, D. D., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3660 · Cited by 152
Self-citation
Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific
Wilson, J., Ogg, G. S., Allen, R. L., Goulder, P., Kelleher, A. D., Sewell, A. K., O’Callaghan, C. A., Rowland‐Jones, S., Callan, M. F. C., & McMichael, A. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.4.785 · Cited by 148
Self-citation
The membrane attack complex of complement induces caspase activation and apoptosis
Nauta, A. J., Daha, M. R., Tijsma, O., van de Water, B., Tedesco, F., & Roos, A. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200203)32:3 · Cited by 147
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 140
Functionally Inert HIV-Specific Cytotoxic T Lymphocytes Do Not Play a Major Role in Chronically Infected Adults and Children
Goulder, P., Tang, Y., Brander, C., Betts, M. R., Altfeld, M. A., Annamalai, K., Piechocka‐Trocha, A., He, S., Rosenberg, E. S., Ogg, G. S., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.12.1819 · Cited by 125
Reconstitution of CD4+ T lymphocytes in HIV-infected individuals following antiretroviral therapy
Carcelain, G., Debré, P., & Autran, B. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00245-4 · Cited by 113
Circulating cytotoxic CD8+ CD28- T cells in ankylosing spondylitis
Schirmer, M., Goldberger, C., Würzner, R., Duftner, C., Pfeiffer, K. P., Clausen, J., Neumayr, G., & Falkenbach, A. (2001) · Arthritis Research & Therapy · doi:10.1186/ar386 · Cited by 108
Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected withnef-Defective HIV Type 1
Dyer, W. B., Ogg, G. S., Demoitié, M., Jin, X., Geczy, A. F., Rowland‐Jones, S., McMichael, A. J., Nixon, D. F., & Sullivan, J. S. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.436-443.1999 · Cited by 103
Self-citation
Dynamics of HIV-Specific CD8+ T Lymphocytes with Changes in Viral Load
Mollet, L., Li, T., Samri, A., Tournay, C., Tubiana, R., Cálvez, V., Debré, P., Katlama, C., Autran, B., & Groups, T. R. A. C. S. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1692 · Cited by 99
Accelerated replicative senescence of the peripheral immune system induced by HIV infection
Bestilny, L. J., Gill, M. J., Mody, C. H., & Riabowol, K. T. (2000) · AIDS · doi:10.1097/00002030-200005050-00002 · Cited by 95
HIV: current opinion in escapology
Klenerman, P., Wu, Y., & Phillips, R. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00339-9 · Cited by 92
Acute Sexually Transmitted Infections Increase Human Immunodeficiency Virus Type 1 Plasma Viremia, Increase Plasma Type 2 Cytokines, and Decrease CD4 Cell Counts
Anzala, A. O., Simonsen, J. N., Kimani, J., Ball, T. B., Nagelkerke, N. J. D., Rutherford, J., NGUGI, E. N., Bwayo, J. J., & Plummer, F. A. (2000) · The Journal of Infectious Diseases · doi:10.1086/315733 · Cited by 84
Increased expression of CD80, CD86 and CD70 on T cells from HIV‐infected individuals upon activation in vitro: regulation by CD4+ T cells
Wolthers, K. C., Otto, S. A., Lens, S. M. A., Kolbach, D. N., van Lier, R. A. W., Miedema, F. F., & Meyaard, L. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260806 · Cited by 74
Comparison between HIV- and CMV-specific T cell responses in long-term HIV infected donors
Papagno, L., Appay, V., SUTTON, J., Rostron, T., Gillespie, G. M. A., Ogg, G. S., King, A. S., MAKADZANHGE, A. T., Waters, A., Balotta, C., et al. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.02005.x · Cited by 58
Self-citation
The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection
Heintel, T., Sester, M., Rodríguez, M. M. B., Krieg, C., Sester, U., Wagner, R., Pees, H. W., Gärtner, B. C., Maier, R., & Meyerhans, A. (2002) · AIDS · doi:10.1097/00002030-200207260-00006 · Cited by 49
HIV: The deadly passenger in dendritic cells
Rowland‐Jones, S. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80155-9 · Cited by 41
Self-citation
Telomeres and HIV disease
Effros, R. B. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00283-5 · Cited by 32
Cytomegalovirus (CMV) infection, CD4+ lymphocyte counts and the development of AIDS in HIV-1-infected haemophiliac patients
Webster, A. D. B., Phillips, A. N., Lee, C. A., Janossy, G., Kernoff, P. B. A., & Griffiths, P. D. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb03030.x · Cited by 29
Chronic immune stimulation accelerates SIV‐induced disease progression
Villinger, F. J., Rowe, T., Parekh, B., Green, T. A., Mayne, A. E., Grimm, B. D., McClure, H. M., Lackner, A. A., Dailey, P. J., Ansari, A. A., et al. (2001) · Journal of Medical Primatology · doi:10.1034/j.1600-0684.2001.d01-57.x · Cited by 27
Pathogenic and protective correlates of T cell proliferation in AIDS. HNRC Group. HIV Neurobehavioral Research Center.
Schrier, R. D., Wiley, C. A., Spina, C. A., McCutchan, J. A., & Grant, I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118845 · Cited by 26
Skewed maturation of virus-specific CTLs?
Gamadia, L. E., ten Berge, I. J. M., Picker, L. J., & van Lier, R. A. W. (2002) · Nature Immunology · doi:10.1038/ni0302-203 · Cited by 22
STI and beyond: the prospects of boosting anti-HIV immune responses
Allen, T. M., Kelleher, A. D., Zaunders, J. J., & Walker, B. D. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02297-4 · Cited by 20
Is age a negative prognostic indicator in HIV infection or AIDS?
Keller, M., Hausdorff, J. M., Kyne, L., & Wei, J. Y. (1999) · Aging Clinical and Experimental Research · doi:10.1007/bf03399634 · Cited by 15

Sorted by citations

The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Immune activation and inflammation in HIV‐1 infection: causes and consequences
Appay, V., & Sauce, D. (2007) · The Journal of Pathology · doi:10.1002/path.2276 · Cited by 780
Self-citation
HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity.
Deeks, S. G., & Phillips, A. N. (2009) · BMJ · doi:10.1136/bmj.a3172 · Cited by 704
Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
Brenchley, J. M., Paiardini, M., Knox, K. S., Asher, A. I., Cervasi, B., Asher, T. E., Scheinberg, P., Price, D. A., Hage, C. A., Kholi, L. M., et al. (2008) · Blood · doi:10.1182/blood-2008-05-159301 · Cited by 670
HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group
High, K. P., Brennan-Ing, M., Clifford, D. B., Cohen, M. H., Currier, J., Deeks, S. G., Deren, S., Effros, R. B., Gebo, K., Goronzy, J. J., et al. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31825a3668 · Cited by 522

See all 173

Authors: Appay, V., & Rowland-Jones, S. L.
Affiliations: John Radcliffe Hospital (GB)
Corresponding author: Appay, Victor
ORCID: Appay, Victor
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2002-12
Volume: 23
Issue: 12
Pages: 580-585
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/s1471-4906(02)02338-4
OpenAlex: W2157134016
Cited by: 173
References: 75
Citations by year: 2026: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 12
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: HIV-1 infection, immunodeficiency, immune activation, cytotoxic T lymphocytes, HIV-specific immune response, HIV pathogenesis
MeSH terms: Acquired Immunodeficiency Syndrome, Humans, CD4-Positive T-Lymphocytes, HIV-1, CD8-Positive T-Lymphocytes, Models, Immunological, Aging, Premature

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Premature ageing of the immune system: the cause of AIDS?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks