Astrocytes: a cellular player in Aβ clearance and degradation
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Reactive astrocytes are involved in the degradation and clearance of Aβ.
“we and others have reported that reactive astrocytes are involved in the degradation and clearance of Aβ [13, 14].”
From Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer’s disease (2021) · cites this paper as [13]
The capability of astrocytes and microglia to internalize and degrade Aβ is strictly correlated with their aberrant activation during Alzheimer's disease progression.
“Importantly, the capability of astrocytes and microglia to internalize and degrade Aβ (Guénette, 2003; Hansen et al., 2018) is strictly correlated with their aberrant activation during the AD progression (Bates et al., 2009; Ries and Sastre, 2016).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Guénette, 2003
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- Authors
- Guénette, S. Y.
- Affiliations
- Harvard University (US)
- Corresponding author
- Guénette, Suzanne Y.
- Venue
- Trends in Molecular Medicine
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 9
- Issue
- 7
- Pages
- 279-280
- ISSN
- 1471-4914 (ISSN-L)
- OpenAlex
- W2029343038
- Cited by
- 64
- References
- 15
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 8 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 6 · 2012: 3
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocytes, amyloid-beta clearance, Alzheimer's disease, amyloid plaques, MCP-1, astrocyte migration, neuroprotection
- MeSH terms
- Animals, Astrocytes, Cell Movement, Hydrolysis, Amyloid beta-Peptides, Chemokine CCL2, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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