Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

ISHIZUKA, KOKO; KIMURA, TAKEMI; IGATA‐YI, RURIKO; KATSURAGI, SHOICHI; TAKAMATSU, JUNICHI; MIYAKAWA, TAIHEI

doi:10.1111/j.1440-1819.1997.tb02375.x

Cited by 245Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

Open access

ISHIZUKA, KOKO, KIMURA, TAKEMI, IGATA‐YI, RURIKO, KATSURAGI, SHOICHI, TAKAMATSU, JUNICHI, MIYAKAWA, TAIHEI·1997·Psychiatry and Clinical Neurosciences

DOI 10.1111/j.1440-1819.1997.tb02375.x

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Abstract

Abstract It has been shown that human monocytes express monocyte chemoattractant protein‐1 (MCP‐1), an inflammatry factor, in response to non‐fibrillar β‐amyloid protein. Reactive microglia and inflammatory factors were reported to be present in β‐amyloid deposits (senile plaques) in Alzheimer's disease, suggesting the presence of MCP‐1 in senile plaques. To address this issue, we examined MCP‐1‐immunoreactivity in senile plaques using a mouse monoclonal anti‐MCP‐1 antibody. Monocyte chemoattractant protein‐1 was found immunohistochemically in mature senile plaques and reactive microglia but not in immature senile plaques of brain tissues from five patients with Alzheimer's disease. These findings suggest that MCP‐1‐related inflammatory events induced by reactive microglia contribute to the maturation of senile plaques.

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From CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models (2010) · cites this paper as [39]
The associated haplotype spans several chemokines, including some proinflammatory factors reported to be elevated in Alzheimer's disease.
“Examination of the regional association plot on chromosome 17 revealed that the associated haplotype spans several chemokines, including some proinflammatory factors reported to be elevated in AD (Figure 3).37”
From Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease (2015) · cites this paper as [37]

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Authors: ISHIZUKA, K., KIMURA, T., IGATA‐YI, R., KATSURAGI, S., TAKAMATSU, J., & MIYAKAWA, T.
Affiliations: Kumamoto University (JP)
Corresponding author: ISHIZUKA, KOKO
Venue: Psychiatry and Clinical Neurosciences
Publisher: Wiley
Published: 1997-06
Volume: 51
Issue: 3
Pages: 135-138
ISSN: 1323-1316 (ISSN-L)
1440-1819
DOI: 10.1111/j.1440-1819.1997.tb02375.x
OpenAlex: W1966081154
Cited by: 245
References: 36
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 17 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 7 · 2013: 16 · 2012: 7
FWCI: 2.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4045 d)
Locations: Psychiatry and Clinical Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: MCP-1, Alzheimer's disease, amyloid plaques, reactive microglia, amyloid-beta, neuroinflammation, plaque maturation, inflammatory mediators, immunohistochemistry
MeSH terms: Aged, Alzheimer Disease, Brain Chemistry, Humans, Immunohistochemistry, Inflammation, Middle Aged, Neurofibrillary Tangles, Microglia, Chemokine CCL2

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Identification of monocyte chemoattractant protein‐1 in senile plaques and reactive microglia of Alzheimer's disease

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