The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Xs and Y of immune responses to viral vaccines
Open accessAbstract
The biological differences associated with an individual’s sex represent a major source of variation that impacts the immune response to vaccination. There are compelling clinical data illustrating that males and females differ in their innate, humoral, and cell-mediated responses to viral vaccines. Sex impacts the frequency and severity of adverse side effects of vaccination, including fever, pain, and inflammation. Pregnancy also can significantly alter immune responses to vaccines. Key aspects of the impact of sex and pregnancy on vaccination are presented using data drawn from clinical trials in humans as well as from animal models of vaccine efficacy and the groundwork is laid for future studies aimed at identifying the biological mechanisms, including genetic and hormonal factors, that underlie sex-specific responses to vaccines. An understanding and appreciation of the impact of sex and pregnancy on immune responses may alter the strategies used by public health officials to initiate efficient vaccination programs in the human population optimizing the timing and dose of the vaccine in order to maximize the number of people immunized, ensure sufficient levels of immune responses, minimize adverse side effects, and allow for more efficient protection of high priority populations.
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Cites
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Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis
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Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children
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Cited by
Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370
Self-citationCancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis
Conforti, F., Pala, L., Bagnardi, V., De Pas, T., Martinetti, M., Viale, G., Gelber, R. D., & Goldhirsch, A. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30261-4 · Cited by 973
Suppressive effects of androgens on the immune system
Trigunaite, A., Dimo, J., & Jørgensen, T. N. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.004 · Cited by 551
Sex and Gender Differences in the Outcomes of Vaccination over the Life Course
Flanagan, K. L., Fink, A. L., Plebanski, M., & Klein, S. L. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060718 · Cited by 508
Self-citationSex differences in vaccine-induced humoral immunity
Fischinger, S., Boudreau, C. M., Butler, A. L., Streeck, H., & Alter, G. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-018-0726-5 · Cited by 410
Metadata
- Authors
- Klein, S. L., Jedlicka, A., & Pekosz, A.
- Venue
- The Lancet Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 10
- Issue
- 5
- Pages
- 338-349
- ISSN
- 1473-3099 (ISSN-L)
- OpenAlex
- W2131643987
- Cited by
- 815
- References
- 7
- FWCI
- 20.87
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
