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Cited by 519

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing

Open access
Mitchell, Alex J, Benito-León, Julián, González, José-Manuel Morales, Rivera-Navarro, Jesús·2005·The Lancet Neurology

Abstract

Health-related quality of life (HRQoL) has been more intensively studied in multiple sclerosis (MS) than in any other neurological disorder. Traditional medical models of impairment and disability are an incomplete summary of disease burden. Quality of life can be thought of as the sum of all sources of satisfaction (including anticipated sources) minus all threats (including anticipated threats). Many psychosocial factors-including coping, mood, self-efficacy, and perceived support-influence the quality of life of patients with MS more than biological variables such as weakness or extent of MRI lesions. Neuropsychiatric complications such as cognitive impairment and fatigue are also important predictors, even in those patients in the early stages of the disease. We review generic and specific HRQoL measures to help clinicians choose the most appropriate therapies. Subjective (self-report) HRQoL measures may serve to alert clinicians to areas that would otherwise be overlooked. Studies of new interventions should include an assessment of HRQoL not just impairment or disability alone.

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Crossref · 10.1016/s1474-4422(05)70166-6

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Metadata

Authors
Mitchell, A. J., Benito-León, J., González, J.-M. M., & Rivera-Navarro, J.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2005-09
Volume
4
Issue
9
Pages
556-566
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2154514379
Cited by
519
References
19
FWCI
6.69
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing. https://app.cochat.ai/papers/10.1016/s1474-4422(05)70166-6
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Mitchell, A. J., Benito-León, J., González, J.-M. M., & Rivera-Navarro, J. (2005). Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing. The Lancet Neurology. https://doi.org/10.1016/s1474-4422(05)70166-6

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.