The Relationship Between Plasma Oxytocin and Executive Functioning in Huntington's Disease: A Pilot Study
Abstract
The role of oxytocin (OT) in social cognition of patients with Huntington’s disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels. Higher OT levels were associated with better executive functioning in premanifest HD participants. Our findings revealed an association between OT levels and depressive symptoms in premanifest and manifest HD participants. The potential role of OT in HD deserves further investigation.
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- Authors
- Fisher, E. R., Rocha, N. P., Morales-Scheihing, D. A., Venna, V. R., Furr-Stimming, E. E., Teixeira, A. L., & Rossetti, M. A.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Department of Neurology, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA
- Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA
- Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA
- Corresponding author
- Rossetti, Maria A.
- Venue
- Journal of Huntington's disease
- Publisher
- SAGE Publications
- Published
- 2021-06-04
- Volume
- 10
- Issue
- 3
- Pages
- 349-354
- ISSN
- 1879-6397 (ISSN-L)
- 1879-6400
- OpenAlex
- W3171796210
- Semantic Scholar
- 12438df13a28f285256ab101163a29b58f0d5bfb
- Cited by
- 8
- References
- 32
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 4
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Huntington s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R37NS096493)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- oxytocin, plasma oxytocin, executive function, Huntington's disease, premanifest Huntington's disease, depressive symptoms, social cognition
- MeSH terms
- Humans, Huntington Disease, Neuropsychological Tests, Oxytocin, Pilot Projects, Executive Function
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