Protective and anti-oxidative effects of curcumin and resveratrol on Aβ-oligomer-induced damage in the SH-SY5Y cell line
Abstract
Alzheimer's disease (AD) is a degenerative disorder characterized by the loss of synapses and neurons in the brain, and results in the accumulation of amyloid-based neurotic plaques. Amyloid-β oligomers (AβO) are widely accepted as the main neurotoxin that induces oxidative stress and neuronal loss in AD. In this study, an oxidative stress model of the neuroblastoma SH-SY5Y cell line exposed to AβO was established to simulate an AD cell model. Exposure to AβO significantly reduced the viability of cultured SH-SY5Y cells (p < 0.05) and significantly increased intracellular reactive oxygen species (ROS) (p < 0.01). AβO exposure also induced oxidative stress in SH-SY5Y cells. Furthermore, AβO significantly increased the level of hyperphosphorylation of tau at sites T181 and T205 in SH-SY5Y cells (p < 0.01). Using edaravone, a free radical scavenger with neuroprotective properties, as the control, the possible protective and anti-oxidative effects of curcumin (40 μM) and resveratrol (20 μM) were evaluated. The results suggest that curcumin and resveratrol decreased ROS generation, attenuated oxidative stress, inhibited tau hyperphosphorylation, and protected SH-SY5Y cells from AβO damage. Both curcumin and resveratrol are promising supplements or medicine as therapeutic agents for the treatment of AD.
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Oxidative stress and tau hyperphosphorylation levels were raised after exposure to amyloid beta oligomers.
“In addition, oxidative stress and tau hyperphosphorylation levels were also raised.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [85]
Curcumin is a promising therapeutic agent for managing Alzheimer's disease.
“Conclusively, curcumin was considered a promising therapeutic agent for managing AD [85].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [85]
The viability of cultured SH-SY5Y cells was considerably decreased after exposure to amyloid beta oligomers.
“Moreover, the viability of cultured SH-SY5Y cells was considerably decreased after exposure to AβO.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [85]
Curcumin reduced reactive oxygen species production, alleviated oxidative stress, prevented tau hyperphosphorylation, and protected SH-SY5Y cells from amyloid beta oligomer damage.
“Furthermore, according to the findings, curcumin reduced ROS production, alleviated oxidative stress, prevented tau hyperphosphorylation, and protected SH-SY5Y cells from AβO damage.”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [85]
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- Authors
- Yu, H., Yamashita, T., Hu, X., Bian, Z., Hu, X., Feng, T., Tadokoro, K., Morihara, R., & Abe, K.
- Affiliations
- Okayama University (JP)
- Corresponding author
- Abe, Koji
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 441
- Pages
- 120356
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W4289339159
- Cited by
- 37
- References
- 40
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 8 · 2023: 8 · 2022: 1
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (7211700121, 7211800049, 7211800130)
- Japan Society for the Promotion of Science (17H0975609, 20 K09370)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, resveratrol, amyloid-beta oligomers, Alzheimer's disease, oxidative stress, reactive oxygen species, tau hyperphosphorylation, neuroprotection, SH-SY5Y cells, edaravone, neurotoxicity
- MeSH terms
- Resveratrol, Edaravone, Alzheimer Disease, Curcumin, Humans, Neuroblastoma, Neurotoxins, Free Radical Scavengers, Amyloid beta-Peptides, Reactive Oxygen Species, Oxidative Stress, Neuroprotective Agents, Cell Line, Tumor
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