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Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study
Open accessAbstract
Background Neurofibrillary pathology has a stereotypical progression in Alzheimer's disease (AD) that is encapsulated in the Braak staging scheme; however, some AD cases are atypical and do not fit into this scheme. We aimed to compare clinical and neuropathological features between typical and atypical AD cases.Methods AD cases with a Braak neurofibrillary tangle stage of more than IV were identified from a brain bank database. By use of thioflavin-S fluorescence microscopy, we assessed the density and the distribution of neurofibrillary tangles in three cortical regions and two hippocampal sectors. These data were used to construct an algorithm to classify AD cases into typical, hippocampal sparing, or limbic predominant. Classified cases were then compared for clinical, demographic, pathological, and genetic characteristics. An independent cohort of AD cases was assessed to validate findings from the initial cohort.Findings 889 cases of AD, 398 men and 491 women with age at death of 37-103 years, were classified with the algorithm as hippocampal sparing (97 cases [11%]), typical (665 [75%]), or limbic predominant (127 [14%]). By comparison with typical AD, neurofibrillary tangle counts per 0.125 mm(2) in hippocampal sparing cases were higher in cortical areas (median 13, IQR 11-16) and lower in the hippocampus (7.5, 5.2-9.5), whereas counts in limbic-predominant cases were lower in cortical areas (4.3, 3.0-5.7) and higher in the hippocampus (27, 22-35). Hippocampal sparing cases had less hippocampal atrophy than did typical and limbic-predominant cases. Patients with hippocampal sparing AD were younger at death (mean 72 years [SD 10]) and a higher proportion of them were men (61 [63%]), whereas those with limbic-predominant AD were older (mean 86 years [SD 6]) and a higher proportion of them were women (87 [69%]). Microtubule-associated protein tau (MAPT) H1H1 genotype was more common in limbic-predominant AD (54 [70%]) than in hippocampal sparing AD (24 [46%]; p=0.011), but did not differ significantly between limbic-predominant and typical AD (204 [59%]; p=0.11). Apolipoprotein E (APOE) ɛ4 allele status differed between AD subtypes only when data were stratified by age at onset. Clinical presentation, age at onset, disease duration, and rate of cognitive decline differed between the AD subtypes. These findings were confirmed in a validation cohort of 113 patients with AD.Interpretation These data support the hypothesis that AD has distinct clinicopathological subtypes. Hippocampal sparing and limbic-predominant AD subtypes might account for about 25% of cases, and hence should be considered when designing clinical, genetic, biomarker, and treatment studies in patients with AD.Funding US National Institutes of Health via Mayo Alzheimer's Disease Research Center, Mayo Clinic Study on Aging, Florida Alzheimer's Disease Research Center, and Einstein Aging Study; and State of Florida Alzheimer's Disease Initiative.
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“clinical features lack specificity for a pathologic process, but rather indicate brain regions or systems affected by the disease process [3, 4].”
From The neuropathological diagnosis of Alzheimer's disease (2019) · cites this paper as [3]
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“Three major subtypes of AD can be classified by the relative density of hippocampal neurofibrillary tangles with respect to neocortical tangles [3].”
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“Genetic analyses of APOE suggest APOE4 is more closely linked to typical or limbic predominant than hippocampal sparing AD [3].”
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“Nonamnestic clinical presentations, that is, language, visuospatial, and executive disorders, may also be due to AD [63–66].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [65]
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“Another challenge of CPC studies is that the molecular, anatomic, and clinical changes of AD may not progress in a uniform fashion (7, 12-15).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [12]
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“and that not all AD cases fall within the same spatial continuum with regard to brain NFT distributions (12, 15, 151).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [12]
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“Nevertheless, Braak staging also masks the fact that marked variability in pathologic lesion density across cases exists within a given Braak stage (7, 12)”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [12]
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Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806
Self-citationNeurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
Amador‐Ortiz, C., Lin, W., Ahmed, Z., Personett, D., Davies, P., Duara, R., Graff‐Radford, N. R., Hutton, M. L., & Dickson, D. W. (2007) · Annals of Neurology · doi:10.1002/ana.21154 · Cited by 916
Self-citationAssociation of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy
Baker, M., Litvan, I., Houlden, H., Adamson, J., Dickson, D., Perez-Tur, J., Hardy, J., Lynch, T., Bigio, E., & Hutton, M. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.711 · Cited by 781
Self-citationBarker, W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., Waters, C., Jimison, P., Shepherd, E., Sevush, S., et al. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200210000-00001 · Cited by 714
Self-citation
Cited by
Sorted by citations
Items 101–200 of 971
Matchett, B. J., Grinberg, L. T., Theofilas, P., & Murray, M. E. (2021) · Acta Neuropathologica · doi:10.1007/s00401-020-02248-1 · Cited by 168
Self-citationWalker, L., Stefanis, L., & Attems, J. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14698 · Cited by 169
Townley, R. A., Graff-Radford, J., Mantyh, W. G., Botha, H., Polsinelli, A. J., Przybelski, S. A., Machulda, M. M., Makhlouf, A. T., Senjem, M. L., Murray, M. E., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa068 · Cited by 145
Self-citationAlzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
Barnes, J., Dickerson, B. C., Frost, C. D., Jiskoot, L. C., Wolk, D. A., & van der Flier, W. M. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.12.007 · Cited by 164
Rabinovici, G. D., Carrillo, M. C., Forman, M. S., DeSanti, S., Miller, D. S., Kozauer, N., Petersen, R. C., RANDOLPH, C. C., Knopman, D. S., Smith, E. E., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.09.002 · Cited by 160
Self-citationEarly Alzheimer's Disease Neuropathology Detected by Proton MR Spectroscopy
Murray, M. E., Przybelski, S. A., Lesnick, T. G., Liesinger, A. M., Spychalla, A. J., Zhang, B., Gunter, J. L., Parisi, J. E., Boeve, B. F., Knopman, D. S., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2027-14.2014 · Cited by 148
Self-citationAtrophy subtypes in prodromal Alzheimer’s disease are associated with cognitive decline
ten Kate, M., Dicks, E., Visser, P. J., van der Flier, W. M., Teunissen, C. E., Barkhof, F., Scheltens, P., Tijms, B. M., & Initiative, A. D. N. (2018) · Brain · doi:10.1093/brain/awy264 · Cited by 150
Recent update on the heterogeneity of the Alzheimer’s disease spectrum
Jellinger, K. A. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02449-2 · Cited by 155
The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome
Drummond, E., Kavanagh, T., Pires, G., Marta-Ariza, M., Kanshin, E., Nayak, S., Faustin, A., Berdah, V., Ueberheide, B., & Wisniewski, T. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01356-1 · Cited by 137
TAR DNA‐binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features
Josephs, K. A., Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Murray, M. E., Liesinger, A. M., Petrucelli, L., Senjem, M. L., Ivnik, R. J., Parisi, J. E., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24493 · Cited by 147
Self-citationRabinovici, G. D., Knopman, D. S., Arbizu, J., Benzinger, T. L. S., Donohoe, K. J., Hansson, O., Herscovitch, P., Kuo, P. H., Lingler, J. H., Minoshima, S., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14338 · Cited by 163
Self-citationDifferential clinicopathologic and genetic features of late-onset amnestic dementias
Murray, M. E., Cannon, A. D., Graff‐Radford, N. R., Liesinger, A. M., Rutherford, N. J., Ross, O. A., Duara, R., Carrasquillo, M. M., Rademakers, R., & Dickson, D. W. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1302-2 · Cited by 146
Self-citationDifferential effects of cognitive reserve and brain reserve on cognition in Alzheimer disease
Groot, C., van Loenhoud, A. C., Barkhof, F., van Berckel, B. N. M., Koene, T., Teunissen, C. E., Scheltens, P., van der Flier, W. M., & Ossenkoppele, R. (2017) · Neurology · doi:10.1212/wnl.0000000000004802 · Cited by 157
Neurodegenerative Disease Tauopathies
Creekmore, B. C., Watanabe, R., & Lee, E. B. (2023) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-120750 · Cited by 155
Challenges of multimorbidity of the aging brain: a critical update
Jellinger, K. A., & Attems, J. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-014-1288-x · Cited by 154
Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease
Baek, M. S., Cho, H., Lee, H. S., Lee, J., Ryu, Y. H., & Lyoo, C. H. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00710-6 · Cited by 137
Joie, R. L., Visani, A. V., Lesman‐Segev, O. H., Baker, S. L., Edwards, L., Iaccarino, L., Soleimani‐Meigooni, D. N., Mellinger, T. J., Janabi, M., Miller, Z., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000011270 · Cited by 140
Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing
Neltner, J. H., Abner, E. L., Baker, S., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Hammack, E., Kukull, W. A., Brenowitz, W. D., et al. (2013) · Brain · doi:10.1093/brain/awt318 · Cited by 130
Janocko, N. J., Brodersen, K. A., Soto-Ortolaza, A., Ross, O., Liesinger, A. M., Duara, R., Graff-Radford, N., Dickson, D., & Murray, M. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1044-y · Cited by 138
Self-citationFDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer’s Type
Madhavan, A. A., Whitwell, J. L., Weigand, S. D., Duffy, J. R., Strand, E. A., Machulda, M. M., Tosakulwong, N., Senjem, M. L., Gunter, J. L., Lowe, V. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062471 · Cited by 126
Self-citationSex and age interact to determine clinicopathologic differences in Alzheimer’s disease
Liesinger, A. M., Graff-Radford, N. R., Duara, R., Carter, R. E., Hanna Al-Shaikh, F. S., Koga, S., Hinkle, K. M., DiLello, S. K., Johnson, M. F., Aziz, A., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1908-x · Cited by 126
Self-citationGenetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126
“This has led many to attempt to identify distinct subtypes of AD (Murray et al., 2011; Petersen, 1998).”
Background18 F-FDG PET in Posterior Cortical Atrophy and Dementia with Lewy Bodies
Whitwell, J. L., Graff‐Radford, J., Singh, T. D., Drubach, D. A., Senjem, M. L., Spychalla, A. J., Tosakulwong, N., Lowe, V. J., & Josephs, K. A. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.179903 · Cited by 124
Tang, M., Ryman, D. C., McDade, E., Jasielec, M. S., Buckles, V. D., Cairns, N. J., Fagan, A. M., Goate, A., Marcus, D. S., Xiong, C., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30229-0 · Cited by 121
Self-citationPetersen, C., Nolan, A. L., de Paula França Resende, E., Miller, Z., Ehrenberg, A. J., Gorno-Tempini, M. L., Rosen, H. J., Kramer, J. H., Spina, S., Rabinovici, G. D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02036-6 · Cited by 113
Distinct tau PET patterns in atrophy‐defined subtypes of Alzheimer's disease
Ossenkoppele, R., Lyoo, C. H., Sudre, C. H., van Westen, D., Cho, H., Ryu, Y. H., Choi, J. Y., Smith, R. A., Strandberg, O. T., Palmqvist, S., et al. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.08.201 · Cited by 119
The amyloid cascade and Alzheimer's disease therapeutics: theory versus observation
Castellani, R. J., Plascencia‐Villa, G., & Perry, G. L. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0231-z · Cited by 130
Byun, M. S., Kim, S. E., Park, J., Yi, D., Choe, Y. M., Sohn, B. K., Choi, H. J., Baek, H., Han, J., Woo, J. I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142756 · Cited by 121
Nonamnestic Presentations of Early-Onset Alzheimer’s Disease
Mendez, M., Lee, A. S., Joshi, A., & Shapira, J. (2012) · American Journal of Alzheimers Disease & Other Dementias · doi:10.1177/1533317512454711 · Cited by 117
Knowles, J. K., Simmons, D. A., Nguyen, T. V., Griend, L. V., Xie, Y., Zhang, H., Yang, T., Pollak, J., Chang, T., Arancio, O., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.015 · Cited by 123
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease
Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., DeTure, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C.-C., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1580-y · Cited by 123
Self-citationDronse, J., Fließbach, K., Bischof, G. N., von Reutern, B., Faber, J., Hammes, J., Kuhnert, G., Neumaier, B., Onur, O. A., Kukolja, J., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160316 · Cited by 122
Neural Correlates of Spatial Navigation Changes in Mild Cognitive Impairment and Alzheimer’s Disease
Vlček, K., & Laczó, J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00089 · Cited by 118
Calderón‐Garcidueñas, A. L., & Duyckaerts, C. J. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00023-7 · Cited by 126
Disease staging of Alzheimer’s disease using a CSF-based biomarker model
Salvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Binette, A. P., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00599-y · Cited by 129
Alzheimer's disease including focal presentations
Villain, N., & Dubois, B. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1681041 · Cited by 113
Kontsekova, E., Zilka, N., Kovacech, B., Skrabana, R., & Novak, M. (2014) · Alzheimer's Research & Therapy · doi:10.1186/alzrt277 · Cited by 112
FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis
Botha, H., Mantyh, W. G., Murray, M. E., Knopman, D. S., Przybelski, S. A., Wiste, H. J., Graff‐Radford, J., Josephs, K. A., Schwarz, C. G., Kremers, W. K., et al. (2018) · Brain · doi:10.1093/brain/awy049 · Cited by 112
Self-citationMRI and MRS predictors of mild cognitive impairment in a population-based sample
Kantarci, K., Weigand, S. D., Przybelski, S. A., Preboske, G. M., Pankratz, V. S., Vemuri, P., Senjem, M. L., Murphy, M. C., Gunter, J. L., Machulda, M. M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31829a3329 · Cited by 112
Self-citationIn vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET
Kikuchi, A., Okamura, N., Hasegawa, T., Harada, R., Watanuki, S., Funaki, Y., Hiraoka, K., Baba, T., Sugeno, N., Oshima, R., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003375 · Cited by 113
Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor
Wang, S. X., Acha, D., Shah, A. J., Hills, F. A., Roitt, I. M., Demosthenous, A., & Bayford, R. H. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.10.077 · Cited by 109
Data-driven FDG-PET subtypes of Alzheimer’s disease-related neurodegeneration
Levin, F., Ferreira, D., Lange, C., Dyrba, M., Westman, E., Buchert, R., Teipel, S. J., Grothe, M. J., & Initiative, F. T. A. D. N. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00785-9 · Cited by 109
Neuropathology and emerging biomarkers in corticobasal syndrome
Koga, S., Josephs, K. A., Aiba, I., Yoshida, M., & Dickson, D. W. (2022) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2021-328586 · Cited by 115
Self-citationIturria-Medina, Y., Adewale, Q., Khan, A. F., Ducharme, S., Rosa-Neto, P., O’Donnell, K., Petyuk, V. A., Gauthier, S., De Jager, P. L., Breitner, J., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo6764 · Cited by 100
Ferman, T. J., Aoki, N., Crook, J. E., Murray, M. E., Graff‐Radford, N. R., van Gerpen, J. A., Uitti, R. J., Wszołek, Z. K., Graff‐Radford, J., Pedraza, O., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.09.014 · Cited by 105
Self-citationYang, Z., Nasrallah, I. M., Shou, H., Wen, J., Doshi, J. J., Habes, M., Erus, G., Abdulkadir, A., Resnick, S. M., Albert, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26703-z · Cited by 112
Self-citationHeterogeneity of Alzheimer’s disease: consequence for drug trials?
Devi, G., & Scheltens, P. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0455-y · Cited by 102
Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies
Kantarci, K., Ferman, T. J., Boeve, B. F., Weigand, S. D., Przybelski, S. A., Vemuri, P., Murray, M. E., Senjem, M. L., Smith, G. E., Knopman, D. S., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31826357a5 · Cited by 102
Self-citationAhnaou, A., Moechars, D., Raeymaekers, L., Biermans, R., Manyakov, N. V., Bottelbergs, A., Wintmolders, C., Van Kolen, K., Van De Casteele, T., Kemp, J. A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13839-6 · Cited by 98
[18F]AV‐1451 clustering of entorhinal and cortical uptake in Alzheimer's disease
Whitwell, J. L., Graff‐Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C. G., Spychalla, A. J., Jones, D. T., Drubach, D. A., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25142 · Cited by 95
Self-citationClinical criteria for limbic‐predominant age‐related TDP‐43 encephalopathy
Wolk, D. A., Nelson, P. T., Apostolova, L. G., Arfanakis, K., Boyle, P. A., Carlsson, C. M., Corriveau‐Lecavalier, N., Dacks, P. A., Dickerson, B. C., Domoto‐Reilly, K., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14202 · Cited by 103
Self-citationon behalf of the MEMENTO cohort Study Group, Dufouil, C., Dubois, B., Vellas, B. J., Pasquier, F., Blanc, F., Hugon, J., Hanon, O., Dartigues, J., Harston, S., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0288-0 · Cited by 99
Oppedal, K., Ferreira, D., Cavallin, L., Lemstra, A. W., ten Kate, M., Padovani, A., Rektorová, I., Bonanni, L., Wahlund, L., Engedal, K., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.09.011 · Cited by 93
Latimer, C. S., Burke, B. T., Liachko, N. F., Currey, H. N., Kilgore, M. D., Gibbons, L. E., Henriksen, J. C., Darvas, M., Domoto‐Reilly, K., Jayadev, S., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0743-1 · Cited by 102
Risk Factors in Late Adolescence for Young-Onset Dementia in Men
Nordström, P., Nordström, A., Eriksson, M., Wahlund, L., & Gustafson, Y. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.9079 · Cited by 98
Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes
Gómez-Isla, T., & Frosch, M. P. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00642-9 · Cited by 96
Tau pathology in frontotemporal lobar degeneration with C9ORF72 hexanucleotide repeat expansion
Bieniek, K. F., Murray, M. E., Rutherford, N. J., Castanedes‐Casey, M., DeJesus‐Hernandez, M., Liesinger, A. M., Baker, M., Boylan, K., Rademakers, R., & Dickson, D. W. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1048-7 · Cited by 98
Self-citationLongitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes
Sintini, I., Graff‐Radford, J., Senjem, M. L., Schwarz, C. G., Machulda, M. M., Martin, P. R., Jones, D. T., Boeve, B. F., Knopman, D. S., Kantarci, K., et al. (2020) · Brain · doi:10.1093/brain/awaa155 · Cited by 99
Self-citationAmyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer’s disease
Tanner, J. A., Iaccarino, L., Edwards, L., Asken, B. M., Gorno‐Tempini, M. L., Kramer, J. H., Pham, J. Q., Perry, D. C., Possin, K. L., Malpetti, M., et al. (2022) · Brain · doi:10.1093/brain/awac229 · Cited by 91
Frontzkowski, L. K., Ewers, M., Brendel, M., Biel, D., Ossenkoppele, R., Hager, P., Steward, A., Dewenter, A., Roemer, S. N., Rubinski, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32592-7 · Cited by 100
Hyperphosphorylated tau in young and middle-aged subjects
El‐Obeid, A., Soininen, H. S., & Alafuzoff, I. I. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0906-z · Cited by 94
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Migliaccio, R., Agosta, F., Possin, K. L., Canu, E., Filippi, M., Rabinovici, G. D., Rosen, H. J., Miller, B. L., & Gorno‐Tempini, M. L. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142292 · Cited by 97
Kamondi, A., Grigg-Damberger, M. M., Löscher, W., Tanila, H., & Horvath, A. A. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00932-4 · Cited by 104
Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition
Ge, T., Sabuncu, M. R., Smoller, J. W., Sperling, R. A., Mormino, E. C., & Initiative, A. D. N. (2018) · Neurology · doi:10.1212/wnl.0000000000005415 · Cited by 94
Raunio, A., Kaivola, K., Tuimala, J., Kero, M., Oinas, M., Polvikoski, T. M., Paetau, A. E., Tienari, P. J., & Myllykangas, L. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02071-3 · Cited by 94
Crist, A. M., Hinkle, K. M., Wang, X., Moloney, C. M., Matchett, B. J., Labuzan, S. A., Frankenhauser, I., Azu, N. O., Liesinger, A. M., Lesser, E. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22399-3 · Cited by 93
Self-citationHu, Z., Li, Y.-Y., Wang, Z., Zhang, S., & Hou, W. (2023) · Comput. Biol. Medicine · doi:10.1016/j.compbiomed.2023.107304 · Cited by 97
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Schneider, J. A. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001137 · Cited by 93
Young, C. B., Winer, J. R., Younes, K., Cody, K. A., Betthauser, T. J., Johnson, S. C., Schultz, A., Sperling, R. A., Greicius, M. D., Cobos, I., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.0676 · Cited by 79
Self-citationApproach to atypical Alzheimer’s disease and case studies of the major subtypes
Dickerson, B. C., McGinnis, S. M., Xia, C., Price, B. H., Atri, A., Murray, M. E., Mendez, M. F., & Wolk, D. A. (2017) · CNS Spectrums · doi:10.1017/s109285291600047x · Cited by 86
Self-citationPrediction of Alzheimer's disease pathophysiology based on cortical thickness patterns
Hwang, J., Kim, C. M., Jeon, S., Lee, J. M., Hong, Y. J., Roh, J. H., Lee, J., Koh, J., Na, D. L., & Initiative, A. D. N. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.11.008 · Cited by 87
Age and Rate of Cognitive Decline in Alzheimer Disease: Implications for Clinical Trials
Bernick, C., Cummings, J., Raman, R., Sun, X., & Aisen, P. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3758 · Cited by 85
Recent Progress in Alzheimer’s Disease Research, Part 1: Pathology
Hane, F. T., Lee, B. Y., & Leonenko, Z. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160882 · Cited by 92
Enfermedad de Alzheimer de inicio precoz y de inicio tardío: ¿son la misma entidad?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2015) · Neurología · doi:10.1016/j.nrl.2015.08.002 · Cited by 86
Neuropathological assessment of the Alzheimer spectrum
Jellinger, K. A. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02232-9 · Cited by 85
Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease
Poulakis, K., Pereira, J. B., Muehlboeck, J., Wahlund, L., Smedby, Ö., Volpe, G., Masters, C. L., Ames, D. J., Niimi, Y., Iwatsubo, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32202-6 · Cited by 92
Heterogeneous cortical atrophy patterns in MCI not captured by conventional diagnostic criteria
Edmonds, E. C., Eppig, J. S., Bondi, M. W., Leyden, K. M., Goodwin, B., Delano‐Wood, L., McDonald, C. R., & Initiative, A. D. N. (2016) · Neurology · doi:10.1212/wnl.0000000000003326 · Cited by 87
pySuStaIn: A Python implementation of the Subtype and Stage Inference algorithm
Aksman, L., Wijeratne, P. A., Oxtoby, N. P., Eshaghi, A., Shand, C., Altmann, A., Alexander, D. C., & Young, A. L. (2021) · SoftwareX · doi:10.1016/j.softx.2021.100811 · Cited by 91
Could Alzheimer’s Disease Originate in the Periphery and If So How So?
Morris, G., Berk, M., Maes, M. H. J., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1092-y · Cited by 86
Neltner, J. H., Abner, E. L., Schmitt, F. A., Denison, S. K., Anderson, S., Patel, E., & Nelson, P. T. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182768de4 · Cited by 85
The MAPT H1 haplotype is associated with tangle-predominant dementia
Santa‐María, I., Haggiagi, A. M., Liu, X., Wasserscheid, J., Nelson, P. T., Dewar, K., Clark, L. N., & Crary, J. F. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1017-1 · Cited by 88
Longitudinal neuroanatomical and cognitive progression of posterior cortical atrophy
Firth, N. C., Primativo, S., Marinescu, R. V., Shakespeare, T. J., Gonzalez, A. S., Lehmann, M., Carton, A. M., Ocal, D., Pavisic, I. M., Paterson, R. W., et al. (2019) · Brain · doi:10.1093/brain/awz136 · Cited by 83
Magnetic resonance spectroscopy in Alzheimer’s disease
Kantarci, K., & Radford, G. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s35440 · Cited by 87
Cognitive subtypes of probable Alzheimer's disease robustly identified in four cohorts
Scheltens, N. M. E., Tijms, B. M., Koene, T., Barkhof, F., Teunissen, C. E., Wolfsgruber, S., Wagner, M., Kornhuber, J., Peters, O., Cohn‐Sheehy, B. I., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.03.002 · Cited by 82
The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework
Macedo, A. C., Tissot, C., Therriault, J., Servaes, S., Wang, Y.-T., Arias, J. F., Rahmouni, N., Lussier, F. Z., Vermeiren, M. R., Bezgin, G., et al. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.122.265200 · Cited by 99
Aphasic variant of Alzheimer disease
Rogalski, E. J., Sridhar, J., Rader, B. M., Martersteck, A., Chen, K., Cobia, D. J., Thompson, C. K., Weıntraub, S., Bigio, E. H., & Mesulam, M. M. (2016) · Neurology · doi:10.1212/wnl.0000000000003165 · Cited by 82
Al‐Shaikh, F. S. H., Duara, R., Crook, J. E., Lesser, E. R., Schaeverbeke, J. M., Hinkle, K. M., Ross, O. A., Ertekin‐Taner, N., Pedraza, O., Dickson, D. W., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.3606 · Cited by 82
Self-citationEarly- and late-onset Alzheimer disease: Are they the same entity?
Tellechea, P., Pujol, N., Esteve‐Belloch, P., Echeveste, B., García-Eulate, M. R., Arbizu, J., & Riverol, M. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.08.009 · Cited by 81
Spectrum of cognition short of dementia
Knopman, D. S., Beiser, A., Machulda, M. M., Fields, J. A., Roberts, R. O., Pankratz, V. S., Aakre, J. A., Cha, R. H., Rocca, W. A., Mielke, M. M., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002100 · Cited by 85
Self-citationRobust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns
Park, J.-Y., Na, H. K., Kim, S. S., Kim, H., Kim, H. J., Seo, S. W., Na, D. L., Han, C. E., Seong, J., Initiative, A. D. N., et al. (2017) · Scientific Reports · doi:10.1038/srep43270 · Cited by 80
Self-citationRuan, Q., D’Onofrio, G., Sancarlo, D., Bao, Z., Greco, A., & Yu, Z. (2016) · BMC Geriatrics · doi:10.1186/s12877-016-0281-7 · Cited by 83
Four Distinct Subtypes of Alzheimer’s Disease Based on Resting-State Connectivity Biomarkers
Chen, P., Yao, H., Tijms, B. M., Wang, P., Wang, D., Song, C., Yang, H., Zhang, Z., Zhao, K., Qu, Y., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.019 · Cited by 81
Tetzloff, K. A., Graff-Radford, J., Martin, P. R., Tosakulwong, N., Machulda, M. M., Duffy, J. R., Clark, H. M., Senjem, M. L., Schwarz, C. G., Spychalla, A. J., et al. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170740 · Cited by 78
The A/T/N biomarker scheme and patterns of brain atrophy assessed in mild cognitive impairment
Ekman, U., Ferreira, D., & Westman, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-26151-8 · Cited by 79
Rabinovici, G. D., Knopman, D. S., Arbizu, J., Benzinger, T. L. S., Donohoe, K. J., Hansson, O., Herscovitch, P., Kuo, P. H., Lingler, J. H., Minoshima, S., et al. (2025) · Journal of Nuclear Medicine · doi:10.2967/jnumed.124.268756 · Cited by 87
Self-citationPal, A., Siotto, M., Prasad, R., & Squitti, R. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141194 · Cited by 76
Ferreira, D., Pereira, J. B., Volpe, G., & Westman, E. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00524 · Cited by 73
CHIMERA: Clustering of Heterogeneous Disease Effects via Distribution Matching of Imaging Patterns
Dong, A., Honnorat, N., Gaonkar, B., & Davatzikos, C. A. (2015) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2015.2487423 · Cited by 77
Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease
Phillips, J. S., Da Re, F., Dratch, L., Xie, S. X., Irwin, D. J., McMillan, C. T., Vaishnavi, S. N., Ferrarese, C., Lee, E. B., Shaw, L. M., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.11.008 · Cited by 74
D’Mello, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115911 · Cited by 80
Metadata
- Authors
- Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W.
- Affiliations
- Mayo Clinic (US)
- Mount Sinai Medical Center (US)
- Corresponding author
- Dickson, Dennis W
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 10
- Issue
- 9
- Pages
- 785-796
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3175379
- OpenAlex
- W2075444764
- Cited by
- 972
- References
- 44
- Citations by year
- 2026: 60 · 2025: 80 · 2024: 78 · 2023: 96 · 2022: 80 · 2021: 104 · 2020: 70 · 2019: 73 · 2018: 56 · 2017: 50 · 2016: 55 · 2015: 37 · 2014: 36 · 2013: 54 · 2012: 35
- FWCI
- 29.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Clinic
- National Institutes of Health
- National Institute on Aging (P50‐AG16574, U01AG06786, P50 AG215711, P01AG03949, U01AG006786, P01AG003949, R21AG038736, P50AG025711, P01AG017216, P50AG016574)
- National Institute of Neurological Disorders and Stroke (P50NS072187)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary tangles, Braak staging, hippocampal sparing, hippocampal atrophy, tau pathology, clinical features, atypical Alzheimer's disease, sex differences, age at death, genetic risk factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Female, Hippocampus, Humans, Limbic System, Male, Middle Aged, Retrospective Studies, Cohort Studies, Neurofibrillary Tangles, tau Proteins, Apolipoprotein E4
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