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Sex differences in Alzheimer's disease and other dementias
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“As sex is a strong factor underlying phenotypic variability in AD”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [5]
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Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676
Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences
Mielke, M., Vemuri, P., & Rocca, W. (2014) · Clinical Epidemiology · doi:10.2147/clep.s37929 · Cited by 1,021
Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
Cosgrove, K. P., Mazure, C. M., & Staley, J. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.001 · Cited by 996
Self-citationSex modifies the APOE ‐related risk of developing Alzheimer disease
Altmann, A., Tian, L., Henderson, V. W., Greicius, M. D., & Alzheimer's Disease Neuroimaging Initiative Investigators (2014) · Annals of Neurology · doi:10.1002/ana.24135 · Cited by 891
Mazure, C. M., & Jones, D. P. (2015) · BMC Women s Health · doi:10.1186/s12905-015-0251-9 · Cited by 339
Self-citationAnalysis of the MIRIAD Data Shows Sex Differences in Hippocampal Atrophy Progression
Ardekani, B. A., Convit, A., & Bachman, A. H. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150780 · Cited by 141
Kim, S., Kim, M. J., Kim, S., Kang, H. S., Lim, S. W., Myung, W., Lee, Y., Hong, C. H., Choi, S. H., Na, D. L., et al. (2015) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2015.07.002 · Cited by 131
Impact of Gender Differences on the Outcome of Alzheimer’s Disease
Sinforiani, E., Citterio, A., Zucchella, C., Bono, G., Corbetta, S., Merlo, P., & Mauri, M. F. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000318842 · Cited by 118
Scacchi, R., Gambina, G., Broggio, E., & Corbo, R. M. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4043 · Cited by 58
Xing, Y., Tang, Y., & Jia, J. (2015) · Behavioural Neurology · doi:10.1155/2015/275256 · Cited by 40
Cited by
Sorted by citations
Items 101–200 of 350
Manca, M., Standke, H. G., Browne, D. F., Huntley, M. L., Thomas, O. R., Orru, C. D., Hughson, A. G., Kim, Y., Zhang, J., Tatsuoka, C. M., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02574-0 · Cited by 34
Picillo, M., Initiative, F. T. P. P. M., Lafontant, D.-E., Bressman, S., Caspell‐Garcia, C., Coffey, C. S., Cho, H. R., Burghardt, E. L., Dahodwala, N. A., Saunders-Pullman, R. J., et al. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212892 · Cited by 34
“Sex as a pivotal variable in biomedical research and sex differences are acknowledged as important determinants of the clinical and therapeutic management of neurodegenerative diseases [1, 2].”
BackgroundNeurochemical and cognitive changes precede structural abnormalities in the TgF344-AD rat model
Fowler, C., Goerzen, D., Devenyi, G. A., Madularu, D., Chakravarty, M. M., & Near, J. (2022) · Brain Communications · doi:10.1093/braincomms/fcac072 · Cited by 33
“and genotype on neuroimaging and behavioural markers, which is crucial for improving diagnostic methods and interventions given that Alzheimer’s disease prevalence andmanifestation can differ between men and women.(49)”
Distinct sex-specific DNA methylation differences in Alzheimer’s disease
C. Silva, T., Zhang, W., Young, J. I., Gomez, L., Schmidt, M. A., Varma, A., Chen, X. S., Martin, E. R., & Wang, L. (2022) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01070-z · Cited by 33
Olmo, B. M. G., Bettes, M. N., DeMarsh, J. W., Zhao, F., Askwith, C. C., & Barrientos, R. M. (2023) · npj Science of Food · doi:10.1038/s41538-023-00211-4 · Cited by 33
Sanfilippo, C., Castrogiovanni, P., Imbesi, R., Tibullo, D., Volti, G. L., Barbagallo, I. A., Vicario, N., Musumeci, G., & Rosa, M. D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.03.008 · Cited by 31
Nguyen, D. H., Cunningham, J. T., & Sumien, N. (2020) · GeroScience · doi:10.1007/s11357-020-00263-4 · Cited by 36
Rabinowitz, J. A., An, Y., He, L., Alfini, A. J., Zipunnikov, V., Wu, M. N., Wanigatunga, S., Schrack, J. A., Jackson, C. L., Ferrucci, L., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.952204 · Cited by 33
“Women (Mazure and Swendsen, 2016), people of color (Mayeda et al.”
BackgroundSex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults
Palta, P., Rippon, B., Tahmi, M., Pardo, M., Johnson, A. S., Tomljanovic, Z., He, H., Laing, K. K., Razlighi, Q. R., Teresi, J. A., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.03.007 · Cited by 33
Progress and challenges in the diagnosis of dementia: a critical review
Paraskevaidi, M., Martin-Hirsch, P. L., & Martin, F. L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00007 · Cited by 31
Boucher, F. J. O., & Chinnah, T. I. (2020) · Adolescent Health Medicine and Therapeutics · doi:10.2147/ahmt.s259168 · Cited by 31
The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening
Rosende‐Roca, M., Ruiz, C. A., Esteban, E., Tartari, J. P., Alarcón‐Martín, E., Martínez‐Atienza, J., González‐Pérez, A., Sáez, M. E., Lafuente, A., Buendía, M., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00833-4 · Cited by 32
“The AD phenotype and progression pattern is affected by well-known sexrelated (referring to biological variations among men and women) as well as gender-related differences (referring to psychosocial and cultural disparities between males and females) with crucial implications for diagnosis, treatment and clinical res…”
BackgroundMarazuela, P., Paez-Montserrat, B., Bonaterra-Pastra, A., Solé, M., & Hernández-Guillamon, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094972 · Cited by 31
“In this regard, the impairment of the intramural periarterial drainage (IPAD) pathway seems to play a fundamental role in CAA [43,44].”
BackgroundBouhaben, J., Delgado‐Lima, A. H., & Delgado‐Losada, M. L. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105425 · Cited by 31
Butler, M. J. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100298 · Cited by 32
“Moreover, women are at an increased risk for developing numerous pathologies, including depression, anxiety, and neurodegenerative disease, which highlight the importance of including sex as a biological variable in future work (Barrientos et al., 2019; Mazure and Swendsen, 2016).”
BackgroundGemmill, A., & Weiss, J. (2021) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbab183 · Cited by 29
Chaudry, O., Ndukwe, K., Xie, L., Figueiredo-Pereira, M., Serrano, P., & Rockwell, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-23801-w · Cited by 28
Mejía-Arango, S., Garcia-Cifuentes, E. R., Samper‐Ternent, R., Borda, M. G., & Cano, C. A. (2020) · Journal of Cross-Cultural Gerontology · doi:10.1007/s10823-020-09418-4 · Cited by 29
Association between exenatide use and incidence of Alzheimer's disease
Zhou, B., Zissimopoulos, J., Nadeem, H., Crane, M. A., Goldman, D. P., & Romley, J. A. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12139 · Cited by 28
The art of matching brain tissue from patients and controls for postmortem research
Bao, A., & Swaab, D. F. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00015-3 · Cited by 29
Stone, D. B., Ryman, S. G., Hartman, A. P., Wertz, C. J., Vakhtin, A. A., & Initiative, A. D. N. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.711579 · Cited by 28
Kommaddi, R. P., Gowaikar, R., Haseena, P. A., Diwakar, L., Singh, K. P., & Mondal, A. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105619 · Cited by 29
IgM response against amyloid-beta in aging: a potential peripheral protective mechanism
Agrawal, S., Abud, E. M., Snigdha, S., & Agrawal, A. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0412-9 · Cited by 29
“Since AD prevalence is higher in women [32], data were also analyzed to investigate the effect of gender differences on the levels of IgG and IgM antibodies.”
BackgroundFractal motor activity regulation and sex differences in preclinical Alzheimer's disease pathology
Gao, L., Li, P., Gaba, A., Musiek, E. S., Ju, Y. S., & Hu, K. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12211 · Cited by 29
Novel Insight in Idiopathic Normal Pressure Hydrocephalus (iNPH) Biomarker Discovery in CSF
Torretta, E., Arosio, B., Barbacini, P., Capitanio, D., Rossi, P. D., Moriggi, M., Clerici, M., Mari, D., Cesari, M., & Gelfi, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158034 · Cited by 27
“Therefore, further studies in this direction can contribute to defining the question of disease prevalence indicated by some studies and better understand the role of glucosylceramides in brain disorders [19–21].”
Association between Adipokines and Biomarkers of Alzheimer’s Disease: A Cross-Sectional Study
Letra, L., Matafome, P. N., Rodrigues, T., Duro, D., Lemos, R., Baldeiras, I., Patrício, M., Castelo-Branco, M. S., Caetano, G., Seiça, R. M. F., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180669 · Cited by 28
“Furthermore, and based on the fact that women with Alzheimer’s disease seem to experience faster hippocampal atrophy [36], we performed the same analysis in this subgroup, but did not observe consistent correlations (Supplementary Table 2).”
Valenchon, J., & Coates, M. (2019) · IEEE International Conference on Acoustics Speech and Signal Processing · doi:10.1109/icassp.2019.8683433 · Cited by 27
“For example, women are more likely to develop Alzheimer’s disease (AD) than men [1, 2].”
BackgroundObesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline
Anderson, T., Sharma, S. K., Kelberman, M. A., Ware, C. B., Guo, N., Qin, Z. S., Weinshenker, D., & Parent, M. B. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15900 · Cited by 26
“…prevalence is higher in women than men, beyond differences attributable to women's longer lifespans (Dubal, 2020; Nichols et al., 2022 ), and many gene interactions in AD pathogen - esis and treatment are sex specific (Mazure & Swendsen, 2016; Mielke, 2018 ; Xiong et al., 2022 ; Yan et al., 2022 ).”
BackgroundQin, R., Zhao, H., Gao, H. Y., & Liu, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0338018 · Cited by 34
Yan, S., Zheng, C., Paranjpe, M. D., Li, J., Benzinger, T. L. S., Lu, J., & Zhou, Y. (2020) · Theranostics · doi:10.7150/thno.48522 · Cited by 27
“The Lancet Neurology Commission has recently asserted that greater attention to sex differences in AD is essential to advancing both disease prevention and treatment strategies in AD [15].”
BackgroundBernard, J. A., Ballard, H. K., & Jackson, T. B. (2021) · Cerebral Cortex Communications · doi:10.1093/texcom/tgab050 · Cited by 25
“In advanced age females are more likely than males to develop Alzheimer’s disease (Carter et al. 2012; Mazure and Swendsen 2016), they are at a greater risk of falls (Stevens and Sogolow 2005; Hartholt et al. 2011), and suffer from frailty to a higher degree than their male counterparts (Puts et…”
BackgroundSanfilippo, C., Giuliano, L., Castrogiovanni, P., Imbesi, R., Ulivieri, M., Fazio, F., Blennow, K., Zetterberg, H., & Rosa, M. D. (2022) · Current Neuropharmacology · doi:10.2174/1570159x21666221207091209 · Cited by 24
“Differences in the incidence and prevalence of AD between female and male subjects are well established; notably, two thirds of AD patients are women [98].”
BackgroundKorthauer, L. E., Goveas, J. S., Espeland, M. A., Shumaker, S. A., Garcia, K. R., Tindle, H. A., Salmoirago‐Blotcher, E., Sink, K. M., Vaughan, L., Rapp, S. R., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx175 · Cited by 26
“Focusing on postmenopausal women has particular public health relevance, as this group is disproportionately affected by Alzheimer’s disease and other dementias (18).”
BackgroundMaj, C., Azevedo, T., Giansanti, V., Borisov, O., Dimitri, G. M., Spasov, S., Initiative, A. D. N., Lió, P., & Merelli, I. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00726 · Cited by 27
“We also focused on non-sex specific tissues, since we wanted to study general potential alterations not involving sex-specific organs, but this could also be a limitation given the different prevalence of AD in females and males (Mazure and Swendsen, 2016).”
BackgroundSanfilippo, C., Castrogiovanni, P., Imbesi, R., & Di Rosa, M. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01667-9 · Cited by 26
Giménez‐Llort, L., Marín-Pardo, D., Marazuela, P., & Hernández‐Guillamón, M. (2021) · Biomedicines · doi:10.3390/biomedicines9060636 · Cited by 26
Sotelo-Orozco, J., Abbeduto, L., Hertz‐Picciotto, I., & Slupsky, C. M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.579538 · Cited by 25
“Interestingly, Alzheimer’s Disease disproportionately affects more women than men in the general population (42) and specifically, more women than men with DS (43).”
BackgroundSex differences in a murine model of Cerebral Amyloid Angiopathy
Maniskas, M. E., Mack, A. F., Morales‐Scheihing, D., Finger, C. E., Zhu, L., Paulter, R., Urayama, A., McCullough, L. D., & Manwani, B. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100260 · Cited by 26
Bonkhoff, A. K., Coughlan, G., Perosa, V., Alhadid, K., Schirmer, M. D., Regenhardt, R. W., van Veluw, S. J., Buckley, R. F., Fox, M., & Rost, N. S. (2025) · Science Advances · doi:10.1126/sciadv.adt9243 · Cited by 26
Association between dementia and hepatitis B and C virus infection
Choi, H. G., Soh, J. S., Lim, J. S., Sim, S. Y., & Lee, S. W. (2021) · Medicine · doi:10.1097/md.0000000000026476 · Cited by 24
“These sexual differences in developing dementia were assumed to be differences in genetic susceptibility, brain anatomy, brain function, and the social and behavioral environment.([38]) In a longitudinal, clinicopathologic cohort study, women had a more global Alzheimer disease pathology, such as more neurofibrillary…”
BackgroundSex Differences in the Relationship between Perceived Stress and Cognitive Trajectories
Paolillo, E. W., You, M. Y., Gontrum, E. Q., Saloner, R., Gaynor, L. S., Kramer, J. H., & Casaletto, K. B. (2022) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2022.11.009 · Cited by 24
Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes
Liang, H., Nie, J., Skike, C. E. V., Valentine, J. M., & Orr, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_10 · Cited by 24
Christensen, A., Liu, J., & Pike, C. J. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00113 · Cited by 23
“Women have a higher lifetime risk of AD than men as well as greater prevalence, with women accounting for approximately twothirds of AD cases (Mazure and Swendsen, 2016; Alzheimer’s Association, 2018).”
BackgroundSystematic Review of Sex‐Specific Reporting of Data: Cholinesterase Inhibitor Example
Mehta, N., Rodrigues, C., Lamba, M., Wu, W., Bronskill, S. E., Herrmann, N., Gill, S. S., Chan, A., Masón, R., Day, S., et al. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15020 · Cited by 23
“Accordingly, the Lancet Neurology Commission urges the incorporation of a sex-based lens to guide and inform the scientific approach on dementia research.(12) This evidence highlights the value of reporting sex specific data, particularly in drug trials for the management of dementia.”
BackgroundLi, X., Zhou, S., Zhu, W., Li, X., Gao, Z., Li, M., Luo, S., Wu, X., Tian, Y., & Yu, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.639529 · Cited by 23
Berezuk, C., Zakzanis, K. K., Ramirez, J., Ruocco, A. C., Edwards, J. D., Callahan, B. L., Black, S. E., & Initiative, A. D. N. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161227 · Cited by 22
“In recent years, there has also been an increased focus on understanding potential gender differences in persons with MCI, AD, and related dementias [5].”
BackgroundA data-driven prospective study of dementia among older adults in the United States
Weiss, J., Puterman, E. M., Prather, A. A., Ware, E. B., & Rehkopf, D. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239994 · Cited by 23
Rabipour, S., Rajagopal, S., Pasvanis, S., & Rajah, M. N. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.03.009 · Cited by 22
Qi, X., Nizamutdinov, D., Berman, M. H., Dougal, G., Chazot, P. L., Wu, E., Stevens, A. B., Yi, S. S., & Huang, J. H. (2021) · Cureus · doi:10.7759/cureus.16188 · Cited by 22
“The tNIR can enhance mitochondrial function and cellular metabolism [32,33], increase regional cerebral blood flow [8], increase axonal transport [34,35], mitigate inflammatory reaction and oxidative stress [36,37], and promote synaptogenesis [38].”
BackgroundLimiting RyR2 open time prevents Alzheimer's disease‐related deficits in the 3xTG‐AD mouse model
Liu, Y., Yao, J., Song, Z., Guo, W., Sun, B., Wei, J., Estillore, J. P., Back, T. G., & Chen, S. R. W. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24936 · Cited by 22
“Studies have suggested that there might be a sex difference in human AD patients (Ferretti et al., 2018; Mazure & Swendsen, 2016).”
BackgroundTrends in Mortality Rates for Alzheimer’s Disease and Other Dementias Over 30 Years in China
Bai, R., & Dong, W. (2021) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175211044884 · Cited by 22
“The results of this study are consistent with those of previous studies,(20,21) which found that women are more vulnerable than men to developing Alzheimer’s disease and other dementias, possibly as a result of gender differences in brain structure, brain development, function, and biochemistry.(20) Our study also fou…”
ResultGhisi, G. L. D. M., Supervía, M., Turk-Adawi, K. I., Beleigoli, A. M. R., Contractor, A., Mampuya, W. M., & Grace, S. L. (2023) · CJC Open · doi:10.1016/j.cjco.2023.10.008 · Cited by 22
“23 Considerable variation was found in delivery of W-F CR elements across the 6 WHO regions, however, with some areas providing more delivery.”
BackgroundSex differences of brain and their implications for personalized therapy
Rezzani, R., Franco, C., & Rodella, L. F. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.030 · Cited by 24
Fertan, E., Wong, A. A., Vienneau, N. A., & Brown, R. E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111937 · Cited by 26
Social Isolation and Cognitive Functioning: A Quasi-Experimental Approach
Okamoto, S., & Kobayashi, E. (2020) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbaa226 · Cited by 23
Silvestri, C., Almici, V., Libri, I., Mattioli, I., Cosseddu, M., Turrone, R., Rivolta, J., Grassini, C., Caratozzolo, S., Alberici, A., et al. (2024) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000200299 · Cited by 26
A large-scale study on the effects of sex on gray matter asymmetry
Núñez, C., Theofanopoulou, C., Senior, C., Cambra-Martí, M. R., Usall, J., Stephan‐Otto, C., & Brébion, G. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1481-4 · Cited by 21
Ballard, H. K., Jackson, T. B., Hicks, T. H., & Bernard, J. A. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.05.014 · Cited by 23
Cutia, C. A., & Christian-Hinman, C. A. (2023) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2023.101084 · Cited by 17
Yokota, R. T. C., Nusselder, W. J., Robine, J., Tafforeau, J., Renard, F., Deboosere, P., & Oyen, H. J. V. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky105 · Cited by 20
5XFAD Mice Show Early Onset Gap Detection Deficits
Kaylegian, K., Stebritz, A. J., Weible, A. P., & Wehr, M. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00066 · Cited by 20
“This contrasts with the prevalence of Alzheimer’s disease in humans, which is higher in women than in men (Mazure and Swendsen, 2016).”
ResultSourial, N., Vedel, I., Godard‐Sebillotte, C., Etches, J., Arsenault‐Lapierre, G., & Bronskill, S. E. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16347 · Cited by 22
Didonna, A., Cantó, E., Shams, H., Isobe, N., Zhao, C., Caillier, S. J., Condello, C., Yamate-Morgan, H., Tiwari-Woodruff, S. K., Mofrad, M. R. K., et al. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.04.003 · Cited by 19
“Also in AD models, Tau neurofibrillary pathology and cognitive impairment are more prominent in females than males [56, 57].”
BackgroundMuntsant-Soria, A., & Giménez‐Llort, L. (2021) · Biomedicines · doi:10.3390/biomedicines9070715 · Cited by 21
“Although sex-specific clinicopathological mechanism is not well understood and are largely unexplored [10], males presented deranged neuro-immuno-endocrine system despite their less harmful neuropathological status [11,12].”
BackgroundKhorani, M., Bobe, G., Matthews, D. G., Magaña, A. A., Caruso, M. A., Gray, N. E., Quinn, J. F., Stevens, J. F., Soumyanath, A., & Maier, C. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215084 · Cited by 18
“We focused on female mice because women are affected disproportionately by AD, having a two times higher risk of developing AD compared to men [16–18].”
Garrido‐Gil, P., Pedrosa, M. A., García-Garrote, M., Pequeño‐Valtierra, A., Rodríguez‐Castro, J., Souto, D. G., Rodriguez-Perez, A. I., & Labandeira-García, J. L. (2022) · Glia · doi:10.1002/glia.24255 · Cited by 19
“It is now known that sex modifies the outcome of many neurological diseases and particularly those related to neuroinflammation (Mazure & Swendsen, 2016; Villapol et al., 2017).”
BackgroundA Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories
Duchesne, S., Rousseau, L., Belzile, F., Welch, L., Cournoyer, B., Arseneau, M., Lapierre, V., Poulin, S., Potvin, O., & Hudon, C. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230772 · Cited by 24
Derreberry, T. M., & Holroyd, S. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2019.02.004 · Cited by 19
D'Amore, F. M., Moscatelli, M. E. M., Malvaso, A., D’Antonio, F., Rodini, M., Panigutti, M., Mirino, P., Carlesimo, G. A., Guariglia, C., & Caligiore, D. (2024) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2024.123361 · Cited by 19
“This discrepancy could arise from various factors, such as different baseline levels of the feature or complex relationships with other unmeasured features.”
Li, H., Huang, Z., Gao, Z., Zhu, W., Li, Y., Zhou, S., Li, X., & Yu, Y. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.12.001 · Cited by 18
“Indeed, almost two-thirds of Americans with AD are female (Mazure and Swendsen, 2016).”
BackgroundShang, X., Roccati, E., Zhu, Z., Kiburg, K., Wang, W., Huang, Y., Zhang, X., Zhang, X., Liu, J., Tang, S., et al. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-022-01140-2 · Cited by 18
“Women are more likely to experience dementia than men [6], particularly at older ages [7, 8].”
BackgroundMapping multimorbidity progression among 190 diseases
Han, S., Li, S., Yang, Y., Liu, L., Ma, L., Leng, Z., Mair, F. S., Butler, C., Nunes, B. P., Miranda, J. J., et al. (2024) · Communications Medicine · doi:10.1038/s43856-024-00563-2 · Cited by 19
“This points to different mechanisms and pathways in Alzheimer ’ s disease in females and males 53,54 .”
BackgroundEpidemiological Investigation of Type 2 Diabetes and Alzheimer’s Disease in a Pakistani Population
Noreen, Z., DeJesus, J., Bhatti, A., Loffredo, C. A., John, P. C. L., Khan, J. S., Nunlee‐Bland, G., & Ghosh, S. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15081582 · Cited by 19
“The Lancet Neurology Commission [41] affirms that, for most regions of the world, the occurrence of AD and other dementias is higher in women than in men, particularly in the most elderly [42].”
BackgroundAn appraisal of folates as key factors in cognition and ageing-related diseases
Craenen, K., Verslegers, M., Baatout, S., & Benotmane, M. A. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1549017 · Cited by 18
Prevalence of Dementia Among Older Patients: A Hospital-Based Study in Iran
Kamalzadeh, L., Moghaddamnia, M., Malakouti, S. K., Rashedi, V., Bahrampour, S., شریفی, ن., Talebi, M., Sina, F., & Shariati, B. (2019) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317519848234 · Cited by 18
Sex Differences in in vivo Alzheimer’s Disease Neuropathology in Late Middle-Aged Hispanics
Luchsinger, J. A., Palta, P., Rippon, B., Soto, L., Ceballos, F., Pardo, M., Laing, K. K., Igwe, K. C., Johnson, A. S., Tomljanovic, Z., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191183 · Cited by 18
“The causes for sex differences in dementia risk are unclear and could include differences in brain structure, biochemistry, function, and susceptibility to developing AD in response to genetic and other factors [3].”
Gallo, G., Bianchi, F., Cotugno, M., Volpe, M., & Rubattu, S. D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072265 · Cited by 18
Sex Differences in the Metabolome of Alzheimer's Disease Progression
Zarzar, T. G., Lee, B., Coughlin, R., Kim, D., Shen, L., & Hall, M. A. (2022) · Frontiers in Radiology · doi:10.3389/fradi.2022.782864 · Cited by 18
“Most cases of AD and dementia occur in women, particularly in the most elderly (2).”
BackgroundPharmaceutical Implications of Sex-Related RNA Divergence in Psychiatric Disorders
Simchovitz, A., & Soreq, H. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.09.003 · Cited by 17
“The underlying sex-related differences in cholinergic brain circuits [24] may mediate this effect.”
BackgroundLiu, C.-T., Wu, B.-Y., Hung, Y., Wang, L.-Y., Lee, Y.-Y., Lin, T., Lin, P.-Y., Chen, W.-F., Chiang, J., Hsu, S.-F., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19094 · Cited by 17
“The occurrence of AD and other dementias is higher in women than in men, particularly in the most elderly, and the burden of dementias is greater for women than for men [44].”
BackgroundBeam, C. R., Kaneshiro, C., Jang, J. Y., Reynolds, C. A., Pedersen, N. L., & Gatz, M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191192 · Cited by 17
“Recent reports suggest a genetic basis for sex differences in ADRD, which are thought to underlie differences in degradation of brain structure and function [9].”
BackgroundComputer-aided diagnosis of Alzheimer’s disease by MRI analysis and evolutionary computing
de Souza, R. G., Silva, G. D. S. L. E., dos Santos, W. P., de Lima, M. E., & Initiative, A. D. N. (2021) · Research on Biomedical Engineering · doi:10.1007/s42600-021-00160-5 · Cited by 15
Low Bone Mineral Density With Risk of Dementia: A Prospective Cohort Study.
Zhang, X., Hsu, W., Sing, C.-W., Li, G., Tan, K., Kung, A.-N. W. C., Wong, J., Wong, I. C., & Cheung, C. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.07.012 · Cited by 17
Miramontes, S., Serras, C. P., Woldemariam, S. R., Khan, U., Li, Y., Tang, A., Tsoy, E., Oskotsky, T., & Sirota, M. (2024) · npj Women s Health · doi:10.1038/s44294-024-00021-3 · Cited by 19
Zheng, Z., Li, R., Xiao, F., He, R., Zhang, S., & Li, J. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00093 · Cited by 17
“, mild cognitive impairment, MCI or Alzheimer’s disease, AD), and for early treatment and prevention of these disorders (Mazure and Swendsen, 2016).”
BackgroundXu, C., Jiang, C., Liu, X., Shi, W., Bai, J., Mubarik, S., & Wang, F. (2025) · International Journal for Equity in Health · doi:10.1186/s12939-025-02530-2 · Cited by 18
“Although some regions have made progress, disparities in disease burden still persist across regions, particularly among gender groups [7, 13].”
Maclagan, L. C., Maxwell, C. J., Harris, D. A., Campitelli, M. A., Diong, C. C., Lapane, K. L., Hogan, D. B., Rochon, P. A., Herrmann, N., & Bronskill, S. E. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00799-2 · Cited by 15
Loss of DEK Expression Induces Alzheimer’s Disease Phenotypes in Differentiated SH-SY5Y Cells
Greene, A. N., Parks, L. G., Solomon, M. B., & Vinnedge, L. M. P. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.594319 · Cited by 15
“Many biological and environmental factors are known to contribute to the risk of AD and associated dementias, including biological sex (Seshadri et al., 1997; Mazure and Swendsen, 2016), race (Chen and Zissimopoulos, 2018), vascular conditions (O’Brien and Markus, 2014), metabolic conditions (Craft, 2009), an educatio…”
BackgroundDaini, E., Secco, V., Liao, W., Zoli, M., & Vilella, A. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135869 · Cited by 15
Bayesian adaptive group lasso with semiparametric hidden Markov models
Kang, K., Song, X., Hu, X. J., & Hongtu Zhu, B. (2018) · Statistics in Medicine · doi:10.1002/sim.8051 · Cited by 15
“39 , 40 Third, for the parametric part, gender has a negative effect on FAQ in the LMCI and AD states, implying that women suffer more serious cognitive decline than men in the late progression period of AD.”
Greco, A., Sánchez-Valle, J., Pancaldi, V., Baudot, A., Barillot, E., Caselle, M., Valencia, A., Zinovyev, A. Y., & Cantini, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133114 · Cited by 16
“Additionally to mitochondria and immune system, community 36 has been associated to gender, in line with the higher risk of females to develop Alzheimer’s disease, in opposition to lung cancer, which is more frequent in men [44,45].”
BackgroundAssociations of Diet Quality with Midlife Brain Volume: Findings from the UK Biobank Cohort Study
Macpherson, H., McNaughton, S. A., Lamb, K. E., & Milte, C. M. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210705 · Cited by 16
“However,Alzheimer’sdis-easeandotherformsofdementiaaffectmorewomen thanmen[40]andwomenhavelessmodifiablerisk factors[41].”
Lu, K., Xiong, X., Wang, X., & Wu, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.706762 · Cited by 15
“About two-thirds of patients diagnosed with AD dementia are women, and healthcare providers focus too much on female patients with ADRD despite evidence showing that there is no sex or gender difference in risk factors or mechanisms (Mazure and Swendsen, 2016).”
BackgroundBrunialti, E., Villa, A. M., Toffoli, M., Pozo, S. L. D., Rizzi, N., Meda, C., Maggi, A. C., Schapira, A. H. V., & Ciana, P. (2023) · Cells · doi:10.3390/cells12030343 · Cited by 14
“Female sex is a risk factor for AD [23] and multiple sclerosis [24], while male sex is a risk factor for motor neuron disorders [25] and PD [22].”
BackgroundAlzheimer’s Disease and Other Dementias: An Introduction
Blank, R. H. (2018) · Springer eBooks · doi:10.1007/978-981-13-0656-3_1 · Cited by 15
In vivo network models identify sex differences in the spread of tau pathology across the brain
Shokouhi, S., Taylor, W. D., Albert, K., Kang, H., Newhouse, P. A., & Initiative, T. A. D. N. (2020) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12016 · Cited by 35
Sex effects on gene expression across the human cerebral cortex at cell type resolution
DeCasien, A. R., Auluck, P. K., Liu, S., Feng, N., Elkahloun, A. G., Xu, Q., Marenco, S., Cookson, M., & Raznahan, A. (2026) · Science · doi:10.1126/science.aea9063 · Cited by 22
Frontal alpha asymmetry during prayerful and resting states: An EEG study in Catholic sisters
Barcelona, J., FAHLMAN, M. M., Churakova, Y., Canjels, R., Mallare, J., & van den Heuvel, M. I. (2020) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2020.04.019 · Cited by 15
Olfactory Dysfunction Associated with Cognitive Decline in an Elderly Population
Alotaibi, M. M., Lessard‐Beaudoin, M., Busch, K., Loudghi, A., Gaudreau, P., & Graham, R. K. (2022) · Experimental Aging Research · doi:10.1080/0361073x.2022.2160597 · Cited by 13
“In general, women are more at risk for dementia (Nebel et al., 2018) and are more affected by AD then men (Mazure & Swendsen, 2016) as well as show enhanced brain atrophy compared to men (Holland, Desikan, Dale, & McEvoy, 2013).”
BackgroundSex differences in limbic network and risk‐taking propensity in healthy individuals
Bajaj, S., & Killgore, W. D. S. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24504 · Cited by 13
“For instance, females show higher rates of depressive disorders (Gobinath, Choleris, & Galea, 2017) as well as Alzheimer's disease than males (Mazure & Swendsen, 2016); however, disorders such as autism spectrum disorders (Baron‐Cohen et al., 2011) and dyslexia (Arnett et al., 2017) are more common…”
Background
Metadata
- Authors
- Mazure, C. M., & Swendsen, J.
- Affiliations
- Yale University (US)
- Université de Bordeaux (FR)
- Corresponding author
- Mazure, Carolyn M
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 15
- Issue
- 5
- Pages
- 451-452
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC4864429
- OpenAlex
- W2297715268
- Cited by
- 350
- References
- 10
- Citations by year
- 2026: 17 · 2025: 26 · 2024: 35 · 2023: 38 · 2022: 33 · 2021: 55 · 2020: 48 · 2019: 53 · 2018: 29 · 2017: 12 · 2016: 3
- FWCI
- 28.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (P50DA033945)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- Alzheimer's disease, dementia, sex differences, sex differences in dementia, dementia costs, population aging, dementia prevention, dementia treatment
- MeSH terms
- Alzheimer Disease, Dementia, Humans, Biomedical Research
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