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Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Open accessAbstract
A concerted effort to tackle the global health problem posed by traumatic brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently recognised, proportions. Worldwide, more than 50 million people have a TBI each year, and it is estimated that about half the world's population will have one or more TBIs over their lifetime. TBI is the leading cause of mortality in young adults and a major cause of death and disability across all ages in all countries, with a disproportionate burden of disability and death occurring in low-income and middle-income countries (LMICs). It has been estimated that TBI costs the global economy approximately $US400 billion annually. Deficiencies in prevention, care, and research urgently need to be addressed to reduce the huge burden and societal costs of TBI. This Commission highlights priorities and provides expert recommendations for all stakeholders—policy makers, funders, health-care professionals, researchers, and patient representatives—on clinical and research strategies to reduce this growing public health problem and improve the lives of people with TBI.
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“In the general population, excluding individuals with a head injury and alteration (but not loss) of consciousness would miss approximately 80% of all injuries considered to be TBIs by commonly used definitions.”
From Traumatic brain injury in homeless and marginally housed individuals: a systematic review and meta-analysis (2020) · cites this paper as [5]
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Metadata
- Authors
- Maas, A. I. R., Menon, D. K., Adelson, P. D., Andelic, N., Bell, M. J., Belli, A., Bragge, P., Brazinova, A., Büki, A., Chesnut, R. M., Citerio, G., Coburn, M., Cooper, D. J., Crowder, A. T., Czeiter, E., Czosnyka, M., Diaz-Arrastia, R., Dreier, J. P., Duhaime, A.-C., Ercole, A., van Essen, T. A., Feigin, V. L., Gao, G., Giacino, J., Gonzalez-Lara, L. E., Gruen, R. L., Gupta, D., Hartings, J. A., Hill, S., Jiang, J.-Y., Ketharanathan, N., Kompanje, E. J. O., Lanyon, L., Laureys, S., Lecky, F., Levin, H., Lingsma, H. F., Maegele, M., Majdan, M., Manley, G., Marsteller, J., Mascia, L., McFadyen, C., Mondello, S., Newcombe, V., Palotie, A., Parizel, P. M., Peul, W., Piercy, J., Polinder, S., Puybasset, L., Rasmussen, T. E., Rossaint, R., Smielewski, P., Söderberg, J., Stanworth, S. J., Stein, M. B., von Steinbüchel, N., Stewart, W., Steyerberg, E. W., Stocchetti, N., Synnot, A., Te Ao, B., Tenovuo, O., Theadom, A., Tibboel, D., Videtta, W., Wang, K. K. W., Williams, W. H., Wilson, L., Yaffe, K., Adams, H., Agnoletti, V., Allanson, J., Amrein, K., Andaluz, N., Anke, A., Antoni, A., van As, A. B., Audibert, G., Azaševac, A., Azouvi, P., Azzolini, M. L., Baciu, C., Badenes, R., Barlow, K. M., Bartels, R., Bauerfeind, U., Beauchamp, M., Beer, D., Beer, R., Belda, F. J., Bellander, B.-M., Bellier, R., Benali, H., Benard, T., Beqiri, V., Beretta, L., Bernard, F., Bertolini, G., Bilotta, F., Blaabjerg, M., den Boogert, H., Boutis, K., Bouzat, P., Brooks, B., Brorsson, C., Bullinger, M., Burns, E., Calappi, E., Cameron, P., Carise, E., Castaño-León, A. M., Causin, F., Chevallard, G., Chieregato, A., Christie, B., Cnossen, M., Coles, J., Collett, J., Della Corte, F., Craig, W., Csato, G., Csomos, A., Curry, N., Dahyot-Fizelier, C., Dawes, H., DeMatteo, C., Depreitere, B., Dewey, D., van Dijck, J., Đilvesi, Đ., Dippel, D., Dizdarevic, K., Donoghue, E., Duek, O., Dulière, G.-L., Dzeko, A., Eapen, G., Emery, C. A., English, S., Esser, P., Ezer, E., Fabricius, M., Feng, J., Fergusson, D., Figaji, A., Fleming, J., Foks, K., Francony, G., Freedman, S., Freo, U., Frisvold, S. K., Gagnon, I., Galanaud, D., Gantner, D., Giraud, B., Glocker, B., Golubovic, J., Gómez López, P. A., Gordon, W. A., Gradisek, P., Gravel, J., Griesdale, D., Grossi, F., Haagsma, J. A., Håberg, A. K., Haitsma, I., Van Hecke, W., Helbok, R., Helseth, E., van Heugten, C., Hoedemaekers, C., Höfer, S., Horton, L., Hui, J., Huijben, J. A., Hutchinson, P. J., Jacobs, B., van der Jagt, M., Jankowski, S., Janssens, K., Jelaca, B., Jones, K. M., Kamnitsas, K., Kaps, R., Karan, M., Katila, A., Kaukonen, K.-M., De Keyser, V., Kivisaari, R., Kolias, A. G., Kolumbán, B., Kolundžija, K., Kondziella, D., Koskinen, L.-O., Kovács, N., Kramer, A., Kutsogiannis, D., Kyprianou, T., Lagares, A., Lamontagne, F., Latini, R., Lauzier, F., Lazar, I., Ledig, C., Lefering, R., Legrand, V., Levi, L., Lightfoot, R., Lozano, A., MacDonald, S., Major, S., Manara, A., Manhes, P., Maréchal, H., Martino, C., Masala, A., Masson, S., Mattern, J., McFadyen, B., McMahon, C., Meade, M., Melegh, B., Menovsky, T., Moore, L., Morgado Correia, M., Morganti-Kossmann, M. C., Muehlan, H., Mukherjee, P., Murray, L., van der Naalt, J., Negru, A., Nelson, D., Nieboer, D., Noirhomme, Q., Nyirádi, J., Oddo, M., Okonkwo, D. O., Oldenbeuving, A. W., Ortolano, F., Osmond, M., Payen, J.-F., Perlbarg, V., Persona, P., Pichon, N., Piippo-Karjalainen, A., Pili-Floury, S., Pirinen, M., Ple, H., Poca, M. A., Posti, J., Van Praag, D., Ptito, A., Radoi, A., Ragauskas, A., Raj, R., Real, R. G. L., Reed, N., Rhodes, J., Robertson, C., Rocka, S., Røe, C., Røise, O., Roks, G., Rosand, J., Rosenfeld, J. V., Rosenlund, C., Rosenthal, G., Rossi, S., Rueckert, D., de Ruiter, G. C. W., Sacchi, M., Sahakian, B. J., Sahuquillo, J., Sakowitz, O., Salvato, G., Sánchez-Porras, R., Sándor, J., Sangha, G., Schäfer, N., Schmidt, S., Schneider, K. J., Schnyer, D., Schöhl, H., Schoonman, G. G., Schou, R. F., Sir, Ö., Skandsen, T., Smeets, D., Sorinola, A., Stamatakis, E., Stevanovic, A., Stevens, R. D., Sundström, N., Taccone, F. S., Takala, R., Tanskanen, P., Taylor, M. S., Telgmann, R., Temkin, N., Teodorani, G., Thomas, M., Tolias, C. M., Trapani, T., Turgeon, A., Vajkoczy, P., Valadka, A. B., Valeinis, E., Vallance, S., Vámos, Z., Vargiolu, A., Vega, E., Verheyden, J., Vik, A., Vilcinis, R., Vleggeert-Lankamp, C., Vogt, L., Volovici, V., Voormolen, D. C., Vulekovic, P., Vande Vyvere, T., Van Waesberghe, J., Wessels, L., Wildschut, E., Williams, G., Winkler, M. K. L., Wolf, S., Wood, G., Xirouchaki, N., Younsi, A., Zaaroor, M., Zelinkova, V., Zemek, R., & Zumbo, F.
- Affiliations
- University of Antwerp (BE)
- University of Cambridge (GB)
- Barrow Neurological Institute (US)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- Monash University (AU)
- University of California San Diego (US)
- University of Washington (US)
- Azienda Ospedaliera San Gerardo (IT)
- Universitätsklinikum Aachen (DE)
- University of Pecs (HU)
- University of Pennsylvania (US)
- Charité – Universitätsmedizin Berlin (DE)
- Harvard University (US)
- Shanghai Jiao Tong University (CN)
- Nanyang Technological University (SG)
- All India Institute of Medical Sciences (IN)
- University of Cincinnati (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Auckland University of Technology (NZ)
- Karolinska Institutet (SE)
- University of Liège (BE)
- University of Sheffield (GB)
- Baylor College of Medicine (US)
- Erasmus MC (NL)
- Witten/Herdecke University (DE)
- University of California, San Francisco (US)
- Johns Hopkins University (US)
- Sapienza University of Rome (IT)
- University of Messina (IT)
- Leiden University Medical Center (NL)
- Assistance Publique – Hôpitaux de Paris (FR)
- John Radcliffe Hospital (GB)
- University of Milan (IT)
- La Trobe University (AU)
- Hospital Posadas (AR)
- University of Florida (US)
- University of Stirling (GB)
- Corresponding author
- Maas, Andrew I R
- Menon, David K
- ORCID
- Maas, Andrew I R
- Menon, David K
- Adelson, P David
- Belli, Antonio
- Bragge, Peter
- Büki, András
- Chesnut, Randall M
- Citerio, Giuseppe
- Coburn, Mark
- Czeiter, Endre
- Czosnyka, Marek
- Diaz-Arrastia, Ramon
- Dreier, Jens P
- Duhaime, Ann-Christine
- Ercole, Ari
- Feigin, Valery L
- Giacino, Joseph
- Gruen, Russell L
- Gupta, Deepak
- Hartings, Jed A
- Ketharanathan, Naomi
- Kompanje, Erwin J O
- Lanyon, Linda
- Laureys, Steven
- Lecky, Fiona
- Levin, Harvey
- Lingsma, Hester F
- Maegele, Marc
- Manley, Geoffrey
- Marsteller, Jill
- Mascia, Luciana
- Mondello, Stefania
- Newcombe, Virginia
- Palotie, Aarno
- Parizel, Paul M
- Peul, Wilco
- Piercy, James
- Puybasset, Louis
- Rasmussen, Todd E
- Rossaint, Rolf
- Smielewski, Peter
- Stanworth, Simon J
- Stein, Murray B
- Steyerberg, Ewout W
- Stocchetti, Nino
- Synnot, Anneliese
- Tenovuo, Olli
- Theadom, Alice
- Tibboel, Dick
- Videtta, Walter
- Wang, Kevin K W
- Williams, W Huw
- Wilson, Lindsay
- Yaffe, Kristine
- Adams, Hadie
- Agnoletti, Vanni
- Allanson, Judith
- Amrein, Krisztina
- Andaluz, Norberto
- Anke, Audny
- Audibert, Gérard
- Azouvi, Philippe
- Azzolini, Maria Luisa
- Baciu, Camelia
- Badenes, Rafael
- Barlow, Karen M
- Bartels, Ronald
- Beauchamp, Miriam
- Beer, Ronny
- Bellander, Bo-Michael
- Benali, Habib
- Beretta, Luigi
- Bertolini, Guido
- Bilotta, Federico
- Blaabjerg, Morten
- Boutis, Kathy
- Bouzat, Pierre
- Brooks, Brian
- Bullinger, Monika
- Burns, Emma
- Cameron, Peter
- Castaño-León, Ana M
- Causin, Francesco
- Chieregato, Arturo
- Christie, Brian
- Cnossen, Maryse
- Coles, Jonathan
- Collett, Johnny
- Craig, William
- Curry, Nicola
- Dawes, Helen
- DeMatteo, Carol
- Depreitere, Bart
- Dewey, Deborah
- Dippel, Diederik
- Donoghue, Emma
- Duek, Or
- Emery, Carolyn A
- English, Shane
- Esser, Patrick
- Fabricius, Martin
- Feng, Junfeng
- Fergusson, Dean
- Figaji, Anthony
- Freedman, Stephen
- Freo, Ulderico
- Frisvold, Shirin K
- Gagnon, Isabelle
- Gantner, Dashiell
- Glocker, Ben
- Gravel, Jocelyn
- Griesdale, Donald
- Grossi, Francesca
- Haagsma, Juanita A
- Helbok, Raimund
- Helseth, Eirik
- Hoedemaekers, Cornelia
- Höfer, Stefan
- Hui, Jiyuan
- Huijben, Jilske Antonia
- Hutchinson, Peter J
- Jacobs, Bram
- Jones, Kelly M
- Kamnitsas, Konstantinos
- Karan, Mladen
- Kivisaari, Riku
- Kolias, Angelos G
- Kondziella, Daniel
- Koskinen, Lars-Owe
- Kramer, Andreas
- Kyprianou, Theodoros
- Lagares, Alfonso
- Lamontagne, François
- Latini, Roberto
- Lauzier, François
- Lazar, Isaac
- Ledig, Christian
- Lefering, Rolf
- Lozano, Angels
- Major, Sebastian
- Manara, Alex
- Martino, Costanza
- Masala, Alessandro
- Masson, Serge
- McFadyen, Bradford
- McMahon, Catherine
- Meade, Maureen
- Melegh, Béla
- Menovsky, Tomas
- Moore, Lynne
- Morganti-Kossmann, Maria Cristina
- Muehlan, Holger
- Mukherjee, Pratik
- Nelson, David
- Nieboer, Daan
- Noirhomme, Quentin
- Oddo, Mauro
- Okonkwo, David O
- Ortolano, Fabrizio
- Osmond, Martin
- Payen, Jean-François
- Perlbarg, Vincent
- Persona, Paolo
- Pichon, Nicolas
- Piippo-Karjalainen, Anna
- Pirinen, Matti
- Poca, Maria Antonia
- Posti, Jussi
- Ptito, Alain
- Ragauskas, Arminas
- Raj, Rahul
- Reed, Nick
- Robertson, Claudia
- Røe, Cecilie
- Røise, Olav
- Roks, Gerwin
- Rosand, Jonathan
- Rosenfeld, Jeffrey V
- Rosenthal, Guy
- Rossi, Sandra
- Rueckert, Daniel
- Sahakian, Barbara J
- Sahuquillo, Juan
- Sakowitz, Oliver
- Salvato, Gerardo
- Sánchez-Porras, Renán
- Sándor, János
- Schäfer, Nadine
- Schmidt, Silke
- Schneider, Kathryn J
- Schnyer, David
- Schoonman, Guus G
- Sir, Özcan
- Skandsen, Toril
- Smeets, Dirk
- Stamatakis, Emmanuel
- Stevens, Robert D
- Sundström, Nina
- Taccone, Fabio Silvio
- Takala, Riikka
- Taylor, Mark Steven
- Temkin, Nancy
- Thomas, Matt
- Tolias, Christos M
- Trapani, Tony
- Turgeon, Alexis
- Vajkoczy, Peter
- Valadka, Alex B
- Valeinis, Egils
- Vallance, Shirley
- Vámos, Zoltán
- Verheyden, Jan
- Vik, Anne
- Vleggeert-Lankamp, Carmen
- Volovici, Victor
- Voormolen, Daphne C
- Wessels, Lars
- Williams, Guy
- Wolf, Stefan
- Wood, Gordon
- Xirouchaki, Nektaria
- Younsi, Alexander
- Zaaroor, Menashe
- Zelinkova, Veronika
- Zemek, Roger
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 16
- Issue
- 12
- Pages
- 987-1048
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2767813783
- Cited by
- 2,609
- References
- 514
- Citations by year
- 2026: 314 · 2025: 358 · 2024: 329 · 2023: 368 · 2022: 350 · 2021: 313 · 2020: 276 · 2019: 209 · 2018: 82 · 2017: 2
- FWCI
- 20.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Lancet Neurology (acceptedVersion, other-oa)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by-nc-nd)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
- Stirling Online Research Repository (University of Stirling) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- IRIS (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, other-oa)
- AIRUS (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Apollo
- Funders
- US Department of Defense
- CIHR
- GlaxoSmithKline
- Canadian Institutes of Health Research
- European Commission
- US National Institutes of Health-National Institute of Neurological Disorders and Stroke
- One Mind
- Fonds de recherche du Québec Santé
- Hotchkiss Brain Institute
- Ontario Brain Institute
- Ontario Neurotrauma Foundation
- Hannelore Kohl Stiftung, Germany
- UK National Institute for Health Research
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
- Keywords
- traumatic brain injury, TBI prevention, clinical care, global health burden, disability, low- and middle-income countries, research priorities, health policy recommendations
- MeSH terms
- Brain Injuries, Traumatic, Brain Injuries, Humans
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