The DOI matches its Crossref record, with a small difference in title or year; 107 of the 108 references it cites were found in a registry or an index.
The JAK/STAT Pathway in Model Organisms
Open accessAbstract
The JAK/STAT pathway was originally identified in mammals. Studies of this pathway in the mouse have revealed that JAK/STAT signaling plays a central role during hematopoeisis and other developmental processes. The role of JAK/STAT signaling in blood appears to be conserved throughout evolution, as it is also required during fly hematopoeisis. Studies in Dictyostelium, Drosophila, and zebrafish have shown that the JAK/STAT pathway is also required in an unusually broad set of developmental decisions, including cell proliferation, cell fate determination, cell migration, planar polarity, convergent extension, and immunity. There is increasing evidence that the versatility of this pathway relies on its cooperation with other signal transduction pathways. In this review, we discuss the components of the JAK/STAT pathway in model organisms and what is known about its requirement in cellular and developmental processes. In particular, we emphasize recent insights into the role that this pathway plays in the control of cell movement.
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“The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signal transduction pathway is an evolutionarily conserved pathway present in Drosophila melanogaster through Homo sapiens (Hou et al., 2002).”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Hou et al., 2002
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Metadata
- Authors
- Hou, S. X., Zheng, Z., Chen, X., & Perrimon, N.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- Howard Hughes Medical Institute (US)
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 3
- Issue
- 6
- Pages
- 765-778
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2074184810
- Cited by
- 251
- References
- 108
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 6 · 2013: 11 · 2012: 12
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- JAK/STAT signaling, hematopoiesis, cell migration, cell fate determination, planar cell polarity, convergent extension, immunity, cell proliferation, evolution of signaling pathways, Drosophila, zebrafish, Dictyostelium, mice, signaling pathways
- MeSH terms
- Animals, Cell Division, Cell Movement, DNA-Binding Proteins, Eukaryotic Cells, Hematopoiesis, Humans, Protein-Tyrosine Kinases, Signal Transduction, Trans-Activators, Cell Polarity, Cell Lineage, Models, Animal, Zebrafish Proteins, STAT1 Transcription Factor, Janus Kinase 1
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