Cited by 251Cytokine Signaling Pathways and InteractionsDevelopmental Biology and Gene RegulationNF-κB Signaling Pathways

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The JAK/STAT Pathway in Model Organisms

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Hou, Steven X., Zheng, Zhiyu, Chen, Xiu, Perrimon, Norbert·2002·Developmental Cell

DOI 10.1016/s1534-5807(02)00376-3

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Abstract

The JAK/STAT pathway was originally identified in mammals. Studies of this pathway in the mouse have revealed that JAK/STAT signaling plays a central role during hematopoeisis and other developmental processes. The role of JAK/STAT signaling in blood appears to be conserved throughout evolution, as it is also required during fly hematopoeisis. Studies in Dictyostelium, Drosophila, and zebrafish have shown that the JAK/STAT pathway is also required in an unusually broad set of developmental decisions, including cell proliferation, cell fate determination, cell migration, planar polarity, convergent extension, and immunity. There is increasing evidence that the versatility of this pathway relies on its cooperation with other signal transduction pathways. In this review, we discuss the components of the JAK/STAT pathway in model organisms and what is known about its requirement in cellular and developmental processes. In particular, we emphasize recent insights into the role that this pathway plays in the control of cell movement.

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Authors: Hou, S. X., Zheng, Z., Chen, X., & Perrimon, N.
Affiliations: Frederick National Laboratory for Cancer Research (US)
Howard Hughes Medical Institute (US)
ORCID: Chen, Xiu
Perrimon, Norbert
Venue: Developmental Cell
Publisher: Elsevier BV
Published: 2002-12
Volume: 3
Issue: 6
Pages: 765-778
ISSN: 1534-5807 (ISSN-L)
DOI: 10.1016/s1534-5807(02)00376-3
OpenAlex: W2074184810
Cited by: 251
References: 108
Citations by year: 2026: 5 · 2025: 8 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 13 · 2015: 11 · 2014: 6 · 2013: 11 · 2012: 12
FWCI: 1.82
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3881 d)
Locations: Developmental Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: JAK/STAT signaling, hematopoiesis, cell migration, cell fate determination, planar cell polarity, convergent extension, immunity, cell proliferation, evolution of signaling pathways, Drosophila, zebrafish, Dictyostelium, mice, signaling pathways
MeSH terms: Animals, Cell Division, Cell Movement, DNA-Binding Proteins, Eukaryotic Cells, Hematopoiesis, Humans, Protein-Tyrosine Kinases, Signal Transduction, Trans-Activators, Cell Polarity, Cell Lineage, Models, Animal, Zebrafish Proteins, STAT1 Transcription Factor, Janus Kinase 1

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The JAK/STAT Pathway in Model Organisms

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