Cited by 1,690Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancerChromatin Remodeling and Cancer

The DOI matches its Crossref record; 115 of the 122 references it cites were found in a registry or an index.

The RB and p53 pathways in cancer

Open access

Sherr, Charles J, McCormick, Frank·2002·Cancer Cell

Open this paper in CoChat — free account Open PDF

Abstract

The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) and the p53 transcription factor. Here, we discuss interconnecting signaling pathways controlled by RB and p53, attempting to explain their potentially universal involvement in the etiology of cancer. Pinpointing the various ways by which the functions of RB and p53 are subverted in individual tumors should provide a rational basis for developing more refined tumor-specific therapies.

Integrity signals

Registry

Crossref · 10.1016/s1535-6108(02)00102-2

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hallmarks of cancer
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
Self-citation
Cancer Cell Cycles
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Self-citation
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“By inducing Arf and Ink4a in primary rodent fibroblasts, oncogenic Ras expression leads to growth arrest and premature senescence (Serrano et al., 1997; Ferbeyre et al., 2002).”
Background
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317
Safety and antitumor activity of recombinant soluble Apo2 ligand
Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6926 · Cited by 2,213
Untitled work
Johnstone (2002) · doi:10.1016/s0092-8674(02)00625-6 · Cited by 1,876
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81079-x · Cited by 1,585

Show all 122 references

Sorted by citations

Items 701–800 of 1,000

S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons
Ye, W., & Blain, S. W. (2010) · Brain · doi:10.1093/brain/awq139 · Cited by 30
Precocious G1/S transitions and genomic instability: the origin connection
Sidorova, J. M., & Breeden, L. L. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.006 · Cited by 30
Zebrafish neurotoxicity from aphantoxins—cyanobacterial paralytic shellfish poisons (PSPs) from Aphanizomenon flos‐aquae DC‐1
Zhang, D., Hu, C., Wang, G., Li, D., Li, G., & Liu, Y. (2011) · Environmental Toxicology · doi:10.1002/tox.20714 · Cited by 29
Targeting FLIP and Mcl‐1 using a combination of aspirin and sorafenib sensitizes colon cancer cells to TRAIL
Pennarun, B., Kleibeuker, J. H., Ek, W. B., Kruyt, F. A. E., Hollema, H., de Vries, E. G. E., & de Jong, S. (2012) · The Journal of Pathology · doi:10.1002/path.4138 · Cited by 29
Non-overlapping Control of Transcriptome by Promoter- and Super-Enhancer-Associated Dependencies in Multiple Myeloma
Fulciniti, M., Lin, C. Y., Samur, M., Lopez, M. A., Singh, I., Lawlor, M. A., Szalat, R. E., Ott, C. J., Avet‐Loiseau, H., Anderson, K. C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.12.016 · Cited by 28
Actinomycin V Suppresses Human Non-Small-Cell Lung Carcinoma A549 Cells by Inducing G2/M Phase Arrest and Apoptosis via the p53-Dependent Pathway
Lin, S., Jia, F., Zhang, C., Liu, F.-Y., Ma, J., Han, Z., Xie, W., & Li, X. (2019) · Marine Drugs · doi:10.3390/md17100572 · Cited by 29
A dynamic switch in Rb+/− mediated neuroendocrine tumorigenesis
Leung, S. W., Wloga, E. H., Castro, A. F., Nguyen, T., Bronson, R. T., & Yamasaki, L. (2004) · Oncogene · doi:10.1038/sj.onc.1207457 · Cited by 29
Overexpression ofE2F3promotes proliferation of functional human β cells without induction of apoptosis
Rady, B., Chen, Y., Vaca, P., Wang, Q., Wang, Y., Salmon, P., & Oberholzer, J. (2013) · Cell Cycle · doi:10.4161/cc.25834 · Cited by 30
The Translation Factor eIF6 Is a Notch-Dependent Regulator of Cell Migration and Invasion
Benelli, D., Cialfi, S., Pinzaglia, M., Talora, C., & Londei, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032047 · Cited by 29
Molecular Biology of Basal and Squamous Cell Carcinomas
Xie, J. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-77574-6_19 · Cited by 29
Prognostic Impact of p16 and p53 Expression in Oropharyngeal Squamous Cell Carcinomas
Shinohara, S., Kikuchi, M., Tona, R., Kanazawa, Y., Kishimoto, I., Harada, H., Imai, Y., & Usami, Y. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyt223 · Cited by 29
Amplifying cancer vaccine responses by modifying pathogenic gene programs in tumor cells
Spaner, D. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0104016 · Cited by 29
A comprehensive review of metal-induced cellular transformation studies
Chen, Q. Y., & Costa, M. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.05.004 · Cited by 29
Neoplasia
Stricker, T. P., & KUMAR, V. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0792-2.50012-2 · Cited by 28
Thermodynamic characterization of interactions between p27Kip1 and activated and non-activated Cdk2: Intrinsically unstructured proteins as thermodynamic tethers
Bowman, P., Galea, C. A., Lacy, E. R., & Kriwacki, R. W. (2006) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.12.016 · Cited by 29
Lactococcus lactis ssp. lactis Inhibits the Proliferation of SNU‐1 Human Stomach Cancer Cells through Induction of G0/G1 Cell Cycle Arrest and Apoptosis via p53 and p21 Expression
Kim, S. Y., Kim, J., Lee, K. W., & Lee, H. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04721.x · Cited by 29
Bioluminescence technology for imaging cell proliferation
Momota, H., & Holland, E. C. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.10.012 · Cited by 29
Combination of E2F-1 promoter-regulated oncolytic adenovirus and cytokine-induced killer cells enhances the antitumor effects in an orthotopic rectal cancer model
Yang, Y., Xu, Y., Zhao, Y., Li, L., Sun, P., Liu, H., Fan, Q., Liang, K., Liang, W., Sun, H., et al. (2013) · Tumor Biology · doi:10.1007/s13277-013-1149-5 · Cited by 28
Protein phosphatase 2A promotes hepatocellular carcinogenesis in the diethylnitrosamine mouse model through inhibition of p53
Duong, F. H. T., Dill, M. T., Matter, M. S., Makowska, Z., Calabrese, D., Dietsche, T., Ketterer, S., Terracciano, L., & Heim, M. H. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt258 · Cited by 28
Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool
Nakajima, R., Zhao, L., Zhou, Y., Shirasawa, M., Uchida, A., Murakawa, H., Fikriyanti, M., Iwanaga, R., Bradford, A. P., Araki, K., et al. (2023) · Genes · doi:10.3390/genes14020393 · Cited by 32
Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma
Boonmars, T., Wu, Z., Boonjaruspinyo, S., Pinlaor, S., Nagano, I., Takahashi, Y., Kaewsamut, B., & Yongvanit, P. (2009) · Parasitology Research · doi:10.1007/s00436-009-1548-0 · Cited by 28
Mitochondrial Changes in Cancer
Rao, S. G. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_40 · Cited by 30
Cytotoxic effects of peanut phenolic compounds possessing histone deacetylase inhibitory activity on human colon cancer cell lines
Saenglee, S., Jogloy, S., Patanothai, A., & Senawong, T. (2016) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1601-23 · Cited by 28
RETRACTED ARTICLE: Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly
Braden, W. A., McClendon, A. K., & Knudsen, E. S. (2008) · Oncogene · doi:10.1038/onc.2008.319 · Cited by 28
Retracted
Identification of Multiple Cell Cycle Regulatory Functions of p57Kip2 in Human T Lymphocytes
Li, G., Domenico, J. M., Lucas, J. J., & Gelfand, E. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2383 · Cited by 28
Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling
Fan, Q., Cheng, Y., Chang, H., Deguchi, M., Hsueh, A. J. W., & Leung, P. C. K. (2017) · Oncotarget · doi:10.18632/oncotarget.15677 · Cited by 27
Novel vitexin-inspired scaffold against leukemia
Ling, T., Lang, W. H., Feng, X., Das, S., Maier, J., Jeffries, C. T., Shelat, A. A., & Rivas, F. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.01.004 · Cited by 27
Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
Zhu, Q., Chen, L., Li, Y., Huang, M.-H., Shao, J., Li, S., Cheng, J., Yang, H., Wu, Y., Zhang, J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109639 · Cited by 28
The Kv10.1 Channel: A Promising Target in Cancer
Luis, E., Anaya‐Hernández, A., León-Sánchez, P., & Durán-Pastén, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158458 · Cited by 29
Dephosphorylation of threonine-821 of the retinoblastoma tumor suppressor protein (Rb) is required for apoptosis induced by UV and Cdk inhibition
Lentine, B., Antonucci, L., Hunce, R., Edwards, J., Marallano, V. J., & Krucher, N. A. (2012) · Cell Cycle · doi:10.4161/cc.21693 · Cited by 26
TP53 and p16INK4A, but not H‐KI‐Ras, are involved in tumorigenesis and progression of pleomorphic adenomas
Augello, C., Gregorio, V., Bazan, V., Cammareri, P., Agnese, V., Cascio, S., Corsale, S., Calò, V., Gullo, A., Passantino, R., et al. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20601 · Cited by 27
Influence of the Linker in Bispyridium Compounds on the Inhibition of Human Choline Kinase
Conejo‐García, A., Báñez-Coronel, M., Sanchez-Martin, R. M., Rodrı́guez-González, A., Ramos, A., de Molina, A. R., Espinosa, A., Gallo, M. Á., Rosa, J. M. C., & Lacal, J. C. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0496537 · Cited by 27
Suppression of the p53-Dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling
Kortlever, R. M., Brummelkamp, T. R., van Meeteren, L. A., Moolenaar, W. H., & Bernards, R. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0066 · Cited by 27
RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
Weinstein, S., Emmanuel, R., Jacobi, A. M., Avigdor, A., Behlke, M. A., Sprague, A., Novobrantseva, T. I., Nagler, A., & Peer, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043343 · Cited by 27
Oxaloacetate decarboxylase FAHD1 – a new regulator of mitochondrial function and senescence
Etemad, S., Petit, M., Weiss, A. K. H., Schrattenholz, A. S., Baraldo, G., & Jansen‐Dürr, P. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.007 · Cited by 27
Analysis of gene expression in normal and neoplastic human testis: new roles of RNA
Novotny, G. W., Nielsen, J. E., Sonne, S. B., Skakkebæk, N. E., Meyts, E. R., & Leffers, H. C. B. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00773.x · Cited by 27
Deregulation of the Cell Cycle by the Epstein–Barr Virus
O’Nions, J., & Allday, M. J. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)92006-4 · Cited by 28
Regulation of Cell Cycle Entry and Exit: A Single Cell Perspective
Coller, H. A. (2019) · Comprehensive physiology · doi:10.1002/cphy.c190014 · Cited by 33
DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology
Xiong, H., Hua, F., Dong, Y., Lin, Y., Ying, J., Liu, J., Wang, X., Zhang, L., & Zhang, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.933015 · Cited by 25
CpG island methylator phenotype of cell-cycle regulators associated with TNM stage and poor prognosis in patients with oesophageal squamous cell carcinoma
Ling, Y., Huang, G., Fan, L., Wei, L., Zhu, J., Liu, Y., Zhu, C., & Zhang, C. (2010) · Journal of Clinical Pathology · doi:10.1136/jcp.2010.082875 · Cited by 26
Genomic Variations in Pancreatic Cancer and Potential Opportunities for Development of New Approaches for Diagnosis and Treatment
Lu, S., Ahmed, T., Du, P., & Wang, Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061201 · Cited by 27
Possible Oncogenic Viruses Associated with Lung Cancer
Hu, Y. W., Ren, S., He, Y., Wang, L., Chen, C., Tang, J., Liu, W., & Yu, F. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s263976 · Cited by 26
The role of complement in the tumor microenvironment
Ain, D., Shaikh, T., Manimala, S., & Ghebrehiwet, B. (2021) · Faculty Reviews · doi:10.12703/r/10-80 · Cited by 26
Nobiletin Induces Inhibitions of Ras Activity and Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Signaling to Suppress Cell Proliferation in C6 Rat Glioma Cells
Aoki, K., Yokosuka, A., Mimaki, Y., Fukunaga, K., & Yamakuni, T. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00824 · Cited by 26
Laforin Negatively Regulates Cell Cycle Progression through Glycogen Synthase Kinase 3β-Dependent Mechanisms
Liu, R., Wang, L., Chen, C., Liu, Y., Zhou, P., Wang, Y., Wang, X., Turnbull, J., Minassian, B. A., Liu, Y., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01334-08 · Cited by 26
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans
Bender, A. M., Kirienko, N. V., Olson, S. K., Esko, J. D., & Fay, D. S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.051 · Cited by 26
Intestinal Dysplasia Induced by Simian Virus 40 T Antigen Is Independent of p53
Markovics, J. A., Carroll, P. A., Robles, M. T. S., Pope, H., Coopersmith, C. M., & Pipas, J. M. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7492-7502.2005 · Cited by 26
Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer
Nguyen, T., & Kugler, J. (2018) · Cancers · doi:10.3390/cancers10040121 · Cited by 24
RBM10, a New Regulator of p53
Jung, J. H., Lee, H., Zeng, S. X., & Lu, H. (2020) · Cells · doi:10.3390/cells9092107 · Cited by 27
The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint
Krohn, M., Skjølberg, H. C., Soltani, H., Grallert, B., & Boye, E. (2008) · Journal of Cell Science · doi:10.1242/jcs.035428 · Cited by 26
Crystal Structure of the Homolog of the Oncoprotein Gankyrin, an Interactor of Rb and CDK4/6
Padmanabhan, B., Adachi, N., Kataoka, K., & Horikoshi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310266200 · Cited by 26
Understanding cellular senescence: pathways involved, therapeutics and longevity aiding
Kumar, A., & Thirumurugan, K. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2287929 · Cited by 31
Systemic treatments for radioiodine-refractory thyroid cancers
Chen, P., Yao, Y., Tan, H., & Li, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1346476 · Cited by 30
Identification of prognostic signature in cancer based on DNA methylation interaction network
Hu, W., & Zhou, X. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0307-9 · Cited by 25
PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors
Bai, F., Liu, S., Liu, X., Hollern, D. P., Scott, A., Wang, C., Zhang, L., Fan, C., Fu, L., Perou, C. M., et al. (2021) · Breast Cancer Research · doi:10.1186/s13058-021-01387-x · Cited by 25
RGS16, a novel p53 and pRb cross-talk candidate inhibits migration and invasion of pancreatic cancer cells
Carper, M. B., Denvir, J., Bošković, G., Primerano, D. A., & Claudio, P. P. (2014) · Genes & Cancer · doi:10.18632/genesandcancer.43 · Cited by 26
Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53
Reed, S. M., Hagen, J., Tompkins, V. S., Thies, K., Quelle, F. W., & Quelle, D. E. (2014) · Cell Cycle · doi:10.4161/cc.28202 · Cited by 25
Cytokine-induced tumor suppressors: A GRIM story
Kalvakolanu, D. V., Nallar, S. C., & Kalakonda, S. (2010) · Cytokine · doi:10.1016/j.cyto.2010.03.009 · Cited by 25
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia
Volanakis, E. J., Williams, R. T., & Sherr, C. J. (2009) · Blood · doi:10.1182/blood-2009-07-233346 · Cited by 26
Self-citation
The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis
Hazar-Rethinam, M. H., Endo‐Munoz, L., Gannon, O. M., & Saunders, N. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12128947 · Cited by 26
p19Ink4d Is a Tumor Suppressor and Controls Pituitary Anterior Lobe Cell Proliferation
Bai, F., Chan, H. L., Smith, M. D., Kiyokawa, H., & Pei, X. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01363-13 · Cited by 27
Loss of p27Kip1 promotes metaplasia in the pancreasviathe regulation of Sox9 expression
Jeannot, P., Callot, C., Baer, R., Duquesnes, N., Guerra, C. E., Guillermet‐Guibert, J., Bachs, O., & Besson, A. (2015) · Oncotarget · doi:10.18632/oncotarget.5770 · Cited by 25
The Role of the Transcriptional Response to DNA Replication Stress
Herlihy, A. E., & de Bruin, R. A. M. (2017) · Genes · doi:10.3390/genes8030092 · Cited by 26
CDKN1C Negatively Regulates RNA Polymerase II C-terminal Domain Phosphorylation in an E2F1-dependent Manner
Ma, Y., Chen, L., Wright, G. M., Pillai, S., Chellappan, S., & Cress, W. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091496 · Cited by 25
Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes
Lévêque, C., Marsaud, V., Renoir, J., & Sola, B. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.04.018 · Cited by 26
Ascochlorin activates p53 in a manner distinct from DNA damaging agents
Jeong, J.-H., Nakajima, H., Magae, J., Furukawa, C., Taki, K., Otsuka, K., Tomita, M., Lee, I., Kim, C., Chang, H., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24259 · Cited by 25
E1A, E1B Double-Restricted Adenovirus with RGD-Fiber Modification Exhibits Enhanced Oncolysis for CAR–Deficient Biliary Cancers
Wakayama, M., Abei, M., Kawashima, R., Seo, E., Fukuda, K., Ugai, H., Murata, T., Tanaka, N., Hyodo, I., Hamada, H., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2103 · Cited by 25
Towards molecular diagnosis and targeted therapy of lymphoid malignancies
Wiestner, A. U., & Staudt, L. M. (2003) · Seminars in Hematology · doi:10.1016/s0037-1963(03)00194-x · Cited by 25
Elucidating the mechanism of corneal epithelial cell repair: unraveling the impact of growth factors
Gong, J., Ding, G., Hao, Z., Li, Y., Deng, A., & Zhang, C. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1384500 · Cited by 26
Tumor Suppressors Condition Differential Responses to the Selective CDK2 Inhibitor BLU-222
Dommer, A. P., Kumarasamy, V. M., Wang, J., O’Connor, T. N., Roti, M., Mahan, S., McLean, K., Knudsen, E. S., & Witkiewicz, A. K. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-2244 · Cited by 25
Cancer and Aging Biomarkers: Classification, Early Detection Technologies and Emerging Research Trends
Ki, M., Kim, D. H., Abdelhamid, M. A. A., & Pack, S. P. (2025) · Biosensors · doi:10.3390/bios15110737 · Cited by 33
Computational Modeling and Verification of Signaling Pathways in Cancer
Gong, H., Zuliani, P., Komuravelli, A., Faeder, J. R., & Clarke, E. M. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-28067-2_7 · Cited by 24
Advances in the biology and therapy of patients with chronic myeloid leukaemia
Jabbour, E. J., Fava, C., & Kantarjian, H. M. (2009) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2009.09.002 · Cited by 24
The hallmarks of ovarian cancer: proliferation and cell growth
López-Reig, R., & López-Guerrero, J. A. (2020) · European Journal of Cancer Supplements · doi:10.1016/j.ejcsup.2019.12.001 · Cited by 24
Proline pre-conditioning of cell monolayers increases post-thaw recovery and viability by distinct mechanisms to other osmolytes
Bailey, T. L., Hernandez-Fernaud, J. R., & Gibson, M. I. (2021) · RSC Medicinal Chemistry · doi:10.1039/d1md00078k · Cited by 24
Evidence for Autoregulation and Cell Signaling Pathway Regulation From Genome-Wide Binding of theDrosophilaRetinoblastoma Protein
Acharya, P., Negre, N. N., Johnston, J., Wei, Y., White, K. P., Henry, R. W., & Arnosti, D. N. (2012) · G3 Genes Genomes Genetics · doi:10.1534/g3.112.004424 · Cited by 24
Re“evolutionary” Regenerative Medicine
Blau, H. M. (2010) · JAMA · doi:10.1001/jama.2010.1938 · Cited by 24
Global Identification of Genes Related to Nutrient Deficiency in Intervertebral Disc Cells in an Experimental Nutrient Deprivation Model
Sudo, H., Yamada, K., Iwasaki, K., Higashi, H., Ito, M., Minami, A., & Iwasaki, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058806 · Cited by 24
Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples
Mizuarai, S., Machida, T., Kobayashi, T., Komatani, H., Itadani, H., & Kotani, H. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-31 · Cited by 23
A novel carbazole derivative, MHY407, sensitizes cancer cells to doxorubicin-, etoposide-, and radiation treatment via DNA damage
Yoon, S., Kim, J.-H., Lee, Y. J., Ahn, M. Y., Choi, G., Kim, W. K., Yang, Z., Lee, H. J., Moon, H. R., & Kim, H. S. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.001 · Cited by 24
Expression of p53 predicts risk of prevalent and incident advanced neoplasia in patients with Barrett's esophagus and epithelial changes indefinite for dysplasia
Horváth, B., Singh, P., Xie, H., Thota, P. N., Sun, X., & Liu, X. (2015) · Gastroenterology report · doi:10.1093/gastro/gov045 · Cited by 24
Evolution of Cancer Defense Mechanisms Across Species
Harris, V. K., Schiffman, J. D., & Boddy, A. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804310-3.00007-7 · Cited by 27
A nonsynonymous single‐nucleotide polymorphism in the PDZ‐Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans
Gu, J. H., Wu, X., Dong, Q., Romeo, M. J., Lin, X., Gutkind, J. S., & Berman, D. M. (2006) · Cancer · doi:10.1002/cncr.21944 · Cited by 23
Isolation of immortalized, INK4a/ARF-deficient cells from the subventricular zone after in utero N-ethyl-N-nitrosourea exposure
Savarese, T. M., Jang, T., Low, H. P., Salmonsen, R. A., Litofsky, N. S., Matijašević, Z., Ross, A. H., & Recht, L. D. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.102.1.0098 · Cited by 23
TATA-binding Protein (TBP)-like Protein Is Required for p53-dependent Transcriptional Activation of Upstream Promoter of p21 Gene
Suzuki, H., Ito, R., Ikeda, K., & Tamura, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.369629 · Cited by 24
Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3)
Su, Z.-Z., Emdad, L., Sarkar, D., Randolph, A. L., Valerie, K. C., Yacoub, A., Dent, P., & Fisher, P. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208420 · Cited by 24
A new cancer diagnostic system based on a CDK profiling technology
Ishihara, H., Yoshida, T., Kawasaki, Y., Kobayashi, H., Yamasaki, M., Nakayama, S., Miki, E., Shohmi, K.-I., Matsushima, T., Tada, S., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.06.001 · Cited by 24
Tumour-suppressor function in the nervous system
Baker, S. J., & McKinnon, P. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1297 · Cited by 24
Early correction of cell cycle perturbations predicts the immunological response to therapy in HIV-infected patients
Paiardini, M., Cervasi, B., Galati, D., Dominici, S., Albrecht, H., Sfacteria, A., Magnani, M., Silvestri, G., & Piedimonte, G. (2004) · AIDS · doi:10.1097/00002030-200402200-00004 · Cited by 24
Differential Gene Expression of p27Kip1 and Rb Knockout Pituitary Tumors Associated with Altered Growth and Angiogenesis
Chien, W.-M., Garrison, K., Caufield, E., Orthel, J., Dill, J., & Fero, M. L. (2007) · Cell Cycle · doi:10.4161/cc.6.6.3986 · Cited by 23
Subclassification, survival prediction and drug target analyses of chemotherapy-naïve muscle-invasive bladder cancer with a molecular screening
Rinaldetti, S. L., Rempel, E., Worst, T. S., Eckstein, M., Steidler, A., Weiss, C. A., Bolenz, C., Hartmann, A., & Erben, P. (2018) · Oncotarget · doi:10.18632/oncotarget.25407 · Cited by 23
Targeted Therapies for the Treatment of Glioblastoma in Adults
Chuang, D. F., & Lin, X. (2019) · Current Oncology Reports · doi:10.1007/s11912-019-0807-1 · Cited by 23
CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-Resistant Melanoma
Li, Z., Wang, B., Gu, S. S., Jiang, P., Sahu, A. D., Chen, C.-H., Han, T., Shi, S., Wang, X., Traugh, N. C., et al. (2020) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2020.02.002 · Cited by 24
TAF15 contributes to the radiation-inducible stress response in cancer
Singh, A. K., Kapoor, V., Thotala, D. K., & Hallahan, D. E. (2020) · Oncotarget · doi:10.18632/oncotarget.27663 · Cited by 24
Involvement of abnormal dystroglycan expression and matriglycan levels in cancer pathogenesis
Quereda, C., Pastor, A. C., & Martín‐Nieto, J. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02812-7 · Cited by 22
Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21Cip1/Waf1
Datta, D., Kumaraswamy, A., Suryaraja, R., Priya, R. S., Desai, P., & Mahalingam, S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.637280 · Cited by 23
Cell Cycle Regulation by Carboxylated Multiwalled Carbon Nanotubes through p53-Independent Induction of p21 under the Control of the BMP Signaling Pathway
Zhang, Y., & Yan, B. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300059m · Cited by 23
Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells
Sun, B., Wingate, H. F., Swisher, S. G., Keyomarsi, K., & Hunt, K. K. (2010) · Cell Cycle · doi:10.4161/cc.9.6.10990 · Cited by 23
Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress
Jeon, B., Kim, M., Yoon, J.-H., Kim, M.-Y., An, H., Noh, H.-J., Choi, W., Koh, D., & Hur, M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku857 · Cited by 22
Wnt signaling and senescence: A tug of war in early neoplasia?
Adams, P. D., & Enders, G. H. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.11.6943 · Cited by 23

Authors: Sherr, C. J., & McCormick, F.
Affiliations: St. Jude Children's Research Hospital (US)
University of California, San Francisco (US)
Corresponding author: Sherr, Charles J
ORCID: Sherr, Charles J
McCormick, Frank
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2002-08
Volume: 2
Issue: 2
Pages: 103-112
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/s1535-6108(02)00102-2
OpenAlex: W1992708996
Cited by: 1,690
References: 122
Citations by year: 2026: 31 · 2025: 40 · 2024: 36 · 2023: 60 · 2022: 56 · 2021: 62 · 2020: 62 · 2019: 67 · 2018: 75 · 2017: 67 · 2016: 60 · 2015: 71 · 2014: 88 · 2013: 81 · 2012: 90
FWCI: 7.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4003 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: retinoblastoma protein, p53, tumor suppressor, malignant transformation, signaling pathways, cancer etiology, tumor-specific therapy, oncogenic transformation
MeSH terms: Cell Cycle, DNA-Binding Proteins, Humans, Neoplasms, Transcription Factors, Signal Transduction, Tumor Suppressor Protein p53, Retinoblastoma Protein, Apoptosis, Cell Cycle Proteins, Cyclin-Dependent Kinase Inhibitor p16, E2F Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The RB and p53 pathways in cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks