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The RB and p53 pathways in cancer
Open accessAbstract
The life history of cancer cells encompasses a series of genetic missteps in which normal cells are progressively transformed into tumor cells that invade surrounding tissues and become malignant. Most prominent among the regulators disrupted in cancer cells are two tumor suppressors, the retinoblastoma protein (RB) and the p53 transcription factor. Here, we discuss interconnecting signaling pathways controlled by RB and p53, attempting to explain their potentially universal involvement in the etiology of cancer. Pinpointing the various ways by which the functions of RB and p53 are subverted in individual tumors should provide a rational basis for developing more refined tumor-specific therapies.
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“p16 is a positive regulator of pRB and tumor suppressor in its own right (Sherr and McCormick, 2002).”
From Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors (2005) · cites this paper as Sherr and McCormick, 2002
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p16-Positive Small Cell Neuroendocrine Carcinoma of the Endometrium
Melgoza, F. U., Brewster, W. R., Wilczynski, S. P., & Rutgers, J. K. L. (2006) · International Journal of Gynecological Pathology · doi:10.1097/01.pgp.0000189242.11404.ae · Cited by 18
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Metadata
- Authors
- Sherr, C. J., & McCormick, F.
- Affiliations
- St. Jude Children's Research Hospital (US)
- University of California, San Francisco (US)
- Corresponding author
- Sherr, Charles J
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 2
- Issue
- 2
- Pages
- 103-112
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W1992708996
- Cited by
- 1,690
- References
- 122
- Citations by year
- 2026: 31 · 2025: 40 · 2024: 36 · 2023: 60 · 2022: 56 · 2021: 62 · 2020: 62 · 2019: 67 · 2018: 75 · 2017: 67 · 2016: 60 · 2015: 71 · 2014: 88 · 2013: 81 · 2012: 90
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- retinoblastoma protein, p53, tumor suppressor, malignant transformation, signaling pathways, cancer etiology, tumor-specific therapy, oncogenic transformation
- MeSH terms
- Cell Cycle, DNA-Binding Proteins, Humans, Neoplasms, Transcription Factors, Signal Transduction, Tumor Suppressor Protein p53, Retinoblastoma Protein, Apoptosis, Cell Cycle Proteins, Cyclin-Dependent Kinase Inhibitor p16, E2F Transcription Factors
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