Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Notch Signaling: Cell Fate Control and Signal Integration in Development

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A simplified system for generating recombinant adenoviruses

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Cancer Statistics, 2002

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100

Notch signalling controls pancreatic cell differentiation

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Control of endodermal endocrine development by Hes-1

Jensen, J. N., Pedersen, E. E., Galante, P. E., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155

Notch Signaling: From the Outside In

Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., Andrieu, P. D. S. I., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E. G., Holsztynska, E. J., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00012.x · Cited by 870

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

Zulewski, H., Abraham, E. J., Gerlach, M. J., Daniel, P. B., Moritz, W., Müller-Stich, B. P., Vallejo, M., Thomas, M. K., & Habener, J. F. (2001) · Diabetes · doi:10.2337/diabetes.50.3.521 · Cited by 785

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

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Clinical Significance of Tumor-associated Antigen RCAS1 Expression in Human Pancreatic Ductal Adenocarcinoma

Giaginis, C., Davides, D., Zarros, A. C., Noussia, O., Zizi‐Serbetzoglou, A., Kouraklis, G. P., & Theocharis, S. E. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0035-7 · Cited by 23

Differential expression of p63 isotypes (ΔN and TA) in salivary gland neoplasms: biological and diagnostic implications

Maruya, S.-I., Kies, M. S., Williams, M. D., Myers, J. N., Weber, R. S., Batsakis, J. G., & El‐Naggar, A. K. (2005) · Human Pathology · doi:10.1016/j.humpath.2005.05.014 · Cited by 23

ADAM proteases, ErbB pathways and cancer

Zhou, B. S., Fridman, J. S., Liu, X., Friedman, S., Newton, R. C., & Scherle, P. (2005) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.14.6.591 · Cited by 23

Management of metastatic pancreatic cancer: Current treatment options and potential new therapeutic targets

Sclafani, F., Iyer, R., Cunningham, D., & Starling, N. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.03.008 · Cited by 22

An Extensive Review on Preclinical and Clinical Trials of Oncolytic Viruses Therapy for Pancreatic Cancer

Nisar, M., Paracha, R. Z., Adil, S., Qureshi, S. N., & Janjua, H. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.875188 · Cited by 22

CD133 Expression Pattern Distinguishes Intraductal Papillary Mucinous Neoplasms From Ductal Adenocarcinomas of the Pancreas

Shimizu, K., Itoh, T., Shimizu, M., Ku, Y., & Hori, Y. (2009) · Pancreas · doi:10.1097/mpa.0b013e3181bb5037 · Cited by 22

Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumors

Dumont, A. G., Yang, Y., Reynoso, D., Katz, D., Trent, J. C., & Hughes, D. P. M. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs221 · Cited by 22

Interplay of Tumor Microenvironment Cell Types with Parenchymal Cells in Pancreatic Cancer Development and Therapeutic Implications

Guturu, P., Shah, V. H., & Urrutia, R. A. (2009) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-009-9071-1 · Cited by 21

Expression and role of Notch signalling in the regeneration of rat tracheal epithelium

Ma, X. ‐., Jia, X., Liu, Y. ‐., Wang, L., Sun, S., Song, N., Wang, E. ‐., & Li, F. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00569.x · Cited by 21

A BAC transgenic Hes1-EGFP reporter reveals novel expression domains in mouse embryos

Klinck, R., Füchtbauer, E., Ahnfelt‐Rønne, J., Serup, P., Jensen, J. N., & Jørgensen, M. C. (2011) · Gene Expression Patterns · doi:10.1016/j.gep.2011.06.004 · Cited by 17

Association of Notch4 with metastasis in human oral squamous cell carcinoma

Harishankar, M. K., Prince, S., Mohan, A. M., Krishnan, K. V., & Devi, A. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.05.019 · Cited by 20

DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer

Drouillard, A., Puleo, F., Bachet, J., Ouazzani, S., Calomme, A., Demetter, P., Verset, G., Laethem, J. V., & Maréchal, R. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.319 · Cited by 21

Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells

Liu, H., Zhou, P., Hong, L., Chen, J., & Zhang, Y.-X. (2016) · Journal of Cancer · doi:10.7150/jca.16739 · Cited by 20

Zebrafish model of KRAS-initiated pancreatic cancer

Park, J. T., & Leach, S. D. (2018) · Animal Cells and Systems · doi:10.1080/19768354.2018.1530301 · Cited by 20

MAPK-dependent phosphorylation modulates the activity of Suppressor of Hairless in Drosophila

Auer, J. S., Nagel, A. C., Schulz, A., Wahl, V., & Preiss, A. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.10.007 · Cited by 20

Notch Signaling in T-Cell Acute Lymphoblastic Leukemia

Weng, A. P., & Lau, A. N. (2005) · Future Oncology · doi:10.2217/14796694.1.4.511 · Cited by 20

Identification of eight genes that are potentially involved in tamoxifen sensitivity in breast cancer cells

Zarubin, T., Jing, Q., New, L., & Han, J. (2005) · Cell Research · doi:10.1038/sj.cr.7290312 · Cited by 20

The pancreatic cancer proteome – recent advances and future promise

Aspinall-O’Dea, M., & Costello, E. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700144 · Cited by 20

FBXW 7 modulates malignant potential and cisplatin‐induced apoptosis in cholangiocarcinoma through NOTCH 1 and MCL 1

Mori, A., Masuda, K., Ohtsuka, H., Shijo, M., Ariake, K., Fukase, K., Sakata, N., Mizuma, M., Morikawa, T., Hayashi, H., et al. (2018) · Cancer Science · doi:10.1111/cas.13829 · Cited by 20

Molecular therapeutics in pancreas cancer

Narayanan, V., & Weekes, C. D. (2016) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v8.i4.366 · Cited by 19

Fringe family genes and their modulation of Notch signaling in cancer

Mugisha, S., Di, X., Disoma, C., Jiang, H., & Zhang, S. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188746 · Cited by 19

The role of Jagged1 as a dynamic switch of cancer cell plasticity in PDAC assembloids

Choi, J.-I., Rim, J. H., Jang, S. I., Park, J. S., Park, H., Cho, J. H., & Lim, J. (2022) · Theranostics · doi:10.7150/thno.71364 · Cited by 19

Context-Dependent Roles of Hes1 in the Adult Pancreas and Pancreatic Tumor Formation

Marui, S., Nishikawa, Y., Shiokawa, M., Yokode, M., Matsumoto, S., Muramoto, Y., Ota, S., Nakamura, T., Yoshida, H. K., Okada, H., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.08.048 · Cited by 19

NOTCH Signaling in Osteosarcoma

Zhang, Z., Wu, W., & Shao, Z. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030146 · Cited by 19

Alteration of the Intrinsic Apoptosis Pathway Is Involved in Notch-induced Chemoresistance to Gemcitabine in Pancreatic Cancer

Du, X. H., Zhao, Y.-P., Zhang, T., Zhou, L., Chen, G., Wang, T., You, L., & Shu, H. (2013) · Archives of Medical Research · doi:10.1016/j.arcmed.2013.10.001 · Cited by 19

A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel

Mato-Berciano, A., Raimondi, G., Maliandi, M. V., Alemany, R., Montoliu, L., & Fillat, C. (2017) · Oncotarget · doi:10.18632/oncotarget.15169 · Cited by 19

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.

Karafin, M. S., Cummings, C. T., Fu, B., & Iacobuzio–Donahue, C. A. (2009) · PubMed Central · Cited by 19

Protein Kinase C Iota Regulates Pancreatic Acinar-to-Ductal Metaplasia

Scotti, M. L., Smith, K. E., Saravia-Butler, A., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P., & Murray, N. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030509 · Cited by 19

Development of the Endocrine and Exocrine Pancreas

Murtaugh, L., Cassiano, J., & Jean-PaulDeLa, O. (2008) · Springer eBooks · doi:10.1007/978-0-387-69252-4_8 · Cited by 12

Characteristics of Notch2+ pancreatic cancer stem‐like cells and the relationship with centroacinar cells

Zhou, Z., Dong, Q., Fu, D., Gong, Y., & Ni, Q. (2013) · Cell Biology International · doi:10.1002/cbin.10102 · Cited by 18

Long-Term Correction of Hyperglycemia in Diabetic Mice After Implantation of Cultured Human Cells Derived From Fetal Pancreas

Wu, F. D., Jagir, M. R., & Powell, J. S. (2004) · Pancreas · doi:10.1097/00006676-200407000-00064 · Cited by 18

Prominin-1 (CD133) Reveals New Faces of Pancreatic Progenitor Cells and Cancer Stem Cells: Current Knowledge and Therapeutic Perspectives

Hori, Y. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5894-4_12 · Cited by 17

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Wang, Z., Wu, J., Tian, X., & Hao, C. (2019) · Frontiers of Medicine · doi:10.1007/s11684-018-0672-6 · Cited by 17

Organotypic Culture of Acinar Cells for the Study of Pancreatic Cancer Initiation

Carrer, A., & Paoli, C. (2020) · Cancers · doi:10.3390/cancers12092606 · Cited by 16

Functional Gene Expression Differentiation of the Notch Signaling Pathway in Female Reproductive Tract Tissues—A Comprehensive Review With Analysis

Orzechowska, M., Anusewicz, D., & Bednarek, A. K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.592616 · Cited by 17

MicroRNA-Regulated Signaling Pathways: Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

Mortoglou, M., Wallace, D., Djordjević, A. B., Djordjevic, V. R., Arısan, E. D., & Onganer, P. U. (2021) · Stresses · doi:10.3390/stresses1010004 · Cited by 17

Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice

Inman, K. S., Liu, Y., Scotti, M. L., Leitges, M., Krishna, M., Crawford, H. C., Fields, A. P., & Murray, N. R. (2022) · Cancers · doi:10.3390/cancers14030796 · Cited by 17

Current Pathology Model of Pancreatic Cancer

Szymoński, K., Milian-Ciesielska, K., Lipiec, E. W., & Adamek, D. (2022) · Cancers · doi:10.3390/cancers14092321 · Cited by 15

Deciphering microRNA targets in pancreatic cancer using miRComb R package

Vila-Casadesús, M., Vila-Navarro, E., Raimondi, G., Fillat, C., Castells, A., Lozano, J. J., & Gironella, M. (2018) · Oncotarget · doi:10.18632/oncotarget.24034 · Cited by 16

Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments

Asayesh, A., Alanentalo, T., Khoo, N. K. S., & Ahlgren, U. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20259 · Cited by 16

Notch1 Contributes to Chemoresistance to Gemcitabine and Serves as an Unfavorable Prognostic Indicator in Pancreatic Cancer

Du, X. H., Zhao, Y., Zhang, T., Zhou, L., Chen, G., Cui, Q., Shi, J., Wang, T., You, L., & Shu, H. (2013) · World Journal of Surgery · doi:10.1007/s00268-013-2010-0 · Cited by 16

Study human pancreatic cancer in mice: How close are they?

Zhang, Y., Chen, L. L., Yang, J., Fleming, J. B., Chiao, P. J., Logsdon, C. D., & Li, M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.11.001 · Cited by 16

The NOTCH Pathway in β-Cell Growth and Differentiation

Bar, Y., & Efrat, S. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800174-5.00015-6 · Cited by 16

Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen‐induced preneoplastic lesions formation

Mathieu, A., Clerc, P., Portolan, G., Bierkamp, C., Lulka, H., Pradayrol, L., Seva, C., Fourmy, D., & Dufresne, M. (2005) · International Journal of Cancer · doi:10.1002/ijc.20861 · Cited by 16

Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila

Pi, H., Huang, Y., Chen, I., Lin, C.-D., Yeh, H.-F., & Pai, L. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-42 · Cited by 15

Role of Dietary Cancer-Preventive Phytochemicals in Pancreatic Cancer Stem Cells

Kumar, G., Farooqui, M., & Rao, C. V. (2018) · Current Pharmacology Reports · doi:10.1007/s40495-018-0145-2 · Cited by 15

Zebrafish model of KRAS-initiated pancreatic endocrine tumor

Oh, S., & Park, J. T. (2019) · Animal Cells and Systems · doi:10.1080/19768354.2019.1610058 · Cited by 15

Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes

Alzhrani, R. M., Alsaab, H. O., Vanamala, K., Bhise, K., Tatiparti, K., Barari, A., Sau, S., & Iyer, A. K. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000262 · Cited by 16

Signaling pathways and their potential therapeutic utility in esophageal squamous cell carcinoma

Kadian, L. K., Arora, M., Prasad, C. P., Pramanik, R., & Chauhan, S. S. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-021-02763-x · Cited by 17

Significant Roles of Notch O-Glycosylation in Cancer

Wang, W., Okajima, T., & Takeuchi, H. (2022) · Molecules · doi:10.3390/molecules27061783 · Cited by 15

Targeting glioblastoma cancer stem cells: the next great hope?

Khan, I. S., & Ehtesham, M. (2014) · Neurosurgical FOCUS · doi:10.3171/2014.9.focus14509 · Cited by 15

SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer

Edelman, H. E., McClymont, S. A., Tucker, T. R., Pineda, S. B., Beer, R. L., McCallion, A. S., & Parsons, M. J. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab064 · Cited by 15

Differential Sensitivity of Mouse Epithelial Tissues to the Polyomavirus Middle T Oncogene

Ceceña, G., Wen, F., Cardiff, R. D., & Oshima, R. G. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050443 · Cited by 15

Pancreas transcription factor 1α expression is regulated in pancreatitis

Molero, X., Adell, T., Skoudy, A., Padilla, M. A., Gómez, J. A., Chalaux, E., Malagelada, J., & Real, F. X. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01856.x · Cited by 16

Cancer stem cells - from initiation to elimination, how far have we reached? (Review)

Scott (2009) · International Journal of Oncology · doi:10.3892/ijo_00000278 · Cited by 14

Pancreatic Cancer: Translating Lessons from Mouse Models and Hereditary Syndromes

Wescott, M. P., & Rustgi, A. K. (2008) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0195 · Cited by 14

Novel Targets in Pancreatic Cancer Therapy - Current Status and Ongoing Translational Efforts

Bisht, S., & Feldmann, G. (2018) · Oncology Research and Treatment · doi:10.1159/000493437 · Cited by 14

Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas

Gigoux, V., Clerc, P., Sanchez, D., Coll, M., Corominola, H., Leung–Theung–Long, S., Pénicaud, L., Gomis, R., Seva, C., Fourmy, D., et al. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2007.08.020 · Cited by 14

Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis

Giaimo, B. D., & Borggrefe, T. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-89512-3_1 · Cited by 15

Elongin C is a mediator of Notch4 activity in human renal tubule cells

Cummins, T. D., Mendenhall, M. D., Lowry, M. N., Korte, E. A., Barati, M. T., Khundmiri, S. J., Salyer, S. A., Klein, J. B., & Powell, D. W. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.09.010 · Cited by 14

Developmental Molecular Biology of the Pancreas

Cleaver, O. B., & MacDonald, R. J. (2009) · Springer eBooks · doi:10.1007/978-0-387-77498-5_4 · Cited by 15

Notch4 overexpression in ameloblastoma correlates with the solid/multicystic phenotype

Siar, C. H., Nagatsuka, H., Chuah, K. S., Rivera, R. S., Nakano, K., Ng, K. H., & Kawakami, T. (2010) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2010.03.009 · Cited by 14

Signaling pathways mediating epithelial- mesenchymal crosstalk in pancreatic cancer: Hedgehog, Notch and TGFβ

Bailey, J. M., & Leach, S. D. (2012) · Cited by 13

Current status of regeneration of pancreatic β‐cells

Minami, K., & Seino, S. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12062 · Cited by 13

Suppression of tongue squamous cell carcinoma growth by inhibition of J agged1 in vitro and in vivo

Zhang, T., Liu, H., Liang, Y., Liang, L., Zheng, G., Huang, H., Wu, J., & Liao, G. (2012) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12013 · Cited by 13

Notch Signaling: Where Pancreatic Cancer and Differentiation Meet?

Jean–Paul De La, O., & Murtaugh, L. C. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.03.022 · Cited by 13

Silencing of Notch3 Using shRNA Driven by Survivin Promoter Inhibits Growth and Promotes Apoptosis of Human T-Cell Acute Lymphoblastic Leukemia Cells

Xiang, J., Ouyang, Y., Cui, Y., Fang, L., Ren, J.-H., Long, M., Chen, X., Wei, J., & Zhang, H. (2011) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2011.07.005 · Cited by 12

Tumor biology and cancer therapy – an evolving relationship

Seufferlein, T. T. W., Ahn, J., Krndija, D., Lother, U., Adler, G., & von Wichert, G. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-19 · Cited by 12

Inhibition of Notch-1 pathway is involved in rottlerin-induced tumor suppressive function in nasopharyngeal carcinoma cells

Hou, Y., Feng, S., Wang, L., Zhao, Z., Su, J., Yin, X., Zheng, N., Zhou, X., Xia, J., & Wang, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.19097 · Cited by 12

Nanotherapeutics promises for colorectal cancer and pancreatic ductal adenocarcinoma

Bhaw‐Luximon, A., Goonoo, N., & Jhurry, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-42863-7.00006-2 · Cited by 12

Primers on Molecular Pathways — Notch

Lomberk, G. A., & Urrutia, R. A. (2008) · Pancreatology · doi:10.1159/000123603 · Cited by 12

Notch signaling pathway in pancreatic tumorigenesis

Chung, W.-C., & Xu, K. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.001 · Cited by 11

Notch1 serves as a prognostic factor and regulates metastasis via regulating EGFR expression in hypopharyngeal squamous cell carcinoma

Tian, J., Liu, X., Liu, X., Jing, P., Sa, N., Wang, H., & Xu, W. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s175423 · Cited by 11

Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome

Dugnani, E., Sordi, V., Pellegrini, S., Chimienti, R., Marzinotto, I., Pasquale, V., Liberati, D., Balzano, G., Doglioni, C., Reni, M., et al. (2018) · Pancreatology · doi:10.1016/j.pan.2018.09.006 · Cited by 11

Are ENT1/ENT1, NOTCH3, and miR-21 Reliable Prognostic Biomarkers in Patients with Resected Pancreatic Adenocarcinoma Treated with Adjuvant Gemcitabine Monotherapy?

Jirásková, L., Ryška, A., Tebbens, J. D., Hornychová, H., Čečka, F., Štaud, F., & Červený, L. (2019) · Cancers · doi:10.3390/cancers11111621 · Cited by 11

Targeting of extracellular proteases required for the progression of pancreatic cancer

Ardito-Abraham, C., Briggs, C. D., & Crawford, H. C. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.5.605 · Cited by 11

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting

Cheung, P. F., Neff, F., Neander, C., Bazarna, A., Savvatakis, K., Liffers, S., Althoff, K., Lee, C., Moding, E. J., Kirsch, D. G., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0052 · Cited by 11

New Insights Into the Cell Lineage of Pancreatic Ductal Adenocarcinoma: Evidence for Tumor Stem Cells in Premalignant Lesions?

Kopp, J. L., & Sander, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.023 · Cited by 11

Oncogenic signaling pathways in pancreatic ductal adenocarcinoma

Agrawal, R., & Natarajan, K. N. (2023) · Advances in cancer research · doi:10.1016/bs.acr.2023.02.006 · Cited by 10

Pancreatic cancer tumour initiating cells: the molecular regulation and therapeutic values

Ni, X., Long, J., Cen, P., Chen, L. L., Yang, J., & Li, M. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01478.x · Cited by 10

MicroRNA co-expression networks exhibit increased complexity in pancreatic ductal compared to Vater's papilla adenocarcinoma

Mazza, T., Copetti, M., Capocefalo, D., Fusilli, C., Biagini, T., Carella, M., Bonis, A. D., Mastrodonato, N., Piepoli, A., Pazienza, V., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22184 · Cited by 9

Notch signaling via regulation of RB and p‑AKT but not PIK3CG contributes to MIA PaCa‑2 cell growth and migration to affect pancreatic carcinogenesis

Zhang, S., Liu, J., Xu, K., & Li, Z. (2017) · Oncology Letters · doi:10.3892/ol.2017.7551 · Cited by 10

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis

Das, K. K., Heeg, S., Pitarresi, J. R., Reichert, M., Bakir, B. S., Takano, S., Kopp, J. L., Wahl‐Feuerstein, A., Hicks, P. D., Sander, M., et al. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24626 · Cited by 10

Genetic and Molecular Abnormalities in Cholangiocarcinogenesis

Hassid, V. J., Orlando, F. A., Awad, Z. T., Tan, D., Khoury, T., Ahmed, B. H., & Alrawi, S. (2009) · Anticancer Research · doi:10.21873/anticanres.16345 · Cited by 10

ZM336372, A Raf-1 Activator, Causes Suppression of Proliferation in a Human Hepatocellular Carcinoma Cell Line

Deming, D. A., Geiger, P. G., Chen, H., Vaccaro, A. M., Kunnimalaiyaan, M., & Holen, K. D. (2008) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-008-0495-x · Cited by 10

Expression of Notch 1 and 3 is related to inhibition of lymph node metastasis and progression in non‐small cell lung carcinomas

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Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC

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Ngn3-Positive Cells Arise from Pancreatic Duct Cells

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Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer

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Calsenilin is required for endocrine pancreas development in zebrafish

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Real-Time Monitoring of miRNA Function in Pancreatic Cell Lines Using Recombinant AAV-Based miRNA Asensors

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Notch Signaling Activation in Pediatric Low-Grade Astrocytoma

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K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions

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Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice

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Where and When Does Pancreatic Carcinoma Start?

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Essential role of Notch/Hes1 signaling in postnatal pancreatic exocrine development

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Clinical significance of pancreatic ductal metaplasia

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Cell of Origin of Pancreatic cancer

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Primers on Molecular Pathways — Notch

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Progress in Role of Notch Signaling Pathway in Pancreas Development and Pancreatic Cancer

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Notch signaling pathway in pancreatic tumorigenesis

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Epithelial differentiation in pancreatic development and neoplasia: new niches for nestin and Notch.

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Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

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