The DOI matches its Crossref record; 65 of the 69 references it cites were found in a registry or an index.
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Open accessAbstract
Notch signaling regulates cell fate decisions in a wide variety of adult and embryonic tissues. Here we show that Notch pathway components and Notch target genes are upregulated in invasive pancreatic cancer, as well as in pancreatic cancer precursors from both mouse and human. In mouse pancreas, ectopic Notch activation results in accumulation of nestin-positive precursor cells and expansion of metaplastic ductal epithelium, previously identified as a precursor lesion for pancreatic cancer. Notch is also activated as a direct consequence of EGF receptor activation in exocrine pancreas and is required for TGF alpha-induced changes in epithelial differentiation. These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“murine acinar cells can de-differentiate to a progenitor-like state with a ductal appearance. This has been termed acinar-to-ductal-metaplasia (ADM)110,111”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [111]
Citations
Cites
Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
A simplified system for generating recombinant adenoviruses
He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209
Jemal, A., Thomas, A., Murray, T., & Thun, M. J. (2002) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.1.23 · Cited by 2,916
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100
Self-citationNotch signalling controls pancreatic cell differentiation
Apelqvist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U., & Edlund, H. (1999) · Nature · doi:10.1038/23716 · Cited by 1,158
Control of endodermal endocrine development by Hes-1
Jensen, J. N., Pedersen, E. E., Galante, P. E., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155
Notch Signaling: From the Outside In
Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., Andrieu, P. D. S. I., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E. G., Holsztynska, E. J., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00012.x · Cited by 870
Zulewski, H., Abraham, E. J., Gerlach, M. J., Daniel, P. B., Moritz, W., Müller-Stich, B. P., Vallejo, M., Thomas, M. K., & Habener, J. F. (2001) · Diabetes · doi:10.2337/diabetes.50.3.521 · Cited by 785
Sandgren, E. P., Luetteke, N., Palmiter, R. D., Brinster, R. L., & Lee, D. C. (1990) · Cell · doi:10.1016/0092-8674(90)90075-p · Cited by 752
Research works printed but not linked: 1
- Wilentz, 2000, Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia, Cancer Res., 60, 2002
Cited by
Sorted by citations
Items 601–643 of 643
Molecular Therapeutics: Pancreatic Cancer
Fogelman, D. R., Javle, M. M., & Abbruzzese, J. L. (2015) · Wiley eBooks · doi:10.1002/9781118468678.ch26
Gene regulatory and pro-tumourigenic mechanisms of the bHLH-PAS transcription factor SIM2s.
Farrall, A. L. (2010) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
The role of PAK4 in pancreatic cancer
King, H. A. (2014)
Shi, G., Zhu, L., Sun, Y., Bettencourt, R., Damsz, B., Hruban, R. H., & Konieczny, S. F. (2009)
Self-citationMetalloproteinase activators of Notch signaling in development and pancreatic disease
Sawey, E. T. (2008) · SUNY Digital Repository Support (State University of New York System)
GPCR Signaling in the Genesis and Progression of Pancreatic Cancer
Gardner, J. A. (2009) · TUScholarShare (Temple University)
Genetics and Molecular Biology of Pancreatic and Biliary Cancers
Maitra, A., & Yeo, C. J. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-3256-4.50020-x
Self-citation[Hyperici herba (Hypericum perforatum L].
Kiniczky, M. (2001) · PubMed
Pancreatic cancer and premalignant tumors
Brody, J. R., Rittenhouse, D. W., Witkiewicz, A. K., & Yeo, C. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1454-8.00008-4
Regulatory Signaling in Pancreatic Organogenesis
Carrière, C., & Korc, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00310-7
Fernandez, N. A. (2010) · TSpace (University of Toronto)
Huh, J.-E. U. (2016) · TSpace (University of Toronto)
Plentz, R. R., Rhim, A. D., Abravanel, D. L., Hezel, A. F., Sharma, S. V., Gurumurthy, S., Deshpande, V., Kenific, C. M., Settleman, J. E., Majumder, P. K., et al. (2009)
a Evaluation of the role of Epsins and Notch1 in oral carcinogenesis
Ahmed, H. F. (2018)
Novel Targeted Treatment Approaches in Pancreatic Cancer
Diab, M., Hamid, M. S., Mohammad, R. M., Philip, P. A., & Azmi, A. S. (2019) · Springer eBooks · doi:10.1007/978-3-030-18890-0_27
O’Neil, J., & Look, A. T. (2019) · CRC Press eBooks · doi:10.1201/9780429114670-22
Tuning cell motility : roles of nestin and vimentin in cancer cell invasion
Hyder, C. L. (2014)
Alzhrani, R. M. (2020) · Human Biology
Zhang, L., Li, Z., Zhou, Y. F., Zhu, J., Jin, C. W., & Mo, J. (2021) · Research Square · doi:10.21203/rs.3.rs-326796/v1 · Cited by 1
Sharifi, S., Rahmani, F., Tirkani, A. N., Mehrabadi, S., Fiuji, H., Khazaei, M., Hassanian, S. M., Rajabian, M., Boromand, N., Parizade, S. M. R., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-881431/v1
Mulder, N. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1128805.585886
Regulation of pancreas development in Xenopus laevis
Pan, F. C. (2006) · doi:10.53846/goediss-3231
Notch Signaling in Pancreatic Morphogenesis and Pancreatic Cancer Pathogenesis
Lomberk, G. A., & Urrutia, R. A. (2018) · Springer eBooks · doi:10.1007/978-1-4939-7193-0_18
The Molecular Pathology of Precursor Lesions of Pancreatic Cancer
Singhi, A. D., & Maitra, A. (2017) · Springer eBooks · doi:10.1007/978-1-4939-6631-8_5-2
Self-citationNotch Signaling in Pancreatic Morphogenesis and Pancreatic Cancer Pathogenesis
Lomberk, G. A., & Urrutia, R. A. (2009) · Springer eBooks · doi:10.1007/978-0-387-77498-5_18
SATOH, K., Kimura, K., KANNO, A., Hamada, S., Hirota, M., & Shimosegawa, T. (2008) · Suizo · doi:10.2958/suizo.23.46
Hedgehog signalling in pancreatic cancer
Hebrok, M. (2007) · Springer eBooks · doi:10.1007/1-4020-2916-0_22
Yang, Y., Pospíšil, P., Iyer, L. K., Adelstein, S. J., & Kassis, A. I. (2009) · PLoS ONE · doi:10.1371/annotation/9fbf88b3-5041-4a5e-b569-bc6c0e5f9c29
Brunet, M., Vargas, C., Fanjul, M., Pieruccioni, L., Varry, D., Labrousse, G., Lulka, H., Capilla, F., Couvelard, A., Gigoux, V., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.08.531649
(2023) · American Registry of PathologyArlington, Virginia eBooks · doi:10.55418/9781933477275-01
Nuclear circGUSBP1 promotes cancer stemness via transcriptional coordination with OCT4
Lee, Y., Lin, Y., Wu, Y.-S., Tsao, Y.-Y., Lin, Y.-C., Lin, H.-H., Hsu, Y.-F., Wu, Y.-C., Lin, C.-C., Tzeng, H.-E., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123707
Differentiation of pancreatic and hepatic cell types
Myatt, E. (2013) · The University of Bath Online Publications Store (The University of Bath)
Efrat, S. (2009) · Humana Press eBooks · doi:10.1007/978-1-60761-366-4_5
Genetics and Epidemiology of Cholangiocarcinoma
Blechacz, B. R. A., & Gores, G. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6082-5_5
Beloribi‐Djefaflia, S. (2014) · theses.fr (ABES) · doi:10.70675/f9c5e21cz2cf8z424dz8a35z45035aaef298
Madriles, F., de Andrés, M. P., Chesnokov, M., de Villarreal, J. M., Alonso‐Curbelo, D., del Pozo, N., Iglesias, M., Pau, E. C. D. S., Iovanna, J., Soriano, F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.22.724502
Acinar-ductal metaplasia in pancreatitis and pancreatic ductal adenocarcinoma
Zhang, X., Zhao, Y., Qin, C., Li, Z., Xie, Y., Yan, Y., Li, T., Huang, L., Shi, H., & Wang, W. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01251-0
Molecular Targeted Therapies in Pancreatic Cancer
Kim, E. J.-H., Abel, E. V., Ghosh, A., & Simeone, D. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6549-2_6
Hedgehog Signaling in Endodermally Derived Tumors
di Magliano, M. P., & Hebrok, M. (2006) · Springer eBooks · doi:10.1007/0-387-33777-6_17
Genesis of Pancreatic Ductal Neoplasia
Centeno, B. A., & Springett, G. M. (2010) · Springer eBooks · doi:10.1007/978-90-481-3725-1_16
Notch Pathway und neurovaskuläre Entwicklung beim humanen Pankreaskarzinom
Schubert, M., Buechler, P., Ceyhan, G. O., Felix, K., Giese, N. A., Buechler, M. W., & Friess, H. (2005) · Springer eBooks · doi:10.1007/3-540-26560-0_23
Metadata
- Authors
- Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., Hruban, R. H., Ball, D. W., Schmid, R. M., & Leach, S. D.
- Affiliations
- Johns Hopkins University (US)
- Universität Ulm (DE)
- Gunma University (JP)
- Fox Chase Cancer Center (US)
- Harvard University (US)
- Corresponding author
- Leach, Steven D.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 3
- Issue
- 6
- Pages
- 565-576
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2148054025
- Cited by
- 643
- References
- 69
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 17 · 2021: 19 · 2020: 15 · 2019: 15 · 2018: 33 · 2017: 27 · 2016: 26 · 2015: 27 · 2014: 34 · 2013: 36 · 2012: 37
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA 70244, F32 CA 76698, R01CA070244, F32CA076698, P50CA062924, CA 62924)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56211, R01DK056211, DK61215, R01DK061215)
- National Institute of Neurological Disorders and Stroke (R01NS041355, NS41355)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- Notch signaling, transforming growth factor-alpha, pancreatic cancer, pancreatic carcinogenesis, epithelial differentiation, pancreatic cancer precursors, EGF receptor activation, tumor initiation, exocrine pancreas
- MeSH terms
- Animals, Cell Differentiation, Cells, Cultured, Epithelial Cells, Humans, Intermediate Filament Proteins, Membrane Proteins, Mice, Transgenic, Neoplasm Invasiveness, Nerve Tissue Proteins, Pancreatic Neoplasms, Signal Transduction, Biomarkers, Up-Regulation, Transforming Growth Factor alpha, Disease Progression, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Carcinoma, Ductal, Mice, Receptors, Notch, Nestin, ErbB Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
