Cited by 643Pancreatic and Hepatic Oncology ResearchDevelopmental Biology and Gene RegulationPancreatic function and diabetes

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Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

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Miyamoto, Yoshiharu, Maitra, Anirban, Ghosh, Bidyut, Zechner, Ulrich, Argani, Pedram, Iacobuzio-Donahue, Christine A., Sriuranpong, Virote, Iso, Tatsuya, Meszoely, Ingrid M., Wolfe, Michael S., Hruban, Ralph H., Ball, Douglas W., Schmid, Roland M., Leach, Steven D.·2003·Cancer Cell

DOI 10.1016/s1535-6108(03)00140-5

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Abstract

Notch signaling regulates cell fate decisions in a wide variety of adult and embryonic tissues. Here we show that Notch pathway components and Notch target genes are upregulated in invasive pancreatic cancer, as well as in pancreatic cancer precursors from both mouse and human. In mouse pancreas, ectopic Notch activation results in accumulation of nestin-positive precursor cells and expansion of metaplastic ductal epithelium, previously identified as a precursor lesion for pancreatic cancer. Notch is also activated as a direct consequence of EGF receptor activation in exocrine pancreas and is required for TGF alpha-induced changes in epithelial differentiation. These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells.

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Notch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909
A simplified system for generating recombinant adenoviruses
He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209
Cancer Statistics, 2002
Jemal, A., Thomas, A., Murray, T., & Thun, M. J. (2002) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.1.23 · Cited by 2,916
A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., et al. (1999) · Nature · doi:10.1038/19083 · Cited by 2,100
Self-citation
Notch signalling controls pancreatic cell differentiation
Apelqvist, Å., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., de Angelis, M. H., Lendahl, U., & Edlund, H. (1999) · Nature · doi:10.1038/23716 · Cited by 1,158
Control of endodermal endocrine development by Hes-1
Jensen, J. N., Pedersen, E. E., Galante, P. E., Hald, J., Heller, R. S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., & Madsen, O. D. (2000) · Nature Genetics · doi:10.1038/71657 · Cited by 1,155
Notch Signaling: From the Outside In
Mumm, J. S., & Kopan, R. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9960 · Cited by 964
Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain
Dovey, H. F., John, V., Anderson, J. P., Chen, L. Z., Andrieu, P. D. S. I., Fang, L. Y., Freedman, S. B., Folmer, B., Goldbach, E. G., Holsztynska, E. J., et al. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00012.x · Cited by 870
Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes
Zulewski, H., Abraham, E. J., Gerlach, M. J., Daniel, P. B., Moritz, W., Müller-Stich, B. P., Vallejo, M., Thomas, M. K., & Habener, J. F. (2001) · Diabetes · doi:10.2337/diabetes.50.3.521 · Cited by 785
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
Sandgren, E. P., Luetteke, N., Palmiter, R. D., Brinster, R. L., & Lee, D. C. (1990) · Cell · doi:10.1016/0092-8674(90)90075-p · Cited by 752

Show all 69 references

Research works printed but not linked: 1

Wilentz, 2000, Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia, Cancer Res., 60, 2002

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Yee, N., Lorent, K., & Pack, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.04.035 · Cited by 130
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Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.
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Tuveson, D. A., & Hingorani, S. R. (2005) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2005.70.040 · Cited by 86
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Self-citation
Prognostic significance of Notch signalling molecules and their involvement in the invasiveness of endometrial carcinoma cells
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Expression of nuclear notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlates with the expression of STAT3 and phosphorylated Akt
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Leptin-Notch signaling axis is involved in pancreatic cancer progression
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Mouse models of pancreatic cancer
Leach, S. D. (2004) · Cancer Cell · doi:10.1016/s1535-6108(03)00337-4 · Cited by 72
Self-citation

Authors: Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., Hruban, R. H., Ball, D. W., Schmid, R. M., & Leach, S. D.
Affiliations: Johns Hopkins University (US)
Universität Ulm (DE)
Gunma University (JP)
Fox Chase Cancer Center (US)
Harvard University (US)
Corresponding author: Leach, Steven D.
ORCID: Maitra, Anirban
Zechner, Ulrich
Argani, Pedram
Sriuranpong, Virote
Iso, Tatsuya
Meszoely, Ingrid M.
Wolfe, Michael S.
Hruban, Ralph H.
Schmid, Roland M.
Leach, Steven D.
Venue: Cancer Cell
Publisher: Elsevier BV
Published: 2003-06
Volume: 3
Issue: 6
Pages: 565-576
ISSN: 1535-6108 (ISSN-L)
DOI: 10.1016/s1535-6108(03)00140-5
OpenAlex: W2148054025
Cited by: 643
References: 69
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 11 · 2022: 17 · 2021: 19 · 2020: 15 · 2019: 15 · 2018: 33 · 2017: 27 · 2016: 26 · 2015: 27 · 2014: 34 · 2013: 36 · 2012: 37
FWCI: 15.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3699 d)
Locations: Cancer Cell (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA 70244, F32 CA 76698, R01CA070244, F32CA076698, P50CA062924, CA 62924)
National Institute of Diabetes and Digestive and Kidney Diseases (DK56211, R01DK056211, DK61215, R01DK061215)
National Institute of Neurological Disorders and Stroke (R01NS041355, NS41355)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: Notch signaling, transforming growth factor-alpha, pancreatic cancer, pancreatic carcinogenesis, epithelial differentiation, pancreatic cancer precursors, EGF receptor activation, tumor initiation, exocrine pancreas
MeSH terms: Animals, Cell Differentiation, Cells, Cultured, Epithelial Cells, Humans, Intermediate Filament Proteins, Membrane Proteins, Mice, Transgenic, Neoplasm Invasiveness, Nerve Tissue Proteins, Pancreatic Neoplasms, Signal Transduction, Biomarkers, Up-Regulation, Transforming Growth Factor alpha, Disease Progression, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Carcinoma, Ductal, Mice, Receptors, Notch, Nestin, ErbB Receptors

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Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

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