The DOI matches its Crossref record; 77 of the 78 references it cites were found in a registry or an index.
NO and angiogenesis
Abstract
Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic factors induce the release of NO from endothelial cells, which mediates a multiplicity of processes involved in angiogenesis. These NO-modulated processes include endothelial cell survival, proliferation, migration, and interaction with the extracellular matrix. Derangements of the NO synthase pathway impair angiogenesis. Accordingly, the competitive inhibitor of the NOS pathway asymmetric dimethylarginine (ADMA) acts as an endogenous inhibitor of angiogenesis. By contrast, agents which increase NO synthesis, such as low dose statins, enhance angiogenesis. Modulation of the NO synthase pathway could become a new therapeutic avenue for angiogenesis-related disorders.
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“Multiple reports indicate that NO serves as an angiogenic signaling model, up-regulating VEGF production and increasing blood vessel growth.213–214”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [213]
Citations
Cites
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
Vásquez-Vivar, J., Kalyanaraman, B., Martásek, P., Hogg, N., Masters, B. S. S., Karoui, H., Tordo, P., & Pritchard, K. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9220 · Cited by 1,484
Kureishi, Y., Luo, Z., Shiojima, I., Bialik, A., Fulton, D. J., Lefer, D. J., Sessa, W. C., & Walsh, K. X. (2000) · Nature Medicine · doi:10.1038/79510 · Cited by 1,438
Statins as a newly recognized type of immunomodulator.
Kwak, B., Mulhaupt, F., Myit, S., & Mach, F. (2000) · Nature Medicine · doi:10.1038/82219 · Cited by 1,383
Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,195
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor
Rubanyi, G. M., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.5.h822 · Cited by 1,193
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,186
Böger, R. H., Bode-Böger, S. M., Szuba, A., Tsao, P. S., Chan, J. R., Tangphao, O., Blaschke, T. F., & Cooke, J. P. (1998) · Circulation · doi:10.1161/01.cir.98.18.1842 · Cited by 1,181
Self-citation
Research works printed but not linked: 3
- Stuhlinger MC, Oka RK, Graf EE, Schmolzer I, Upson BM, Kapoor O, Szuba A, Malinow MR, Wascher TC, Pachinger O, Cooke JP. Endothelial dysfunction induced by hyperhomocysteinemia: role of ADMA. Circulation (in press).
- Dayoub H., Achan V., Jacobi J., Stuehlinger M., Wang B.-Y.,Adimoolam S., Tsao P., Kimoto M., Vallance P., Patterson A.J., Cooke J.P., DDAH regulates NO synthesis: genetic and physiological evidence. Circulation (in press).
- Urbich, 2002, Double-edged role of statins in angiogenesis signaling, Circ. Res., 90, 737, 10.1161/01.RES.0000014081.30867.F8 · DOI
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Oxidative Stress and Oxidative Damage in Carcinogenesis
Klaunig, J. E., Kamendulis, L. M., & Hocevar, B. A. (2009) · Toxicologic Pathology · doi:10.1177/0192623309356453 · Cited by 990
Hypoxia: A key regulator of angiogenesis in cancer
Liao, D., & Johnson, R. S. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9066-y · Cited by 737
Oxidative stress and oxidative damage in chemical carcinogenesis
Klaunig, J. E., Wang, Z., Pu, X., & Zhou, S. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.11.028 · Cited by 486
Zhao, Y. D., Courtman, D. W., Deng, Y., Kugathasan, L., Zhang, Q., & Stewart, D. J. (2005) · Circulation Research · doi:10.1161/01.res.0000157672.70560.7b · Cited by 469
Pathological aspects of lipid peroxidation
Nègre‐Salvayre, A., Augè, N., Ayala, V., Başağa, H., Boada, J., Brenke, R., Chapple, S. J., Cohen, G., Fehér, J., Grune, T., et al. (2010) · Free Radical Research · doi:10.3109/10715762.2010.498478 · Cited by 465
Metadata
- Authors
- Cooke, J. P.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Cooke, John P.
- ORCID
- Cooke, John P.
- Venue
- Atherosclerosis Supplements
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 4
- Issue
- 4
- Pages
- 53-60
- ISSN
- 1567-5688 (ISSN-L)
- OpenAlex
- W2075124894
- Cited by
- 266
- References
- 78
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 17
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis Supplements (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1z01hl000204-29)
- National Institute on Aging (P01 AG18784, P01AG018784)
- National Heart, Lung, and Blood Institute (R01 HL-63685, R01HL063685)
- National Institute of Allergy and Infectious Diseases (P01AI050153, P01AI50153)
- National Center for Complementary and Integrative Health (R01 AT/HL00204)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, angiogenesis, endothelial cells, nitric oxide synthase, asymmetric dimethylarginine, endothelial cell migration, endothelial cell proliferation, endothelial cell survival, extracellular matrix, statins
- MeSH terms
- Arginine, Cardiovascular Diseases, Cell Movement, Cell Survival, Endothelium, Vascular, Enzyme Inhibitors, Humans, Nitric Oxide, Angiogenesis Inhibitors, Endothelial Cells
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