Cited by 266Nitric Oxide and Endothelin EffectsAngiogenesis and VEGF in CancerEicosanoids and Hypertension Pharmacology

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NO and angiogenesis

Cooke, John P.·2003·Atherosclerosis Supplements

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Abstract

Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic factors induce the release of NO from endothelial cells, which mediates a multiplicity of processes involved in angiogenesis. These NO-modulated processes include endothelial cell survival, proliferation, migration, and interaction with the extracellular matrix. Derangements of the NO synthase pathway impair angiogenesis. Accordingly, the competitive inhibitor of the NOS pathway asymmetric dimethylarginine (ADMA) acts as an endogenous inhibitor of angiogenesis. By contrast, agents which increase NO synthesis, such as low dose statins, enhance angiogenesis. Modulation of the NO synthase pathway could become a new therapeutic avenue for angiogenesis-related disorders.

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Stuhlinger MC, Oka RK, Graf EE, Schmolzer I, Upson BM, Kapoor O, Szuba A, Malinow MR, Wascher TC, Pachinger O, Cooke JP. Endothelial dysfunction induced by hyperhomocysteinemia: role of ADMA. Circulation (in press).
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Authors: Cooke, J. P.
Affiliations: Stanford Medicine (US)
Corresponding author: Cooke, John P.
ORCID: Cooke, John P.
Venue: Atherosclerosis Supplements
Publisher: Elsevier BV
Published: 2003-12
Volume: 4
Issue: 4
Pages: 53-60
ISSN: 1567-5688 (ISSN-L)
DOI: 10.1016/s1567-5688(03)00034-5
OpenAlex: W2075124894
Cited by: 266
References: 78
Citations by year: 2026: 3 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 17
FWCI: 2.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis Supplements (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1z01hl000204-29)
National Institute on Aging (P01 AG18784, P01AG018784)
National Heart, Lung, and Blood Institute (R01 HL-63685, R01HL063685)
National Institute of Allergy and Infectious Diseases (P01AI050153, P01AI50153)
National Center for Complementary and Integrative Health (R01 AT/HL00204)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide, angiogenesis, endothelial cells, nitric oxide synthase, asymmetric dimethylarginine, endothelial cell migration, endothelial cell proliferation, endothelial cell survival, extracellular matrix, statins
MeSH terms: Arginine, Cardiovascular Diseases, Cell Movement, Cell Survival, Endothelium, Vascular, Enzyme Inhibitors, Humans, Nitric Oxide, Angiogenesis Inhibitors, Endothelial Cells

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