The DOI matches its Crossref record; 77 of the 78 references it cites were found in a registry or an index.
NO and angiogenesis
Abstract
Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic factors induce the release of NO from endothelial cells, which mediates a multiplicity of processes involved in angiogenesis. These NO-modulated processes include endothelial cell survival, proliferation, migration, and interaction with the extracellular matrix. Derangements of the NO synthase pathway impair angiogenesis. Accordingly, the competitive inhibitor of the NOS pathway asymmetric dimethylarginine (ADMA) acts as an endogenous inhibitor of angiogenesis. By contrast, agents which increase NO synthesis, such as low dose statins, enhance angiogenesis. Modulation of the NO synthase pathway could become a new therapeutic avenue for angiogenesis-related disorders.
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“Multiple reports indicate that NO serves as an angiogenic signaling model, up-regulating VEGF production and increasing blood vessel growth.213–214”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [213]
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Metadata
- Authors
- Cooke, J. P.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Cooke, John P.
- ORCID
- Cooke, John P.
- Venue
- Atherosclerosis Supplements
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 4
- Issue
- 4
- Pages
- 53-60
- ISSN
- 1567-5688 (ISSN-L)
- OpenAlex
- W2075124894
- Cited by
- 266
- References
- 78
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 15 · 2012: 17
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Atherosclerosis Supplements (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1z01hl000204-29)
- National Institute on Aging (P01 AG18784, P01AG018784)
- National Heart, Lung, and Blood Institute (R01 HL-63685, R01HL063685)
- National Institute of Allergy and Infectious Diseases (P01AI050153, P01AI50153)
- National Center for Complementary and Integrative Health (R01 AT/HL00204)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, angiogenesis, endothelial cells, nitric oxide synthase, asymmetric dimethylarginine, endothelial cell migration, endothelial cell proliferation, endothelial cell survival, extracellular matrix, statins
- MeSH terms
- Arginine, Cardiovascular Diseases, Cell Movement, Cell Survival, Endothelium, Vascular, Enzyme Inhibitors, Humans, Nitric Oxide, Angiogenesis Inhibitors, Endothelial Cells
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