Cited by 142Tryptophan and brain disordersTreatment of Major DepressionAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 105 of the 108 references it cites were found in a registry or an index.

Oxidative stress markers in affective disorders

Open access

Siwek, Marcin, Sowa-Kućma, Magdalena, Dudek, Dominika, Styczeń, Krzysztof, Szewczyk, Bernadeta, Kotarska, Katarzyna, Misztak, Paulina, Pilc, Agnieszka, Wolak, Małgorzata, Nowak, Gabriel·2013·Pharmacological Reports

DOI 10.1016/s1734-1140(13)71517-2

Open this paper in CoChat — free account Open PDF

Abstract

Affective disorders are a medical condition with a complex biological pattern of etiology, involving genetic and epigenetic factors, along with different environmental stressors. Increasing numbers of studies indicate that induction of oxidative and nitrosative stress (O&NS) pathways, which is accompanied by immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying many major psychiatric disorders, including depression and bipolar disorder. Reactive oxygen and nitrogen species have been shown to impair the brain function by modulating activity of principal neurotransmitter (e.g., glutamatergic) systems involved in the neurobiology of depression. Both preclinical and clinical studies revealed that depression is associated with altered levels of oxidative stress markers and typically reduced concentrations of several endogenous antioxidant compounds, such as glutathione, vitamin E, zinc and coenzyme Q10, or enzymes, including glutathione peroxidase, and with an impairment of the total antioxidant status. These oxidative stress parameters can be normalized by successful antidepressant therapy. On the other hand, some antioxidants (zinc, N-acetylcysteine, omega-3 free fatty acids) may exhibit antidepressant properties or enhance standard antidepressant therapy. These observations introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present paper reviews selected animal and human studies providing evidence that oxidative stress is implicated in the pathophysiology and treatment of depression and bipolar disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s1734-1140(13)71517-2

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Free radicals and antioxidants in normal physiological functions and human disease
Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269
A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress
Rio, D. D., Stewart, A. J., & Pellegrini, N. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.05.003 · Cited by 2,789
Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
Janero, D. R. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90131-2 · Cited by 2,735
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Protein carbonyl groups as biomarkers of oxidative stress
Dalle‐Donne, I., Rossi, R., Giustarini, D., Milzani, A., & Colombo, R. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00003-2 · Cited by 2,352
Biochemistry of oxidative stress
Halliwell, B. B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351147 · Cited by 1,591
Oxidative stress: From basic research to clinical application
Sies, H. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90281-2 · Cited by 1,365
Biochemistry of Oxidative Stress
Sies, H. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198610581 · Cited by 1,316
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140

Show all 108 references

Sorted by citations

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications
Wang, J., Um, P. S., Dickerman, B. A., & Liu, J. (2018) · Nutrients · doi:10.3390/nu10050584 · Cited by 357
Roles of oxidative stress in polycystic ovary syndrome and cancers
Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319
Selected biomarkers of depression: what are the effects of cytokines and inflammation
Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299
Sodium Butyrate Abolishes Lipopolysaccharide-Induced Depression-like Behaviors and Hippocampal Microglial Activation in Mice
Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., et al. (2018) · Brain Research · doi:10.1016/j.brainres.2017.12.004 · Cited by 204
Superoxide dismutase and neurological disorders
Chidambaram, S. B., Anand, N., Varma, S. R., Ramamurthy, S., Vichitra, C., Sharma, A., Mahalakshmi, A. M., & Essa, M. M. (2024) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2023.11.007 · Cited by 162
Antioxidant defense in schizophrenia and bipolar disorder: A meta-analysis of MRS studies of anterior cingulate glutathione
Das, T. K., Javadzadeh, A., Dey, A., Sabesan, P., Théberge, J., Raduà, J., & Palaniyappan, L. K. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.006 · Cited by 114
Biomarkers for major depressive disorder
Hacımusalar, Y., & Eşel, E. (2017) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2017.19482 · Cited by 123
N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant
Sahasrabudhe, S. A., Terluk, M. R., & Kartha, R. V. (2023) · Antioxidants · doi:10.3390/antiox12071316 · Cited by 102
The social nature of mitochondria: Implications for human health
Picard, M. A., & Sandi, C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.017 · Cited by 107
Animal models for the study of depressive disorder
Song, J., & Kim, Y. (2021) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13622 · Cited by 112
Antioxidant activities of the polysaccharides of Chuanminshen violaceum
Fan, J., Feng, H., Yu, Y., Sun, M., Liu, Y., Li, T., Sun, X. S., Liu, S., & Sun, M. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.10.040 · Cited by 90
Zinc as a marker of affective disorders
Siwek, M., Szewczyk, B., Dudek, D., Styczeń, K., Sowa-Kućma, M., Młyniec, K., Siwek, A., Witkowski, L., Pochwat, B., & Nowak, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71512-3 · Cited by 77
Self-citation
Association of Oxidative Stress with Psychiatric Disorders
Hassan, W., Noreen, H., Gomes, V. D. C., Mohammadzai, I., da Rocha, J. B. T., & Landeira-Fernández, J. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160307145931 · Cited by 76
Differential biomarker signatures in unipolar and bipolar depression: A machine learning approach
Wollenhaupt-Aguiar, B., Librenza‐Garcia, D., Bristot, G., Przybylski, L., Stertz, L., Burque, R. K., Ceresér, K. M., Spanemberg, L., Caldieraro, M. A., Frey, B. N., et al. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867419888027 · Cited by 68
The Neurobiology of Bipolar Disorder: An Integrated Approach
Muneer, A. (2016) · Chonnam Medical Journal · doi:10.4068/cmj.2016.52.1.18 · Cited by 68
Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review
Cecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2021.105269 · Cited by 68
Therapeutic Interventions to Mitigate Mitochondrial Dysfunction and Oxidative Stress–Induced Damage in Patients with Bipolar Disorder
Madireddy, S., & Madireddy, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031844 · Cited by 76
Study of the Serum Copper Levels in Patients with Major Depressive Disorder
Styczeń, K., Sowa-Kućma, M., Siwek, M., Dudek, D., Reczyński, W., Misztak, P., Szewczyk, B., Topór‐Mądry, R., Opoka, W., & Nowak, G. (2016) · Biological Trace Element Research · doi:10.1007/s12011-016-0720-5 · Cited by 63
Self-citation
Oxidative Stress Markers and Antioxidant Enzymes in Children and Adolescents with Depressive Disorder and Impact of Omega-3 Fatty Acids in Randomised Clinical Trial
Katrenčíková, B., Vaváková, M., Paduchová, Z., Nagyová, Z., Garaiová, I., Muchová, J., Ďuračková, Z., & Trebatická, J. (2021) · Antioxidants · doi:10.3390/antiox10081256 · Cited by 63
ω-3 and folic acid act against depressive-like behavior and oxidative damage in the brain of rats subjected to early- or late-life stress
Réus, G. Z., Maciel, A. L., Abelaira, H. M., de Moura, A. B., de Souza, T. G., dos Santos, T. R., Darabas, A. C., Parzianello, M., Matos, D., Abatti, M. R., et al. (2018) · Nutrition · doi:10.1016/j.nut.2018.03.006 · Cited by 56
Subacute poisoning of mice with deltamethrin produces memory impairment, reduced locomotor activity, liver damage and changes in blood morphology in the mechanism of oxidative stress
Nieradko‐Iwanicka, B., & Borzęcki, A. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.012 · Cited by 52
WY-14643, a selective agonist of peroxisome proliferator-activated receptor-α, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice
Yang, R., Wang, P., Chen, Z., Hu, W., Gong, Y. L., Zhang, W., & Huang, C. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.12.010 · Cited by 52
Antidepressant‐like effects of quercetin in diabetic rats are independent of hypothalamic–pituitary–adrenal axis
Demir, E. A., Gergerlioğlu, H. S., & Oz, M. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.45 · Cited by 51
Thiobarbituric Acid-Reactive Substances: Markers of an Acute Episode and a Late Stage of Bipolar Disorder
Siwek, M., Sowa-Kućma, M., Styczeń, K., Misztak, P., Szewczyk, B., Topór‐Mądry, R., Nowak, G., Dudek, D., & RYBAKOWSKI, J. K. (2016) · Neuropsychobiology · doi:10.1159/000444491 · Cited by 46
Self-citation
Neuropeptide VGF C-Terminal Peptide TLQP-62 Alleviates Lipopolysaccharide-Induced Memory Deficits and Anxiety-like and Depression-like Behaviors in Mice: The Role of BDNF/TrkB Signaling
Li, C., Li, M., Yu, H., Shen, X., Wang, J., Sun, X., Wang, Q., & Wang, C. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00154 · Cited by 46
Effect of fluoxetine treatment on mitochondrial bioenergetics in central and peripheral rat tissues
da Silva, A. I., Braz, G. R. F., Silva‐Filho, R., Pedroza, A. A. D. S., Ferreira, D. J. S., Manhães‐de‐Castro, R., & Lagranha, C. J. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0462 · Cited by 41
Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress
Réus, G. Z., Abelaira, H. M., Maciel, A. L., dos Santos, M. A. B., Carlessi, A. S., Steckert, A. V., Ferreira, G. K., Prá, S. D.-T. D., STRECK, E. L., Macêdo, D. S., et al. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9602-8 · Cited by 39
Alterations of Bio-elements, Oxidative, and Inflammatory Status in the Zinc Deficiency Model in Rats
Doboszewska, U., Szewczyk, B., Sowa-Kućma, M., Noworyta, K., Misztak, P., Gołębiowska, J., Młyniec, K., Ostachowicz, B., Krośniak, M., Wojtanowska-Krośniak, A., et al. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9571-7 · Cited by 38
Self-citation
Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms
Júnior, A. L. G., Tchekalarova, J. D., Atanasova, M., Machado, K. D. C., Rios, M. A. D. S., Paz, M. F. C. J., Găman, M., Găman, A. M., Yele, S., Shill, M. C., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.121 · Cited by 39
Hippocampus and cerebellum damage in sepsis induced by lipopolysaccharide in aged rats - Pregabalin can prevent damage
Aslankoç, R., Savran, M., Özmen, Ö., & Aşcı, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.162 · Cited by 38
Cardiovascular and psychiatric characteristics associated with oxidative stress markers among adolescents with bipolar disorder
Hatch, J., Andreazza, A., Olowoyeye, O., Rezin, G. T., Moody, A., & Goldstein, B. I. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2015.04.005 · Cited by 39
n-3 Fatty acids as resolvents of inflammation in the A549 cells
Gdula‐Argasińska, J., Czepiel, J., Woźniakiewicz, A., Wojtoń, K., Grzywacz, A., Woźniakiewicz, M., Jurczyszyn, A. J., Perucki, W. H., & Librowski, T. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.01.001 · Cited by 37
Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats
Biała, G., Pękała, K., Boguszewska‐Czubara, A., Michalak, A., Kruk-Słomka, M., Grot, K., & Budzyńska, B. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0585-4 · Cited by 39
Association between the antioxidant uric acid and depression and antidepressant medication use in 96 989 individuals
Wium‐Andersen, M. K., Kobylecki, C. J., Afzal, S., & Nordestgaard, B. G. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12793 · Cited by 37
DNA redox modulations and global DNA methylation in bipolar disorder: Effects of sex, smoking and illness state
Ceylan, D., Scola, G., Tunca, Z., Isaacs-Trepanier, C., Can, G., Andreazza, A. C., Young, L. T., & Özerdem, A. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.051 · Cited by 36
Behavioral tests and oxidative stress evaluation in mitochondria isolated from the brain and liver of mice treated with riparin A
Nunes, G. B. L., Costa, L. M., Gutierrez, S. J. C., Satyal, P., & de Freitas, R. M. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.11.018 · Cited by 36
Neural correlates of clinical improvement in response to N-acetylcysteine in adolescents with non-suicidal self-injury
Cullen, K. R., Schreiner, M. W., Klimes-Dougan, B., Eberly, L. E., LaRiviere, L. L., Lim, K. O., Camchong, J., & Mueller, B. A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109778 · Cited by 34
Oxidative markers of Myeloperoxidase and Catalase and their diagnostic performance in bipolar disorder
Selek, S., Altındağ, A., Saraçoğlu, G., & Aksoy, N. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.058 · Cited by 34
Oxidatively-induced DNA damage and base excision repair in euthymic patients with bipolar disorder
Ceylan, D., Tuna, G., Kırkalı, G., Tunca, Z., Can, G., Arat, H. E., Kant, M., Dizdaroğlu, M., & Özerdem, A. (2018) · DNA repair · doi:10.1016/j.dnarep.2018.03.006 · Cited by 32
The serum concentration of copper in bipolar disorder
Siwek, M., Styczeń, K., Sowa-Kućma, M., Dudek, D., Reczyński, W., Szewczyk, B., Misztak, P., Opoka, W., Topór‐Mądry, R., Nowak, G., et al. (2016) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/65250 · Cited by 32
Self-citation
Analysis of urinary 8-isoprostane as an oxidative stress biomarker by stable isotope dilution using automated online in-tube solid-phase microextraction coupled with liquid chromatography–tandem mass spectrometry
Mizuno, K., & Kataoka, H. (2015) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2015.04.020 · Cited by 31
Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress
Lehman, B. J., López-Díaz, F. J., Santisakultarm, T. P., Fang, L., Shokhirev, M. N., Diffenderfer, K. E., Manor, U., & Emerson, B. M. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009277 · Cited by 31
Extraction, characterization and antioxidant activity of mycelial polysaccharides from Paecilomyces hepiali HN1
Wu, Z., Zhang, M., Xie, M., Dai, Z., Wang, X., Hu, B., Ye, H., & Zeng, X. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.11.010 · Cited by 29
The impact of childhood maltreatment on redox state: Relationship with oxidative damage and antioxidant defenses in adolescents with no psychiatric disorder
do Prado, C. H., Grassi-Oliveira, R., Wieck, A., Zaparte, A., Filho, L. D., da Silva Morrone, M., Moreira, J. C., & Bauer, M. E. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.01.062 · Cited by 28
Age-dependent effects of esculetin on mood-related behavior and cognition from stressed mice are associated with restoring brain antioxidant status
Martín‐Aragón, S., Villar, Á., & Benedı́, J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.007 · Cited by 29
Imbalance of Essential Metals in Traumatic Brain Injury and Its Possible Link with Disorders of Consciousness
Squitti, R., Reale, G., Tondolo, V., Crescenti, D., Bellini, S., Moci, M., Caliandro, P., Padua, L., & Rongioletti, M. C. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076867 · Cited by 26
Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes
Xiong, L., Huang, J., Wang, S., Yuan, Q., Yang, D., Zheng, Z., Wu, Y., Wu, C., Gao, Y., Zou, L., et al. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03225-1 · Cited by 26
State-of-the-Art: Inflammatory and Metabolic Markers in Mood Disorders
Mucci, F., Marazziti, D., Vecchia, A. D., Baroni, S., Morana, P., Carpita, B., Mangiapane, P., Morana, F., Morana, B., & Dell’Osso, L. (2020) · Life · doi:10.3390/life10060082 · Cited by 29
Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice
Khurana, K., & Bansal, N. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01667-6 · Cited by 27
The Importance of α-Klotho in Depression and Cognitive Impairment and Its Connection to Glutamate Neurotransmission—An Up-to-Date Review
Pańczyszyn-Trzewik, P., Czechowska, E., Stachowicz, K., & Sowa-Kućma, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015268 · Cited by 24
Self-citation
The Brain Protective Effect of rTMS (Repetitive Transcranial Magnetic Stimulation) in Depression: A Mini-Review in Animal Studies
Yuluğ, B., Hanoğlu, L., Tavlı, A. M., lmaz, N. H. Y., & c, E. K. L. (2016) · Medicinal Chemistry · doi:10.2174/1573406411666151005110321 · Cited by 23
Protection against Oxygen-Glucose Deprivation/Reperfusion Injury in Cortical Neurons by Combining Omega-3 Polyunsaturated Acid with Lyciumbarbarum Polysaccharide
Shi, Z., Wu, D., Yao, J., Yao, X., Huang, Z., Li, P., Wan, J., He, C., & Su, H. (2016) · Nutrients · doi:10.3390/nu8010041 · Cited by 23
Efficacy of empagliflozin as adjunctive therapy to citalopram in major depressive disorder: a randomized double-blind, placebo-controlled clinical trial
Zandifar, A., Panahi, M., Badrfam, R., & Qorbani, M. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05627-0 · Cited by 25
Cognitive psychotherapy treatment decreases peripheral oxidative stress parameters associated with major depression disorder
Kaufmann, F. N., Gazal, M., Mondin, T. C., Cardoso, T. A., Quevedo, L. D. Á., Souza, L. D. D. M., Jansen, K., Braganhol, E., Oses, J. P., Pinheiro, R. T., et al. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.08.001 · Cited by 22
Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index
Yirun, M. C., Ünal, K., Altunsoy, N., Yirün, O., Aydemir, Ç., & Göka, E. (2015) · Nöro Psikiyatri Arşivi · doi:10.5152/npa.2015.10123 · Cited by 22
The effects of n-acetylcysteine and/or deferoxamine on manic-like behavior and brain oxidative damage in mice submitted to the paradoxal sleep deprivation model of mania
Arent, C. O., Valvassori, S. S., Steckert, A. V., Resende, W. R., Dal-Pont, G. C., Lopes-Borges, J., Amboni, R. T., Bianchini, G., & Quevedo, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.011 · Cited by 21
Staging of unipolar affective illness
Ferensztajn‐Rochowiak, E., Remlinger-Molenda, A., & RYBAKOWSKI, J. K. (2014) · Psychiatria Polska · doi:10.12740/pp/24239 · Cited by 20
4,4′-Dichlorodiphenyl diselenide reverses a depressive-like phenotype, modulates prefrontal cortical oxidative stress and dysregulated glutamatergic neurotransmission induced by subchronic dexamethasone exposure to mice
Heck, S. O., Zborowski, V. A., Quines, C. B., & Nogueira, C. W. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.027 · Cited by 20
Molecular Imaging for Depressive Disorders
Lee, T. S., Quek, S., & Krishnan, K. R. R. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3965 · Cited by 19
How do antidepressants influence the BOLD signal in the developing brain?
Harris, J. J., & Reynell, C. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.12.003 · Cited by 20
Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress
Wei, X., Ma, Y., Li, F., He, H., Huang, H., Huang, C., Chen, Z., Chen, D., Chen, J., & Yuan, X. (2021) · Inflammation · doi:10.1007/s10753-021-01423-0 · Cited by 19
The Wicked Relationship between Depression and Metabolic Syndrome.
Marazziti, D., Arone, A., Palermo, S., Annuzzi, E., Cappellato, G., Chiarantini, I., Prete, L. D., & Dell’Osso, L. (2023) · PubMed Central · doi:10.36131/cnfioritieditore20230202 · Cited by 19
Nutritional Psychology: Review the Interplay Between Nutrition and Mental Health
Horovitz, O. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae158 · Cited by 22
The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine
Valvassori, S. S., Resende, W. R., Varela, R. B., Arent, C. O., Gava, F. F., Peterle, B. R., Dal-Pont, G. C., Carvalho, A. F., Andersen, M. L., & Quevedo, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0384-y · Cited by 18
Environmental Enrichment Rescues Oxidative Stress and Behavioral Impairments Induced by Maternal Care Deprivation: Sex- and Developmental-Dependent Differences
Réus, G. Z., Abitante, M. S., Manosso, L. M., de Moura, A. B., Borba, L. A., Botelho, M. E. M., Darabas, A. C., Demo, J. P., Behenck, J. P., Arent, C. O., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02588-3 · Cited by 16
Lithium-based antioxidants: electrochemical properties and influence on immune cells
Plotnikov, E. V., Korotkova, E. I., Voronova, O. A., Дорожко, Е. В., Bohan, N., & Плотников, С. А. (2015) · Cited by 17
Studying the potential ameliorative effect of biosynthesized selenium nanoparticles using epigallocatechin gallate against depression in rats
Alam-ElDein, K. M., Faraag, A. H. I., El-Yamany, N. A., Moneim, A. E. A., Abdelfattah, M. S., El‐Khadragy, M. F., & Elmasry, H. A. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1691567 · Cited by 16
Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase
Misztak, P., Sowa-Kućma, M., Pańczyszyn-Trzewik, P., Szewczyk, B., & Nowak, G. (2021) · Molecules · doi:10.3390/molecules27010022 · Cited by 17
Self-citation
Cyclooxygenase-2 inhibitors alleviated depressive and anxious-like behaviors in mice exposed to lipopolysaccharide: Involvement of oxidative stress and neuroinflammation
da Silva, D. M. A., Lopes, I. S., Oliveira, J. V. S., Júnior, M. A. S., Rebouças, M. D. O., Valentim, J. T., Vale, L. D. C., Capibaribe, V. C. C., de Carvalho, M. A. J., de Aquino, P. É. A., et al. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173778 · Cited by 17
Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions
Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Díaz, R., López-González, L., Monserrat, J., Barrena-Blázquez, S., Álvarez-Mon, M. Á., Lahera, G., & Álvarez‐Mon, M. (2024) · Military Medical Research · doi:10.1186/s40779-024-00577-w · Cited by 21
Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity
Mohyeldin, S. M., Samy, W. M., Ragab, D., Abdelmonsif, D. A., Aly, R. G. M., & Elgindy, N. A. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s296726 · Cited by 15
Increased malondialdehyde and nitric oxide formation, lowered total radical trapping capacity coupled with psychological stressors are strongly associated with the phenome of first-episode mild depression in undergraduate students
Brinholi, F. F., Vasupanrajit, A., Semeão, L. D. O., Michelin, A. P., Matsumoto, A. K., Almulla, A. F., Tunvirachaisakul, C., Barbosa, D. S., & Maes, M. H. J. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.06.003 · Cited by 14
Can the Mediterranean diet decrease the risk of depression in older persons – a systematic review
Rudzińska, A. K., Perera, I., Gryglewska, B., Gąsowski, J., & Piotrowicz, K. (2022) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/140465 · Cited by 14
Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression
Erzin, G., Özkaya, G., Topçuoğlu, C., Yüksel, R., Erel, Ö., Yurt, E., Göka, E., & Gülöksüz, S. (2020) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2020.18.3.395 · Cited by 10
Eugenia uniflora fruit extract exerts neuroprotective effect on chronic unpredictable stress‐induced behavioral and neurochemical changes
Flores, N. P., Bona, N. P., Luduvico, K. P., Cardoso, J. D. S., Soares, M. S. P., Gamaro, G. D., Spanevello, R. M., Lencina, C. L., Gazal, M., & Stefanello, F. M. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13442 · Cited by 15
Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings
Tatay-Manteiga, A., Balanzá‐Martínez, V., Bristot, G., Tabarés‐Seisdedos, R., Kapczinski, F. P., & Cauli, O. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666190307165355 · Cited by 13
Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression
(2023) · doi:10.1038/s44184-023-00024-z · Cited by 12
Association Between Serum Uric Acid Levels and Suicide Attempts in Adolescents and Young Adults with Major Depressive Disorder: A Retrospective Study
Kong, Y., Liu, C., Zhang, C., Wang, W., Li, Y., Qiu, H., Wang, G.-M., Li, D., Chen, X., Lv, Z., et al. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s368471 · Cited by 12
A 50-bp Ins/Del polymorphism at the promoter region of the superoxide dismutase-1 and bipolar disorder type 1
Kordestanian, N., & Saadat, M. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1357754 · Cited by 12
Age and Sex Dependent Effects of Maternal Deprivation on Anxiety-Like and Depressive-Like Behaviors and Oxidative Stress in the Prefrontal Cortex of Rats
Nassiri, A., Lamtai, M., Berkiks, I., Benmhammed, H., Coulibaly, S. M., Chakit, M., Ibouzine‐Dine, L., Mesfioui, A., & El-Hessni, A. (2024) · Advances in Animal and Veterinary Sciences · doi:10.17582/journal.aavs/2024/12.3.457.466 · Cited by 11
Gallic acid protects cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction in an experimental model of manic‐like behavior: Comparison with lithium effects
Recart, V. M., Spohr, L., Soares, M. S. P., de Mattos, B. D. S., Bona, N. P., Pedra, N. S., Teixeira, F. C., Gamaro, G. D., Stefanello, F. M., & Spanevello, R. M. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10086 · Cited by 11
Sex differences on the response to antidepressants and psychobiotics following early life stress in rats
Carlessi, A. S., Botelho, M. E. M., Manosso, L. M., Borba, L. A., Maciel, L. R., Andrade, N. M., Martinello, N. S., Padilha, A. P. Z., Generoso, C. M., Bencke, C. V., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173468 · Cited by 11
New trends in the neurobiology and pharmacology of affective disorders
Lasoń, W., Budziszewska, B., Basta‐Kaim, A., Kubera, M., & Maes, M. H. J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71504-4 · Cited by 11
Neuroprotective effects of goji berry (Lycium barbarum L.) polysaccharides on depression-like behavior in ovariectomized rats: behavioral and biochemical evidence
Soytürk, H., BOZAT, B. G., Karakaş, F. P., Coşkun, H., & Fırat, T. (2023) · Croatian Medical Journal · doi:10.3325/cmj.2023.64.231 · Cited by 10
How Deltamethrin Produces Oxidative Stress in Liver and Kidney
Nieradko‐Iwanicka, B., & Borzęcki, A. (2016) · Polish Journal of Environmental Studies · doi:10.15244/pjoes/61818 · Cited by 10
Novel Heme Oxygenase-1 Inducers Palliate Inflammatory Pain and Emotional Disorders by Regulating NLRP3 Inflammasome and Activating the Antioxidant Pathway
Pérez-Fernández, M., Suárez-Rojas, I., Bai, X., Martínez-Martel, I., Ciaffaglione, V., Pittalà, V., Salerno, L., & Pol, O. (2023) · Antioxidants · doi:10.3390/antiox12101794 · Cited by 9
Repeated Sulforaphane Treatment Reverses Depressive-like Behavior and Exerts Antioxidant Effects in the Olfactory Bulbectomy Model in Mice
Pańczyszyn-Trzewik, P., Stachowicz, K., Misztak, P., Nowak, G., & Sowa-Kućma, M. (2024) · Pharmaceuticals · doi:10.3390/ph17060762 · Cited by 9
Self-citation
Zinc and copper concentration do not differentiate bipolar disorder from major depressive disorder
Styczeń, K., Sowa-Kućma, M., Dudek, D., Siwek, M., Reczyński, W., Szewczyk, B., Misztak, P., Topór‐Mądry, R., Opoka, W., & Nowak, G. (2017) · Psychiatria Polska · doi:10.12740/pp/onlinefirst/80069 · Cited by 9
Self-citation
Glucagon-like peptide-1 receptor agonist semaglutide through the lens of psychiatry: a systematic review of potential benefits and risks
Carminati, M., Tondello, M., Concina, A., Olgiati, P., & Zanardi, R. (2025) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000595 · Cited by 8
Identifying Biological Signatures of N-Acetylcysteine for Non-Suicidal Self-Injury in Adolescents and Young Adults
Sahasrabudhe, S. A., Silamongkol, T., Park, Y. W., Colette, A. A., Eberly, L. E., Klimes‐Dougan, B., Coles, L. D., Öz, G., Mueller, B. A., Kartha, R. V., et al. (2021) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20210007 · Cited by 8
Polaprezinc (Zinc–l-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions
Sakae, K., Suka, M., & Yanagisawa, H. (2020) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001284 · Cited by 8
Vorinostat (SAHA) May Exert Its Antidepressant-Like Effects Through the Modulation of Oxidative Stress Pathways
Misztak, P., Sowa-Kućma, M., Szewczyk, B., & Nowak, G. (2021) · Neurotoxicity Research · doi:10.1007/s12640-020-00317-7 · Cited by 8
Self-citation
LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes
Moreira, L. K. D. S., Turones, L. C., Campos, H. M., Martins, A. N., Thomaz, D. V., Gil, E. D. S., Ghedini, P. C., da Rocha, F. F., Menegatti, R., Fajemiroye, J. O., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121199 · Cited by 9
Oxidative stress and neurodegenerative diseases: Exploring natural antioxidants for therapeutic potential
Doke, R. R., Kallur, S., Suryawanshi, A. P., Utarade, A., Kandalkar, P., Morde, R., & Bhagwat, A. A. (2023) · IP International Journal of Comprehensive and Advanced Pharmacology · doi:10.18231/j.ijcaap.2023.026 · Cited by 8
Childhood depression and oxidative stress
Miniksar, D. Y., & Göçmen, A. Y. (2022) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-022-00518-1 · Cited by 7
Preventing intellectual disability during pregnancy: what are the potentially high yield targets?
Wang, Y., McDermott, S. W., Mann, J. R., & Hardin, J. W. (2015) · Journal of Perinatal Medicine · doi:10.1515/jpm-2015-0059 · Cited by 6
Ethnopharmacological approaches in mood and anxiety disorders. The relevance of the oxidative stress status
Foyet, H. S., Balmuș, I.-M., Hervé, N. A. H., Acha, A. E., Guenné, S., Kiendrébeogo, M., & Ciobica, A. S. (2017) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2016-0059 · Cited by 6
Depression and diabetic retinopathy: an underexplored connection
Li, J., Sun, H., Li, L., Xin, X., Zhang, X., Lv, W., & Tan, S. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1557105 · Cited by 6
Boltzmann’s Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders
Ferber, S. G., Weller, A., & Soreq, H. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240315100326 · Cited by 5

Authors: Siwek, M., Sowa-Kućma, M., Dudek, D., Styczeń, K., Szewczyk, B., Kotarska, K., Misztak, P., Pilc, A., Wolak, M., & Nowak, G.
Affiliations: Jagiellonian University (PL)
Maj Institute of Pharmacology (PL)
Corresponding author: Siwek, Marcin
Sowa-Kućma, Magdalena
ORCID: Siwek, Marcin
Sowa-Kućma, Magdalena
Dudek, Dominika
Styczeń, Krzysztof
Szewczyk, Bernadeta
Kotarska, Katarzyna
Misztak, Paulina
Wolak, Małgorzata
Nowak, Gabriel
Venue: Pharmacological Reports
Publisher: Springer Science and Business Media LLC
Published: 2013-11
Volume: 65
Issue: 6
Pages: 1558-1571
ISSN: 1734-1140 (ISSN-L)
DOI: 10.1016/s1734-1140(13)71517-2
OpenAlex: W2040817682
Cited by: 142
References: 108
Citations by year: 2026: 5 · 2025: 6 · 2024: 17 · 2023: 14 · 2022: 12 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 6 · 2013: 2
FWCI: 0.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Reports (publishedVersion)
PubMed (publishedVersion)
Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
BOA (University of Milano-Bicocca) (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, nitrosative stress, mood disorders, depression, bipolar disorder, antioxidant biomarkers, glutathione, vitamin E, zinc, coenzyme Q10, glutathione peroxidase, total antioxidant status, reactive oxygen species, reactive nitrogen species, glutamatergic system, immune-inflammatory response, antidepressant treatment, N-acetylcysteine, omega-3 fatty acids, antioxidant therapy
MeSH terms: Animals, Antidepressive Agents, Humans, Biomarkers, Oxidative Stress, Mood Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative stress markers in affective disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks