Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review

Cecerska-Heryć, Elżbieta; Polikowska, Aleksandra; Serwin, Natalia; Roszak, Marta; Grygorcewicz, Bartłomiej; Heryć, Rafał; Michalczyk, Anna; Dołęgowska, Barbara

doi:10.1016/j.neuint.2021.105269

Cited by 68Antioxidant Activity and Oxidative StressRedox biology and oxidative stressTrace Elements in Health

Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review

Cecerska-Heryć, Elżbieta, Polikowska, Aleksandra, Serwin, Natalia, Roszak, Marta, Grygorcewicz, Bartłomiej, Heryć, Rafał, Michalczyk, Anna, Dołęgowska, Barbara·2022·Neurochemistry International

DOI 10.1016/j.neuint.2021.105269

Open this paper in CoChat — free account

Abstract

Oxidative stress is defined as the persistent imbalance between the activity of toxic reactive forms of both oxygen and nitrogen and the antioxidant defense. In low concentrations, they are essential for the proper functioning of the body. Still, their excessive amount contributes to the damage of the biomolecules, consequently leading to various pathologies of the organism. Due to the lipid-rich brain structure, enormous oxygen consumption, and the lack of a sufficient antioxidant barrier make it highly susceptible to oxidative imbalance. Hence, oxidative stress has been linked to various psychiatric disorders. These diseases include all behavioral, emotional, and cognitive abnormalities associated with a significant impediment to social life. Each of the diseases in question: Alzheimer's disease, schizophrenia, depression, and bipolar disorder, is characterized by excessive oxidative stress. Considerable damages to DNA, RNA, proteins, lipids, and mitochondrial dysfunction, are observed. All conditions show increased lipid peroxidation, which appears to be typical of psychiatric disorders because the brain contains large amounts of these types of molecules. In addition, numerous abnormalities in the antioxidant defense are noted, but the results of studies on the activity of antioxidant enzymes differ significantly. The most promising biomarkers seem to be GSH in Alzheimer's disease as an early-stage marker of the disease and thioredoxin in schizophrenia as a marker for therapy monitoring. Data from the literature are consistent with the decrease in antioxidants such as vitamin C, E, uric acid, albumin, etc. Despite these numerous inconsistencies, it seems that oxidative stress is present in the course of psychiatric diseases. Still, it cannot be conclusively determined whether it is the direct cause of development, a consequence of other abnormalities at the biochemical or molecular level, or the result of the disease itself.

Integrity signals

Registry

Crossref · 10.1016/j.neuint.2021.105269

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genetic examination found an association between polymorphism of genes and oxidative stress markers in schizophrenia.
“In addition, the genetic examination found an association between polymorphism of genes and oxidative stress markers in schizophrenia (Cecerska-Heryć et al. 2022).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Cecerska-Heryć et al. 2022
Incidence of bipolar disorder is between 1 and 3% of world's population with average age between 20 and 30 years.
“The incidence of bipolar disorder is between 1 and 3% of the world’s population with average age between 20 and 30 years.”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Cecerska-Heryc et al. 2022

Oxidative Stress: Harms and Benefits for Human Health
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8416763 · Cited by 4,837 · see citing works
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · see citing works
Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
Singh, A., Kukreti, R., Saso, L., & Kukreti, S. (2019) · Molecules · doi:10.3390/molecules24081583 · Cited by 2,305 · see citing works
Oxidative Stress and the Central Nervous System
Salim, S. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237503 · Cited by 1,268 · see citing works
A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
Maes, M., Galecki, P., Chang, Y. S., & Berk, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.004 · Cited by 1,140 · see citing works
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works
Role of oxidative stress in Alzheimer’s disease
HUANG, W.-J., ZHANG, X., & CHEN, W.-W. (2016) · Biomedical Reports · doi:10.3892/br.2016.630 · Cited by 1,023 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800 · see citing works
Is depression associated with increased oxidative stress? A systematic review and meta-analysis
Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711 · see citing works
Toward clinical application of the Keap1-Nrf2 pathway
Suzuki, T., Motohashi, H., & Yamamoto, M. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.04.005 · Cited by 680 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Oxidative stress in the progression of Alzheimer disease in the frontal cortex
Ansari, M. A., & Scheff, S. W. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5af4 · Cited by 605 · see citing works
Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders
Gawryluk, J. W., Wang, J.-F., Andreazza, A. C., Shao, L., & Young, L. T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000805 · Cited by 594 · see citing works
Oxidative stress in neurodegenerative diseases.
Chen, X., Guo, C., & Kong, J. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.05.009 · Cited by 572 · see citing works
Oxidative Stress and Psychological Disorders
Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120230309 · Cited by 557 · see citing works
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540 · see citing works
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets
Zhang, J.-C., Yao, W., & Hashimoto, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094646 · Cited by 538 · see citing works
Oxidative stress markers in bipolar disorder: A meta-analysis
Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526 · see citing works
Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease
Marcus, D. L., Thomas, C., Rodriguez, C., Simberkoff, K., Tsai, J. S., Strafaci, J. A., & Freedman, M. L. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6750 · Cited by 513 · see citing works
Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems
Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486 · see citing works
A Meta-analysis of oxidative stress markers in depression
Liu, T., Zhong, S., Liao, X., Chen, J., He, T., Lai, S., & Jia, Y. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138904 · Cited by 485 · see citing works
Oxidative stress in schizophrenia: An integrated approach
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.008 · Cited by 474 · see citing works
Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors
Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works
Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder
Andreazza, A. C., Shao, L., Wang, J.-F., & Young, L. T. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.22 · Cited by 448 · see citing works
Metal dyshomeostasis and oxidative stress in Alzheimer’s disease
Greenough, M. A., Camakaris, J., & Bush, A. I. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.014 · Cited by 439 · see citing works
Free radicals, antioxidant defense systems, and schizophrenia
Wu, J. Q., Kosten, T. R., & Zhang, X. Y. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.02.015 · Cited by 420 · see citing works
Oxidative Stress in Neurodegenerative Diseases
Crichton, R. R., & Ward, R. J. (2013) · Wiley eBooks · doi:10.1002/9781118553480.ch04 · Cited by 372 · see citing works
Antioxidant enzyme activities and oxidative stress in affective disorders
Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368 · see citing works
An updated meta-analysis of oxidative stress markers in bipolar disorder
Brown, N. C., Andreazza, A. C., & Young, L. T. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.04.005 · Cited by 333 · see citing works
Role of Oxidative Stress in the Progression of Alzheimer's Disease
Rukhsana Sultana, A., & Butterfield, D. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1222 · Cited by 327 · see citing works
Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Vaváková, M., Ďuračková, Z., & Trebatická, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/898393 · Cited by 324 · see citing works
Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment
Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322 · see citing works
Altered glutathione redox state in schizophrenia.
Yao, J. K., Leonard, S., & Reddy, R. (2006) · Disease Markers · doi:10.1155/2006/248387 · Cited by 321 · see citing works
Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
Kuloglu, M., Ustundag, B., Atmaca, M., Canatan, H., Tezcan, A. E., & Cinkilinc, N. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.940 · Cited by 321 · see citing works
Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: A possible role for lithium antioxidant effects
Machado‐Vieira, R., Andreazza, A. C., Viale, C. I., Zanatto, V. C., Ceresér, V. H., Vargas, R. D. S., Kapczinski, F. P., Portela, L. V., Souza, D. O., Salvador, M. M., et al. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.05.016 · Cited by 314 · see citing works
Serum S100B and antioxidant enzymes in bipolar patients
Andreazza, A. C., Cassini, C., Rosa, A. R., Leite, M. C., de Almeida, L. M. V., Nardin, P., da Cunha, A. B., Ceresér, K. M. M., Santin, A. M. P., Gottfried, C., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.07.013 · Cited by 307 · see citing works
Depression and Oxidative Stress: Results From a Meta-Analysis of Observational Studies
Palta, P., Samuel, L. J., Miller, E. R., & Szanton, S. L. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000009 · Cited by 277 · see citing works
Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease
Lovell, M. A., Xie, C., & Markesbery, W. R. (1998) · Neurology · doi:10.1212/wnl.51.6.1562 · Cited by 275 · see citing works
Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism
Smaga, I., Niedzielska, E., Gawlik, M., Moniczewski, A., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.015 · Cited by 252 · see citing works
Oxidative Stress in Schizophrenia
Grabnar, I., Vovk, T., Plesničar, B. K., & Boskovic, M. (2011) · Current Neuropharmacology · doi:10.2174/157015911795596595 · Cited by 250 · see citing works
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression
Bouvier, E., Brouillard, F., Molet, J., Claverie, D., Cabungcal, J.-H., Cresto, N., Doligez, N., Rivat, C., Do, K. Q., Bernard, C., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.144 · Cited by 248 · see citing works
Nitric oxide and major depression
Dhir, A., & Kulkarni, S. K. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.02.002 · Cited by 239 · see citing works
Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment
Ahmed, N., Ahmed, U., Thornalley, P. J., Häger, K., Fleischer, G., & Münch, G. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02864.x · Cited by 238 · see citing works
Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia
Herken, H., Uz, E., Özyurt, H., Söğüt, S., Vırıt, O., & Akyol, Ö. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000789 · Cited by 238 · see citing works
Peripheral biomarkers and illness activity in bipolar disorder
Kapczinski, F. P., Dal‐Pizzol, F., Teixeira, A. L., Magalhães, P. V. D. S., Kauer‐Sant’Anna, M., Klamt, F., Moreira, J. C. F., Pasquali, M. A. D. B., Fries, G. R., Quevedo, J., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.05.015 · Cited by 236 · see citing works
The role of oxidative stress in anxiety disorder: cause or consequence?
Fedoce, A. G., Ferreira, F. R., Bota, R. G., Bonet-Costa, V., Sun, P. Y., & Davies, K. J. A. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1475733 · Cited by 235 · see citing works
Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress
Martins, R. N., Harper, C. G., Stokes, G. B., & Masters, C. L. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb00615.x · Cited by 234 · see citing works
Oxidative Stress and Major Depression
Bajpai, A. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/10258.5292 · Cited by 222 · see citing works
Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221 · see citing works
Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—A postmortem study
Michel, T. M., Frangou, S., Thiemeyer, D., Camara, S., Jecel, J., Nara, K., Brunklaus, A., Zoechling, R., & Riederer, P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.04.013 · Cited by 218 · see citing works
Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment
Gałecki, P., Szemraj, J., Bieńkiewicz, M., Florkowski, A., & Gałecka, E. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70084-2 · Cited by 214 · see citing works
Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study
Matsuzawa, D., Obata, T., Shirayama, Y., Nonaka, H., Kanazawa, Y., Yoshitome, E., Takanashi, J., Matsuda, T., Shimizu, E., Ikehira, H., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001944 · Cited by 201 · see citing works
Reduced plasma antioxidants in first-episode patients with schizophrenia
Reddy, R. D. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00407-3 · Cited by 194 · see citing works
DNA damage in bipolar disorder
Andreazza, A. C., Frey, B. N., Erdtmann, B., Salvador, M. M., Rombaldi, F., Santin, A. M. P., Gonçalves, C. A., & Kapczinski, F. P. (2007) · Psychiatry Research · doi:10.1016/j.psychres.2006.03.025 · Cited by 187 · see citing works
The relevance of oxidative stress status in first episode and recurrent depression
Stefanescu, C., & Ciobica, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.022 · Cited by 179 · see citing works
Decreased glutathione levels and antioxidant enzyme activities in untreated and treated schizophrenic patients
Raffa, M., Mechri, A., Othman, L. B., Fendri, C., Gaha, L., & Kerkeni, A. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.018 · Cited by 173 · see citing works
Evaluation of antioxidant enzymes activities and lipid peroxidation in schizophrenic patients treated with typical and atypical antipsychotics
Pădurariu, M., Ciobica, A. S., Dobrin, I., & Ștefănescu, C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.088 · Cited by 171 · see citing works
Oxidative stress and schizophrenia
Emiliani, F. E., Sedlak, T. W., & Sawa, A. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000054 · Cited by 168 · see citing works
Impaired antioxidant defense at the onset of psychosis
Mukherjee, S., Mahadik, S. P., Scheffer, R. E., Correnti, E. E., & Kelkar, H. S. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(95)00048-8 · Cited by 162 · see citing works
Enzymes of the antioxidant defense system in chronic schizophrenic patients
Reddy, R. D., Mahadik, S. P., Mukherjee, S., & Murthy, J. N. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90298-z · Cited by 156 · see citing works
Role of calcium, glutamate and NMDA in major depression and therapeutic application
Deutschenbaur, L., Beck, J., Kiyhankhadiv, A., Mühlhauser, M., Borgwardt, S., Walter, M., Hasler, G., Sollberger, D., & Lang, U. E. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.015 · Cited by 155 · see citing works
Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness
Che, Y., Wang, J.-F., Shao, L., & Young, L. T. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.090083 · Cited by 155 · see citing works
Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice
Yao, W., Zhang, J.-C., Ishima, T., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, J., Suganuma, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30659 · Cited by 154 · see citing works
Specific subcellular changes in oxidative stress in prefrontal cortex from patients with bipolar disorder
Andreazza, A. C., Wang, J., Salmasi, F., Shao, L., & Young, L. T. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12316 · Cited by 146 · see citing works
Increased Nitric Oxide Radicals in Postmortem Brain From Patients With Schizophrenia
YAO, J. K., Leonard, S. S., & Reddy, R. D. (2004) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007142 · Cited by 146 · see citing works
Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: Impact of past episodes
SAVAS, H. A., Gergerlioğlu, H. S., Armutçu, F., Herken, H., Yılmaz, H. R., Koçoğlu, E., Selek, S., Tutkun, H., Zoroğlu, S. S., & Akyol, Ö. (2006) · The World Journal of Biological Psychiatry · doi:10.1080/15622970510029993 · Cited by 143 · see citing works
Oxidative stress markers in affective disorders
Siwek, M., Sowa-Kućma, M., Dudek, D., Styczeń, K., Szewczyk, B., Kotarska, K., Misztak, P., Pilc, A., Wolak, M., & Nowak, G. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71517-2 · Cited by 142 · see citing works
Inflammatory Biomarkers as Differential Predictors of Antidepressant Response
Hashimoto, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047796 · Cited by 138 · see citing works
Erythrocyte Superoxide Dismutase and Glutathione Peroxidase Activities, and Malondialdehyde and Reduced Glutathione Levels in Schizophrenic Patients
Altuntaş, İ., Aksoy, H., Coşkun, İ., Çayköylü, A., & Akçay, F. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.201 · Cited by 131 · see citing works
Effects of haloperidol on antioxidant defense system enzymes in schizophrenia
Yao, J. K., Reddy, R. D., McElhinny, L. G., & van Kammen, D. P. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00028-4 · Cited by 127 · see citing works
Oxidative stress in schizophrenia - focusing on the main markers.
Ciobica, A. S., Pădurariu, M., Dobrin, I., Ștefănescu, C., & Dobrin, R. (2011) · PubMed · Cited by 126 · see citing works
Reduced level of plasma antioxidant uric acid in schizophrenia
Yao, J. K., Reddy, R. D., & van Kammen, D. P. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00051-1 · Cited by 121 · see citing works
Depression and oxidative damage to lipids
Yager, S., Forlenza, M. J., & Miller, G. E. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.010 · Cited by 120 · see citing works
Increased xanthine oxidase in the thalamus and putamen in depression
Michel, T. M., Camara, S., Tatschner, T., Frangou, S., Sheldrick, A. J., Riederer, P., & Grünblatt, E. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970802123695 · Cited by 114 · see citing works
Evidence for Oxidative DNA Damage in the Hippocampus of Elderly Patients With Chronic Schizophrenia
Nishioka, N., & Arnold, S. E. (2004) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200403000-00008 · Cited by 114 · see citing works
Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation
Zhang, J., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., Han, M., Wu, J., Ushida, Y., Suganuma, H., et al. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.10.004 · Cited by 113 · see citing works
Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
Yao, W., Lin, S., Su, J. Y., Cao, Q., Chen, Y., Chen, J., Zhang, Z., Hashimoto, K., Qi, Q., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01261-6 · Cited by 106 · see citing works
Medial temporal lobe glutathione concentration in first episode psychosis: A 1H-MRS investigation
Wood, S. J., Berger, G. E., Wellard, R. M., Proffitt, T., McConchie, M., Berk, M., McGorry, P. D., & Pantelis, C. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.11.018 · Cited by 105 · see citing works
Low plasma vitamin E levels in major depression: diet or disease?
Owen, A. J., Batterham, M. J., Probst, Y., Grenyer, B. F. S., & Tapsell, L. C. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602072 · Cited by 105 · see citing works
Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
Neuronal and Vascular Oxidative Stress in Alzheimers Disease
Massaad, C. A. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376244 · Cited by 102 · see citing works
Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions
Hassan, W., Barroso Silva, C., Mohammadzai, I. U., Teixeira da Rocha, J., & Landeira-Fernandez, J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120232135 · Cited by 100 · see citing works
Therapeutic Modulation of Glutamate Receptors in Major Depressive Disorder
Jaso, B. A., Niciu, M. J., Iadarola, N. D., Lally, N., Richards, E. M., Park, M., Ballard, E. D., Nugent, A. C., Machado‐Vieira, R., & Zarate, C. A. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160321123221 · Cited by 98 · see citing works
Reduced antioxidant defense systems in schizophrenia and bipolar I disorder
Raffa, M., Barhoumi, S., Atig, F., Fendri, C., Kerkeni, A., & Mechri, A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.013 · Cited by 95 · see citing works
Increased Plasma Nitric Oxide Metabolites in Suicide Attempters
Lee, B.-H., Lee, S.-W., Yoon, D., Lee, H., Yang, J.-C., Shim, S.-H., Kim, D., Ryu, S., Han, C., & Kim, Y. (2006) · Neuropsychobiology · doi:10.1159/000092542 · Cited by 88 · see citing works
Low nNOS protein in the locus coeruleus in major depression
Karolewicz, B., Szebeni, K., Stockmeier, C. A., Konick, L. C., Overholser, J. C., Jurjus, G., Roth, B. L., & Ordway, G. A. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02792.x · Cited by 84 · see citing works
Oxidative stress in blood platelets from schizophrenic patients
Dietrich‐Muszalska, A., Olas, B., & Rabe‐Jabłońska, J. (2005) · Platelets · doi:10.1080/09537100500128872 · Cited by 84 · see citing works
Psychiatric disorders and mitochondrial dysfunctions.
Marazziti, D., Baroni, S., Picchetti, M., Landi, P., Silvestri, S., Vatteroni, E., & Dell’Osso, M. C. (2012) · PubMed · Cited by 83 · see citing works
DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia
Buttner, N., Bhattacharyya, S., Walsh, J., & Benes, F. M. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.01.030 · Cited by 75 · see citing works
Oxidative stress in Alzheimer's disease: Primary villain or physiological by-product?
Sutherland, G. T., Chami, B., Youssef, P., & Witting, P. K. (2013) · Redox Report · doi:10.1179/1351000213y.0000000052 · Cited by 75 · see citing works
Association of Oxidative Stress with Psychiatric Disorders
Hassan, W., Noreen, H., Gomes, V. D. C., Mohammadzai, I., da Rocha, J. B. T., & Landeira-Fernández, J. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160307145931 · Cited by 73 · see citing works
Expression of nNOS and soluble guanylate cyclase in schizophrenic brain
Baba, H., Suzuki, T., Arai, H., & Emson, P. C. (2004) · Neuroreport · doi:10.1097/00001756-200403220-00020 · Cited by 70 · see citing works
Lipid peroxidation in patients with schizophrenia
Dietrich‐Muszalska, A., & Kontek, B. (2010) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02132.x · Cited by 69 · see citing works
Red blood cell nitric oxide levels in patients with schizophrenia
Herken, H., Uz, E., Özyurt, H., & Akyol, Ö. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00169-9 · Cited by 69 · see citing works
Glutathione peroxidase and CT scan abnormalities in schizophrenia
Buckman, T. D., Kling, A. S., Eiduson, S., Sutphin, M. S., & Steinberg, A. M. (1987) · Biological Psychiatry · doi:10.1016/0006-3223(87)90069-2 · Cited by 68 · see citing works
Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 1. Chemical aspects and biological sources of oxidative stress in the brain
Moniczewski, A., Gawlik, M. T., Smaga, I., Niedzielska, E., Krzek, J., Przegaliński, E., Pera, J., & Filip, M. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.12.014 · Cited by 66 · see citing works
Keap1-Nrf2 signaling pathway confers resilience versus susceptibility to inescapable electric stress
Zhang, J.-C., Yao, W., Dong, C., Han, M., Shirayama, Y., & Hashimoto, K. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0848-0 · Cited by 66 · see citing works
Nitric Oxide and Major Depressive Disorder: Pathophysiology and Treatment Implications
Kudlow, P. A., Cha, D. S., Carvalho, A. F., & McIntyre, R. S. (2016) · Current Molecular Medicine · doi:10.2174/1566524016666160126144722 · Cited by 63 · see citing works
A pilot study of cortical glutathione in youth with depression
Freed, R. D., Hollenhorst, C. N., Weiduschat, N., Mao, X., Kang, G., Shungu, D. C., & Gabbay, V. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.10.001 · Cited by 60 · see citing works
Isoprostenes as indicators of oxidative stress in schizophrenia
Dietrich‐Muszalska, A., & Olas, B. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701361263 · Cited by 59 · see citing works
Elevated plasma superoxide dismutase in first-episode and drug naive patients with schizophrenia: Inverse association with positive symptoms
Wu, Z., Zhang, X., Wang, H., Tang, W., Xia, Y., Zhang, F., Liu, J., Fu, Y., Hu, J., Chen, Y., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.08.018 · Cited by 58 · see citing works
Increased lipid peroxidation and neuron specific enolase in treatment refractory schizophrenics
Medina-Hernández, V., Ramos‐Loyo, J., Luquı́n, S., Sánchez, L. F. C., Garcı́a‐Estrada, J., & Navarro-Ruiz, A. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.02.010 · Cited by 56 · see citing works
Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
Madireddy, S., & Madireddy, S. (2020) · Brain Sciences · doi:10.3390/brainsci10100742 · Cited by 55 · see citing works
Decreased expression of heme oxygenase is associated with depressive symptoms and may contribute to depressive and hypertensive comorbidity
Robaczewska, J., Kędziora–Kornatowska, K., Kucharski, R., Nowak, M., Muszalik, M., Kornatowski, M., & Kędziora, J. (2016) · Redox Report · doi:10.1080/13510002.2015.1101889 · Cited by 40 · see citing works
Evidence of altered DNA integrity in the brain regions of suicidal victims of Bipolar Depression
Rao, T. S., Mustak, M. S., Hegde, M. L., Dinesh, A., Britton, G. B., Berrocal, R., Rao, K., Shamasundar, N., & Rao, K. S. J. (2010) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.70974 · Cited by 37 · see citing works
The Relationship between the Number of Manic Episodes and Oxidative Stress Indicators in Bipolar Disorder
Akarsu, S., Bolu, A., Aydemir, E., Zincir, S. B., Kurt, Y. G., Zincir, S., Erdem, M., & Uzun, Ö. (2018) · Psychiatry Investigation · doi:10.30773/pi.2016.12.31 · Cited by 35 · see citing works
Oxidative stress markers, cognitive functions, and psychosocial functioning in bipolar disorder: an empirical cross-sectional study
Aydemır, Ö., Çubukçuoğlu, Z., Erdin, S., Taş, C., Onur, E., & Berk, M. (2014) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1299 · Cited by 31 · see citing works
Alteration of the pro-oxidant xanthine oxidase (XO) in the thalamus and occipital cortex of patients with schizophrenia
Michel, T. M., Sheldrick, A. J., Camara, S., Grünblatt, E., Schneider, F. W., & Riederer, P. F. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.526146 · Cited by 30 · see citing works
Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression
Yao, W., Zhang, J., Ishima, T., Ren, Q., Yang, C., Dong, C., Ma, M., Saito, A., Honda, T., & Hashimoto, K. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.10.037 · Cited by 29 · see citing works
Lithium increases nitric oxide levels in subjects with bipolar disorder during depressive episodes
SOUSA, R. T. D., Zanetti, M. V., Busatto, G. F., Mouro, M. G., Zarate, C. A., Gattaz, W. F., Higa, E. M. S., & Machado‐Vieira, R. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.03.023 · Cited by 27 · see citing works
Relationship Between Oxidative Stress and Anxiety: Emerging Role of Antioxidants Within Therapeutic or Preventive Approaches
Bouayed, J. (2011) · InTech eBooks · doi:10.5772/19214 · Cited by 23 · see citing works
Thiobarbituric acid reactive substances in the cerebrospinal fluid in schizophrenia
Skinner, A. O., Mahadik, S. P., & Garver, D. L. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.10.010 · Cited by 23 · see citing works
Salivary glutathione in bipolar disorder: A pilot study
Ngamchuea, K., Batchelor‐McAuley, C., Williams, C., Godlewska, B. R., Sharpley, A. L., Cowen, P. J., & Compton, R. G. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.05.041 · Cited by 17 · see citing works
Alzheimer’s disease: psychiatric or neurological disorder?
Gzil, F. (2008) · Poiesis & Praxis · doi:10.1007/s10202-008-0061-3 · Cited by 3 · see citing works

Flagged first, then by citations

Sorted by citations

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
Biological hypotheses, risk factors, and biomarkers of schizophrenia
Fišar, Z. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110626 · Cited by 97 · see citing works
Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials
Wang, H., Jin, M., Xie, M., Yang, Y., Xue, F., Li, W., Zhang, M., Li, Z., Li, X., Jia, N., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.072 · Cited by 80 · see citing works
The Influence of Circadian Rhythm on the Activity of Oxidative Stress Enzymes
Budkowska, M., Cecerska‐Heryć, E., Marcinowska, Z., Siennicka, A., & Dołęgowska, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214275 · Cited by 64 · see citing works
Self-citation
Wavelet Transform, Reconstructed Phase Space, and Deep Learning Neural Networks for EEG-Based Schizophrenia Detection
Fahoum, A. S. A., & Zyout, A. (2024) · International Journal of Neural Systems · doi:10.1142/s0129065724500461 · Cited by 47 · see citing works
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Madrer, N., Perera, N. D., Uccelli, N. A., Abbondanza, A., Andersen, J. V., Carsana, E. V., Demmings, M. D., Fernandez, R. F., de Fragas, M. G., Gbadamosi, I., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70084 · Cited by 35 · see citing works
Role of reactive oxygen species in myelodysplastic syndromes
Jing, Q., Zhou, C., Zhang, J., Zhang, P., Wu, Y., Zhou, J., Tong, X., Li, Y., Du, J., & Wang, Y. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00570-0 · Cited by 33 · see citing works
The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders
Queiroz, S. A. L., Ton, A. M. M., Pereira, T. D. M. C., Campagnaro, B. P., Martinelli, L., Picos, A., Campos‐Toimil, M., & Vasquez, E. C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.872594 · Cited by 32 · see citing works
Current Progress on Neuroprotection Induced by Artemisia, Ginseng, Astragalus, and Ginkgo Traditional Chinese Medicines for the Therapy of Alzheimer’s Disease
Li, Q., Rubin, L., Silva, M., Li, S., Yang, C., Lazarovici, P., & Zheng, W. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3777021 · Cited by 27 · see citing works
Antioxidant Properties of New Phenothiazine Derivatives
Voronova, O. A., Петрович, Ж. С., Korotkova, E. I., Artamonov, A. A., & Plotnikov, E. V. (2022) · Antioxidants · doi:10.3390/antiox11071371 · Cited by 20 · see citing works
Psychiatric Symptoms in Wilson’s Disease—Consequence of ATP7B Gene Mutations or Just Coincidence?—Possible Causal Cascades and Molecular Pathways
Gromadzka, G., Antos, A., Sorysz, Z., & Litwin, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212354 · Cited by 18 · see citing works
Uric acid levels and risk of cognitive impairment: Dose-response meta-analysis of prospective cohort studies
Liu, Q., Peng, M., Yang, T., & Si, G. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293832 · Cited by 15 · see citing works
Peripheral non-enzymatic antioxidants as biomarkers for mood disorders: Evidence from a machine learning prediction model
Gong, Y., Lu, Z., Kang, Z., Feng, X., Zhang, Y., Sun, Y., Chen, W., Xun, G., & Yue, W. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1019618 · Cited by 14 · see citing works
Comparison of oxidative stress parameters, thiol-disulfide homeostasis, and pro-inflammatory cytokines levels in patients with bipolar disorder and their first-degree relatives
Polat, N., Beyaztaş, H., Aktaş, S., Maden, Ö., & Güler, E. M. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.05.022 · Cited by 13 · see citing works
Relationship Between Obesity and Depression Considering the Inflammatory Theory
Oracz, A. J., Zwierz, M., Naumowicz, M., Suprunowicz, M., & Waszkiewicz, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26114966 · Cited by 14 · see citing works
Hemoglobin as a pseudoperoxidase and drug target for oxidative stress-related diseases
Won, W., Lee, E. H., Gotina, L., Chun, H., Lee, J., Bhalla, M., Park, U., Kim, D., Kim, T. Y., Choi, J. W., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02366-w · Cited by 16 · see citing works
Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia
Li, D., Huang, Y., Lu, H., Zhou, S., Feng, S., Li, H., Li, X., Guo, Y., Fu, C., Chen, G., et al. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06335-5 · Cited by 13 · see citing works
Anxiolytic, Antidepressant and Healthy Sleep-Promoting Potential of Rosmarinic Acid: Mechanisms and Molecular Targets
Priya, V., Srinivasan, D., Priyadarsini, S., Dabaghzadeh, F., Rana, S. S., Chengaiyan, J. G., Sudesh, R., & Ahmad, F. (2025) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s501597 · Cited by 13 · see citing works
Role of Blood–Brain Barrier Permeability in Delirium Pathophysiology and Treatment
Gruenbaum, B. F., Zlotnik, A. A., Dubilеt, M., Negev, S., Zeldetz, V., Merchant, K. S., & Boyko, M. (2025) · Anesthesiology · doi:10.1097/aln.0000000000005722 · Cited by 13 · see citing works
Characterization of the gut microbiome in Alzheimer disease and mild cognitive impairment among older adults in Uganda: A case–control study
Lwere, K., Muwonge, H., Sendagire, H., Sajatovic, M., Williams, S. M., Gumukiriza-Onoria, J. L., Buwembo, D., Buwembo, W., Nassanga, R., Nakimbugwe, R., et al. (2025) · Medicine · doi:10.1097/md.0000000000042100 · Cited by 12 · see citing works
Mangiferin: A natural neuroprotective polyphenol with anti-inflammatory and anti-oxidant properties for depression
Lan, L., Chen, C.-Y., Wang, Y., Guo, Z., & Zhang, Y. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111401 · Cited by 13 · see citing works
Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, and therapeutic implications
Yang, F.-G., Yang, H., Han, S.-W., Wang, J.-T., Gao, W. B., Ye, Q.-Y., Zhang, M.-M., Yu, Y., & Li, H.-L. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103050 · Cited by 11 · see citing works
Pro/antioxidant status and selenium, zinc and arsenic concentration in patients with bipolar disorder treated with lithium and valproic acid
Róg, J., Łobejko, Ł., Hordejuk, M., Marciniak, W., Derkacz, R., Kiljańczyk, A., Matuszczak, M., Lubiński, J., Nesterowicz, M., Żendzian‐Piotrowska, M., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1441575 · Cited by 13 · see citing works
Honokiol ameliorates reserpine-induced fibromyalgia through antioxidant, anti-inflammatory, neurotrophic, and anti-apoptotic mechanisms
Khodir, S. A., Sweed, E. M., El-Haroun, H., Abd-el-Hamid, T., Derbaly, S. A. E., Mahmoud, A. R., & Motawea, S. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-07209-w · Cited by 8 · see citing works
Analysis of urinary 8-hydroxy-2-deoxyguanosine as a biomarker of oxidative DNA damage in pediatric children with autism spectrum disorder
Zaky, E. A., Elhameed, S. A. A., Ismail, S. M., Eldamer, N. M., & Abdelaziz, A. W. (2023) · Research in Autism · doi:10.1016/j.rasd.2023.102129 · Cited by 8 · see citing works
State assessment of 110–220 kV intelligent substation based on multisensor fusion algorithm control and image vision
Zhao, W., Cui, A., Fang, M., Yang, L., Chen, K., & Gong, X. (2023) · Frontiers in Energy Research · doi:10.3389/fenrg.2022.1047359 · Cited by 7 · see citing works
Anxiolytic and antidepressant effects of the essential oil of Moroccan Cannabis sativa in mice exposed to unpredictable chronic mild stress: Behavioral and biochemical evidences
Kabdy, H., Baslam, A., Baba, A. A., Laaradia, M. A., Aboufatima, R., Belbachir, A., & Chait, A. (2023) · South African Journal of Botany · doi:10.1016/j.sajb.2023.12.012 · Cited by 7 · see citing works
Assessment of brain-derived neurotrophic factor levels in serum of children with autism spectrum disorders
Elhamid, S. A. A., Alkherkhisy, M. M., & Kasem, R. E. (2024) · Middle East Current Psychiatry · doi:10.1186/s43045-024-00403-y · Cited by 7 · see citing works
Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health
Kołodziejczyk-Czepas, J. (2024) · Foods · doi:10.3390/foods13071118 · Cited by 7 · see citing works
The involvement of reactive oxygen species in causing chronic cardiovascular and neurodegenerative diseases and some cancers
Tiwana, J., Shah, A. K., & Dhalla, N. S. (2024) · Scripta Medica · doi:10.5937/scriptamed55-48730 · Cited by 7 · see citing works
Assessment of Opuntia ficus-indica supplementation on enhancing antioxidant levels
Zaman, R., Tan, E. S. S., Bustami, N. A., Amini, F., Seghayat, M. S., Ho, Y. B., & Tan, C. K. (2025) · Scientific Reports · doi:10.1038/s41598-025-87680-7 · Cited by 7 · see citing works
Differential Cellular Interactome in Schizophrenia and Bipolar Disorder—Discriminatory Biomarker Role
Menéndez‐Valle, I., Cachán-Vega, C., Boga, J. A., González‐Blanco, L., Antuña, E., Potes, Y., Caballero, B., Vega‐Naredo, I., Sáiz, P. A., Bobes, J., et al. (2023) · Antioxidants · doi:10.3390/antiox12111948 · Cited by 7 · see citing works
Therapeutic Potential of Fingolimod on Psychological Symptoms and Cognitive Function in Neuropsychiatric and Neurological Disorders
Rahmati-Dehkordi, F., Khanifar, H., Najari, N., Tamtaji, Z., Taheri, A. T., Aschner, M., Ardestani, M. S., Mirzaei, H., Dadgostar, E., Nabavizadeh, F., et al. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04199-5 · Cited by 5 · see citing works
Association between dietary diversity and risk of depressive symptoms in Chinese children, adolescents, and college students
Ren, Z., Gao, L., Hao, Z., Zhao, B., Li, J., Li, G., Cao, J., & Tang, X. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1575351 · Cited by 5 · see citing works
Smoking Affects the Predictive Roles of Antioxidant Enzymes in the Clinical Response to Risperidone in Schizophrenia: A Large-scale Cohort Study
Xiu, M., Song, X., Yang, H., Huang, X., Wu, F., & Zhang, X. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230502125800 · Cited by 5 · see citing works
(R)-ketamine attenuates neurodevelopmental disease-related phenotypes in a mouse model of maternal immune activation
de Oliveira, E. G., de Lima, D. A., Júnior, J. C. D. S., Barbosa, M. V. D. S., Silva, S. C. D. A., de Santana, J. H., dos Santos, O. H., Lira, E. C., Lagranha, C. J., Duarte, F. S., et al. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01629-3 · Cited by 5 · see citing works
Positioning berries in nutritional psychiatry: potential for prevention and co-therapy in mental health
Fernández-Demeneghi, R., Domínguez-Pantoja, M., Moreno, A. G. M., Vargas-Moreno, I., & Ramírez-Rodríguez, R. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1622242 · Cited by 4 · see citing works
Impact of chronic lithium treatment on brain oxidative stress and anxiety-like behaviors in rats: Dose-dependent effects
Eraslan, E., Matur, E., Akyol, S., Ekiz, E. E., Akyazı, İ., Bala, D. A., Gürsel, F. E., & Darıyerli, N. (2024) · General Physiology and Biophysics · doi:10.4149/gpb_2024006 · Cited by 4 · see citing works
Certification of visinin-like protein-1 (VILIP-1) certified reference material by amino acid-based and sulfur-based liquid chromatography isotope dilution mass spectrometry
Zang, Y., Zhou, X., Pan, M., Lu, Y., Liu, H., Xiong, J., & Feng, L. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-022-04401-z · Cited by 4 · see citing works
Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F 2 Cross of Selectively-Bred RatsPreprint
Hebda‐Bauer, E. K., Hagenauer, M. H., Munro, D. B., Blandino, P., Meng, F., Arakawa, K., Chitre, A. S., Ozel, A. B., Mohammadi, P., Watson, S. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.14.500129 · Cited by 4 · see citing works
Preclinical evidence and potential mechanisms of tanshinone ⅡA on cognitive function in animal models of Alzheimer’s disease: a systematic review and meta-analysis
Rong, Y., Li, Q., Du, Y., Wang, W., Su, W., Zhang, J., & He, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1603861 · Cited by 3 · see citing works
Oxidative Stress and Psychiatric Symptoms in Wilson’s Disease
Gromadzka, G., Karpińska, A., Szafrański, T., & Litwin, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146774 · Cited by 3 · see citing works
Rutin prevents memory impairment by reducing brain oxidative stress and fungal burden in a rat model of cryptococcosis
Justen, C. E., Chitolina, A. B. D. M., Finamor, I., Pavanato, M. A., Maurente, M. M., Vieira, I. M., da Veiga, M. L., Saab, E., Tamiosso, R. T., & Baldissera, M. D. (2025) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2025.2538591 · Cited by 3 · see citing works
Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament
Hebda‐Bauer, E. K., Hagenauer, M. H., Munro, D. B., Blandino, P., Meng, F., Arakawa, K., Stead, J. D. H., Chitre, A. S., Ozel, A. B., Mohammadi, P., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1469467 · Cited by 2 · see citing works
Sodium benzoate treatment linked to increased glutathione levels and improved positive and negative symptoms, global function, and quality of life in patients with clozapine-resistant schizophrenia: secondary analysis of a randomized clinical trial
Lin, C., & Lane, H. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.11.010 · Cited by 2 · see citing works
Smoke, GPx activity and symptoms improvement in patients with drug-naive first-episode schizophrenia: A large-scale 12-week follow-up study
Chen, N., Liu, H., Yao, J., Chen, S., Xiu, M., Wu, F., & Zhang, X. (2022) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2022.103267 · Cited by 2 · see citing works
COVID-19 and mental health risks in children: A role for biomarkers of inflammation, stress and the gut-brain axis
Carmichael, D., Prichett, L. M., Kumra, T., Zeng, Y., Young, A. S., Yolken, R. H., & Severance, E. G. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100080 · Cited by 2 · see citing works
Fermented goat milk by selenium‐enriched Lactobacillus paracasei alleviates depressive psychological disturbance
Sun, Y., Zhao, H., Chang, M., Yue, T., Yuan, Y., & Shi, Y. (2024) · Journal of Food Science · doi:10.1111/1750-3841.17167 · Cited by 3 · see citing works
Cognitive impairments in schizophrenia and their impact on oxidative stress
Piatoikina, A. S., Zhilyaeva, T. V., & Mazo, G. E. (2022) · V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY · doi:10.31363/2313-7053-2022-56-3-66-79 · Cited by 1 · see citing works
Smoking, Symptoms Improvement, and Total Antioxidant Capacity in Patients with Drug-naive First-episode Schizophrenia: A Prospective Cohort Study
宋修丽, Xiu, M., Yao, J., Wu, F., Zhang, X., & Zhang, X. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231019105328 · Cited by 1 · see citing works
Short Overview of Oxidative Stress in Mental Disorders
Tan, J. R., & Puşcaş, A. (2023) · Acta Biologica Marisiensis · doi:10.2478/abmj-2023-0013 · Cited by 1 · see citing works
Mendelian randomization analysis of the causal links between immune cells, metabolites, and ectopic pregnancy
Cai, J., & Li, Q. (2025) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2025.114797 · Cited by 1 · see citing works
Plasma neurofilament light chain and regional brain atrophy mediate the association of neuropsychiatric symptoms with cognition in Alzheimer’s disease: evidence from two population-based studies
Wang, Y., Zhu, H.-Y., Miao, W., Wang, Z., Qin, J.-J., Song, X.-H., Wang, Y.-H., Sun, Z.-W., Zhou, X., Yu, X.-F., et al. (2026) · Psychological Medicine · doi:10.1017/s003329172610484x · Cited by 1 · see citing works
A Novel Multi-Supplement Based on Guarana, Selenium, and L-Carnitine Reduces Organ-Specific Oxidative Stress But Not Oxidative Stress-Induced Anxiety
Moretto, J. G., Vargas, J. E., da Silva, J. S., Pasinato, A. Z., Kunz, J. L., Marengo, P., Teixeira, C. F., Azzolin, V. F., da Cruz, I. B. M., Trindade, C., et al. (2024) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-024-00519-6 · Cited by 1 · see citing works
Maternal chromium supplementation improves oxidation resistance, immunity, and intestinal morphology of goat kids injected with lipopolysaccharide
Li, Y., Dai, C., Fang, X., Spears, J. W., Gao, Y., Jiang, F., Shi, H., & Huang, Y. (2024) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2024.08.025 · Cited by 1 · see citing works
Targeting TRP channels for anxiety relief and improving mental health
SZALLASI, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18653-0.00009-5
INTELLIGENT DECISION–MAKING SYSTEMS (IDMS) FOR DETECTION AND RECOGNITION OF ALZHEIMER DISEASE AND PERSISTENCE MONITORING OF PATIENTS
SATHISH, R., & Muthukumar, R. (2024) · Journal of Mechanics in Medicine and Biology · doi:10.1142/s0219519424500428
The role of antioxidant supplementation in neuronal disorders
ShamsEldeen, A. M., Ammar, H. I., Al-Hashem, F. H., Alrefaie, Z. A., Aly, M. H., & Hanna, M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27333-9.00004-x
Reactive oxygen species and psychiatric disorders
Knežević, N. N., Nenic, K., Knezevic, E., & Janković, T. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27333-9.00016-6
Comparative effects of different molecular forms of eicosapentaenoic acid in ameliorating 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease via inhibition of ferroptosis in C57BL/6 mice
Wu, J., Wang, C., Wang, Y., Xue, C., Wang, Y., Zhang, L., Abdelnaby, T., El-Waseif, M., & Zhang, T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108174
Oxidative stress biomarkers across mood episodes in bipolar disorder: potential roles of TrxR1 and PRDX1
Gökçen, O., Karataş, K. S., Akkuş, M., Dönmez, F., Koçak, A., Gündüz, M. K., & Kaymak, G. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08179-7
Anxiety disorders: a cross-sectional study of clinical and biological associations
Fernandes, J. L., Amboni, G., Arent, C. O., Pedro, L. C., Mondo, G. S., Niero, F. S., Pereira, J. G., Bagatini, M. D., Ignácio, Z. M., Ceretta, L. B., et al. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03169-1
Phytochemicals in treatment of neurological diseases
Gök, B., Kurtur, O. B., Cakmakci, N., İNAN, P., Egil, A. C., & Budama‐Kilinc, Y. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-32888-6.00006-2
Effects of Dietary Supplementation with Eucommia ulmoides Extract on Growth Performance, Immune Parameters, and Intestinal Microbiota of Largemouth Bass (Micropterus salmoides)
Huo, R., Gong, H., Cao, L., Tang, D., Chen, Y., Yang, M., & Wei, S. (2026) · Microorganisms · doi:10.3390/microorganisms14081740
Allergic and neuropsychiatric comorbidities: Epidemiological associations, shared pathogenesis, and diagnostic and therapeutic implications
Akhtar, M. H., Akhtar, A., Sun, Y., Yar, M., Sun, Y., & Xia, X. (2026) · Allergy medicine. · doi:10.1016/j.allmed.2026.100128
Antioxidant activity and chemical profile of estuarine gastropods in port-exposed and conservation zones
Rozirwan, R., Fitri, D. N., Khotimah, N. N., Putri, W. A. E., Isnaini, Fauziyah, F., Chaidir, Ulqodry, T. Z., & Nugroho, R. Y. (2026) · Fisheries and aquatic sciences · doi:10.47853/fas.2026.e43
K34 (3,3″-Dihydroxy-6′-desmethyl Terphenyllin) Promotes Hemoglobin-Supported H2O2 Decomposition and Attenuates Neurodegenerative Phenotypes in APP/PS1 Mice with Focal GiD
Park, Y. M., Choi, B.-K., Park, M. G., Kim, M., Won, W., Shin, H. J., & Lee, C. J. (2026) · Antioxidants · doi:10.3390/antiox15101293
Examining the links between vitamin C and schizophrenia spectrum disorders: a systematic review and meta-analysis on circulating levels and supplementation outcomes
Suresh, G., Chengaiyan, J. G., Dabaghzadeh, F., & Ahmad, F. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1965059

Red blood cell nitric oxide levels in patients with schizophrenia
Herken, H., Uz, E., Özyurt, H., & Akyol, Ö. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00169-9 · Cited by 69 · see citing works
[Role of oxidative stress in the pathophysiology of neuropsychiatric disorders].
Nunomura, A., Tamaoki, T., & Motohashi, N. (2014) · PubMed · Cited by 12 · see citing works
Oxidative Stress is a New Avenue for Treatment of Neuropsychiatric Disorders: Hype of Hope?
Negah, S. S., & Forouzanfar, F. (2023) · Current Molecular Medicine · doi:10.2174/1566524023666230904150907 · Cited by 7 · see citing works
Oxidative stress in psychiatric disorders: evidence base and therapeutic implications
Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works
Oxidative/Nitrosative Stress in Psychiatric Disorders: Are We There Yet?
O’Donnell, P., Do, K. Q., & Arango, C. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu048 · Cited by 29 · see citing works

Authors: Cecerska-Heryć, E., Polikowska, A., Serwin, N., Roszak, M., Grygorcewicz, B., Heryć, R., Michalczyk, A., & Dołęgowska, B.
Affiliations: Pomeranian Medical University (PL)
ORCID: Polikowska, Aleksandra
Serwin, Natalia
Roszak, Marta
Grygorcewicz, Bartłomiej
Michalczyk, Anna
Dołęgowska, Barbara
Venue: Neurochemistry International
Publisher: Elsevier BV
Published: 2022-02
Volume: 153
Pages: 105269
ISSN: 0197-0186 (ISSN-L)
DOI: 10.1016/j.neuint.2021.105269
OpenAlex: W4200062926
Cited by: 68
References: 115
Citations by year: 2026: 11 · 2025: 19 · 2024: 15 · 2023: 12 · 2022: 11
FWCI: 0.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurochemistry International (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: oxidative stress, neuropsychiatric disorders, Alzheimer's disease, schizophrenia, depression, bipolar disorder, lipid peroxidation, antioxidant defense, biomarkers, glutathione, thioredoxin, mitochondrial dysfunction, reactive oxygen species, vitamin C, vitamin E, uric acid
MeSH terms: Alzheimer Disease, Antioxidants, Humans, Oxidation-Reduction, Lipid Peroxidation, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Importance of oxidative stress in the pathogenesis, diagnosis, and monitoring of patients with neuropsychiatric disorders, a review

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks