Cited by 142Tryptophan and brain disordersTreatment of Major DepressionAntioxidant Activity and Oxidative Stress

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Oxidative stress markers in affective disorders

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Siwek, Marcin, Sowa-Kućma, Magdalena, Dudek, Dominika, Styczeń, Krzysztof, Szewczyk, Bernadeta, Kotarska, Katarzyna, Misztak, Paulina, Pilc, Agnieszka, Wolak, Małgorzata, Nowak, Gabriel·2013·Pharmacological Reports

DOI 10.1016/s1734-1140(13)71517-2

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Abstract

Affective disorders are a medical condition with a complex biological pattern of etiology, involving genetic and epigenetic factors, along with different environmental stressors. Increasing numbers of studies indicate that induction of oxidative and nitrosative stress (O&NS) pathways, which is accompanied by immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying many major psychiatric disorders, including depression and bipolar disorder. Reactive oxygen and nitrogen species have been shown to impair the brain function by modulating activity of principal neurotransmitter (e.g., glutamatergic) systems involved in the neurobiology of depression. Both preclinical and clinical studies revealed that depression is associated with altered levels of oxidative stress markers and typically reduced concentrations of several endogenous antioxidant compounds, such as glutathione, vitamin E, zinc and coenzyme Q10, or enzymes, including glutathione peroxidase, and with an impairment of the total antioxidant status. These oxidative stress parameters can be normalized by successful antidepressant therapy. On the other hand, some antioxidants (zinc, N-acetylcysteine, omega-3 free fatty acids) may exhibit antidepressant properties or enhance standard antidepressant therapy. These observations introduce new potential targets for the development of therapeutic interventions based on antioxidant compounds. The present paper reviews selected animal and human studies providing evidence that oxidative stress is implicated in the pathophysiology and treatment of depression and bipolar disorder.

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Authors: Siwek, M., Sowa-Kućma, M., Dudek, D., Styczeń, K., Szewczyk, B., Kotarska, K., Misztak, P., Pilc, A., Wolak, M., & Nowak, G.
Affiliations: Jagiellonian University (PL)
Maj Institute of Pharmacology (PL)
Corresponding author: Siwek, Marcin
Sowa-Kućma, Magdalena
ORCID: Siwek, Marcin
Sowa-Kućma, Magdalena
Dudek, Dominika
Styczeń, Krzysztof
Szewczyk, Bernadeta
Kotarska, Katarzyna
Misztak, Paulina
Wolak, Małgorzata
Nowak, Gabriel
Venue: Pharmacological Reports
Publisher: Springer Science and Business Media LLC
Published: 2013-11
Volume: 65
Issue: 6
Pages: 1558-1571
ISSN: 1734-1140 (ISSN-L)
DOI: 10.1016/s1734-1140(13)71517-2
OpenAlex: W2040817682
Cited by: 142
References: 108
Citations by year: 2026: 5 · 2025: 6 · 2024: 17 · 2023: 14 · 2022: 12 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 6 · 2013: 2
FWCI: 0.88
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Reports (publishedVersion)
PubMed (publishedVersion)
Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
BOA (University of Milano-Bicocca) (submittedVersion)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidative stress, nitrosative stress, mood disorders, depression, bipolar disorder, antioxidant biomarkers, glutathione, vitamin E, zinc, coenzyme Q10, glutathione peroxidase, total antioxidant status, reactive oxygen species, reactive nitrogen species, glutamatergic system, immune-inflammatory response, antidepressant treatment, N-acetylcysteine, omega-3 fatty acids, antioxidant therapy
MeSH terms: Animals, Antidepressive Agents, Humans, Biomarkers, Oxidative Stress, Mood Disorders

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