Polymeric micelles for siRNA delivery
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Hydrophilic molecules are mostly loaded by chemical conjugation with the unimers, or via electrostatic interactions by using polyion complex micelles.
“Actually, hydrophilic molecules are mostly loaded by chemical conjugation with the unimers, or via electrostatic interactions by using polyion complex micelles.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [111]
RNA is generally loaded through the incorporation of polycations in the structure of amphiphilic block copolymers and then used for RNA condensation.
“For instance, RNA is generally loaded through the incorporation of polycations in the structure of amphiphilic block copolymers and then used for RNA condensation [111,112].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [111]
Drug localization inside polymeric micelles depends on polarity: hydrophobic APIs are solubilized in the lipophilic core, molecules with intermediate polarity are located in an intermediate position, and highly hydrophilic molecules are located on the surface.
“Thus, drug localization inside the micelles depends on their polarity: hydrophobic APIs will be solubilized in the micellar lipophilic core while molecules with intermediate polarity or highly hydrophilic will be located respectively in an intermediate position or on the surface of the system [109,110].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [110]
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Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
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Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works
Polymeric micelles in mucosal drug delivery: challenges towards clinical translation
Sosnik, A., & Menaker Raskin, M. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.01.003 · Cited by 154 · see citing works
- Authors
- Falamarzian, A., Xiong, X.-B., Uludag, H., & Lavasanifar, A.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Lavasanifar, A.
- Venue
- Journal of Drug Delivery Science and Technology
- Publisher
- Elsevier BV
- Published
- 2012
- Volume
- 22
- Issue
- 1
- Pages
- 43-54
- ISSN
- 1773-2247 (ISSN-L)
- OpenAlex
- W2004021625
- Cited by
- 25
- References
- 105
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Drug Delivery Science and Technology (publishedVersion)
- Funders
- Cancer Research Institute
- Alberta Cancer Foundation
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- polymeric micelles, siRNA delivery, siRNA, post-transcriptional gene silencing, siRNA chemical modification, targeted gene silencing, siRNA carriers, systemic drug delivery, off-target effects, immunogenicity, siRNA stability
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