Cited by 876Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesOral microbiology and periodontitis research

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Obesity, inflammation, and the gut microbiota

Cox, Amanda J, West, Nicholas P, Cripps, Allan W·2015·The Lancet Diabetes & Endocrinology

DOI 10.1016/s2213-8587(14)70134-2

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Abstract

As the prevalence of obesity and associated disease continues to rise and concerns for the spiralling economic and social costs also escalate, innovative management strategies beyond primary prevention and traditional lifestyle interventions are urgently needed. The biological basis of disease is one avenue for further exploration in this context. Several key inflammatory markers have been consistently associated with both obesity and risk of adverse outcomes in obesity-associated diseases, which suggests that a persistent, low-grade, inflammatory response is a potentially modifiable risk factor. In this Review, we provide evidence supporting perturbation of the intestinal microbiota and changes in intestinal permeability as potential triggers of inflammation in obesity. Further characterisation of the mechanisms underpinning the triggers of such inflammatory responses in overweight and obese individuals could offer unique opportunities for intervention strategies to help ameliorate the risk of obesity-associated disease.

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Authors: Cox, A. J., West, N. P., & Cripps, A. W.
Affiliations: Griffith University (AU)
Corresponding author: Cox, Amanda J
ORCID: Cox, Amanda J
West, Nicholas P
Cripps, Allan W
Venue: The Lancet Diabetes & Endocrinology
Publisher: Elsevier BV
Published: 2015-03
Volume: 3
Issue: 3
Pages: 207-215
ISSN: 2213-8587 (ISSN-L)
DOI: 10.1016/s2213-8587(14)70134-2
OpenAlex: W1996175687
Cited by: 869
References: 106
Citations by year: 2026: 41 · 2025: 77 · 2024: 115 · 2023: 105 · 2022: 103 · 2021: 99 · 2020: 96 · 2019: 77 · 2018: 50 · 2017: 37 · 2016: 31 · 2015: 33
FWCI: 3.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet Diabetes & Endocrinology (publishedVersion)
PubMed (publishedVersion)
Griffith Research Online (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: obesity, inflammation, gut microbiota, intestinal permeability, low-grade inflammation, obesity-related comorbidities, overweight, inflammatory markers
MeSH terms: Humans, Inflammation, Models, Biological, Obesity, Permeability, Biomarkers, Prevalence, Gastrointestinal Tract, Microbiota

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