Hippocampus atrophy and the longitudinal course of late-life depression

Taylor, Warren D.; McQuoid, Douglas R.; Payne, Martha E.; Zannas, Anthony S.; MacFall, James R.; Steffens, David C.

doi:10.1016/j.jagp.2013.11.004

Cited by 134Treatment of Major DepressionStress Responses and CortisolDementia and Cognitive Impairment Research

Hippocampus atrophy and the longitudinal course of late-life depression

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Taylor, Warren D., McQuoid, Douglas R., Payne, Martha E., Zannas, Anthony S., MacFall, James R., Steffens, David C.·2014·The American Journal of Geriatric Psychiatry

DOI 10.1016/j.jagp.2013.11.004PMC PMC4031313

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Abstract

Objectives Smaller hippocampal volumes are observed in depression but it remains unclear how antidepressant response and persistent depression relate to changes in hippocampal volume. We examined the longitudinal relationship between hippocampal atrophy and course of late-life depression.Setting Academic medical center.Participants Depressed and never-depressed cognitively intact subjects age 60 years or older.Measurements Depression severity was measured every three months with the Montgomery-Asberg Depression Rating Scale (MADRS). Participants also completed cranial 1.5-T magnetic resonance imaging every 2 years. We compared 2-year change in hippocampal volume based on remission status, then in expanded analyses examined how hippocampal volumes predicted MADRS score.Results In analyses of 92 depressed and 70 never-depressed subjects, over 2 years the cohort whose depression never remitted exhibited greater hippocampal atrophy than the never-depressed cohort. In expanded analyses of a broader sample of 152 depressed elders, depression severity was significantly predicted by a hippocampus × time interaction where smaller hippocampus volumes over time were associated with greater depression severity.Conclusions Hippocampal atrophy is associated with greater and persistent depression severity. Neuropathological studies are needed to determine if this atrophy is related to the toxic effects of persistent depression or related to underlying Alzheimer disease.

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Longitudinal studies show that hippocampal and medial prefrontal cortex volume loss is greater when depressive symptoms fail to remit.
“longitudinal work has shown that hippocampal and mPFC volume reductions become more pronounced when depressive symptoms do not remit (35,38).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [35]
Smaller hippocampal and medial prefrontal cortex volumes are consistently linked to non-remission or treatment resistance in major depressive disorder.
“and non-remission/treatment resistance (28,31–38).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [35]

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Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression
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Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression
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A Cross Sectional Examination of the Relation Between Depression and Frequency of Leisure Time Physical Exercise among the Elderly in Jinan, China
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Cognitive behavioral therapy for patients with mild to moderate depression: Treatment effects and neural mechanisms
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Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression
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A Systematic Analysis on the Genes and Their Interaction Underlying the Comorbidity of Alzheimer's Disease and Major Depressive Disorder
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Depression and Mild Cognitive Impairment in the General Population: Results of the Heinz Nixdorf Recall Study
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Deficits in Regional Cerebral Blood Flow on Brain SPECT Predict Treatment Resistant Depression
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Hippocampal subregion volume in high-risk offspring is associated with increases in depressive symptoms across the transition to adolescence
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Do Unremitted Psychotic Symptoms Have an Effect on the Brain? A 2-Year Follow-up Imaging Study in First-Episode Psychosis
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Stopping Cognitive Decline in Patients With Late-Life Depression: A New Front in the Fight Against Dementia
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Neurological Changes and Depression
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Human adult hippocampal neurogenesis in health and disease
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Lack of a Role for Alzheimer’s Disease Pathology in Late-Life Depression, or Just No Relationship With Amyloid?
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The association between depressive symptoms with fear of falling and cognitive decline in older adults in the Korean community: An analysis of the Korean Longitudinal Study of Aging (KLoSA), 2006–2020
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Brain Structural Abnormalities of Major Depressive Disorder
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Does depression in mid-life predispose to greater cognitive decline in later life in the Whitehall II cohort?
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Depression and dementia: differentiation and comorbidity
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Causal effect of three autoimmune diseases on brain functional networks and cerebrospinal fluid metabolites to underlie the pathogenesis of autoimmune psychosis: a two-sample mendelian randomization analysis
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Cognitive Functioning in Late-life Depression: A Critical Review of Sociodemographic, Neurobiological, and Treatment Correlates
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Depression and Pseudodementia: Decoding the Intricate Bonds in an Italian Outpatient Setting
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Hippocampal Atrophy and Subsequent Depressive Symptoms in Older Men and Women: Results From a 10-Year Prospective Cohort
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Change in Hippocampal Volume on Magnetic Resonance Imaging and Cognitive Decline Among Older Depressed and Nondepressed Subjects in the Neurocognitive Outcomes of Depression in the Elderly Study
Steffens, D. C., McQuoid, D. R., Payne, M. E., & Potter, G. G. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181d6c245 · Cited by 125 · see citing works
Self-citation
A Study of the Bidirectional Association Between Hippocampal Volume on Magnetic Resonance Imaging and Depression in the Elderly
den Heijer, T., Tiemeier, H. W., Luijendijk, H. J., van der Lijn, F., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.04.014 · Cited by 56 · see citing works
Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults
Brown, E. S., Hughes, C. W., McColl, R. W., Peshock, R. M., King, K. S., & Rush, A. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.271 · Cited by 68 · see citing works
Longitudinal changes in hippocampal volumes and cognition in remitted geriatric depressive disorder
Hou, Z., Yuan, Y., Zhang, Z., Bai, F., Hou, G., & You, J. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.025 · Cited by 39 · see citing works

Authors: Taylor, W. D., McQuoid, D. R., Payne, M. E., Zannas, A. S., MacFall, J. R., & Steffens, D. C.
Affiliations: Vanderbilt University Medical Center (US)
Duke Medical Center (US)
UConn Health (US)
Corresponding author: Taylor, Warren D.
ORCID: Taylor, Warren D.
Zannas, Anthony S.
MacFall, James R.
Steffens, David C.
Venue: The American Journal of Geriatric Psychiatry
Publisher: Elsevier BV
Published: 2014-12
Volume: 22
Issue: 12
Pages: 1504-1512
ISSN: 1064-7481 (ISSN-L)
DOI: 10.1016/j.jagp.2013.11.004
PMC: PMC4031313
OpenAlex: W2013004783
Cited by: 134
References: 56
Citations by year: 2026: 9 · 2025: 14 · 2024: 4 · 2023: 9 · 2022: 13 · 2021: 15 · 2020: 16 · 2019: 8 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 5 · 2014: 1
FWCI: 4.66
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal of Geriatric Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: NIMH (R01 MH077745, R01 MH054846, K24 MH070027, P50 MH60451)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: hippocampal atrophy, geriatric depression, dysthymia, remission, hippocampal volume, depression severity, longitudinal course, older adults, antidepressant response, Alzheimer's disease
MeSH terms: Aged, Aged, 80 and over, Antidepressive Agents, Atrophy, Depressive Disorder, Major, Major Depressive Disorder, Female, Hippocampus, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Recurrence, Remission Induction, Severity of Illness Index, Disease Progression

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Hippocampus atrophy and the longitudinal course of late-life depression

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