Pan-resistant Candida auris: New York subcluster susceptible to antifungal combinations
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Abstract
Abstract Four pan-resistant Candia auris strains from New York outbreak were 100% inhibited in vitro by combinations of two antifungal drugs using fixed concentrations achievable in vivo . Pan-resistant C. auris strains have mutations in eleven gene targets associated with major antifungal drugs, and constituted a distinct sub-cluster among NY strains.
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Some Candida auris isolates are pan-drug-resistant, tolerating all available antifungal drugs.
“Recently, some C. auris isolates were classified as pan-drug-resistant, tolerating all available antifungal drugs [12,13].”
From Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i> (2024) · cites this paper as [12]
Antifungal combination therapy has potential to treat multidrug- and pandrug-resistant C. auris, as previously reported.
“The potential of antifungal combination therapy to treat multidrug- and pandrug-resistant C. auris has been previously reported [12].”
From Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i> (2024) · cites this paper as [12]
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Cites
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Tyers, M., & Wright, G. D. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0141-x · Cited by 825 · see citing works
Chow, N. A., Muñoz, J. F., Gade, L., Berkow, E., Li, X., Welsh, R. M., Forsberg, K., Lockhart, S. R., Adam, R., Alanio, A., et al. (2020) · doi:10.1101/2020.01.06.896548 · Cited by 463 · see citing works
Candida auris Isolates Resistant to Three Classes of Antifungal Medications — New York, 2019
Ostrowsky, B. E., Greenko, J. A., Adams, E. H., Quinn, M., O’Brien, B., Chaturvedi, V. P., Berkow, E. L., Vallabhaneni, S., Forsberg, K., Chaturvedi, S., et al. (2020) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6901a2 · Cited by 247 · see citing works
Self-citationGenomic epidemiology of the UK outbreak of the emerging human fungal pathogen <i>Candida auris</i>
Rhodes, J., Abdolrasouli, A., Farrer, R. A., Cuomo, C. A., Aanensen, D. M., Armstrong-James, D., Fisher, M. C., & Schelenz, S. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0045-x · Cited by 246 · see citing works
Zhu, Y., O’Brien, B., Leach, L., Clark, A., Bates, M., Adams, E. H., Ostrowsky, B. E., Quinn, M., Dufort, E. M., Southwick, K. L., et al. (2019) · Journal of Clinical Microbiology · doi:10.1128/jcm.01503-19 · Cited by 166 · see citing works
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Carolus, H., Pierson, S., Muñoz, J. F., Subotić, A., Cruz, R. B., Cuomo, C. A., & Van Dijck, P. (2021) · mBio · doi:10.1128/mbio.03333-20 · Cited by 211 · see citing works
Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents
Jacobs, S. E., Jacobs, J. L., Dennis, E. K., Taimur, S., Rana, M., Patel, D., Gitman, M., Patel, G., Schaefer, S., Iyer, K., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00053-22 · Cited by 190 · see citing works
Self-citationLyman, M., Forsberg, K., Reuben, J., Dang, T., Free, R., Seagle, E. E., Sexton, D. J., Soda, E., Jones, H., Hawkins, D., et al. (2021) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7029a2 · Cited by 104 · see citing works
Burrack, L. S., Todd, R. T., Soisangwan, N., Wiederhold, N. P., & Selmecki, A. (2022) · mBio · doi:10.1128/mbio.00842-22 · Cited by 82 · see citing works
Salama, E. A., Elgammal, Y., Wijeratne, A., Lanman, N. A., Utturkar, S. M., Farhangian, A., Li, J., Meunier, B., Hazbun, T. R., & Seleem, M. N. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2322649 · Cited by 16 · see citing works
- Authors
- O'Brien, B., Liang, J., Chaturvedi, S., Jacobs, J. L., & Chaturvedi, V.
- Affiliations
- New York State Department of Health (US)
- Corresponding author
- Chaturvedi, Vishnu
- Venue
- The Lancet Microbe
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 1
- Issue
- 5
- Pages
- e193-e194
- ISSN
- 2666-5247 (ISSN-L)
- OpenAlex
- W3047505143
- Cited by
- 60
- References
- 5
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 17 · 2023: 9 · 2022: 7 · 2021: 3 · 2020: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Lancet Microbe (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- U.S. Department of Health and Human Services (NU50CK000516)
- New York State Department of Health
- New York State Department of Health - Wadsworth Center
- Centers for Disease Control and Prevention (NU50CK000516)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida auris, pan-drug resistance, combination antifungal therapy, 5-fluorocytosine, amphotericin B, echinocandins, azoles, time-kill kinetics, fungicidal activity, antifungal susceptibility, multidrug resistance, antifungal resistance surveillance, New York Hospital, antifungal resistance
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