Candida auris Pan-Drug-Resistant to Four Classes of Antifungal Agents
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Candida auris is an urgent antimicrobial resistance threat due to its global emergence, high mortality, and persistent transmissions. Nearly half of C. auris clinical and surveillance cases in the United States are from the New York and New Jersey Metropolitan area.
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A recent study highlighted pan-drug-resistant isolates that do not respond to combination therapy.
“However, a recent study highlighted the alarming problem of pan-drug-resistant isolates that do not respond to combination therapy [55].”
From Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i> (2024) · cites this paper as [55]
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“…spp., upregulation of the efflux transporter genes CDR1 , MDR1 and mutations in transcriptional factor TAC1B and in the genes ERG11 and ERG3 [82,84–87], which result in for example, primary sequence changes Y132F and R398I in C. parapsilosis lanosterol 14 α -demethylase [85], have been…”
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- Authors
- Jacobs, S. E., Jacobs, J. L., Dennis, E. K., Taimur, S., Rana, M., Patel, D., Gitman, M., Patel, G., Schaefer, S., Iyer, K., Moon, J., Adams, V., Lerner, P., Walsh, T. J., Zhu, Y., Anower, M. R., Vaidya, M. M., Chaturvedi, S., & Chaturvedi, V.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- American Type Culture Collection (US)
- New York State Department of Health (US)
- Mount Sinai Hospital (US)
- Cornell University (US)
- Wadsworth Center New York State Department of Health, Albany, New York, USA
- Corresponding author
- Chaturvedi, Vishnu
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2022-07-19
- Volume
- 66
- Issue
- 7
- Pages
- e0005322-e0005322
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC9295560
- OpenAlex
- W4283727654
- Cited by
- 190
- References
- 58
- Citations by year
- 2026: 46 · 2025: 64 · 2024: 47 · 2023: 30 · 2022: 3
- FWCI
- 17.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | Centers for Disease Control and Prevention (NU50CK000423)
- HHS | National Institutes of Health (1R21AI156573-01A1)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida auris, pan-drug resistance, antifungal resistance, amphotericin B resistance, non-synonymous mutations, SNP phylogeny
- MeSH terms
- Candida auris, Antifungal Agents, Humans, Microbial Sensitivity Tests, Phylogeny, Drug Resistance, Fungal
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