Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety
Open accessAbstract
Weight gain and risk of type 2 diabetes are inversely associated with a high intake of insoluble cereal fibres. Because nutrient-induced changes of ‘satiety hormones’ from the gut may play a role in this process, we evaluated the effects of purified insoluble fibres on postprandial responses of plasma peptide YY (PYY), serum ghrelin and satiety as secondary outcome measures of a study investigating effects of cereal fibres on parameters of glucose metabolism. Fourteen healthy women were studied on six occasions in a randomized, single-blind, controlled crossover design. After 24 h run-in periods and 10 h overnight fasts, subjects ingested isoenergetic and macronutrient matched portions of control white bread or fibre-enriched bread (wheat-fibre or oat-fibre) at 08.15 hours. Gut hormones and hunger scores were measured for 300 min. Basal PYY and ghrelin concentrations were not different between the test meals (P>0·15). Postprandial responses of PYY and ghrelin were blunted after the intake of wheat-fibre (total area under the curve (AUC) PYY, 177·9 (sem 8·1) (pmol/l) min; P=0·016; ghrelin 51·0 (sem 2·5) (pmol/l) min; P=0·003), but not after oat-fibre (PYY 226·7 (sem 25·7) (pmol/l) min; P>0·15; ghrelin 46·2 (sem 1·6) (pmol/l) min; P=0·127), compared to control (PYY 247·5 (sem 25·6) (pmol/l) min; ghrelin 42·5 (sem 1·3) (pmol/l) min). Postprandial hunger scores were unaffected by the different test meals (P>0·15). Thus, oat- and wheat-fibre consumption result in different postprandial responses of PYY and ghrelin, but interestingly do not differ in satiety effects.
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Cites
Inhibition of Food Intake in Obese Subjects by Peptide YY <sub>3–36</sub>
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works
Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion.
Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M. S., Tanaka, M., Nozoe, S., Hosoda, H., Kangawa, K., & Matsukura, S. (2002) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.87.1.8129 · Cited by 1,390 · see citing works
Human distribution and release of a putative new gut hormone, peptide YY
Adrian, T. E., Ferri, G., Bacarese-Hamilton, A. J., Fuessl, H. S., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90211-2 · Cited by 1,064 · see citing works
Cummings, D. E., Frayo, R. S., Marmonier, C., Aubert, R., & Chapelot, D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00582.2003 · Cited by 528 · see citing works
A satiety index of common foods.
Holt, S., Miller, J. C., Petocz, P., & Farmakalidis, E. (1995) · PubMed · Cited by 498 · see citing works
The influence of insulin on circulating ghrelin
Flanagan, D., Evans, M. L., Monsod, T. P., Rife, F., Heptulla, R. A., Tamborlane, W. V., & Sherwin, R. S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00569.2001 · Cited by 367 · see citing works
Jenkins, D. J. A., Kendall, C. W. C., Axelsen, M., Augustin, L. S. A., & Vuksan, V. V. V. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200002000-00008 · Cited by 315 · see citing works
GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans
Näslund, E. B., Bogefors, J., Skogar, S., Grybäck, P., Jacobsson, H., Holst, J. J., & Hellström, P. M. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.3.r910 · Cited by 286 · see citing works
Self-citationGut hormones in the control of appetite
Murphy, K. G., & Bloom, S. R. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2004.027789 · Cited by 251 · see citing works
Akamizu, T., Takaya, K., Irako, T., Hosoda, H., Teramukai, S., Matsuyama, A., Tada, H., Miura, K., Shimizu, A., Fukushima, M., et al. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500447 · Cited by 231 · see citing works
Erdmann, J., Töpsch, R., Lippl, F., Gussmann, P., & SCHUSDZIARRA, V. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031610 · Cited by 220 · see citing works
Insulin, Unlike Food Intake, Does Not Suppress Ghrelin in Human Subjects
Caixàs, A., Bashore, C. J., Nash, W., Pi‐Sunyer, F. X., & Laferrère, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8538 · Cited by 211 · see citing works
Role of the Duodenum and Macronutrient Type in Ghrelin Regulation
Overduin, J., Frayo, R. S., Grill, H. J., Kaplan, J. M., & Cummings, D. E. (2004) · Endocrinology · doi:10.1210/en.2004-0609 · Cited by 208 · see citing works
Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin
Schaller, G., Schmidt, A., Pleiner, J., Woloszczuk, W., Wolzt, M., & Luger, A. (2003) · Diabetes · doi:10.2337/diabetes.52.1.16 · Cited by 205 · see citing works
Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans
Möhlig, M., Spranger, J., Otto, B., Ristow, M., Tschöp, M., & Pfeiffer, A. F. H. (2002) · Journal of Endocrinological Investigation · doi:10.1007/bf03344062 · Cited by 196 · see citing works
Self-citationImpact of cereal fibre on glucose-regulating factors
Weickert, M. O., Mohlig, M., Koebnick, C., Holst, J. J., Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1941-x · Cited by 194 · see citing works
Self-citationPeripheral administration of PYY3–36 produces conditioned taste aversion in mice
Halatchev, I. G., & Cone, R. D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.003 · Cited by 186 · see citing works
Pedersen‐Bjergaard, U., Høt, U., Kelbæk, H., Schifter, S., Rehfeld, J. F., Faber, J. O., & Christensen, N. J. (1996) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519609088805 · Cited by 136 · see citing works
Gut hormones and the control of appetite
SMALL, C., & Bloom, S. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.06.002 · Cited by 118 · see citing works
Effects of Modified Sham Feeding on Ghrelin Levels in Healthy Human Subjects
Arosio, M., Ronchi, C. L., Beck‐Peccoz, P., Gebbia, C., Giavoli, C., Cappiello, V., Conte, D., & PERACCHI, M. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032222 · Cited by 106 · see citing works
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The Health Benefits of Dietary Fibre
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2020) · Nutrients · doi:10.3390/nu12103209 · Cited by 892 · see citing works
Self-citationMetabolic effects of dietary fiber consumption and prevention of diabetes
Weickert, M. O., & Pfeiffer, A. F. H. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.3.439 · Cited by 683 · see citing works
Self-citationThe effect of fiber on satiety and food intake: a systematic review
Clark, M. J., & Slavin, J. L. (2013) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.791194 · Cited by 368 · see citing works
Isken, F., Klaus, S., Osterhoff, M., Pfeiffer, A. F. H., & Weickert, M. O. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.12.012 · Cited by 201 · see citing works
Self-citationGruendel, S., Otto, B., Garcia, A. L., Wagner, K., Mueller, C., Weickert, M. O., Heldwein, W., & Koebnick, C. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507701642 · Cited by 59 · see citing works
Self-citationLiu, L.-K., Chen, L.-Y., Yeh, K.-P., Lin, M.-H., Hwang, A.-C., Peng, L.-N., & Chen, L.-K. (2014) · Journal of Clinical Gerontology and Geriatrics · doi:10.1016/j.jcgg.2014.01.002 · Cited by 26 · see citing works
Blundell, J. E., Finlayson, G., & Halford, J. C. G. (2009) · Clinical Obesity in Adults and Children · doi:10.1002/9781444307627.ch11 · Cited by 1 · see citing works
- Authors
- Weickert, M. O., Spranger, J., Holst, J. J., Otto, B., Koebnick, C., Möhlig, M., & Pfeiffer, A. F. H.
- Affiliations
- German Institute of Human Nutrition (DE)
- University of Copenhagen (DK)
- University of Southern California (US)
- Corresponding author
- Weickert, Martin O.
- ORCID
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2006-11
- Volume
- 96
- Issue
- 5
- Pages
- 795-798
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W1992478202
- Semantic Scholar
- 4be79550e8cf0bbdb12215f96ffa8b8ebcb53479
- Cited by
- 111
- References
- 20
- Citations by year
- 2025: 2 · 2023: 3 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 10
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- wheat fiber, oat fiber, insoluble dietary fiber, peptide YY, ghrelin, satiety, postprandial hormone response, hunger, type 2 diabetes risk, weight gain
- MeSH terms
- Bread, Dietary Fiber, Female, Humans, Hunger, Satiety Response, Triticum, Single-Blind Method, Avena, Cross-Over Studies, Postprandial Period, Peptide YY, Peptide Hormones, Ghrelin
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