The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders
Open accessAbstract
A comparative, randomised, double-blind trial was performed in the medical departments of five hospitals to study the effects of regular consumption of short-chain fructo-oligosaccharides (sc-FOS) on the digestive comfort of subjects with minor functional bowel disorders (FBD). In step 1, 2235 subjects were questioned to assess the incidence and intensity of digestive disorders. In step 2, 105 of these patients diagnosed with minor FBD were randomised into two groups to receive either 5 g sc-FOS or 5 g placebo (sucrose and maltodextrins) per d over a 6-week period. The incidence and intensity of digestive disorders were assessed at the end of the treatment period (day 43) using the step 1 questionnaires. A quality-of-life questionnaire was also completed at the start and end of the treatment period to assess potential effects on well-being and social performance. In step 1, 44 % of the subjects questioned presented FBD, of whom 57·1 % suffered from minor FBD. In step 2, on day 43, the intensity of digestive disorders decreased by 43·6 % in the sc-FOS group v. a 13·8 % increase in the placebo group (P = 0·026). Symptoms were experienced less frequently by 75·0 % of subjects in the sc-FOS group, while 53·8 % of controls experienced no change (P = 0·064). Using the functional digestive disorders quality of life questionnaire, the discomfort item scores increased in the sc-FOS group (P = 0·031). However, expressed as change in quality of life (improvement, worsening or unchanged), daily activities were significantly improved in the sc-FOS group (P = 0.022). Regular consumption of sc-FOS may improve digestive comfort in a working population not undergoing medical treatment.
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FOS ameliorated symptoms in IBS.
“with FOS ameliorating symptoms [268]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [268]
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Cites
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440 · see citing works
The functional gastrointestinal disorders and the Rome III process
Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416 · see citing works
Drossman, D. A., Li, Z., Andruzzi, E., Temple, R. D., Talley, N. J., Grant Thompson, W., Whitehead, W. E., Janssens, J., Funch-Jensen, P., Corazziari, E., et al. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303162 · Cited by 2,198 · see citing works
Generic and Disease-Specific Measures in Assessing Health Status and Quality of Life
Patrick, D. L., & Deyo, R. A. (1989) · Medical Care · doi:10.1097/00005650-198903001-00018 · Cited by 1,779 · see citing works
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,325 · see citing works
Self-citationEffects of Fructooligosaccharides on Intestinal Flora and Human Health
Hidaka, H., Eida, T., Takizawa, T., Tokunaga, T., & TASHIRO, Y. (1986) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.5.1_37 · Cited by 598 · see citing works
Lindsay, J. O. (2006) · Gut · doi:10.1136/gut.2005.074971 · Cited by 471 · see citing works
Drossman, D. A. (1994) · Medical Entomology and Zoology · Cited by 470 · see citing works
Medical costs in community subjects with irritable bowel syndrome
Talley, N. J., Gabriel, S. E., Harmsen, W. S., Zinsmeister, A. R., & Evans, R. W. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90738-6 · Cited by 460 · see citing works
Bouhnik, Y., Raskine, L., Simoneau, G., Vicaut, É., Neut, C., Flourié, B., Brouns, F. J. P. H., & Bornet, F. R. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1658 · Cited by 402 · see citing works
Self-citationBouhnik, Y., Vahedi, K., Achour, L., Attar, A., Salfati, J., Pochart, P., Marteau, P. R., Flourié, B., Bornet, F. R. J., & Rambaud, J. (1999) · Journal of Nutrition · doi:10.1093/jn/129.1.113 · Cited by 384 · see citing works
Self-citationChang, L., Toner, B. B., Fukudo, S., Guthrie, E., Locke, G. R., Norton, N. J., & Sperber, A. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.09.071 · Cited by 374 · see citing works
Gastrointestinal tract symptoms and self-reported abuse: A population-based study
Talley, N. J., Fett, S. L., ZINSMEISTER, A. R., & Melton, L. J. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90228-3 · Cited by 355 · see citing works
The functional gastrointestinal disorders and the Rome II process
Drossman, D. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii1 · Cited by 313 · see citing works
Irritable Bowel Syndrome, Health Care Use, and Costs: A U.S. Managed Care Perspective
Longstreth, G. F., Wilson, A., Knight, K., Wong, J. B., Chiou, C. F., Barghout, V. E., Frech, F. H., & Ofman, J. J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07296.x · Cited by 294 · see citing works
Buddington, R. K., Williams, C., Chen, S., & Witherly, S. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.5.709 · Cited by 292 · see citing works
Review article: irritable bowel syndrome
Camilleri, M., & Choi, M. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.84256000.x · Cited by 287 · see citing works
Costs of Irritable Bowel Syndrome in the UK and US
Maxion‐Bergemann, S., Thielecke, F., Abel, F., & Bergemann, R. (2006) · PharmacoEconomics · doi:10.2165/00019053-200624010-00002 · Cited by 261 · see citing works
Oral butyrate for mildly to moderately active Crohn's disease
Sabatino, A. D., Morera, R., Ciccocioppo, R., Cazzola, P., GOTTI, S., Tinozzi, F. P., Tinozzi, S., & Corazza, G. R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02639.x · Cited by 245 · see citing works
Rumessen, J. J., & Gudmand-Höyer, E. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80016-7 · Cited by 241 · see citing works
Digestion, excretion, and energy value of fructooligosaccharides in healthy humans
Molis, C., Flourié, B., Ouarné, F., Gailing, M., Lartigue, S., Guibert, A., Bornet, F. R. J., & Jp, G. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.3.324 · Cited by 230 · see citing works
Self-citationIntestinal microecology and quality of life in irritable bowel syndrome patients
Si, J.-M. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i12.1802 · Cited by 218 · cited 1× · see citing works
“Contrary to previous studies 2,27–30 , a specific quality-of-life questionnaire devoted to functional digestive disorders was used to assess each patient’s own evaluation of his or her health status 25 .”
MethodSpiller, R. E. (2000) · Gut · doi:10.1136/gut.46.5.741b · Cited by 197 · see citing works
Irritable bowel syndrome in developing countries – a disorder of civilization or colonization?
Gwee, K. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00627.x · Cited by 193 · see citing works
Validation of a specific quality of life questionnaire for functional digestive disorders
Chassany, O., Marquis, P., Scherrer, B., Read, N. W., Finger, T., Bergmann, J. F., Fraitag, B., Geneve, J., & Caulin, C. (1999) · Gut · doi:10.1136/gut.44.4.527 · Cited by 180 · see citing works
Sainsbury, A., & Heatley, R. V. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02380.x · Cited by 160 · see citing works
NYMAN, M. E. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002533 · Cited by 158 · see citing works
Short‐chain fatty acid content and pH in caecum of rats given various sources of carbohydrates
Berggren, A., Björck, I., NYMAN, M. E., & Eggum, B. O. (1993) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740630405 · Cited by 157 · see citing works
Effects of Short-Chain Fatty Acids on Gastrointestinal Motility.
Cherbut, C., Aubé, A., Blottière, H., & Galmiche, J. (1997) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1997.11720720 · Cited by 155 · see citing works
Self-citationImpact of functional dyspepsia on quality of life
Talley, N. J., Weaver, A. L., & Zinsmeister, A. R. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064375 · Cited by 146 · see citing works
Irritable bowel syndrome: the view from general practice
Thompson, G. W., Heaton, K. W., Smyth, T. G., & Smyth, C. (1997) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199707000-00008 · Cited by 145 · see citing works
Bouhnik, Y., Raskine, L., Simoneau, G., Paineau, D., & Bornet, F. R. J. (2006) · Nutrition Journal · doi:10.1186/1475-2891-5-8 · Cited by 142 · see citing works
Self-citationImpact of irritable bowel syndrome (IBS) on health-related quality of life (HRQOL)
Amouretti, M., Le Pen, C., Gaudin, A.-F., Bommelaer, G., Frexinos, J., Ruszniewski, P., Poynard, T., Maurel, F., Priol, G., & El Hasnaoui, A. (2006) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(06)73160-8 · Cited by 110 · see citing works
Reasons for consultation in irritable bowel syndrome: symptoms and patient characteristics.
Kettell, J., Jones, R. H., & LYDEARD, S. (1992) · Europe PMC (PubMed Central) · Cited by 109 · see citing works
Briet, F., Achour, L., Flourié, B., et al. (1995) · PubMed · Cited by 108 · see citing works
Factors of importance when evaluating quality of life in clinical trials
Wiklund, I. E., Dimenäs, E., & Wahl, M. (1990) · Controlled Clinical Trials · doi:10.1016/0197-2456(90)90011-p · Cited by 97 · see citing works
[Descriptive study of digestive functional symptoms in the French general population].
Frexinos, J., Denis, P., Allemand, H., et al. (1998) · PubMed · Cited by 82 · see citing works
Performance of the EQ-5D in Patients with Irritable Bowel Syndrome
Bushnell, D. M., Martin, M. L., Ricci, J.-F., & Bracco, A. (2006) · Value in Health · doi:10.1111/j.1524-4733.2006.00086.x · Cited by 71 · see citing works
Quality of life in managed care patients with irritable bowel syndrome.
Wilson, A., Longstreth, G. F., Knight, K. K., Wong, J. B., Wade, S. W., Chiou, C., Barghout, V. E., Frech, F. H., & Ofman, J. J. (2004) · PubMed · Cited by 55 · see citing works
In vitro contractile effects of short chain fatty acids in the rat terminal ileum.
Cherbut, C., Aubé, A.-C., Blottière, H. M., et al. (1996) · Gut · doi:10.1136/gut.38.1.53 · Cited by 46 · see citing works
Stimulation of ileal emptying by short-chain fatty acids
Fich, A., Phillips, S. F., Hakim, N. S., Brown, M. L., & Zinsmeister, A. R. (1989) · Digestive Diseases and Sciences · doi:10.1007/bf01537103 · Cited by 26 · see citing works
Quality of Life in Upper Gastrointestinal Disorders
Wilhelmsen, I. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509090288 · Cited by 22 · see citing works
Dapoigny, M. C., Dyard, F., Jc, G., et al. (2003) · PubMed · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary fibre in gastrointestinal health and disease
Gill, S. K., Rossi, M., Bajka, B., & Whelan, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00375-4 · Cited by 979 · see citing works
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320 · see citing works
Prebiotics, immune function, infection and inflammation: a review of the evidence
Lomax, A. R., & Calder, P. C. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508055608 · Cited by 257 · see citing works
The intestinal microbiome, probiotics and prebiotics in neurogastroenterology
Saulnier, D. M., Ringel, Y., Heyman, M. B., Foster, J. A., Bercik, P., Shulman, R. J., Versalovic, J., Verdu, E. F., Dinan, T. G., Hecht, G., et al. (2013) · Gut Microbes · doi:10.4161/gmic.22973 · Cited by 248 · see citing works
World Gastroenterology Organisation Global Guidelines: Probiotics and Prebiotics
Guarner, F., Sanders, M. E., Szajewska, H., Cohen, H., Eliakim, R., Herrera-deGuise, C., Karakan, T., Merenstein, D., Piscoya, A., Ramakrishna, B., et al. (2024) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000002002 · Cited by 209 · see citing works
Immunological properties of inulin-type fructans
Vogt, L., Meyer, D., Pullens, G., Faas, M., Smelt, M., Venema, K., Ramasamy, U., Schols, H. A., & De Vos, P. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.656772 · Cited by 195 · see citing works
Parkes, G. C., Brostoff, J., Whelan, K., & Sanderson, J. D. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01869.x · Cited by 167 · see citing works
The gut microbiome and irritable bowel syndrome
Menees, S., & Chey, W. (2018) · F1000Research · doi:10.12688/f1000research.14592.1 · Cited by 159 · see citing works
“Paineau et al . performed a double-blind, placebo-controlled trial in 105 IBS subjects with a short-chain inulin-type fructan dosed at 5 g/day over the course of 6 weeks 32 .”
BackgroundProbiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13632 · Cited by 160 · see citing works
Whelan, K. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834b8082 · Cited by 120 · see citing works
Oral prebiotics and the influence of environmental conditions in vitro
Slomka, V., Herrero, E. R., Boon, N., Bernaerts, K., Trivedi, H. M., Daep, C., Quirynen, M., & Teughels, W. (2018) · Journal of Periodontology · doi:10.1002/jper.17-0437 · Cited by 54 · see citing works
- Authors
- Paineau, D., Payen, F., Panserieu, S., Coulombier, G., Sobaszek, A., Lartigau, I., Brabet, M., Galmiche, J.-P., Tripodi, D., Sacher-Huvelin, S., Chapalain, V., Zourabichvili, O., Respondek, F., Wagner, A., & Bornet, F. R. J.
- Affiliations
- Hôpital Avicenne (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Hôpital Claude Huriez (FR)
- Hôpital Saint Eloi (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Corresponding author
- Respondek, Frédérique
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-02
- Volume
- 99
- Issue
- 2
- Pages
- 311-318
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2115618203
- Cited by
- 142
- References
- 45
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 11 · 2013: 11 · 2012: 9
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- short-chain fructooligosaccharides, functional bowel disorders, prebiotics, quality of life, dietary intervention, working population, symptom intensity
- MeSH terms
- Activities of Daily Living, Adult, Colonic Diseases, Functional, Digestion, Double-Blind Method, Female, Fructose, Humans, Male, Oligosaccharides, Patient Compliance, Quality of Life, Severity of Illness Index, Treatment Outcome, Dietary Supplements
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