Prebiotics, immune function, infection and inflammation: a review of the evidence

Lomax, Amy R.; Calder, Philip C.

doi:10.1017/s0007114508055608

Cited by 257Microbial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsGut microbiota and health

Prebiotics, immune function, infection and inflammation: a review of the evidence

Open access

Lomax, Amy R., Calder, Philip C.·2008·British Journal Of Nutrition

DOI 10.1017/s0007114508055608

Open this paper in CoChat — free account Open PDF

Abstract

Beta2-1 fructans are carbohydrate molecules with prebiotic properties. Through resistance to digestion in the upper gastrointestinal tract, they reach the colon intact, where they selectively stimulate the growth and/or activity of beneficial members of the gut microbiota. Through this modification of the intestinal microbiota, and by additional mechanisms, beta2-1 fructans may have beneficial effects upon immune function, ability to combat infection, and inflammatory processes and conditions. In this paper, we have collated, summarised and evaluated studies investigating these areas. Twenty-one studies in laboratory animals suggest that some aspects of innate and adaptive immunity of the gut and the systemic immune systems are modified by beta2-1 fructans. In man, two studies in children and nine studies in adults indicate that the adaptive immune system may be modified by beta2-1 fructans. Thirteen studies in animal models of intestinal infections conclude a beneficial effect of beta2-1 fructans. Ten trials involving infants and children have mostly reported benefits on infectious outcomes; in fifteen adult trials, little effect was generally seen, although in specific situations, certain beta2-1 fructans may be beneficial. Ten studies in animal models show benefit of beta2-1 fructans with regard to intestinal inflammation. Human studies report some benefits regarding inflammatory bowel disease (four positive studies) and atopic dermatitis (one positive study), but findings in irritable bowel syndrome are inconsistent. Therefore, overall the results indicate that beta2-1 fructans are able to modulate some aspects of immune function, to improve the host's ability to respond successfully to certain intestinal infections, and to modify some inflammatory conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0007114508055608

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Microbiota composition and related local intestinal metabolism undergo significant changes in various disease states characterised by chronic inflammation, such as inflammatory bowel disease, colorectal cancer and obesity.
“The microbiota composition and the related local intestinal metabolism undergoes significant changes in various disease states that are characterised by chronic inflammation, such as inflammatory bowel disease (823) , colorectal cancer and obesity (824,825) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [823]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Innate immune recognition
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394 · see citing works
Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics
Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
Gibson, G. R., Probert, H. M., Loo, J. V., Rastall, R. A., & Roberfroid, M. B. (2004) · Nutrition Research Reviews · doi:10.1079/nrr200479 · Cited by 2,539 · see citing works
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651 · see citing works
A new receptor for β-glucans
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579 · see citing works
Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin
Gibson, G. R., Beatty, E. R., Wang, X., & Cummings, J. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90192-2 · Cited by 1,529 · see citing works
On the presence of Inulin and Oligofructose as natural ingredients in the western diet
Loo, J. V., Coussement, P., Leenheer, L. D., Hoebregs, H., & Smits, G. (1995) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399509527714 · Cited by 837 · see citing works
Introducing inulin-type fructans
Roberfroid, M. B. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041350 · Cited by 799 · see citing works
The Bifidogenic Nature of Chicory Inulin and Its Hydrolysis Products
Roberfroid, M. B., Loo, J. V., & Gibson, G. R. (1998) · Journal of Nutrition · doi:10.1093/jn/128.1.11 · Cited by 781 · see citing works
Synbiotic therapy ( Bifidobacterium longum /Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial
Furrie, E., Macfarlane, S., Kennedy, A., Cummings, J. H., Walsh, S. V., O’Neil, D. A., & Macfarlane, G. T. (2005) · Gut · doi:10.1136/gut.2004.044834 · Cited by 766 · see citing works
A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age
Moro, G. E. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2006.098251 · Cited by 633 · see citing works
Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients
Rafter, J. J., Bennett, M., Caderni, G., Clune, Y., Hughes, R., Karlsson, P. C., Klinder, A., O'Riordan, M., O’Sullivan, G. C., Pool-Zobel, B. L., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.488 · Cited by 591 · see citing works
Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
Nilsson, N. E., Kotarsky, K., Owman, C., & Olde, B. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00488-1 · Cited by 540 · see citing works
Fermentation of Fructooligosaccharides by Lactic Acid Bacteria and Bifidobacteria
Kaplan, H., & Hutkins, R. W. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.6.2682-2684.2000 · Cited by 492 · see citing works
Supply of Pre- and Probiotics Reduces Bacterial Infection Rates After Liver Transplantation—A Randomized, Double-Blind Trial
Rayes, N., Seehofer, D., Theruvath, T. P., Schiller, R. A., Langrehr, J. M., Jonas, S., Bengmark, S., & Neuhaus, P. (2005) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00649.x · Cited by 477 · see citing works
Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease
Lindsay, J. O. (2006) · Gut · doi:10.1136/gut.2005.074971 · Cited by 471 · see citing works
Science and Technology of Fructans
鈴木, 通., & CHATTERTON, N. J. (1993) · Medical Entomology and Zoology · Cited by 383 · see citing works
Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
Barcelo, A., Claustre, J., Moro, F., Chayvialle, J.-A., Cuber, J.-C., & Plaisancié, P. (2000) · Gut · doi:10.1136/gut.46.2.218 · Cited by 375 · see citing works
Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains.
Taylor, M. E., Conary, J. T., Lennartz, M. R., Stahl, P. D., & Drickamer, K. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38325-5 · Cited by 371 · see citing works
The immune-enhancing effects of dietary fibres and prebiotics
Schley, P. D., & C.J.*, F. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn/2002541 · Cited by 351 · see citing works
Supplemental Fructooligosaccharides and Mannanoligosaccharides Influence Immune Function, Ileal and Total Tract Nutrient Digestibilities, Microbial Populations and Concentrations of Protein Catabolites in the Large Bowel of Dogs
Swanson, K. S., Grieshop, C. M., Flickinger, E. A., Bauer, L. L., Healy, H.-P., Dawson, K. A., Merchen, N. R., & Fahey, G. C., Jr. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.980 · Cited by 321 · see citing works
Inulin, oligofructose and immunomodulation
Watzl, B., Girrbach, S., & Roller, M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041357 · Cited by 315 · see citing works
Relationship of prebiotics and food to intestinal microflora
Blaut, M. (2002) · European Journal of Nutrition · doi:10.1007/s00394-002-1102-7 · Cited by 299 · see citing works
Effect of Dietary Inulin Supplementation on Inflammation of Pouch Mucosa in Patients With an Ileal Pouch-Anal Anastomosis
Welters, C. F. M., Heineman, E., Thunnissen, E., van den Bogaard, A. E. J. M., Soeters, P. B., & Baeten, C. G. M. I. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6257-2 · Cited by 294 · see citing works
Markers to measure immunomodulation in human nutrition intervention studies
Albers, R., Antoine, J., Bourdet‐Sicard, R., Calder, P. C., Gleeson, M., Lesourd, B., Samartı́n, S., Sanderson, I. R., Loo, J. V., Dias, F. W. V., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051469 · Cited by 284 · see citing works
Self-citation
Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus rhamnosus and Bifidobacterium lactis Modulates Intestinal Immune Functions in Rats
Roller, M., Rechkemmer, G., & Watzl, B. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.153 · Cited by 281 · see citing works
Dectin-1 and its role in the recognition of β-glucans by macrophages
Herre, J. (2003) · Molecular Immunology · doi:10.1016/j.molimm.2003.10.007 · Cited by 278 · see citing works
The immune-enhancing effects of dietary fibres and prebiotics
Schley, P. D., & Field, C. J. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002541 · Cited by 278 · see citing works
Oral oligofructose‐enriched inulin supplementation in acute ulcerative colitis is well tolerated and associated with lowered faecal calprotectin
Casellas, F., Borruel, N., Torrejón, A., Varela, E., Antolı́n, M., Guarner, F., & Malagelada, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03288.x · Cited by 260 · see citing works
Innate protection conferred by fucosylated oligosaccharides of human milk against diarrhea in breastfed infants
Newburg, D. S., Ruiz-Palacios, G. M., Altaye, M., Chaturvedi, P., Meinzen‐Derr, J. K., Guerrero, M. D. L., & Morrow, A. L. (2003) · Glycobiology · doi:10.1093/glycob/cwh020 · Cited by 252 · see citing works
Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.)
López-Molina, D., Navarro-Martínez, M. D., Rojas‐Melgarejo, F., Hiner, A. N. P., Chazarra, S., & Rodríguez‐López, J. N. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.04.003 · Cited by 249 · see citing works
Nondigestibility of a New Sweetener, “Neosugar,” in the Rat
Oku, T., Tokunaga, T., & HOSOYA, N. (1984) · Journal of Nutrition · doi:10.1093/jn/114.9.1574 · Cited by 240 · see citing works
Benefits of a Synbiotic Formula (Synbiotic 2000Forte ® ) in Critically Ill Trauma Patients: Early Results of a Randomized Controlled Trial
Kotzampassi, K. E., Giamarellos-Bourboulis, E. J., Voudouris, A., Kazamias, P., & Eleftheriadis, E. (2006) · World Journal of Surgery · doi:10.1007/s00268-005-0653-1 · Cited by 238 · see citing works
Digestion, excretion, and energy value of fructooligosaccharides in healthy humans
Molis, C., Flourié, B., Ouarné, F., Gailing, M., Lartigue, S., Guibert, A., Bornet, F. R. J., & Jp, G. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.3.324 · Cited by 230 · see citing works
Effect of Enteral Nutrition and Synbiotics on Bacterial Infection Rates After Pylorus-preserving Pancreatoduodenectomy
Rayes, N., Seehofer, D., Theruvath, T. P., Mogl, M. T., Langrehr, J. M., Nüssler, N. C., Bengmark, S., & Neuhaus, P. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000259442.78947.19 · Cited by 228 · see citing works
Inulin and Oligofructose: Review of Experimental Data on Immune Modulation
Seifert, S., & Watzl, B. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2563s · Cited by 227 · see citing works
Effect of the Prebiotic Oligofructose on Relapse of Clostridium difficile-Associated Diarrhea: A Randomized, Controlled Study
Lewis, S., Burmeister, S., & Brazier, J. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00677-9 · Cited by 226 · see citing works
Effects of oligosaccharide on the faecal flora and non-specific immune system in elderly people
Guigoz, Y., Rochat, F., Perruisseau-Carrier, G., Rochat, I., & Schiffrin, E. J. (2002) · Nutrition Research · doi:10.1016/s0271-5317(01)00354-2 · Cited by 221 · see citing works
Dietary Fructooligosaccharides Induce Immunoregulation of Intestinal IgA Secretion by Murine Peyer's Patch Cells
Hosono, A., OZAWA, A., Kato, R., Ohnishi, Y., NAKANISHI, Y., Kimura, T., & Nakamura, R. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.758 · Cited by 220 · see citing works
Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture
Gibson, G. R., & Wang, X. (1994) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1994.tb06813.x · Cited by 219 · see citing works
Reduction of Colitis by Prebiotics in HLA-B27 Transgenic Rats Is Associated with Microflora Changes and Immunomodulation
Hoentjen, F., Welling, G. W., Harmsen, H. J. M., Zhang, X., Snart, J., Tannock, G. W., Lien, K. A., Churchill, T. A., Lupicki, M., & Dieleman, L. A. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000183421.02316.d5 · Cited by 218 · see citing works
Oligosaccharides in Human Milk and Bacterial Colonization
Newburg, D. S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200000002-00003 · Cited by 212 · see citing works
Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial
Jain, P. K., McNaught, C. E., Anderson, A. D. G., Macfie, J., & Mitchell, C. J. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2003.12.002 · Cited by 211 · see citing works
Dietary Oligofructose and Inulin Protect Mice from Enteric and Systemic Pathogens and Tumor Inducers
Buddington, K. K., Donahoo, J. B., & Buddington, R. K. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.472 · Cited by 211 · see citing works
Dietary Inulin Improves Distal Colitis Induced by Dextran Sodium Sulfate in the Rat
Videla, S., Vilaseca, J., Antolín, M., García-Lafuente, A., Guarner, F., Crespo, E., Casalots, J., Salas, A., & Malagelada, J. R. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03802.x · Cited by 209 · see citing works
Inulin, Oligofructose and Intestinal Function
Jenkins, D., Kendall, C. W. C., & Vuksan, V. V. V. (1999) · Journal of Nutrition · doi:10.1093/jn/129.7.1431s · Cited by 200 · see citing works
Randomised clinical trial of synbiotic therapy in elective surgical patients
Anderson, A. D. G., McNaught, C. E., Jain, P. K., & MacFie, J. (2004) · Gut · doi:10.1136/gut.2003.024620 · Cited by 199 · see citing works
Faecal SIgA secretion in infants fed on pre‐ or probiotic infant formula
Bakker‐Zierikzee, A. M., van Tol, E. A. F., Kroes, H., Alles, M., Kok, F. J., & BINDELS, J. G. (2006) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2005.00370.x · Cited by 199 · see citing works
The Prebiotic Characteristics of Fructooligosaccharides Are Necessary for Reduction of TNBS-Induced Colitis in Rats
Cherbut, C., Michel, C., & Lecannu, G. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.21 · Cited by 195 · see citing works
Prebiotics and other microbial substrates for gut functionality
Ouwehand, A. C., Derrien, M., de Vos, W., Tiihonen, K., & Rautonen, N. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.01.007 · Cited by 192 · see citing works
Failure of Synbiotic 2000 to Prevent Postoperative Recurrence of Crohn’s Disease
Chermesh, I., Tamir, A., Reshef, R., Chowers, Y., Suissa, A., Katz, D., Gelber, M., Halpern, Z., Bengmark, S., & Eliakim, R. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9549-7 · Cited by 178 · see citing works
Recovery of inulin from Jerusalem artichoke (Helianthus tuberosus L.) in the small intestine of man
Knudsen, B., & Hessov, I. (1995) · British Journal Of Nutrition · doi:10.1079/bjn19950110 · Cited by 175 · see citing works
Dietary Fructooligosaccharides Affect Intestinal Barrier Function in Healthy Men
ten Bruggencate, S., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., Katan, M., & van der Meer, R. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.70 · Cited by 169 · see citing works
Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice.
Pierre, F. H. F., Perrin, P., Champ, M. M. J., Bornet, F., Méflah, K., & Ménanteau, J. (1997) · PubMed · Cited by 165 · see citing works
A study of fructo oligosaccharides in the prevention of travellers’ diarrhoea
Cummings, J. H., Christie, S., & Cole, T. J. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01043.x · Cited by 164 · see citing works
Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium
ten Bruggencate, S. J. M. (2004) · Gut · doi:10.1136/gut.2003.023499 · Cited by 150 · see citing works
Dietary fructo-oligosaccharides and lactulose inhibit intestinal colonisation but stimulate translocation of salmonella in rats
Bovee-Oudenhoven, I. M. J. (2003) · Gut · doi:10.1136/gut.52.11.1572 · Cited by 148 · see citing works
Dietary Fructooligosaccharides Increase Intestinal Permeability in Rats
ten Bruggencate, S. J. M., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., & van der Meer, R. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.837 · Cited by 147 · see citing works
Restoration of the integrity of rat caeco-colonic mucosa by resistant starch, but not by fructo-oligosaccharides, in dextran sulfate sodium-induced experimental colitis
Moreau, N. M., Martin, L. J. M., Toquet, C. S., LABOISSE, C. L., Nguyen, P., Siliart, B. S., Dumon, H. J., & Champ, M. M. J. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2003867 · Cited by 146 · see citing works
Effects of a nutritional supplement on the immune response and cytokine production in free‐living Chilean elderly
Bunout, D. C., Barrera, G. F., Hirsch, S., Gattas, V., de la Maza, M., Haschke, F., Steenhout, P. G., Klassen, P., Hager, C., Avendano, M., et al. (2004) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607104028005348 · Cited by 143 · see citing works
Oligosaccharides in Human Milk and Bacterial Colonization
Newburg, D. S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200003002-00003 · Cited by 143 · see citing works
Probiotics and prebiotics in the elderly
Hamilton-Miller, J. M. T. (2004) · Postgraduate Medical Journal · doi:10.1136/pgmj.2003.015339 · Cited by 142 · see citing works
The effects of regular consumption of short-chain fructo-oligosaccharides on digestive comfort of subjects with minor functional bowel disorders
Paineau, D., Payen, F., Panserieu, S., Coulombier, G., Sobaszek, A., Lartigau, I., Brabet, M., Galmiche, J.-P., Tripodi, D., Sacher-Huvelin, S., et al. (2008) · British Journal of Nutrition · doi:10.1017/s000711450779894x · Cited by 142 · see citing works
Bifidobacterium infantisstrains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats
Osman, N., Adawi, D., Molin, G., Ahrné, S., Berggren, A., & Jeppsson, B. W. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-31 · Cited by 141 · see citing works
Efficacy, safety, and tolerability of fructooligosaccharides in the treatment of irritable bowel syndrome
Olesen, M., & Gudmand-Höyer, E. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1570 · Cited by 140 · see citing works
Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy
Reddy, B. S., Macfie, J. M., Gatt, M., Larsen, C. N., Jensen, S. S., & Leser, T. D. (2007) · British journal of surgery · doi:10.1002/bjs.5705 · Cited by 138 · see citing works
A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model
Vos, A. P., Haarman, M., Buco, A., Govers, M. J., Knol, J., Garssen, J., Stahl, B., Boehm, G., & M’Rabet, L. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.010 · Cited by 136 · see citing works
Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice
Nakamura, Y., NOSAKA, S., Suzuki, M., NAGAFUCHI, S., Takahashi, T., Yajima, T., Takenouchi‐Ohkubo, N., Iwase, T., & Moro, I. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02487.x · Cited by 135 · see citing works
Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity—a randomized, double-blind, placebo-controlled study
Shadid, R., Haarman, M., Knol, J., Theis, W., Beermann, C., Rjosk-Dendorfer, D., Schendel, D. J., Koletzko, B. V., & Krauss‐Etschmann, S. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1426 · Cited by 133 · see citing works
Intestinal immunity of rats with colon cancer is modulated by oligofructose-enriched inulin combined with Lactobacillus rhamnosus and Bifidobacterium lactis
Roller, M., Femia, A. P., Caderni, G., Rechkemmer, G., & Watzl, B. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041289 · Cited by 133 · see citing works
Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics
Puccio, G., Cajozzo, C., Meli, F., Rochat, F., Grathwohl, D., & Steenhout, P. G. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.007 · Cited by 128 · see citing works
Neonatal necrotizing enterocolitis: An update
Neu, J. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb02163.x · Cited by 127 · see citing works
Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients
Roller, M., Clune, Y., Collins, K., Rechkemmer, G., & Watzl, B. (2007) · British Journal of Nutrition · doi:10.1017/s0007114507450292 · Cited by 125 · see citing works
Oligofructose-supplemented infant cereal: 2 randomized, blinded, community-based trials in Peruvian infants
Duggan, C., Penny, M. E., Hibberd, P. L., Gil, A. M., Huapaya, A., Cooper, A., Coletta, F. A., Emenhiser, C., & Kleinman, R. E. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.4.937 · Cited by 122 · see citing works
Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre
Waligora‐Dupriet, A., Campeotto, F., Nicolis, I., Bonet, A., Soulaines, P., Dupont, C. M., & Butel, M. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.07.009 · Cited by 114 · see citing works
Dietary Fructo-Oligosaccharides Dose-Dependently Increase Translocation of Salmonella in Rats
ten Bruggencate, S. J. M., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., & van der Meer, R. (2003) · Journal of Nutrition · doi:10.1093/jn/133.7.2313 · Cited by 114 · see citing works
Effect of regular ingestion of Saccharomyces boulardii plus inulin or Lactobacillus acidophilus LB in children colonized by Helicobacter pylori
Gotteland, M., Poliak, L., Cruchet, S., & Brunser, O. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb01848.x · Cited by 111 · see citing works
Gastrointestinal and immunological responses of senior dogs to chicory and mannan-oligosaccharides
Grieshop, C. M., Flickinger, E. A., Bruce, K. J., Patil, A. R., Czarnecki‐Maulden, G. L., & Fahey, G. C., Jr. (2004) · Archives of Animal Nutrition · doi:10.1080/00039420400019977 · Cited by 109 · see citing works
Inulin and Oligofructose in Chronic Inflammatory Bowel Disease
Leenen, C. H., & Dieleman, L. A. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2572s · Cited by 107 · see citing works
Effects of prebiotics on the immune response to vaccination in the elderly
Bunout, D., Hirsch, S., de la Maza, M., Munoz, C., Haschke, F., Steenhout, P., Klassen, P., Barrera, G., Gattas, V, & Petermann, M. (2002) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607102026006372 · Cited by 107 · see citing works
Immune Responses in Rhesus Rotavirus-Challenged Balb/c Mice Treated with Bifidobacteria and Prebiotic Supplements
Qiao, H., Duffy, L. C., Griffiths, E. A., Dryja, D., Leavens, A., Rossman, J., Rich, G. A., Riepenhoff-Talty, M., & Locniskar, M. F. (2002) · Pediatric Research · doi:10.1203/00006450-200206000-00015 · Cited by 102 · see citing works
Controlled Trial of Oligofructose in the Management of Irritable Bowel Syndrome
Hunter, J. O., Tuffnell, Q., & Lee, A. J. (1999) · Journal of Nutrition · doi:10.1093/jn/129.7.1451s · Cited by 101 · see citing works
Investigations of the lymphokine system in elderly individuals
Sindermann, J. R., Kruse, A., Frercks, H.-J., Schütz, R., & Kirchner, H. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90066-z · Cited by 98 · see citing works
Fermentable Fiber Reduces Recovery Time and Improves Intestinal Function in Piglets Following Salmonella typhimurium Infection
Correa‐Matos, N. J., Donovan, S. M., Isaacson, R. E., Gaskins, H. R., White, B. A., & Tappenden, K. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1845 · Cited by 98 · see citing works
Dietary oligofructose and inulin modulate immune functions in mice
Kelly-Quagliana, K., Nelson, P. D., & Buddington, R. K. (2003) · Nutrition Research · doi:10.1016/s0271-5317(02)00516-x · Cited by 95 · see citing works
Feeding a Diet Containing a Fructooligosaccharide Mix Can Enhance Salmonella Vaccine Efficacy in Mice
Benyacoub, J., Rochat, F., Saudan, K.-Y., Rochat, I., Antille, N., Cherbut, C., von der Weid, T., Schiffrin, E. J., & Blum, S. (2008) · Journal of Nutrition · doi:10.1093/jn/138.1.123 · Cited by 85 · see citing works
Effects of Feeding a Probiotic Preparation (SIM) Containing Inulin on the Severity of Colitis and on the Composition of the Intestinal Microflora in HLA-B27 Transgenic Rats
Schultz, M., Munro, K., Tannock, G. W., Melchner, I., Göttl, C., Schwietz, H., Schölmerich, J., & Rath, H. C. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.3.581-587.2004 · Cited by 83 · see citing works
The fermentable fiber content of the diet alters the function and composition of canine gut associated lymphoid tissue
Field, C. J., McBurney, M. I., Massimino, S., Hayek, M. G., & Sunvold, G. D. (1999) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(99)00148-8 · Cited by 78 · see citing works
Nonopsonic phagocytosis of strains of Pseudomonas aeruginosa from cystic fibrosis patients
Speert, D. P., Eftekhar, F., & Puterman, M. (1984) · Infection and Immunity · doi:10.1128/iai.43.3.1006-1011.1984 · Cited by 76 · see citing works
Assessment of various treatments to reduce carriage of Salmonella in swine.
Letellier, A., Messier, S. J., Lessard, L., & Quessy, S. (2000) · Europe PMC (PubMed Central) · Cited by 74 · see citing works
Studies with Inulin-Type Fructans on Intestinal Infections, Permeability, and Inflammation
Guarner, F. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2568s · Cited by 73 · see citing works
Oral Rehydration Solution Containing a Mixture of Non-Digestible Carbohydrates in the Treatment of Acute Diarrhea: A Multicenter Randomized Placebo Controlled Study on Behalf of the ESPGHAN Working Group on Intestinal Infections
Hoekstra, J. H., Szajewska, H., Zikri, M. A., Micetic‐Turk, D., Weizman, Z., Papadopoulou, A., Guarino, A., Dias, J. A., & Oostvogels, B. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200409000-00003 · Cited by 72 · see citing works
Nutritional Formula Enhanced Immune Function and Reduced Days of Symptoms of Upper Respiratory Tract Infection in Seniors
Langkamp‐Henken, B., Bender, B. S., Gardner, E. M., Herrlinger‐Garcia, K. A., Kelley, M. J., Murasko, D. M., Schaller, J. P., Stechmiller, J. K., Thomas, D. J., & Wood, S. M. (2003) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52003.x · Cited by 69 · see citing works
Oligofructose and experimental model of neonatal necrotising enterocolitis
M.-J.*, B., Waligora‐Dupriet, A., & Szylit, O. (2002) · British Journal Of Nutrition · doi:10.1079/bjnbjn/2002540 · Cited by 69 · see citing works
Influence of fructooligosaccharides on Peyer’s patch lymphocyte numbers in healthy and endotoxemic mice
Manhart, N., Spittler, A., Bergmeister, H., Mittlböck, M., & Roth, E. (2003) · Nutrition · doi:10.1016/s0899-9007(03)00059-5 · Cited by 68 · see citing works
Failure of dietary oligofructose to prevent antibiotic‐associated diarrhoea
Lewis, S., Burmeister, S., Cohen, S., Brazier, J., & Awasthi, A. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02304.x · Cited by 66 · see citing works
The association of prolonged breastfeeding and allergic disease in poor urban children
Obihara, C. C., Marais, B. J., Gie, R. P., Potter, P., Bateman, E. D., Lombard, C. J., Beyers, N., & Kimpen, J. L. L. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00116504 · Cited by 66 · see citing works
Effects of Supplemental Fructooligosaccharides Plus Mannanoligosaccharides on Immune Function and Ileal and Fecal Microbial Populations in Adult Dogs
Swanson, K. S., Grieshop, C. M., Flickinger, E. A., Healy, H.-P., Dawson, K. A., Merchen, N. R., Merchen, N. R., & Fahey, G. C., Jr. (2002) · Archiv für Tierernaehrung · doi:10.1080/00039420214344 · Cited by 65 · see citing works
Oligofructose and experimental model of neonatal necrotising enterocolitis
Butel, M., Waligora‐Dupriet, A., & Szylit, O. (2002) · British Journal Of Nutrition · doi:10.1079/bjn/2002540 · Cited by 62 · see citing works
The impact of diets varying in carbohydrates resistant to endogenous enzymes and lignin on populations of Ascaris suum and Oesophagostomum dentatum in pigs.
Petkevičius, S., Knudsen, K. E. B., Nansen, P., Roepstorff, A., Skjøth, F., & Jensen, K. (1997) · PubMed · Cited by 57 · see citing works
Nutritional Formula Improved Immune Profiles of Seniors Living in Nursing Homes
Langkamp‐Henken, B., Wood, S. M., Herrlinger‐Garcia, K. A., Thomas, D. J., Stechmiller, J. K., Bender, B. S., Gardner, E. M., DeMichele, S. J., Schaller, J. P., & Murasko, D. M. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00982.x · Cited by 57 · see citing works
Influence of prebiotics and antioxidants in bread on the immune system, antioxidative status and antioxidative capacity in male smokers and non-smokers
Seidel, C., Boehm, V., Vogelsang, H., Wagner, A., Persin, C., Glei, M., Pool-Zobel, B. L., & Jahreis, G. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507328626 · Cited by 54 · see citing works
Enhancement of Immune Response of Murine Peyer's Patches by a Diet Supplemented With Yogurt
Simone, C. D., Vesely, R., Negri, R., Salvadori, B. B., Zanzoglu, S., Cilli, A., & Lucci, L. (1987) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923978709035203 · Cited by 54 · see citing works
The effect of inulin and sugar beet fibre on Oesophagostomum dentatum infection in pigs
PETKEVIČIUS, S., Knudsen, K. E. B., Murrell, K. D., & Wachmann, H. (2003) · Parasitology · doi:10.1017/s0031182003003251 · Cited by 54 · see citing works
Fructan Supplementation and Infection Affect Food Intake, Fever, and Epithelial Sloughing from Salmonella Challenge in Weanling Puppies , ,3
Apanavicius, C. J., Powell, K. L., Vester, B. M., Karr‐Lilienthal, L. K., Pope, L. L., Fastinger, N. D., Wallig, M. A., Tappenden, K. A., & Swanson, K. S. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1923 · Cited by 53 · see citing works
Fructo-oligosaccharide Reduces Inflammation in a Dextran Sodium Sulphate Mouse Model of Colitis
Winkler, J., Butler, R. N., & Symonds, E. L. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9224-z · Cited by 53 · see citing works
The effects of inulin supplementation of diets with or without hydrolysed protein sources on digestibility, faecal characteristics, haematology and immunoglobulins in dogs
Verlinden, A., Hesta, M., Hermans, J. M., & Janssens, G. P. J. (2006) · British Journal Of Nutrition · doi:10.1017/bjn20061912 · Cited by 53 · see citing works
Inulin as the soluble fiber in liquid enteral nutrition
Sobotka, L., Brátová, M., S̆lemrová, M., Maňák, J., Vizda, J., & Zadák, Z. (1997) · Nutrition · doi:10.1016/s0899-9007(97)90874-1 · Cited by 51 · see citing works
Dietary fructo-oligosaccharides in healthy adults do not negatively affect faecal cytotoxicity: a randomised, double-blind, placebo-controlled crossover trial
Scholtens, P. A. M. J., Alles, M. S., Willemsen, L. E. M., van den Braak, C., BINDELS, J. G., Boehm, G., & Govers, M. J. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061765 · Cited by 49 · see citing works
Allergic Airway Eosinophilia Is Suppressed in Ovalbumin-Sensitized Brown Norway Rats Fed Raffinose and α-Linked Galactooligosaccharide
Sonoyama, K., Watanabe, H., Watanabe, J., Yamaguchi, N., Yamashita, A., Hashimoto, H., Kishino, E., Fujita, K., Okada, M., Shigeharu, M. O. R. I., et al. (2005) · Journal of Nutrition · doi:10.1093/jn/135.3.538 · Cited by 46 · see citing works
Proportional Hazards Analysis of Diarrhea due to Enterotoxigenic Escherichia coli and Breast Feeding in a Cohort of Urban Mexican Children
Long, K. Z., Wood, J. W., Gariby, E. V., Weiss, K. M., Mathewson, J. J., de la Cabada, F. J., DuPont, H. L., & Wilson, R. A. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116981 · Cited by 45 · see citing works
Prebiotic ingestion does not improve gastrointestinal barrier function in burn patients
Olguin, F. G., Araya, M., Hirsch, S., Brunser, O., Ayala, V., Rivera, R., & Gotteland, M. (2005) · Burns · doi:10.1016/j.burns.2004.11.017 · Cited by 44 · see citing works
Effects of dietary scFOS on immunoglobulins in colostrums and milk of bitches
Adogony, V., Respondek, F., Biourge, V. C., Rudeaux, F., Delaval, J., Bind, J.-L., & Salmon, H. (2007) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2007.00688.x · Cited by 43 · see citing works
GASTRO-INTESTINAL FUNCTION IN INFANTS CONSUMING A WEANING FOOD SUPPLEMENTED WITH OLIGOFRUCTOSE, A PREBIOTIC
Saavedra, J. M., Tschernia, A., Moore, N. D., Abi‐Hanna, A., Coletta, F. A., Emenhiser, C., & Yolken, R. H. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199910000-00121 · Cited by 42 · see citing works
Increased Number of CCR4-positive Cells in the Duodenum of Ovalbumin-induced Food Allergy Model NC/jic Mice and Antiallergic Activity of Fructooligosaccharides
Fujitani, S., Ueno, K., Kamiya, T., Tsukahara, T., Ishihara, K., Kitabayashi, T., & Itabashi, K. (2007) · Allergology International · doi:10.2332/allergolint.o-06-450 · Cited by 41 · see citing works
The effect of inulin on new and on patent infections ofTrichuris suisin growing pigs
Petkevičius, S., Thomsen, L. E., Knudsen, K. E. B., Murrell, K. D., Roepstorff, A., & Boes, J. (2006) · Parasitology · doi:10.1017/s0031182006000977 · Cited by 39 · see citing works
The effect of early nutritional supplementation with a mixture of probiotic, prebiotic, fiber and micronutrients in infants with acute diarrhea in Indonesia.
Agustina, R., Lukito, W., Firmansyah, A., Suhardjo, H. N., Murniati, D. E., & BINDELS, J. G. (2007) · PubMed · Cited by 37 · see citing works
Dietary Modulation of GALT
Sanderson, I. R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.11.2557s · Cited by 37 · see citing works
[Combination of early nasojejunal feeding with modern synbiotic therapy in the treatment of severe acute pancreatitis (prospective, randomized, double-blind study)].
Oláh, A., Belágyi, T., Issekutz, Á., & Olgyai, G. (2005) · PubMed · Cited by 37 · see citing works
EARLY ADMINISTRATION OF GOS/FOS PREVENTS INTESTINAL AND RESPIRATORY INFECTIONS IN INFANTS
Bruzzese, E., VOLPICELLI, M., Salvini, F. M., Bisceglia, M., Lionetti, P., Cinquetti, M., Iacono, G., & Guarino, A. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2006.tb01777.x · Cited by 34 · see citing works
Host response to various treatments to reduce Salmonella infections in swine.
Letellier, A., Messier, S. J., Lessard, L., Chénier, S., & Quessy, S. (2001) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
The influence of dietary carbohydrates on experimental infection withTrichuris suisin pigs
Thomsen, L. E., Petkevičius, S., Knudsen, K. E. B., & Roepstorff, A. (2005) · Parasitology · doi:10.1017/s0031182005008620 · Cited by 30 · see citing works
The effect of dietary carbohydrates with different digestibility on the populations ofOesophagostomum dentatumin the intestinal tract of pigs
Petkevičius, S., Knudsen, K. E. B., Nansen, P., & Murrell, K. D. (2001) · Parasitology · doi:10.1017/s0031182001008472 · Cited by 28 · see citing works
Dietary Supplementation with Fructooligosaccharides Increase Survival Time in a Hamster Model of Clostridium difficile-Colitis
Wolf, B. W., Meulbroek, J. A., Jarvis, K., WHEELER, K. B., & Garleb, K. A. (1997) · Bioscience and Microflora · doi:10.12938/bifidus1996.16.59 · Cited by 27 · see citing works
Dietary Fructo-oligosaccharide Modulates Large Intestinal Inflammatory Responses toClostridium difficilein Antibiotic-compromised Mice
Gaskins, H. R., Mackie, R. I., May, T., & Garleb, K. A. (1996) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v9i4.8365 · Cited by 24 · see citing works
Fructooligosaccharide and Diarrhea
Juffrie, M. (2002) · Bioscience and Microflora · doi:10.12938/bifidus1996.21.31 · Cited by 21 · see citing works
EFFECTS OF LONG-TERM CONSUMPTION OF A WEANING FOOD SUPPLEMENTED WITH OLIGOFRUCTOSE, A PREBIOTIC, ON GENERAL INFANT HEALTH STATUS
Tschernia, A., Moore, N. D., Abi‐Hanna, A., Yolken, R., Coletta, F. A., Emenhiser, C., & Saavedra, J. M. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199910000-00084 · Cited by 20 · see citing works
Treatment of irritable bowel syndrome. A case control experience.
Astegiano, M., Pellicano, R., Terzi, E., Simondi, D., & Rizzetto, M. (2006) · PubMed · Cited by 19 · see citing works
Dietary Fructo-oligosaccharide Modulates Large Intestinal Inflammatory Responses toClostridium difficilein Antibiotic-compromised Mice
Gaskins, H. R., Mackie, R. I., May, T., & Garleb, K. A. (1996) · Microbial Ecology in Health and Disease · doi:10.3109/08910609609166456 · Cited by 19 · see citing works
The Effect ofLactobacillus paracaseiand Raftilose P95 Upon the Non-specific Immune Response of Piglets
Herich, R., Révajová, V., Levkut, M., Bomba, A., Nemcová, R., Guba, P., & Gancarčíková, S. (2002) · Food and Agricultural Immunology · doi:10.1080/09540100220145000e · Cited by 16 · see citing works
Effects of Oesophagostomum dentatum and dietary carbohydrates on morphology of the large intestine of pigs
Petkevičius, S., Knudsen, K. E. B., & Murrell, K. D. (2003) · Veterinary Parasitology · doi:10.1016/s0304-4017(03)00260-7 · Cited by 13 · see citing works
Diabetes-prone BioBreeding rats do not have a normal immune response when weaned to a diet containing fermentable fibre
Stillie, R., Bell, R. C., & Field, C. J. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051408 · Cited by 12 · see citing works
[The influence of dietary inulin and oligofructose on the cell-mediated and humoral immunity in rats].
Ēn, T., Martynova, E. A., Db, N., Мустафина, О. К., & Baĭgarin, E. K. (2005) · PubMed · Cited by 12 · see citing works
Protective Effect of Dietary Oligofructose against Cecitis Induced by Clostridia in Gnotobiotic Quails
Butel, M., Catala, I., Waligora‐Dupriet, A., Taper, H., Tessèdre, A., Durao, J., & Szylit, O. (2001) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v13i3.8021 · Cited by 9 · see citing works
Protective Effect of DietaryOligofructose against Cecitis Induced by Clostridia in Gnotobiotic Quails
Marie-José Butel, I. C. (2001) · Microbial Ecology in Health and Disease · doi:10.1080/089106001750462722 · Cited by 6 · see citing works
INTESTINAL PERMEABILITY AND FAECAL FLORA OF INFANTS FED WITH A PREBIOTIC SUPPLEMENTED FORMULA: A DOUBLE BLIND PLACEBO CONTROLLED STUDY
Francavilla, R., Castellaneta, S. P., Masciale, A., Straziuso, S., Polimeno, L., Gagliardi, F., Bohem, G., & Miniello, V. L. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/j.1536-4801.2006.tb01967.x · Cited by 5 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

British Journal of Nutrition https://doi.org/10.1017/S0007114508055608 Published online by Cambridge University Press References

Sorted by citations

Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
Self-citation
Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era
Preidis, G. A., & Versalovic, J. A. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.072 · Cited by 485 · see citing works
Prebiotics from marine macroalgae for human and animal health applications
O’Sullivan, L., Murphy, B., McLoughlin, P., Duggan, P., Lawlor, P. G., Hughes, H., & Gardiner, G. E. (2010) · Marine Drugs · doi:10.3390/md8072038 · Cited by 421 · see citing works
Ageing of the human metaorganism: the microbial counterpart
Biagi, E., Candela, M., Fairweather‐Tait, S. J., Franceschi, C., & Brigidi, P. (2011) · AGE · doi:10.1007/s11357-011-9217-5 · Cited by 365 · see citing works
Inulin as texture modifier in dairy products
Meyer, D., BAYARRI, S., Tárrega, A., & Costell, E. (2011) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2011.04.012 · Cited by 359 · see citing works
Exercise, inflammation and aging.
(2012) · Europe PMC (PubMed Central) · Cited by 345 · see citing works
Immunological Effects of Human Milk Oligosaccharides
Triantis, V., Bode, L., & van Neerven, R. J. J. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00190 · Cited by 309 · see citing works
Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health
Rastall, R. A., & Gibson, G. R. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.002 · Cited by 299 · see citing works
Micro- and nano bio-based delivery systems for food applications: In vitro behavior
Simões, L. S., Madalena, D. A., Pinheiro, A. C., Teixeira, J. A., Vicente, A. A., & Ramos, Ó. L. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.02.010 · Cited by 299 · see citing works
Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis
McLoughlin, R. F., Berthon, B. S., Jensen, M. E., Baines, K. J., & Wood, L. G. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156265 · Cited by 293 · see citing works
Application of inulin in cheese as prebiotic, fat replacer and texturizer: A review
Karimi, R., Azizi, M. H., Ghasemlou, M., & Vaziri, M. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.11.029 · Cited by 284 · see citing works
Feeding the immune system
Calder, P. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001286 · Cited by 283 · see citing works
Self-citation
Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties
Lecerf, J.-M., Dépeint, F., Clerc, E., Dugenet, Y., Niamba, C. N., Rhazi, L., Cayzeele, A., Abdelnour, G., Jaruga, A., Younes, H., et al. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511007252 · Cited by 262 · see citing works
Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol
Caccialanza, R., Laviano, A., Lobascio, F., Montagna, E., Bruno, R., Ludovisi, S., Corsico, A. G., Sabatino, A. D., Belliato, M., Calvi, M., et al. (2020) · Nutrition · doi:10.1016/j.nut.2020.110835 · Cited by 257 · see citing works
Mechanisms of probiosis and prebiosis: considerations for enhanced functional foods
Saulnier, D. M. A., Spinler, J. K., Gibson, G. R., & Versalovic, J. A. (2009) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2009.01.002 · Cited by 231 · see citing works
The gut microbiota and its role in the development of allergic disease: A wider perspective
West, C. E., Jenmalm, M. C., & Prescott, S. L. (2015) · Clinical & Experimental Allergy · doi:10.1111/cea.12332 · Cited by 223 · see citing works
Prevalence and severity of malnutrition in hospitalized COVID-19 patients
Bedock, D., Lassen, P. B., Mathian, A., Moreau, P., Couffignal, J., Ciangura, C., Poitou, C., Jeannin, A.-C., Mosbah, H., Fadlallah, J., et al. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.09.018 · Cited by 210 · see citing works
Prebiotics and synbiotics: Recent concepts in nutrition
Mohanty, D., Misra, S., Mohapatra, S., & Sahu, P. S. (2018) · Food Bioscience · doi:10.1016/j.fbio.2018.10.008 · Cited by 209 · see citing works
The food additives inulin and stevioside counteract oxidative stress
Stoyanova, S., Geuns, J., Hideg, É., & den Ende, W. V. (2010) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2010.523416 · Cited by 202 · see citing works
Maternal inflammation, growth retardation, and preterm birth: Insights into adult cardiovascular disease
Rogers, L. K., & Velten, M. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.07.017 · Cited by 199 · see citing works
In Vitro Fermentation of Selected Prebiotics and Their Effects on the Composition and Activity of the Adult Gut Microbiota
Fehlbaum, S., Prudence, K., Kieboom, J., Heerikhuisen, M., van den Broek, T., Schuren, F. H. J., Steinert, R. E., & Raederstorff, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103097 · Cited by 193 · see citing works
Fructans: Prebiotics and immunomodulators
Peshev, D., & Van den Ende, W. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.04.005 · Cited by 175 · see citing works
Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study
Childs, C. E., Röytiö, H., Alhoniemi, E. J., Fekete, A. A., Forssten, S. D., Hudjec, N., Lim, Y. N., Steger, C. J., Yaqoob, P., Tuohy, K. M., et al. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513004261 · Cited by 169 · see citing works
Functional intestinal microbiome, new frontiers in prebiotic design
Candela, M., Maccaferri, S., Turroni, S., Carnevali, P., & Brigidi, P. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.04.017 · Cited by 153 · see citing works
Prebiotics in foods
Charalampopoulos, D., & Rastall, R. A. (2012) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.12.028 · Cited by 151 · see citing works
Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health
Albers, R., Bourdet-Sicard, R., Braun, D., Calder, P. C., Herz, U., Lambert, C., Lenoir-Wijnkoop, I., Méheust, A., Ouwehand, A., Phothirath, P., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513001505 · Cited by 150 · see citing works
Self-citation
Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis
Spyropoulos, B. G., Misiakos, E. P., Fotiadis, C., & Stoidis, C. N. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1307-1 · Cited by 141 · see citing works
Immunological Tolerance and Function: Associations Between Intestinal Bacteria, Probiotics, Prebiotics, and Phages
Vitetta, L., Vitetta, G., & Hall, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02240 · Cited by 134 · see citing works
Implication of Fructans in Health: Immunomodulatory and Antioxidant Mechanisms
Franco‐Robles, E., & López, M. G. (2015) · The Scientific World JOURNAL · doi:10.1155/2015/289267 · Cited by 133 · see citing works
Microbial cultivation and the role of microbial resource centers in the omics era
Prakash, O., Shouche, Y. S., Jangid, K., & Kostka, J. E. (2012) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4533-y · Cited by 128 · see citing works
Galacto-oligosaccharides and colorectal cancer: Feeding our intestinal probiome
Bruno-Bárcena, J. M., & Azcárate-Peril, M. A. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.10.029 · Cited by 127 · see citing works
Disease prevention by natural antioxidants and prebiotics acting as ROS scavengers in the gastrointestinal tract
den Ende, W. V., Peshev, D., & Gara, L. D. (2011) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2011.07.005 · Cited by 129 · see citing works
Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota
Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 136 · see citing works
Self-citation
A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms
Saeed, M., Arain, M. A., Fazlani, S. A., Marghazani, I. B., Umar, M., Soomro, J., Bhutto, Z. A., Soomro, F., Noreldin, A. E., El-Hack, M. E. A., et al. (2021) · Aquaculture Nutrition · doi:10.1111/anu.13233 · Cited by 126 · see citing works
Probiotic yogurt and acidified milk similarly reduce postprandial inflammation and both alter the gut microbiota of healthy, young men
Burton, K. J., Rosikiewicz, M., Pimentel, G., Bütikofer, U., von Ah, U., Voirol, M.-J., Croxatto, A., Aeby, S., Drai, J., McTernan, P. G., et al. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000885 · Cited by 121 · see citing works
Relevance of pre- and postnatal nutrition to development and interplay between the microbiota and metabolic and immune systems
Nauta, A. J., Amor, K. B., Knol, J., Garssen, J., & van der Beek, E. M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.039644 · Cited by 110 · see citing works
Prebiotic inulin: Useful dietary adjuncts to manipulate the livestock gut microflora
Samanta, A. K., Jayapal, N., Senani, S., Kolte, A. P., & Sridhar, M. (2013) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822013005000023 · Cited by 102 · see citing works
Probiotics and prebiotics: prospects for public health and nutritional recommendations
Sanders, M. E., Lenoir‐Wijnkoop, I., Salminen, S., Merenstein, D. J., Gibson, G. R., Petschow, B. W., Nieuwdorp, M., Tancredi, D. J., Cifelli, C. J., Jacques, P. F., et al. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12377 · Cited by 102 · see citing works
Structure and function of non-digestible carbohydrates in the gut microbiome
Rastall, R. A., Díez‐Municio, M., Forssten, S. D., Hamaker, B. R., Meynier, A., Moreno, F. J., Respondek, F., Stahl, B., Venema, K., & Wiese, M. (2022) · Beneficial Microbes · doi:10.3920/bm2021.0090 · Cited by 99 · see citing works
The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma
van Esch, B. C. A. M., Porbahaie, M., Abbring, S., Garssen, J., Potaczek, D. P., Savelkoul, H. F. J., & van Neerven, R. J. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02141 · Cited by 97 · see citing works
Bioactive Compounds from Kefir and Their Potential Benefits on Health: A Systematic Review and Meta‐Analysis
Vieira, C. P., Rosario, I. L. D. S., Lelis, C. A., Rekowsky, B. S. D. S., de Carvalho, A. P. A., do Rosário, D. K. A., Elias, T. A., da Costa, M. P., Foguel, D., & Conte‐Júnior, C. A. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9081738 · Cited by 96 · see citing works
Manufacturing of Short-Chain Fructooligosaccharides: from Laboratory to Industrial Scale
Sánchez−Martínez, M. J., Soto−Jover, S., Antolinos, V., Martínez–Hernández, G. B., & López–Gómez, A. (2020) · Food Engineering Reviews · doi:10.1007/s12393-020-09209-0 · Cited by 93 · see citing works
Prebiotics as functional food ingredients preventing diet-related diseases
Florowska, A., Krygier, K., Florowski, T., & Dłużewska, E. (2016) · Food & Function · doi:10.1039/c5fo01459j · Cited by 92 · see citing works
Mucins, gut microbiota, and postbiotics role in colorectal cancer
Pothuraju, R., Chaudhary, S., Rachagani, S., Kaur, S., Roy, H. K., Bouvet, M., & Batra, S. K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1974795 · Cited by 84 · see citing works
Childhood Obesity: A Role for Gut Microbiota?
Sánchez, M., Panahi, S., & Tremblay, A. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120100162 · Cited by 86 · see citing works
Mucosal Immune Development in Early Life: Setting the Stage
Brugman, S., Perdijk, O., van Neerven, R. J. J., & Savelkoul, H. F. J. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0329-y · Cited by 85 · see citing works
Gallic Acid Alleviates Gut Dysfunction and Boosts Immune and Antioxidant Activities in Puppies Under Environmental Stress Based on Microbiome–Metabolomics Analysis
Yang, K., Deng, X., Jian, S., Zhang, M., Wen, C., Xin, Z., Zhang, L., Tong, A., Ye, S., Liao, P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.813890 · Cited by 79 · see citing works
Effect of dam parity on litter performance, transfer of passive immunity, and progeny microbial ecology1
Hinkle, E., Tran, H., Bundy, J. W., Moreno, R., Miller, P. S., & Burkey, T. E. (2013) · Journal of Animal Science · doi:10.2527/jas.2011-4874 · Cited by 76 · see citing works
Sensory evaluation of ovine milk yoghurt with inulin addition
Balthazar, C. F., Gaze, L. V., da Silva, H. L. A., Pereira, C. S., Franco, R. M., Conte‐Júnior, C. A., Freitas, M. Q., & Silva, A. C. D. O. (2015) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12189 · Cited by 75 · see citing works
Use of coconut water (Cocus nucifera L) for the development of a symbiotic functional drink
Segura-Badilla, O., Lazcano-Hernández, M., Kammar‐García, A., Verá-López, O., Aguilar‐Alonso, P., Ramírez-Calixto, J., & Navarro-Cruz, A. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03653 · Cited by 78 · see citing works
Recent advances in polysaccharide biomodification by microbial fermentation: production, properties, bioactivities, and mechanisms
Wang, G., Xie, L., Huang, Z., & Xie, J. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2259461 · Cited by 73 · see citing works
Immunomodulatory and Prebiotic Effects of 2′-Fucosyllactose in Suckling Rats
Azagra-Boronat, I., Massot‐Cladera, M., Mayneris‐Perxachs, J., Knipping, K., Land, B. V., Tims, S., Stahl, B., Garssen, J., Franch, À., Castell, M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01773 · Cited by 72 · see citing works
Efficiency of Resistant Starch and Dextrins as Prebiotics: A Review of the Existing Evidence and Clinical Trials
Włodarczyk, M., & Śliżewska, K. (2021) · Nutrients · doi:10.3390/nu13113808 · Cited by 73 · see citing works
β2-1 Fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults
Clarke, S. T., Green-Johnson, J. M., Brooks, S. P. J., Ramdath, D. D., Berčík, P., Avila, C., Inglis, G. D., Green, J., Yanke, L. J., Selinger, L. B., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000908 · Cited by 68 · see citing works
Effects of dietary fructooligosaccharide levels and feeding modes on growth, immune responses, antioxidant capability and disease resistance of blunt snout bream (Megalobrama amblycephala)
Zhang, C., Li, X., Jiang, G., Zhang, D., Tian, H., Li, J.-Y., & Liu, W. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.10.005 · Cited by 66 · see citing works
Effect of synbiotic supplementation on migraine characteristics and inflammatory biomarkers in women with migraine: results of a randomized controlled trial
Ghavami, A., Khorvash, F., Heidari, Z., Khalesi, S., & Askari, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105668 · Cited by 62 · see citing works
Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections
Govers, C., Calder, P. C., Savelkoul, H. F. J., Albers, R., & van Neerven, R. J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.841532 · Cited by 66 · see citing works
Self-citation
Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects
Slavin, J. L., & Feirtag, J. M. (2010) · Food & Function · doi:10.1039/c0fo00101e · Cited by 61 · see citing works
Ageing alters the impact of nutrition on immune function
Yaqoob, P. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000781 · Cited by 58 · see citing works
Babies, Bugs, and Barriers: Dietary Modulation of Intestinal Barrier Function in Early Life
Wells, J. M., Gao, Y., de Groot, N., Vonk, M. M., Ulfman, L. H., & van Neerven, R. J. J. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122221-103916 · Cited by 58 · see citing works
Respiratory viral infections in children with asthma: do they matter and can we prevent them?
Ahanchian, H., Jones, C. M., Chen, Y.-S., & Sly, P. D. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-147 · Cited by 59 · see citing works
Yacon (Smallanthus Sonchifolius): A Food with Multiple Functions
Paula, H. A. D. A., Abranches, M. V., & Ferreira, C. L. D. L. F. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.645259 · Cited by 58 · see citing works
Innovative and fortified food: Probiotics, prebiotics, GMOs, and superfood
Varzakas, T. H., Kandylis, P., Dimitrellou, D., Salamoura, C., Zakynthinos, G., & Proestos, C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-101892-7.00006-7 · Cited by 58 · see citing works
Short-Chain Fructo-oligosaccharide and Inulin Modulate Inflammatory Responses and Microbial Communities in Caco2-bbe Cells and in a Mouse Model of Intestinal Injury
Johnson‐Henry, K. C., Pinnell, L. J., Waskow, A., Irrazábal, T., Martín, A., Hausner, M., & Sherman, P. M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.195081 · Cited by 57 · see citing works
Egg Protein-Derived Bioactive Peptides: Preparation, Efficacy, and Absorption
Liao, W., Jahandideh, F., Fan, H., Son, M., & Wu, J. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2018.02.001 · Cited by 57 · see citing works
Surface and Adhesion Properties of Lactobacilli
Deepika, G., & Charalampopoulos, D. (2010) · Advances in applied microbiology · doi:10.1016/s0065-2164(10)70004-6 · Cited by 55 · see citing works
Early-life nutritional exposures and lifelong health: immediate and long-lasting impacts of probiotics, vitamin D, and breastfeeding
Berti, C., Agostoni, C. V., Davanzo, R., Hyppönen, E., Isolauri, E., Meltzer, H. M., Steegers‐Theunissen, R. P. M., & Cetin, I. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw056 · Cited by 57 · see citing works
IgA in human health and diseases: Potential regulator of commensal microbiota
Takeuchi, T., & Ohno, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1024330 · Cited by 53 · see citing works
Lactobacillus acidophilus attenuates Salmonella-induced intestinal inflammation via TGF-β signaling
Huang, I., Lin, I.-C., Liu, P., Cheng, M., Liu, Y., Hsieh, Y., Chen, J., Chen, C., Chang, H., & Shu, C. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0546-x · Cited by 53 · see citing works
Increased parasite resistance of greater amberjack (Seriola dumerili Risso 1810) juveniles fed a cMOS supplemented diet is associated with upregulation of a discrete set of immune genes in mucosal tissues
Fernández-Montero, Á., Torrecillas, S., Izquierdo, M., Caballero, M. J., Milne, D. J., Secombes, C. J., Sweetman, J. W., Silva, P. D., Acosta, F., & Montero, D. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.10.034 · Cited by 53 · see citing works
Validation of a food frequency questionnaire to measure intakes of inulin and oligofructose
Dunn, S., Datta, A., Kallis, S., Law, E., Myers, C. E., & Whelan, K. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.272 · Cited by 51 · see citing works
Difructose Dianhydrides (DFAs) and DFA-Enriched Products as Functional Foods
Mellet, C. O., & Fernández, J. M. G. (2010) · Topics in current chemistry · doi:10.1007/128_2010_50 · Cited by 50 · see citing works
THE EFFECT OF INULIN ON TRIBOLOGY AND SENSORY PROFILES OF SKIMMED MILK
Meyer, D., VERMULST, J., Tromp, R. H., & de Hoog, E. H. A. (2011) · Journal of Texture Studies · doi:10.1111/j.1745-4603.2011.00298.x · Cited by 48 · see citing works
β2-1 Fructans have a bifidogenic effect in healthy middle-aged human subjects but do not alter immune responses examined in the absence of an in vivo immune challenge: results from a randomised controlled trial
Lomax, A. R., Cheung, L. V. Y., Tuohy, K. M., Noakes, P. S., Miles, E. A., & Calder, P. C. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007276 · Cited by 47 · see citing works
Self-citation
Dairy-Derived and Egg White Proteins in Enhancing Immune System Against COVID-19
Batiha, G. E., Alqarni, M. A., Awad, D. A. B., Algammal, A. M., Nyamota, R., Wahed, M. I. I., Shah, M. A., Amin, M. N., Adetuyi, B. O., Hetta, ‏. F., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.629440 · Cited by 50 · see citing works
The effects of prebiotic, probiotic, and synbiotic supplementation on blood parameters of renal function: A systematic review and meta-analysis of clinical trials
Firouzi, S., & Haghighatdoost, F. (2018) · Nutrition · doi:10.1016/j.nut.2018.01.007 · Cited by 46 · see citing works
Gut microbiota in older subjects: variation, health consequences and dietary intervention prospects
O’Connor, E. M., O’Herlihy, E. A., & O’Toole, P. W. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000597 · Cited by 45 · see citing works
Inulin-Type Fructan Supplementation of 3- to 6-Year-Old Children Is Associated with Higher Fecal Bifidobacterium Concentrations and Fewer Febrile Episodes Requiring Medical Attention
Lohner, S., Jakobik, V., Mihályi, K., Soldi, S., Vasileiadis, S., Theis, S., Sailer, M., Sieland, C., Berényi, K., Boehm, G., et al. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy120 · Cited by 47 · see citing works
Improved body weight and performance status and reduced serum PGE2 levels after nutritional intervention with a specific medical food in newly diagnosed patients with esophageal cancer or adenocarcinoma of the gastro‐esophageal junction
Faber, J., Uitdehaag, M. J., Spaander, M. C. W., van Steenbergen‐Langeveld, S., Vos, P., Berkhout, M., Lamers, C., Rümke, H. C., Tilanus, H. W., Siersema, P. D., et al. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12009 · Cited by 43 · see citing works
Impact of Dietary Polydextrose Fiber on the Human Gut Metabolome
Lamichhane, S., Yde, C. C., Forssten, S. D., Ouwehand, A. C., Saarinen, M., Jensen, H. M., Gibson, G. R., Rastall, R. A., Fava, F., & Bertram, H. C. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5031218 · Cited by 43 · see citing works
Chain length‐dependent effects of inulin‐type fructan dietary fiber on human systemic immune responses against hepatitis‐B
Vogt, L. M., Elderman, M. E., Borghuis, T., de Haan, B. J., Faas, M. M., & de Vos, P. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700171 · Cited by 42 · see citing works
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra
Williams, A. C., Hill, L. J., & Ramsden, D. B. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/302875 · Cited by 41 · see citing works
The Utilisation of Prebiotics and Synbiotics in Dogs
Pinna, C., & Biagi, G. (2014) · Italian Journal of Animal Science · doi:10.4081/ijas.2014.3107 · Cited by 39 · see citing works
Certain dietary carbohydrates promote Listeria infection in a guinea pig model, while others prevent it
Ebersbach, T., Jørgensen, J. B., Heegaard, P. M. H., Lahtinen, S. J., Ouwehand, A. C., Poulsen, M., Frøkiær, H., & Licht, T. R. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.03.030 · Cited by 39 · see citing works
Design and rationale of the INSYTE study: A randomised, placebo controlled study to test the efficacy of a synbiotic on liver fat, disease biomarkers and intestinal microbiota in non-alcoholic fatty liver disease
Scorletti, E., Afolabi, P. R., Miles, E. A., Smith, D. E., Almehmadi, A., Alshathry, A. S., Moyses, H. E., Clough, G. F., Wright, M., Patel, J., et al. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.05.010 · Cited by 38 · see citing works
Self-citation
An overview of the functionality of inulin in meat and poultry products
Yousefi, M., Khorshidian, N., & Hosseini, H. (2018) · Nutrition & Food Science · doi:10.1108/nfs-11-2017-0253 · Cited by 38 · see citing works
Microbiota-independent immunological effects of non-digestible oligosaccharides in the context of inflammatory bowel diseases
Fabbro, S. D., Calder, P. C., & Childs, C. E. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120006953 · Cited by 38 · see citing works
Self-citation
Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence
Przemska-Kosicka, A., Childs, C. E., Enani, S. M., Maidens, C. M., Dong, H., Bindayel, I. A., Tuohy, K. M., Todd, S., Gosney, M., & Yaqoob, P. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0061-4 · Cited by 37 · see citing works
Prebiotic potential of Jerusalem artichoke (Helianthus tuberosus L.) in Wistar rats: effects of levels of supplementation on hindgut fermentation, intestinal morphology, blood metabolites and immune response
Samal, L., Chaturvedi, V. B., Saikumar, G., Somvanshi, R., & Pattanaik, A. K. (2014) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6873 · Cited by 36 · see citing works
International Journal of Chemistry and Pharmaceutical Sciences
Dhani, P. R. (2014) · ADVANCED SCIENCES INDEX · Cited by 36 · see citing works
Covid 19: Diet Composition and Health
Skrajnowska, D., Brumer, M., Kankowska, S., Matysek, M., Miazio, N., & Bobrowska‐Korczak, B. (2021) · Nutrients · doi:10.3390/nu13092980 · Cited by 37 · see citing works
Lacticaseibacillus paracasei PS23 Effectively Modulates Gut Microbiota Composition and Improves Gastrointestinal Function in Aged SAMP8 Mice
Chen, L., Wang, M.-F., Chang, C., Huang, S., Pan, C., Yeh, Y., Huang, C., Chan, C.-H., & Huang, H.-Y. (2021) · Nutrients · doi:10.3390/nu13041116 · Cited by 37 · see citing works
Optimisation of inulin extraction from globe artichoke (Cynara cardunculus L. subsp. scolymus (L.) Hegi.) by electromagnetic induction heating process
Terkmane, N., Krea, M., & Moulaï-Mostefa, N. (2016) · International Journal of Food Science & Technology · doi:10.1111/ijfs.13167 · Cited by 33 · see citing works
Study of the effect exerted by fructo-oligosaccharides from yacon (Smallanthus sonchifolius) root flour in an intestinal infection model with Salmonella Typhimurium
Vélez, E. M. D. M., Castillo, N. A., Mesón, O., Grau, A., Bonet, M. E. B., & Perdigón, G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512004230 · Cited by 33 · see citing works
Alternative approaches to therapeutics and subtherapeutics for sustainable poultry production
Tabashsum, Z., Scriba, A., & Biswas, D. (2023) · Poultry Science · doi:10.1016/j.psj.2023.102750 · Cited by 32 · see citing works
Inulin-Type β2-1 Fructans have Some Effect on the Antibody Response to Seasonal Influenza Vaccination in Healthy Middle-Aged Humans
Lomax, A. R., Cheung, L. V. Y., Noakes, P. S., Miles, E. A., & Calder, P. C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00490 · Cited by 32 · see citing works
Self-citation
Obesity as the 21st Century's major disease: The role of probiotics and prebiotics in prevention and treatment
Włodarczyk, M., & Śliżewska, K. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101115 · Cited by 32 · see citing works
Irritable bowel syndrome: an integrated explanatory model for clinical practice
Hungin, A. P. S., Becher, A., Cayley, B., Heidelbaugh, J. J., Muris, J. W. M., Rubin, G. P., Seifert, B., Russell, A., & de Wit, N. J. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12524 · Cited by 31 · see citing works
Assessment of the modulating effects of fructo-oligosaccharides on fecal microbiota using human flora–associated piglets
Shen, J., Zhang, B., Wei, H., Che, C., Ding, D., Hua, X., Bucheli, P., Wang, L., Li, Y., Pang, X., et al. (2010) · Archives of Microbiology · doi:10.1007/s00203-010-0628-y · Cited by 30 · see citing works

β2-1 Fructans have a bifidogenic effect in healthy middle-aged human subjects but do not alter immune responses examined in the absence of an in vivo immune challenge: results from a randomised controlled trial
Lomax, A. R., Cheung, L. V. Y., Tuohy, K. M., Noakes, P. S., Miles, E. A., & Calder, P. C. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511007276 · Cited by 47 · see citing works
Self-citation
The Immunomodulatory Properties of β-2,6 Fructans: A Comprehensive Review
Young, I. D., Latousakis, D., & Juge, N. (2021) · Nutrients · doi:10.3390/nu13041309 · Cited by 38 · see citing works
β2-1 Fructan supplementation alters host immune responses in a manner consistent with increased exposure to microbial components: results from a double-blinded, randomised, cross-over study in healthy adults
Clarke, S. T., Green-Johnson, J. M., Brooks, S. P. J., Ramdath, D. D., Berčík, P., Avila, C., Inglis, G. D., Green, J., Yanke, L. J., Selinger, L. B., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516000908 · Cited by 68 · see citing works
β2→1-Fructans Modulate the Immune System In Vivo in a Microbiota-Dependent and -Independent Fashion
Fransen, F., Sahasrabudhe, N. M., Elderman, M. E., Bosveld, M., Aidy, S. E., Hugenholtz, F., Borghuis, T., Kousemaker, B., Winkel, S. L., Jongh, C. E. V. D. G., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00154 · Cited by 68 · see citing works
Prebiotics and human immune function
Lomax, A. R. (2010) · ePrints Soton (University of Southampton)
Self-citation

Authors: Lomax, A. R., & Calder, P. C.
Affiliations: University of Southampton (GB)
Corresponding author: Lomax, Amy R.
ORCID: Calder, Philip C.
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2008-09-25
Volume: 101
Issue: 5
Pages: 633-658
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114508055608
OpenAlex: W1991759182
Cited by: 257
References: 137
Citations by year: 2026: 4 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 18 · 2021: 19 · 2020: 20 · 2019: 20 · 2018: 20 · 2017: 16 · 2016: 14 · 2015: 10 · 2014: 23 · 2013: 17 · 2012: 16
FWCI: 1.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: prebiotics, gut microbiota, immune function, innate immunity, adaptive immunity, intestinal infection, intestinal inflammation, inflammatory bowel disease, atopic dermatitis, irritable bowel syndrome, infants and children
MeSH terms: Adult, Aged, Animals, Child, Child, Preschool, Disease Models, Animal, Female, Fructans, Humans, Immune System, Infant, Infant, Newborn, Inflammation, Intestines, Lymphoid Tissue, Male, Middle Aged, Opportunistic Infections, Evidence-Based Medicine, Young Adult, Prebiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prebiotics, immune function, infection and inflammation: a review of the evidence

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks