The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
Open accessAbstract
Among procyanidins (PC), monomers, such as catechin and epicatechin, have been widely studied, whereas dimer and trimer oligomers have received much less attention, despite their abundance in our diet. Recent studies have showed that as dimers and trimers could be important in determining the biological effects of procyanidin-rich food, understanding their bioavailability and metabolism is fundamental. The purpose of the present work is to study the stability of PC under digestion conditions, the metabolism and the bioavailability by using a combination of in vitro and in vivo models. Simultaneously, the matrix effect of a carbohydrate-rich food on the digestibility and bioavailability of PC is investigated. The results show a high level of stability of PC under gastric and duodenal digestion conditions. However, the pharmacokinetic study revealed limited absorption. Free forms of dimers and trimers have been detected in rat plasma, reaching the maximum concentration 1 h after oral intake of a grape seed extract.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658
Comparison of Five In Vitro Digestion Models To Study the Bioaccessibility of Soil Contaminants
Oomen, A. G., Hack, A., Minekus, M., Zeijdner, E., Cornelis, C., Schoeters, G., Verstraete, W., Van de Wiele, T., Wragg, J., Rompelberg, C. J. M., et al. (2002) · Environmental Science & Technology · doi:10.1021/es010204v · Cited by 800
Charman, W. N., Porter, C. J. H., Mithani, S., & Dressman, J. B. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960085v · Cited by 617
A Review of the Health Effects of Green Tea Catechins in In Vivo Animal Models
Crespy, V., & Williamson, G. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.12.3431s · Cited by 598
Yang, C. S., Chen, L., Lee, M.-J., Balentine, D. A., Kuo, M. C., & Schantz, S. P. (1998) · PubMed · Cited by 566
BERMUDEZSOTO, M., TOMASBARBERAN, F., & GARCIACONESA, M. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2006.06.025 · Cited by 548
Holt, R. R., Lazarus, S. A., Sullards, M. C., Zhu, Q. Y., Schramm, D. D., Hammerstone, J. F., Fraga, C. G., Schmitz, H. H., & Keen, C. L. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.798 · Cited by 521
Spencer, J. P. E., Abd El Mohsen, M. M., Minihane, A.-M., & Mathers, J. C. (2008) · British Journal of Nutrition · doi:10.1017/s0007114507798938 · Cited by 489
Stability of Green Tea Catechins
Zhu, Q. Y., Zhang, A., Tsang, D., Huang, Y., & Chen, Z.-Y. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9706080 · Cited by 437
Cited by
Dirir, A. M., Daou, M., Yousef, A. F., & Yousef, L. F. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-021-09773-1 · Cited by 586
Phenolic compounds in fruits – an overview
Haminiuk, C. W. I., Maciel, G. M., Plata‐Oviedo, M. S. V., & Peralta, R. M. (2012) · International Journal of Food Science & Technology · doi:10.1111/j.1365-2621.2012.03067.x · Cited by 566
Kawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563
Yilmazer-Musa, M., Griffith, A. M., Michels, A. J., Schneider, E., & Frei, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf301147n · Cited by 411
Absorption and metabolism of proanthocyanidins
Ou, K., & Gu, L. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2013.08.004 · Cited by 406
Metadata
- Authors
- Serra, A., Macià, A., Romero, M.-P., Valls, J., Bladé, C., Arola, L., & Motilva, M.-J.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-12-14
- Volume
- 103
- Issue
- 7
- Pages
- 944-952
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2009429426
- Cited by
- 276
- References
- 46
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. https://app.cochat.ai/papers/10.1017/s0007114509992741
- The paper
- Serra, A., Macià, A., Romero, M.-P., Valls, J., Bladé, C., Arola, L., & Motilva, M.-J. (2010). Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models. British Journal of Nutrition. https://doi.org/10.1017/s0007114509992741
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
