Cited by 182Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthNutritional Studies and Diet

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Dietary cholesterol: from physiology to cardiovascular risk

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Lecerf, Jean-Michel, de Lorgeril, Michel·2011·British Journal of Nutrition

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Abstract

Dietary cholesterol comes exclusively from animal sources, thus it is naturally present in our diet and tissues. It is an important component of cell membranes and a precursor of bile acids, steroid hormones and vitamin D. Contrary to phytosterols (originated from plants), cholesterol is synthesised in the human body in order to maintain a stable pool when dietary intake is low. Given the necessity for cholesterol, very effective intestinal uptake mechanisms and enterohepatic bile acid and cholesterol reabsorption cycles exist; conversely, phytosterols are poorly absorbed and, indeed, rapidly excreted. Dietary cholesterol content does not significantly influence plasma cholesterol values, which are regulated by different genetic and nutritional factors that influence cholesterol absorption or synthesis. Some subjects are hyper-absorbers and others are hyper-responders, which implies new therapeutic issues. Epidemiological data do not support a link between dietary cholesterol and CVD. Recent biological data concerning the effect of dietary cholesterol on LDL receptor-related protein may explain the complexity of the effect of cholesterol on CVD risk.

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Authors: Lecerf, J.-M., & de Lorgeril, M.
Affiliations: Institut Pasteur de Lille (FR)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Lecerf, Jean-Michel
ORCID: Lecerf, Jean-Michel
Venue: British Journal of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2011-03-09
Volume: 106
Issue: 1
Pages: 6-14
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114511000237
OpenAlex: W2079096694
Cited by: 182
References: 79
Citations by year: 2026: 6 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 10 · 2021: 18 · 2020: 20 · 2019: 12 · 2018: 19 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 8 · 2013: 13 · 2012: 2
FWCI: 1.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: dietary cholesterol, cardiovascular risk, serum cholesterol, cholesterol absorption, enterohepatic circulation, bile acids, phytosterols, cholesterol biosynthesis, LDL receptor-related protein, hyper-responders
MeSH terms: Cardiovascular Diseases, Cholesterol, Cholesterol, Dietary, Humans, Intestinal Absorption, Phytosterols, Risk Factors

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