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Cited by 333Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismNutritional Studies and Diet

Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis

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Weggemans, Rianne M, Zock, Peter L, Katan, Martijn B·2001·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/73.5.885
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Abstract

Background Several epidemiologic studies found no effect of egg consumption on the risk of coronary heart disease. It is possible that the adverse effect of eggs on LDL-cholesterol is offset by their favorable effect on HDL cholesterol.Objective The objective was to review the effect of dietary cholesterol on the ratio of total to HDL cholesterol.Design Studies were identified by MEDLINE and Biological Abstracts searches (from 1974 to June 1999) and by reviewing reference lists. In addition, we included data from a more recently published study. Studies were included if they had a crossover or parallel design with a control group, if the experimental diets differed only in the amount of dietary cholesterol or number of eggs and were fed for > or =14 d, and if HDL-cholesterol concentrations were reported. Of the 222 studies identified, 17 studies involving 556 subjects met these criteria.Results The addition of 100 mg dietary cholesterol/d increased the ratio of total to HDL cholesterol by 0.020 units (95% CI: 0.010, 0.030), total cholesterol concentrations by 0.056 mmol/L (2.2 mg/dL) (95% CI: 0.046, 0.065 mmol/L; 1.8, 2.5 mg/dL), and HDL-cholesterol concentrations by 0.008 mmol/L (0.3 mg/dL) (95% CI: 0.005, 0.010 mmol/L; 0.2, 0.4 mg/dL).Conclusions Dietary cholesterol raises the ratio of total to HDL cholesterol and, therefore, adversely affects the cholesterol profile. The advice to limit cholesterol intake by reducing consumption of eggs and other cholesterol-rich foods may therefore still be valid.

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Authors
Weggemans, R. M., Zock, P. L., & Katan, M. B.
Affiliations
Wageningen University & Research (NL)
ORCID
Zock, Peter L
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2001-05
Volume
73
Issue
5
Pages
885-891
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/73.5.885
OpenAlex
W2134666762
Cited by
333
References
66
Citations by year
2025: 3 · 2024: 8 · 2023: 14 · 2022: 8 · 2021: 11 · 2020: 20 · 2019: 14 · 2018: 22 · 2017: 27 · 2016: 10 · 2015: 30 · 2014: 14 · 2013: 20 · 2012: 20
FWCI
1.93
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
dietary cholesterol, egg consumption, TC/HDL-C ratio, HDL cholesterol, LDL cholesterol, coronary heart disease risk, dietary intervention studies
MeSH terms
Cholesterol, Cholesterol, Dietary, Coronary Disease, Eggs, Humans, Cholesterol, HDL, Research Design, Risk Factors, MEDLINE

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