Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats
Open accessAbstract
Growing evidence suggests that intake of flavonoid-containing foods may exert cardiovascular benefits in human subjects. We have investigated the effects of a 10-week blueberry (BB) supplementation on blood pressure (BP) and vascular reactivity in rats fed a high-fat/high-cholesterol diet, known to induce endothelial dysfunction. Rats were randomly assigned to follow a control chow diet, a chow diet supplemented with 2 % (w/w) BB, a high-fat diet (10 % lard; 0·5 % cholesterol) or the high fat plus BB for 10 weeks. Rats supplemented with BB showed significant reductions in systolic BP (SBP) of 11 and 14 %, at weeks 8 and 10, respectively, relative to rats fed the control chow diet (week 8 SBP: 107·5 (sem 4·7) v. 122·2 (sem 2·1) mmHg, P= 0·018; week 10 SBP: 115·0 (sem 3·1) v. 132·7 (sem 1·5) mmHg, P< 0·0001). Furthermore, SBP was reduced by 14 % in rats fed with the high fat plus 2 % BB diet at week 10, compared to those on the high-fat diet only (SBP: 118·2 (sem 3·6) v. 139·5 (sem 4·5) mmHg, P< 0·0001). Aortas harvested from BB-fed animals exhibited significantly reduced contractile responses (to l-phenylephrine) compared to those fed the control chow or high-fat diets. Furthermore, in rats fed with high fat supplemented with BB, aorta relaxation was significantly greater in response to acetylcholine compared to animals fed with the fat diet. These data suggest that BB consumption can lower BP and improve endothelial dysfunction induced by a high fat, high cholesterol containing diet.
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Increased consumption of blueberries containing high content of anthocyanins improved endothelial functions and optimized blood pressure in rats fed with a high-fat diet.
“Increased consumption of blueberries containing high content of anthocyanins improved endothelial functions and optimized blood pressure in rats fed with a high-fat diet (Rodriguez-Mateos et al. 2013).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Rodriguez-Mateos et al. 2013
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works
- Authors
- Rodriguez-Mateos, A., Ishisaka, A., Mawatari, K., Vidal-Diez, A., Spencer, J. P. E., & Terao, J.
- Affiliations
- Tokushima University (JP)
- University of Reading (GB)
- Corresponding author
- Spencer, Jeremy P. E.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-10-09
- Volume
- 109
- Issue
- 10
- Pages
- 1746-1754
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2170161428
- Cited by
- 58
- References
- 68
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 8
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/G005702/1)
- Japan Society for the Promotion of Science (24500857)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- blueberry, flavonoids, blood pressure, vascular reactivity, endothelial dysfunction, high-fat diet, high-cholesterol diet, aortic contractility, acetylcholine-induced relaxation, dietary supplementation, hypertension
- MeSH terms
- Acetylcholine, Animals, Aorta, Blood Pressure, Cholesterol, Dietary, Dietary Fats, Endothelium, Vascular, Flavonoids, Fruit, Male, Phytotherapy, Muscle, Smooth, Vascular, Phenylephrine, Vascular Diseases, Vasoconstriction, Vasodilator Agents, Rats, Wistar, Dietary Supplements, Plant Preparations, Vaccinium, Rats, Diet, High-Fat
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