Metabolomic profiling of urine: response to a randomised, controlled feeding study of select fruits and vegetables, and application to an observational study
Open accessAbstract
Metabolomic profiles were used to characterise the effects of consuming a high-phytochemical diet compared with a diet devoid of fruits and vegetables (F&V) in a randomised trial and cross-sectional study. In the trial, 8 h fasting urine from healthy men (n 5) and women (n 5) was collected after a 2-week randomised, controlled trial of two diet periods: a diet rich in cruciferous vegetables, citrus and soya (F&V), and a fruit- and vegetable-free (basal) diet. Among the ions found to differentiate the diets, 176 were putatively annotated with compound identifications, with forty-six supported by MS/MS fragment evidence. Metabolites more abundant in the F&V diet included markers of the dietary intervention (e.g. crucifers, citrus and soya), fatty acids and niacin metabolites. Ions more abundant in the basal diet included riboflavin, several acylcarnitines and amino acid metabolites. In the cross-sectional study, we compared the participants based on the tertiles of crucifers, citrus and soya from 3 d food records (n 36) and FFQ (n 57); intake was separately divided into the tertiles of total fruit and vegetable intake for FFQ. As a group, ions individually differential between the experimental diets differentiated the observational study participants. However, only four ions were significant individually, differentiating the third v. first tertile of crucifer, citrus and soya intake based on 3 d food records. One of these ions was putatively annotated: proline betaine, a marker of citrus consumption. There were no ions significantly distinguishing tertiles by FFQ. The metabolomic assessment of controlled dietary interventions provides a more accurate and stronger characterisation of the diet than observational data.
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Using food-frequency questionnaires may directly identify biomarkers of habitual dietary exposure, but their lower accuracy and smaller number of documented foods may limit their usefulness for discovery studies.
“The use of food-frequency questionnaires may directly lead to the identification of biomarkers of habitual dietary exposure, but the lower accuracy and lower number of foods documented may limit their value for such discovery studies (105).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [105]
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Yang, S. H., Kim, Y. J., Lee, H., Seo, W. D., Kwon, E. Y., & Kim, J. K. (2023) · Food Science and Biotechnology · doi:10.1007/s10068-023-01479-8
Wong, N. M. Y., Ting, M., Liu, M. H., & Kim, J. E. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2652523
- Authors
- May, D. H., Navarro, S. L., Ruczinski, I., Hogan, J., Ogata, Y., Schwarz, Y., Levy, L., Holzman, T., McIntosh, M. W., & Lampe, J. W.
- Affiliations
- Fred Hutch Cancer Center (US)
- Johns Hopkins University (US)
- Corresponding author
- Lampe, Johanna W.
- ORCID
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-05-09
- Volume
- 110
- Issue
- 10
- Pages
- 1760-1770
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC3818452
- OpenAlex
- W2131308179
- Cited by
- 69
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 4
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- M.J. Murdock Charitable Trust
- National Institutes of Health
- National Cancer Institute (R56 CA70913, R01CA142695, R25 CA 94880, R25CA094880, R56CA070913, P30CA015704)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- urine metabolomics, dietary intervention, fruit and vegetable intake, cruciferous vegetables, citrus, soybean, proline betaine, dietary biomarkers, fatty acids, acylcarnitines, riboflavin, food frequency questionnaire, 3-day food record
- MeSH terms
- Adult, Carnitine, Citrus, Cross-Sectional Studies, Diet, Fatty Acids, Feeding Behavior, Female, Fruit, Humans, Ions, Male, Niacin, Proline, Surveys and Questionnaires, Riboflavin, Glycine max, Vegetables, Biomarkers, Nutrition Assessment, Diet Records, Brassicaceae, Metabolomics, Metabolome, Young Adult, Phytochemicals
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