Mass spectrometry-based metabolomics for the discovery of biomarkers of fruit and vegetable intake: citrus fruit as a case study
Abstract
Elucidation of the relationships between genotype, diet, and health requires accurate dietary assessment. In intervention and epidemiological studies, dietary assessment usually relies on questionnaires, which are susceptible to recall bias. An alternative approach is to quantify biomarkers of intake in biofluids, but few such markers have been validated so far. Here we describe the use of metabolomics for the discovery of nutritional biomarkers, using citrus fruits as a case study. Three study designs were compared. Urinary metabolomes were profiled for volunteers that had (a) consumed an acute dose of orange or grapefruit juice, (b) consumed orange juice regularly for one month, and (c) reported high or low consumption of citrus products for a large cohort study. Some signals were found to reflect citrus consumption in all three studies. Proline betaine and flavanone glucuronides were identified as known biomarkers, but various other biomarkers were revealed. Further, many signals that increased after citrus intake in the acute study were not sensitive enough to discriminate high and low citrus consumers in the cohort study. We propose that urine profiling of cohort subjects stratified by consumption is an effective strategy for discovery of sensitive biomarkers of consumption for a wide range of foods.
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Metabolomics constitutes a comprehensive approach to identify new panels of biomarkers that are specific or common to particular foods or food groups, as shown for citrus fruit.
“Metabolomics constitutes a comprehensive approach to identify new panels of biomarkers that are specific or common to particular foods or food groups, as shown recently for citrus fruit (49).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [49]
New biomarkers for citrus fruit intake and coffee have been successfully identified using 24-hour dietary recalls and food-frequency questionnaires.
“Both 24-h dietary recalls and food-frequency questionnaires have been used, and new biomarkers for citrus fruit intake or coffee were successfully identified (49, 88) (Table 3).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [49]
High-resolution LC-Q-TOF MS with electrospray ionization has successfully detected compounds such as terpene metabolites, diketopiperazine metabolites, phenylvalerolactones, and benzoxazinoid metabolites, which are candidate biomarkers of food intake not easily detected by NMR or GC-MS.
“This technique has been successful in detecting compounds such as terpene metabolites, diketopiperazine metabolites, phenylvalerolactones, and benzoxazinoid metabolites, which are interesting candidate biomarkers of food intake that would not be easily detected in biofluids by NMR or GC-MS (49,86,96).”
From The food metabolome: a window over dietary exposure (2014) · cites this paper as [49]
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- Authors
- Pujos-Guillot, E., Hubert, J., Martin, J.-F., Lyan, B., Quintana, M., Claude, S., Chabanas, B., Rothwell, J. A., Bennetau-Pelissero, C., Scalbert, A., Comte, B., Hercberg, S., Morand, C., Galan, P., & Manach, C.
- Affiliations
- INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France
- Université Clermont Auvergne (FR)
- Université Bordeaux, Physiopathologie de la plasticité neuronale, U862, F-33000 Bordeaux, France
- Centre international de recherche sur le cancer (FR)
- Research Unit on Nutritional Epidemiology, Université Paris 13, Sorbonne Paris cité, INSERM U557, INRA U1125, CNAM, F-93017 Bobigny, France
- Conservatoire National des Arts et Métiers (FR)
- Corresponding author
- Manach, Claudine
- ORCID
- Venue
- Journal of Proteome Research
- Publisher
- American Chemical Society (ACS)
- Published
- 2013-03-05
- Volume
- 12
- Issue
- 4
- Pages
- 1645-1659
- ISSN
- 1535-3893 (ISSN-L)
- 1535-3907
- OpenAlex
- W2048213069
- Cited by
- 166
- References
- 49
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 14 · 2021: 14 · 2020: 15 · 2019: 12 · 2018: 14 · 2017: 21 · 2016: 11 · 2015: 13 · 2014: 22 · 2013: 6
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Proteome Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-10-ALIA-0007)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- dietary biomarkers, fruit and vegetable intake, urinary metabolome, proline betaine, orange juice, grapefruit juice, dietary assessment, biomarker discovery, cohort studies
- MeSH terms
- Adult, Beverages, Citrus, Fruit, Humans, Male, Proline, Mass Spectrometry, Vegetables, Cohort Studies, Biomarkers, Urinalysis, Flavanones, Metabolomics
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