The complex links between dietary phytochemicals and human health deciphered by metabolomics

Polyphenols: Food sources and bioavailability

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Dietary polyphenols and the prevention of diseases

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Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

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Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action

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Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis

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Mass spectrometry‐based metabolomics

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Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals

Liu, R. H. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.517s · Cited by 2,186 · see citing works

Flavonoids: antioxidants or signalling molecules?

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Polyphenols and disease risk in epidemiologic studies

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Polyphenols: Antioxidants and beyond

Scalbert, A., Johnson, I. T., & Saltmarsh, M. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.215s · Cited by 1,836 · see citing works

Chemometrics in Metabonomics

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Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants

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The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones

Setchell, K. D. R., Brown, N. M., & Lydeking-Olsen, E. (2002) · The Journal of Nutrition · doi:10.1093/jn/132.12.3577 · Cited by 1,209 · see citing works

Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk

Ríboli, E., & Norat, T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.559s · Cited by 1,173 · see citing works

Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials

Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., & Cassidy, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.38 · Cited by 1,097 · see citing works

Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels

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Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

Brindle, J. T., Antti, H., Holmes, E. C., Tranter, G. E., Nicholson, J. K., Bethell, H., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., et al. (2002) · Nature Medicine · doi:10.1038/nm1202-802 · Cited by 1,031 · see citing works

Gut microorganisms, mammalian metabolism and personalized health care

Nicholson, J. K., Holmes, E., & Wilson, I. D. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1152 · Cited by 945 · see citing works

Plant-based foods and prevention of cardiovascular disease: an overview

Hu, F. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.544s · Cited by 700 · see citing works

Metabolomics: applications to food science and nutrition research

Wishart, D. S. (2008) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2008.03.003 · Cited by 672 · see citing works

Phytochemical dictionary. A handbook of bioactive compounds from plants.

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Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise

Khan, N., Afaq, F., & Mukhtar, H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1740 · Cited by 592 · see citing works

A Liquid Chromatography-Mass Spectrometry-Based Metabolome Database for Tomato

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Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

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Polyphenolic phytochemicals – just antioxidants or much more?

Stevenson, D. E., & Hurst, R. D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7237-1 · Cited by 551 · see citing works

Carotenoid Content of U.S. Foods: An Update of the Database

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C AROTENOID B IOAVAILABILITY AND B IOCONVERSION

Yeum, K., & Russell, R. M. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102834 · Cited by 535 · see citing works

Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

Spencer, J. P. E., Mohsen, M. M. A. E., Minihane, A.-M., & Mathers, J. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507798938 · Cited by 490 · see citing works

Metabolomics in human nutrition: opportunities and challenges

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Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

Orešič, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081800 · Cited by 449 · see citing works

Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability

Cerdá, B., Tomás-Barberán, F. A., & Espı́n, J. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 448 · see citing works

A critical review of the bioavailability of glucosinolates and related compounds

Holst, B., & Williamson, G. (2004) · Natural Product Reports · doi:10.1039/b204039p · Cited by 425 · see citing works

Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions

Mullen, W., Edwards, C. A., & Crozier, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061809 · Cited by 421 · see citing works

Intestinal absorption of dietary carotenoids

Yonekura, L., & Nagao, A. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600145 · Cited by 409 · see citing works

Effects of Dosing Condition on the Oral Bioavailability of Green Tea Catechins after Single-Dose Administration of Polyphenon E in Healthy Individuals

Chow, H.-H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., & Alberts, D. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2549 · Cited by 400 · see citing works

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

Shaham, O., Wei, R., Wang, T. J., Ricciardi, C., Lewis, G. D., Vasan, R. S., Carr, S. A., Thadhani, R., Gerszten, R. E., & Mootha, V. K. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.50 · Cited by 399 · see citing works

Activity and Concentration of Polyphenolic Antioxidants in Apple: Effect of Cultivar, Harvest Year, and Storage Conditions

van der Sluis, A. A., Dekker, M., de Jager, A., & Jongen, W. M. F. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf001493u · Cited by 398 · see citing works

Flavonoids: modulators of brain function?

Spencer, J. P. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508965776 · Cited by 385 · see citing works

Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection

Brown, M. J., Ferruzzi, M. G., Nguyen, M. L., Cooper, D. A., Eldridge, A. L., Schwartz, S. J., & White, W. S. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.396 · Cited by 376 · see citing works

The human cerebrospinal fluid metabolome

Wishart, D. S., Lewis, M., Morrissey, J. A., Flegel, M. D., Jeroncic, K., Xiong, Y., Cheng, D., Eisner, R., Gautam, B., Tzur, D., et al. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.05.001 · Cited by 346 · see citing works

Detection of epithelial ovarian cancer using 1 H‐NMR‐based metabonomics

Odunsi, K. O., Wollman, R. M., Ambrosone, C. B., Hutson, A. D., McCann, S. E., Tammela, J., Geisler, J. P., Miller, G., Sellers, T. A., Cliby, W. A., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20651 · Cited by 319 · see citing works

Plant Secondary Metabolites: Occurrence, Structure And Role In The Human Diet

Crozier, A., Clifford, M. B., & Ashihara, H. (2014) · Wiley eBooks · doi:10.1002/9780470988558 · Cited by 287 · see citing works

Nutritional metabonomics: applications and perspectives.

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Nonlinear Data Alignment for UPLC−MS and HPLC−MS Based Metabolomics: Quantitative Analysis of Endogenous and Exogenous Metabolites in Human Serum

Nordström, A., O’Maille, G., Qin, C., & Siuzdak, G. E. (2006) · Analytical Chemistry · doi:10.1021/ac060245f · Cited by 273 · see citing works

Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk

Grace, P. B., Taylor, J. I., Low, Y.-L., Luben, R. N., Mulligan, A. A., Botting, N. P., Dowsett, M., Welch, A. A., Khaw, K.-T., Wareham, N. J., et al. (2004) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.698.13.5 · Cited by 264 · see citing works

The role of analytical sciences in medical systems biology

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Structure elucidation of phase II metabolites by tandem mass spectrometry: an overview

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A Metabonomic Strategy for the Detection of the Metabolic Effects of Chamomile (Matricaria recutita L.) Ingestion

Wang, Y., Tang, H., Nicholson, J. K., Hylands, P. J., Sampson, J. N., & Holmes, E. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0403282 · Cited by 237 · see citing works

Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation11G. Loo, K. Takahashi, A. Powolny, R.A. Hopkins, Induction of GADD45 gene expression by phenylethyl isothiocyanate in HCT-116 human colon adenocarcinoma cells, FASEB J 16 (2002) A264-A265 (abstract #216.15). Also, unpublished data. (review)

Loo, G. T. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00251-6 · Cited by 215 · see citing works

Phytochemicals and cancer

Johnson, I. T. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005459 · Cited by 213 · see citing works

Mass spectrometry for the identification of the discriminating signals from metabolomics: Current status and future trends

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Diagnosis of liver cancer using HPLC-based metabonomics avoiding false-positive result from hepatitis and hepatocirrhosis diseases

Yang, J., Xu, G., ZHENG, Y., Kong, H., Pang, T., Sagbo Ada, L. V., & Yang, Q. X. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.09.032 · Cited by 210 · see citing works

Serum lycopene concentrations and carotid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study

Rissanen, T. H., Voutilainen, S., Nyyssönen, K., Salonen, R., Kaplan, G. A., & Salonen, J. T. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.133 · Cited by 206 · see citing works

Development of a food composition database for the estimation of dietary intakes of glucosinolates, the biologically active constituents of cruciferous vegetables

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Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods

Mennen, L. I., Sapinho, D., Ito, H., Bertrais, S., Galan, P., Hercberg, S., & Scalbert, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061808 · Cited by 174 · see citing works

Metabonomics Approach To Determine Metabolic Differences between Green Tea and Black Tea Consumption

van Dorsten, F. A., Daykin, C. A., MULDER, T. P. J., & van Duynhoven, J. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061016x · Cited by 170 · see citing works

Polyphenol levels in human urine after intake of six different polyphenol-rich beverages

Ito, H., Gonthier, M., Manach, C., Morand, C., Mennen, L. I., Rémésy, C., & Scalbert, A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051522 · Cited by 165 · see citing works

Absorption of lycopene from single or daily portions of raw and processed tomato

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Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake

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Variations in Isoflavone Levels in Soy Foods and Soy Protein Isolates and Issues Related to Isoflavone Databases and Food Labeling

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Statistical methods for comparing comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts

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Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables

Erlund, I., Silaste, M.-L., Alfthan, G., Rantala, M., Kesäniemi, Y. A., & Aro, A. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601409 · Cited by 151 · see citing works

Metabolomics: an emerging post-genomic tool for nutrition

Whitfield, P. D., German, A. J., & Noble, P. M. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041243 · Cited by 150 · see citing works

Biofluid 1H NMR-based metabonomic techniques in nutrition research — metabolic effects of dietary isoflavones in humans

Solanky, K. S., Bailey, N. J. C., Beckwith-Hall, B. M., Bingham, S. A., Davis, A. L., Holmes, E. C., Nicholson, J. K., & Cassidy, A. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.005 · Cited by 148 · see citing works

Health Effects of Phytoestrogens

Branca, F., & Lorenzetti, S. (2005) · Forum of nutrition/Bibliotheca Nutritio et dieta · doi:10.1159/000083773 · Cited by 145 · see citing works

Influence of acute phytochemical intake on human urinary metabolomic profiles

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Computer systems for the prediction of xenobiotic metabolism

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Assessment of usual dietary intake in population studies of gene–diet interaction

Tucker, K. L. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.07.010 · Cited by 137 · see citing works

Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids

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Interindividual differences in phytochemical metabolism and disposition

Lampe, J. W., & Chang, J. H. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.05.003 · Cited by 135 · see citing works

Soy isoflavone genistein in prevention and treatment of prostate cancer

Perabo, F., Löw, E. C. V., Ellinger, J., von Rücker, A., Müller, S. C., & Bastian, P. J. (2007) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4501000 · Cited by 128 · see citing works

Is Molecular Profiling Ready for Use in Clinical Decision Making?

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Detection of Urinary Drug Metabolite (Xenometabolome) Signatures in Molecular Epidemiology Studies via Statistical Total Correlation (NMR) Spectroscopy

Holmes, E. C., Loo, R. L., Cloarec, O., Coen, M., Tang, H., Maibaum, E., Bruce, S., Chan, Q. M., Elliott, P., Stamler, J., et al. (2007) · Analytical Chemistry · doi:10.1021/ac062305n · Cited by 124 · see citing works

Absorption of lycopene from single or daily portions of raw and processed tomato

Porrini, M., Riso, P., & Testolin, G. (1998) · British Journal Of Nutrition · doi:10.1079/096582198388300 · Cited by 122 · see citing works

Health‐related Interactions of Phytochemicals

Lila, M. A., & Raskin, I. (2005) · Journal of Food Science · doi:10.1111/j.1365-2621.2005.tb09054.x · Cited by 114 · see citing works

An integrated functional genomics and metabolomics approach for defining poor prognosis in human neuroendocrine cancers

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GC–MS methods for metabolic profiling of microbial fermentation products of dietary polyphenols in human and in vitro intervention studies

Grün, C. H., van Dorsten, F. A., Jacobs, D. M., Belleguic, M. L., van Velzen, E. J. J., Bingham, M. O., Janssen, H., & van Duynhoven, J. (2008) · Journal of Chromatography B · doi:10.1016/j.jchromb.2008.04.039 · Cited by 101 · see citing works

Intracellular signaling network as a prime chemopreventive target of (–)‐epigallocatechin gallate

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Food sources of plant sterols in the EPIC Norfolk population

Klingberg, S., Andersson, H., Mulligan, A. A., Bhaniani, A., Welch, A., Bingham, S. A., Khaw, K., Andersson, S., & Ellegård, L. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602765 · Cited by 96 · see citing works

Regulation of Nrf2, NF-κB, and AP-1 Signaling Pathways by Chemopreventive Agents

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Lycopene in Cancer Prevention and Treatment

Seren, S., Lieberman, R., Bayraktar, U. D., Heath, E. I., Şahin, K., Andiç, F., & Küçük, Ö. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e31804c7120 · Cited by 94 · see citing works

Chemopreventive Functions of Isothiocyanates

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Pattern Recognition Used to Investigate Multivariate Data in Analytical Chemistry

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A Liquid Chromatography−Quadrupole Time-of-Flight (LC−QTOF)-based Metabolomic Approach Reveals New Metabolic Effects of Catechin in Rats Fed High-Fat Diets

Fardet, A., Llorach, R., Martin, J., Besson, C., Lyan, B., Pujos‐Guillot, E., & Scalbert, A. (2008) · Journal of Proteome Research · doi:10.1021/pr800034h · Cited by 73 · see citing works

Metabolomics in Practice: Emerging Knowledge to Guide Future Dietetic Advice toward Individualized Health

German, J. B., Watkins, S. M., & Fay, L. B. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.06.006 · Cited by 73 · see citing works

Metabolomic approach to identifying bioactive compounds in berries: Advances toward fruit nutritional enhancement

Stewart, D., McDougall, G. J., Sungurtas, J., Verrall, S. R., Graham, J., & Martinussen, I. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700056 · Cited by 72 · see citing works

Metabolomics Provide New Insight on the Metabolism of Dietary Phytochemicals in Rats

Fardet, A., Llorach, R., Orsoni, A., Martin, J., Pujos‐Guillot, E., Lapierre, C., & Scalbert, A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.7.1282 · Cited by 70 · see citing works

Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats

Felgines, C., Texier, O., Besson, C., Lyan, B., Lamaison, J., & Scalbert, A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507764772 · Cited by 70 · see citing works

Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects – variability and possible use as biomarkers of polyphenol intake

Mennen, L. I., Sapinho, D., Ito, H., Galan, P., Herçberg, S., & Scalbert, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602744 · Cited by 66 · see citing works

Biomarkers for diet and cancer prevention research: potentials and challenges

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